메뉴 건너뛰기




Volumn 65, Issue 6, 2013, Pages 993-1002

Improved antibody production in Chinese hamster ovary cells by ATF4 overexpression

Author keywords

Activating transcription factor 4; Antibody production; Chinese hamster ovary cells; Specific production rate

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; MESSENGER RNA;

EID: 84891040487     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-013-9631-x     Document Type: Conference Paper
Times cited : (28)

References (41)
  • 1
    • 59849088809 scopus 로고    scopus 로고
    • Diabody-based recombinant formats of humanized IgG-like bispecific antibody with effective retargeting of lymphocytes to tumor cells
    • 10.1097/CJI.0b013e3181849071 10.1097/CJI.0b013e3181849071 1:CAS:528:DC%2BD1cXhtFCrtLzK
    • Asano R, Kawaguchi H, Watanabe Y, Nakanishi T, Umetsu M, Hayashi H, Katayose Y, Unno M, Kudo T, Kumagai I (2008) Diabody-based recombinant formats of humanized IgG-like bispecific antibody with effective retargeting of lymphocytes to tumor cells. J Immunother 31:752-761. doi: 10.1097/CJI. 0b013e3181849071
    • (2008) J Immunother , vol.31 , pp. 752-761
    • Asano, R.1    Kawaguchi, H.2    Watanabe, Y.3    Nakanishi, T.4    Umetsu, M.5    Hayashi, H.6    Katayose, Y.7    Unno, M.8    Kudo, T.9    Kumagai, I.10
  • 2
    • 33746772688 scopus 로고    scopus 로고
    • Mammalian cell factories for efficient and stable protein expression
    • 10.1016/j.copbio.2006.06.005 10.1016/j.copbio.2006.06.005 1:CAS:528:DC%2BD28XotFWluro%3D
    • Barnes LM, Dickson AJ (2006) Mammalian cell factories for efficient and stable protein expression. Curr Opin Biotechnol 17:381-386. doi: 10.1016/j.copbio.2006.06.005
    • (2006) Curr Opin Biotechnol , vol.17 , pp. 381-386
    • Barnes, L.M.1    Dickson, A.J.2
  • 3
    • 0942265267 scopus 로고    scopus 로고
    • Molecular definition of predictive indicators of stable protein expression in recombinant NS0 myeloma cells
    • 10.1002/bit.10893 10.1002/bit.10893 1:CAS:528:DC%2BD2cXitleltA%3D%3D
    • Barnes LM, Bentley CM, Dickson AJ (2004) Molecular definition of predictive indicators of stable protein expression in recombinant NS0 myeloma cells. Biotechnol Bioeng 85:115-121. doi: 10.1002/bit.10893
    • (2004) Biotechnol Bioeng , vol.85 , pp. 115-121
    • Barnes, L.M.1    Bentley, C.M.2    Dickson, A.J.3
  • 4
    • 12344256887 scopus 로고    scopus 로고
    • Building an antibody factory: A job for the unfolded protein response
    • 10.1038/ni1149 10.1038/ni1149 1:CAS:528:DC%2BD2cXhtFSjtr3N
    • Brewer JW, Hendershot LM (2005) Building an antibody factory: a job for the unfolded protein response. Nat Immunol 6:23-29. doi: 10.1038/ni1149
    • (2005) Nat Immunol , vol.6 , pp. 23-29
    • Brewer, J.W.1    Hendershot, L.M.2
  • 5
    • 84870990715 scopus 로고    scopus 로고
    • Recent advances in technology supporting biopharmaceutical production from mammalian cells
    • 10.1007/s00253-012-4451-z 10.1007/s00253-012-4451-z 1:CAS:528: DC%2BC38XhsFGqsbzF
    • Butler M, Meneses-Acosta A (2012) Recent advances in technology supporting biopharmaceutical production from mammalian cells. Appl Microbiol Biotechnol 96:885-894. doi: 10.1007/s00253-012-4451-z
