Overexpression of CHOP alone and in combination with chaperones is effective in improving antibody production in mammalian cells

Applied Microbiology and Biotechnology

Volumn 97, Issue 6, 2013, Pages 2531-2539

  Nishimiya, Daisuke ^a   Mano, Takashi ^a   Miyadai, Kenji ^a   Yoshida, Hiroko ^a   Takahashi, Tohru ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Antibody production; CHOP; ER chaperone; UPR

Indexed keywords

ANTIBODY PRODUCTION; BIOCHEMICAL CHARACTERISTICS; CHOP; MAMMALIAN CELL LINES; RECOMBINANT ANTIBODY PRODUCTION; THERAPEUTIC PROTEIN; UNFOLDED PROTEIN RESPONSE; UPR;

CELL CULTURE; GENES; PROTEIN FOLDING; RECOMBINANT PROTEINS; TRANSCRIPTION;

ANTIBODIES;

CHAPERONE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153;

ANTIBODY; CYTOLOGY; GENE EXPRESSION; PROTEIN; RECOMBINATION; SECRETION;

ANTIBODY PRODUCTION; ARTICLE; CHO CELL; CHOP GENE; GENE; GENE OVEREXPRESSION; MAMMAL; PROTEIN FOLDING; UNFOLDED PROTEIN RESPONSE;

ANIMALS; ANTIBODIES; BIOTECHNOLOGY; CHO CELLS; CRICETINAE; CRICETULUS; HEAT-SHOCK PROTEINS; RECOMBINANT PROTEINS; TRANSCRIPTION FACTOR CHOP;

MAMMALIA;

EID: 84878854474     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-012-4365-9     Document Type: Article

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