CHO gene expression profiling in biopharmaceutical process analysis and design

Biotechnology and Bioengineering

Volumn 105, Issue 2, 2010, Pages 431-438

  Schaub, Jochen ^a   Clemens, Christoph ^a   Schorn, Peter ^a   Hildebrandt, Tobias ^a   Rust, Werner ^a   Mennerich, Detlev ^a   Kaufmann, Hitto ^a   Schulz, Torsten W ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Biopharmaceuticals; CHO; Gene expression profiling; Mammalian cell culture; Process analysis and design; Rational medium design

Indexed keywords

BASAL MEDIUM; BIO-MOLECULAR; BIOLOGICAL FUNCTIONS; BIOPHARMACEUTICALS; CELLULAR GROWTH; CHO CELL; FED-BATCH PROCESS; GENE EXPRESSION PROFILING; IN-CELL; KNOWLEDGE-BASED APPROACH; LIPID METABOLISMS; MAMMALIAN CELL CULTURE; MAMMALIAN CELLS; MEDIUM DESIGN; METABOLIC PATHWAYS; PROCESS ANALYSIS; PROCESS CONDITION; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; PROCESS UNDERSTANDING; PRODUCT YIELDS; PROTEIN PRODUCTION; RECOMBINANT PROTEIN; SERUM-FREE MEDIA; SYSTEM-LEVEL ANALYSIS; TIME COURSE; TRANSCRIPTOMICS;

ANIMAL CELL CULTURE; BATCH DATA PROCESSING; BIOACTIVITY; CELL DEATH; DESIGN; GENE EXPRESSION; MAMMALS; METABOLISM; OPTIMIZATION; PROCESS CONTROL; PROTEINS;

CELL CULTURE;

IMMUNOGLOBULIN G;

ANIMAL CELL; ANTIBODY TITER; ARTICLE; BIOLOGICAL ACTIVITY; CELL DEATH; CELL GROWTH; CELL LINE; CHO CELL; CONTROLLED STUDY; CULTURE MEDIUM; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; LIPID METABOLISM; NONHUMAN; PROCESS DEVELOPMENT; TRANSCRIPTOMICS;

ANIMALS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; GENE EXPRESSION PROFILING;

MAMMALIA;

EID: 74849136448     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22549     Document Type: Article

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