    • (2012) Appl Microbiol Biotechnol , vol.96 , pp. 885-894
    • Butler, M.1    Meneses-Acosta, A.2
  • 6
    • 66449119429 scopus 로고    scopus 로고
    • An unfolded CH1 domain controls the assembly and secretion of IgG antibodies
    • 10.1016/j.molcel.2009.04.028 10.1016/j.molcel.2009.04.028 1:CAS:528:DC%2BD1MXpsFCnu7s%3D
    • Feige MJ, Groscurth S, Marcinowski M, Shimizu Y, Kessler H, Hendershot LM, Buchner J (2009) An unfolded CH1 domain controls the assembly and secretion of IgG antibodies. Mol Cell 34:569-579. doi: 10.1016/j.molcel.2009.04.028
    • (2009) Mol Cell , vol.34 , pp. 569-579
    • Feige, M.J.1    Groscurth, S.2    Marcinowski, M.3    Shimizu, Y.4    Kessler, H.5    Hendershot, L.M.6    Buchner, J.7
  • 7
    • 77950995010 scopus 로고    scopus 로고
    • How antibodies fold
    • 10.1016/j.tibs.2009.11.005 10.1016/j.tibs.2009.11.005 1:CAS:528:DC%2BC3cXksVegs78%3D
    • Feige MJ, Hendershot LM, Buchner J (2010) How antibodies fold. Trends Biochem Sci 35:189-198. doi: 10.1016/j.tibs.2009.11.005
    • (2010) Trends Biochem Sci , vol.35 , pp. 189-198
    • Feige, M.J.1    Hendershot, L.M.2    Buchner, J.3
  • 8
    • 41149118021 scopus 로고    scopus 로고
    • A decrease in cellular energy status stimulates PERK-dependent eIF2alpha phosphorylation and regulates protein synthesis in pancreatic beta-cells
    • 10.1042/BJ20071367 10.1042/BJ20071367 1:CAS:528:DC%2BD1cXisVWgtrc%3D
    • Gomez E, Powell ML, Bevington A, Herbert TP (2008) A decrease in cellular energy status stimulates PERK-dependent eIF2alpha phosphorylation and regulates protein synthesis in pancreatic beta-cells. Biochem J 410:485-493. doi: 10.1042/BJ20071367
    • (2008) Biochem J , vol.410 , pp. 485-493
    • Gomez, E.1    Powell, M.L.2    Bevington, A.3    Herbert, T.P.4
  • 9
    • 0036437307 scopus 로고    scopus 로고
    • Transcriptional and translational control in the Mammalian unfolded protein response
    • 10.1146/annurev.cellbio.18.011402.160624 10.1146/annurev.cellbio.18. 011402.160624 1:CAS:528:DC%2BD38XptVOqs70%3D
    • Harding HP, Calfon M, Urano F, Novoa I, Ron D (2002) Transcriptional and translational control in the Mammalian unfolded protein response. Annu Rev Cell Dev Biol 18:575-599. doi: 10.1146/annurev.cellbio.18.011402.160624
    • (2002) Annu Rev Cell Dev Biol , vol.18 , pp. 575-599
    • Harding, H.P.1    Calfon, M.2    Urano, F.3    Novoa, I.4    Ron, D.5
  • 11
    • 84863629890 scopus 로고    scopus 로고
    • Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae
    • 10.1111/j.1567-1364.2012.00810.x 10.1111/j.1567-1364.2012.00810.x 1:CAS:528:DC%2BC38XhtFegtL7O
    • Hou J, Tyo KE, Liu Z, Petranovic D, Nielsen J (2012) Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae. FEMS Yeast Res 12:491-510. doi: 10.1111/j.1567-1364.2012.00810.x
    • (2012) FEMS Yeast Res , vol.12 , pp. 491-510
    • Hou, J.1    Tyo, K.E.2    Liu, Z.3    Petranovic, D.4    Nielsen, J.5
  • 12
    • 0031055289 scopus 로고    scopus 로고
    • Coexpression of molecular chaperone BiP improves immunoglobulin solubility and IgG secretion from Trichoplusia ni insect cells
    • 10.1021/bp960088d 10.1021/bp960088d 1:CAS:528:DyaK2sXmtVymtw%3D%3D
    • Hsu TA, Betenbaugh MJ (1997) Coexpression of molecular chaperone BiP improves immunoglobulin solubility and IgG secretion from Trichoplusia ni insect cells. Biotechnol Prog 13:96-104. doi: 10.1021/bp960088d
    • (1997) Biotechnol Prog , vol.13 , pp. 96-104
    • Hsu, T.A.1    Betenbaugh, M.J.2
  • 13
    • 79952202624 scopus 로고    scopus 로고
    • Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment
    • 10.1002/btpr.436 10.1002/btpr.436 1:CAS:528:DC%2BC3cXhtl2msLzP
    • Huang YM, Hu W, Rustandi E, Chang K, Yusuf-Makagiansar H, Ryll T (2010) Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment. Biotechnol Prog 26:1400-1410. doi: 10.1002/btpr.436
    • (2010) Biotechnol Prog , vol.26 , pp. 1400-1410
    • Huang, Y.M.1    Hu, W.2    Rustandi, E.3    Chang, K.4    Yusuf-Makagiansar, H.5    Ryll, T.6
  • 14
    • 54249169966 scopus 로고    scopus 로고
    • Engineering of chaperone systems and of the unfolded protein response
    • 10.1007/s10616-008-9157-9 10.1007/s10616-008-9157-9 1:CAS:528: DC%2BD1cXht1Grs7nE
    • Khan SU, Schroder M (2008) Engineering of chaperone systems and of the unfolded protein response. Cytotechnology 57:207-231. doi: 10.1007/s10616-008- 9157-9
    • (2008) Cytotechnology , vol.57 , pp. 207-231
    • Khan, S.U.1    Schroder, M.2
  • 16
    • 34447534486 scopus 로고    scopus 로고
    • Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic beta-cells
    • 10.1152/ajpendo.00620.2006 10.1152/ajpendo.00620.2006 1:CAS:528:DC%2BD2sXmvF2mtro%3D
    • Kitiphongspattana K, Khan TA, Ishii-Schrade K, Roe MW, Philipson LH, Gaskins HR (2007) Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic beta-cells. Am J Physiol Endocrinol Metab 292:E1543-E1554. doi: 10.1152/ajpendo.00620.2006
    • (2007) Am J Physiol Endocrinol Metab , vol.292
    • Kitiphongspattana, K.1    Khan, T.A.2    Ishii-Schrade, K.3    Roe, M.W.4    Philipson, L.H.5    Gaskins, H.R.6
  • 17
    • 84874195223 scopus 로고    scopus 로고
    • Optimized signal peptides for the development of high expressing CHO cell lines
    • 10.1002/bit.24776 10.1002/bit.24776 1:CAS:528:DC%2BC3sXosF2itQ%3D%3D
    • Kober L, Zehe C, Bode J (2013) Optimized signal peptides for the development of high expressing CHO cell lines. Biotechnol Bioeng 110:1164-1173. doi: 10.1002/bit.24776
    • (2013) Biotechnol Bioeng , vol.110 , pp. 1164-1173
    • Kober, L.1    Zehe, C.2    Bode, J.3
  • 18
    • 37549030190 scopus 로고    scopus 로고
    • Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cells
    • 10.1002/bit.21562 10.1002/bit.21562 1:CAS:528:DC%2BD2sXhsVOrsLjL
    • Ku SC, Ng DT, Yap MG, Chao SH (2008) Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cells. Biotechnol Bioeng 99:155-164. doi: 10.1002/bit.21562
    • (2008) Biotechnol Bioeng , vol.99 , pp. 155-164
    • Ku, S.C.1    Ng, D.T.2    Yap, M.G.3    Chao, S.H.4
  • 19
    • 43549125786 scopus 로고    scopus 로고
    • ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo
    • 10.1084/jem.20071460 10.1084/jem.20071460 1:CAS:528:DC%2BD1cXlvFWrsLw%3D
    • Lange PS, Chavez JC, Pinto JT, Coppola G, Sun CW, Townes TM, Geschwind DH, Ratan RR (2008) ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo. J Exp Med 205:1227-1242. doi: 10.1084/jem.20071460
    • (2008) J Exp Med , vol.205 , pp. 1227-1242
    • Lange, P.S.1    Chavez, J.C.2    Pinto, J.T.3    Coppola, G.4    Sun, C.W.5    Townes, T.M.6    Geschwind, D.H.7    Ratan, R.R.8
  • 20
    • 84891826628 scopus 로고    scopus 로고
    • CHO cell engineering to prevent polypeptide aggregation and improve therapeutic protein secretion
    • doi: 10.1016/j.ymben.2012.12.003
    • Le Fourn V, Girod PA, Buceta M, Regamey A, Mermod N (2013) CHO cell engineering to prevent polypeptide aggregation and improve therapeutic protein secretion. Metab Eng. doi: 10.1016/j.ymben.2012.12.003
    • (2013) Metab Eng
    • Le Fourn, V.1    Girod, P.A.2    Buceta, M.3    Regamey, A.4    Mermod, N.5
  • 21
    • 84879418366 scopus 로고    scopus 로고
    • Rapid construction of transgene-amplified CHO cell lines by cell cycle checkpoint engineering
    • doi: 10.1007/s00253-013-4923-9
    • Lee KH, Onitsuka M, Honda K, Ohtake H, Omasa T (2013) Rapid construction of transgene-amplified CHO cell lines by cell cycle checkpoint engineering. Appl Microbiol Biotechnol 97:5731-5741. doi: 10.1007/s00253-013-4923-9
    • (2013) Appl Microbiol Biotechnol , vol.97 , pp. 5731-5741
    • Lee, K.H.1    Onitsuka, M.2    Honda, K.3    Ohtake, H.4    Omasa, T.5
  • 22
    • 35048827454 scopus 로고    scopus 로고
    • Effect of doxycycline-regulated protein disulfide isomerase expression on the specific productivity of recombinant CHO cells: Thrombopoietin and antibody
    • 10.1002/bit.21453 10.1002/bit.21453 1:CAS:528:DC%2BD2sXhtFansLbF
    • Mohan C, Park SH, Chung JY, Lee GM (2007) Effect of doxycycline-regulated protein disulfide isomerase expression on the specific productivity of recombinant CHO cells: thrombopoietin and antibody. Biotechnol Bioeng 98:611-615. doi: 10.1002/bit.21453
    • (2007) Biotechnol Bioeng , vol.98 , pp. 611-615
    • Mohan, C.1    Park, S.H.2    Chung, J.Y.3    Lee, G.M.4
  • 23
    • 84878854474 scopus 로고    scopus 로고
    • Overexpression of CHOP alone and in combination with chaperones is effective in improving antibody production in mammalian cells
    • 10.1007/s00253-012-4365-9 10.1007/s00253-012-4365-9 1:CAS:528: DC%2BC3sXjsFGnt7c%3D
    • Nishimiya D, Mano T, Miyadai K, Yoshida H, Takahashi T (2013) Overexpression of CHOP alone and in combination with chaperones is effective in improving antibody production in mammalian cells. Appl Microbiol Biotechnol 97:2531-2539. doi: 10.1007/s00253-012-4365-9
    • (2013) Appl Microbiol Biotechnol , vol.97 , pp. 2531-2539
    • Nishimiya, D.1    Mano, T.2    Miyadai, K.3    Yoshida, H.4    Takahashi, T.5
  • 25
    • 44449161504 scopus 로고    scopus 로고
    • Improved production of recombinant human antithrombin III in Chinese hamster ovary cells by ATF4 overexpression
    • 10.1002/Bit.21758 10.1002/bit.21758 1:CAS:528:DC%2BD1cXlslCktrg%3D
    • Ohya T, Hayashi T, Kiyama E, Nishii H, Miki H, Kobayashi K, Honda K, Omasa T, Ohtake H (2008) Improved production of recombinant human antithrombin III in Chinese hamster ovary cells by ATF4 overexpression. Biotechnol Bioeng 100:317-324. doi: 10.1002/Bit.21758
    • (2008) Biotechnol Bioeng , vol.100 , pp. 317-324
    • Ohya, T.1    Hayashi, T.2    Kiyama, E.3    Nishii, H.4    Miki, H.5    Kobayashi, K.6    Honda, K.7    Omasa, T.8    Ohtake, H.9
  • 26
    • 0036965795 scopus 로고    scopus 로고
    • Gene amplification and its application in cell and tissue engineering
    • S1389-1723(02)80201-8 1:CAS:528:DC%2BD3sXhsVOnsbw%3D
    • Omasa T (2002) Gene amplification and its application in cell and tissue engineering. J Biosci Bioeng 94:600-605. doi: S1389-1723(02)80201-8
    • (2002) J Biosci Bioeng , vol.94 , pp. 600-605
    • Omasa, T.1
  • 27
    • 58149136228 scopus 로고    scopus 로고
    • Overexpression of GADD34 enhances production of recombinant human antithrombin III in Chinese hamster ovary cells
    • 10.1263/Jbb.106.568 10.1263/jbb.106.568 1:CAS:528:DC%2BD1MXis1ajtb4%3D
    • Omasa T, Takami T, Ohya T, Kiyama E, Hayashi T, Nishii H, Miki H, Kobayashi K, Honda K, Ohtake H (2008) Overexpression of GADD34 enhances production of recombinant human antithrombin III in Chinese hamster ovary cells. J Biosci Bioeng 106:568-573. doi: 10.1263/Jbb.106.568
    • (2008) J Biosci Bioeng , vol.106 , pp. 568-573
    • Omasa, T.1    Takami, T.2    Ohya, T.3    Kiyama, E.4    Hayashi, T.5    Nishii, H.6    Miki, H.7    Kobayashi, K.8    Honda, K.9    Ohtake, H.10
  • 28
    • 77950881484 scopus 로고    scopus 로고
    • Cell engineering and cultivation of Chinese hamster ovary (CHO) cells
    • BSP/CPB/E-Pub/0042-11-3 10.2174/138920110791111960 1:CAS:528: DC%2BC3cXmtFegsrw%3D
    • Omasa T, Onitsuka M, Kim WD (2010) Cell engineering and cultivation of Chinese hamster ovary (CHO) cells. Curr Pharm Biotechnol 11:233-240. doi: BSP/CPB/E-Pub/0042-11-3
    • (2010) Curr Pharm Biotechnol , vol.11 , pp. 233-240
    • Omasa, T.1    Onitsuka, M.2    Kim, W.D.3
  • 29
    • 84858441807 scopus 로고    scopus 로고
    • Enhancement of sialylation on humanized IgG-like bispecific antibody by overexpression of alpha2, 6-sialyltransferase derived from Chinese hamster ovary cells
    • 10.1007/s00253-011-3814-1 10.1007/s00253-011-3814-1 1:CAS:528: DC%2BC38XjvFKrsr4%3D
    • Onitsuka M, Kim WD, Ozaki H, Kawaguchi A, Honda K, Kajiura H, Fujiyama K, Asano R, Kumagai I, Ohtake H, Omasa T (2012) Enhancement of sialylation on humanized IgG-like bispecific antibody by overexpression of alpha2, 6-sialyltransferase derived from Chinese hamster ovary cells. Appl Microbiol Biotechnol 94:69-80. doi: 10.1007/s00253-011-3814-1
    • (2012) Appl Microbiol Biotechnol , vol.94 , pp. 69-80
    • Onitsuka, M.1    Kim, W.D.2    Ozaki, H.3    Kawaguchi, A.4    Honda, K.5    Kajiura, H.6    Fujiyama, K.7    Asano, R.8    Kumagai, I.9    Ohtake, H.10    Omasa, T.11
  • 30
    • 0029347117 scopus 로고
    • Multicopy overexpression of bovine pancreatic trypsin inhibitor saturates the protein folding and secretory capacity of Saccharomyces cerevisiae
    • 10.1006/prep.1995.1071 10.1006/prep.1995.1071 1:CAS:528: DyaK2MXntlSmsrk%3D
    • Parekh R, Forrester K, Wittrup D (1995) Multicopy overexpression of bovine pancreatic trypsin inhibitor saturates the protein folding and secretory capacity of Saccharomyces cerevisiae. Protein Expr Purif 6:537-545. doi: 10.1006/prep.1995.1071
    • (1995) Protein Expr Purif , vol.6 , pp. 537-545
    • Parekh, R.1    Forrester, K.2    Wittrup, D.3
  • 31
    • 77949888224 scopus 로고    scopus 로고
    • Identification and analysis of specific chromosomal region adjacent to exogenous Dhfr-amplified region in Chinese hamster ovary cell genome
    • 10.1016/j.jbiosc.2009.10.019 10.1016/j.jbiosc.2009.10.019 1:CAS:528:DC%2BC3cXpslynurw%3D
    • Park JY, Takagi Y, Yamatani M, Honda K, Asakawa S, Shimizu N, Omasa T, Ohtake H (2010) Identification and analysis of specific chromosomal region adjacent to exogenous Dhfr-amplified region in Chinese hamster ovary cell genome. J Biosci Bioeng 109:504-511. doi: 10.1016/j.jbiosc.2009.10.019
    • (2010) J Biosci Bioeng , vol.109 , pp. 504-511
    • Park, J.Y.1    Takagi, Y.2    Yamatani, M.3    Honda, K.4    Asakawa, S.5    Shimizu, N.6    Omasa, T.7    Ohtake, H.8
  • 32
    • 0026597551 scopus 로고
    • J chain synthesis and secretion of hexameric IgM is differentially regulated by lipopolysaccharide and interleukin 5
    • 10.1073/pnas.89.3.962 1:CAS:528:DyaK38Xht1KmsrY%3D
    • Randall TD, Parkhouse RM, Corley RB (1992) J chain synthesis and secretion of hexameric IgM is differentially regulated by lipopolysaccharide and interleukin 5. Proc Natl Acad Sci USA 89:962-966
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 962-966
    • Randall, T.D.1    Parkhouse, R.M.2    Corley, R.B.3
  • 33
    • 0345960852 scopus 로고    scopus 로고
    • Overexpression of recombinant human antithrombin III in Chinese hamster ovary cells results in malformation and decreased secretion of recombinant protein
    • 10.1002/(SICI)1097-0290(19970320)53:6<547: AID-BIT2>3.0.CO;2-M 10.1002/(SICI)1097-0290(19970320)53:6<547: AID-BIT2>3.0.CO;2-M 1:STN:280:DC%2BD1cvlslOjtw%3D%3D
    • Schroder M, Friedl P (1997) Overexpression of recombinant human antithrombin III in Chinese hamster ovary cells results in malformation and decreased secretion of recombinant protein. Biotechnol Bioeng 53:547-559. doi: 10.1002/(SICI)1097-0290(19970320)53:6<547:AID-BIT2>3.0.CO;2-M
    • (1997) Biotechnol Bioeng , vol.53 , pp. 547-559
    • Schroder, M.1    Friedl, P.2
  • 34
    • 84934442760 scopus 로고    scopus 로고
    • Organization of the functions and components of the endoplasmic reticulum
    • 10.1007/978-0-387-39975-1-4 10.1007/978-0-387-39975-1-4
    • Shimizu Y, Hendershot LM (2007) Organization of the functions and components of the endoplasmic reticulum. Adv Exp Med Biol 594:37-46. doi: 10.1007/978-0-387-39975-1-4
    • (2007) Adv Exp Med Biol , vol.594 , pp. 37-46
    • Shimizu, Y.1    Hendershot, L.M.2
  • 35
    • 68949196897 scopus 로고    scopus 로고
    • Oxidative folding: Cellular strategies for dealing with the resultant equimolar production of reactive oxygen species
    • 10.1089/ARS.2009.2501 10.1089/ars.2009.2501 1:CAS:528: DC%2BD1MXpvFaqs7s%3D
    • Shimizu Y, Hendershot LM (2009) Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species. Antioxid Redox Signal 11:2317-2331. doi: 10.1089/ARS.2009.2501
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2317-2331
    • Shimizu, Y.1    Hendershot, L.M.2
  • 36
    • 33646078130 scopus 로고    scopus 로고
    • Xbp1-based engineering of secretory capacity enhances the productivity of Chinese hamster ovary cells
    • 10.1016/j.ymben.2006.01.006 10.1016/j.ymben.2006.01.006 1:CAS:528:DC%2BD28XjvVGgsbo%3D
    • Tigges M, Fussenegger M (2006) Xbp1-based engineering of secretory capacity enhances the productivity of Chinese hamster ovary cells. Metab Eng 8:264-272. doi: 10.1016/j.ymben.2006.01.006
    • (2006) Metab Eng , vol.8 , pp. 264-272
    • Tigges, M.1    Fussenegger, M.2
  • 37
    • 0842266604 scopus 로고    scopus 로고
    • Oxidative protein folding in eukaryotes: Mechanisms and consequences
    • 10.1083/jcb.200311055 10.1083/jcb.200311055 1:CAS:528: DC%2BD2cXhtVaiu7g%3D
    • Tu BP, Weissman JS (2004) Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol 164:341-346. doi: 10.1083/jcb.200311055
    • (2004) J Cell Biol , vol.164 , pp. 341-346
    • Tu, B.P.1    Weissman, J.S.2
  • 38
    • 4544365911 scopus 로고    scopus 로고
    • Economic aspects of commercial manufacture of biopharmaceuticals
    • 10.1016/j.jbiotec.2004.04.036 10.1016/j.jbiotec.2004.04.036 1:CAS:528:DC%2BD2cXnslOhtLw%3D
    • Werner RG (2004) Economic aspects of commercial manufacture of biopharmaceuticals. J Biotechnol 113:171-182. doi: 10.1016/j.jbiotec.2004.04.036
    • (2004) J Biotechnol , vol.113 , pp. 171-182
    • Werner, R.G.1
  • 39
    • 8344271026 scopus 로고    scopus 로고
    • Production of recombinant protein therapeutics in cultivated mammalian cells
    • 10.1038/nbt1026 10.1038/nbt1026 1:CAS:528:DC%2BD2cXptlSls7k%3D
    • Wurm FM (2004) Production of recombinant protein therapeutics in cultivated mammalian cells. Nat Biotechnol 22:1393-1398. doi: 10.1038/nbt1026
    • (2004) Nat Biotechnol , vol.22 , pp. 1393-1398
    • Wurm, F.M.1
  • 40
    • 0034281451 scopus 로고    scopus 로고
    • Amplified gene location in chromosomal DNA affected recombinant protein production and stability of amplified genes
    • 10.1021/bp000114e 10.1021/bp000114e 1:CAS:528:DC%2BD3cXmsFeisbc%3D
    • Yoshikawa T, Nakanishi F, Ogura Y, Oi D, Omasa T, Katakura Y, Kishimoto M, Suga K (2000) Amplified gene location in chromosomal DNA affected recombinant protein production and stability of amplified genes. Biotechnol Prog 16:710-715. doi: 10.1021/bp000114e
    • (2000) Biotechnol Prog , vol.16 , pp. 710-715
    • Yoshikawa, T.1    Nakanishi, F.2    Ogura, Y.3    Oi, D.4    Omasa, T.5    Katakura, Y.6    Kishimoto, M.7    Suga, K.8
  • 41
    • 81255197729 scopus 로고    scopus 로고
    • The impact of glycosylation on monoclonal antibody conformation and stability
    • 10.4161/mabs.3.6.17922 10.4161/mabs.3.6.17922
    • Zheng K, Bantog C, Bayer R (2011) The impact of glycosylation on monoclonal antibody conformation and stability. MAbs 3:568-576. doi: 10.4161/mabs.3.6.17922
    • (2011) MAbs , vol.3 , pp. 568-576
    • Zheng, K.1    Bantog, C.2    Bayer, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.