메뉴 건너뛰기




Volumn 29, Issue 3, 2013, Pages 697-706

A CHO cell line engineered to express XBP1 and ERO1-Lα has increased levels of transient protein expression

Author keywords

Chinese hamster ovary (CHO) cells; Endoplasmic reticulum oxidoreductase (ERO1 L alpha); X box binding protein (XBP 1)

Indexed keywords

BINDING PROTEINS; CHINESE HAMSTER OVARY CELLS; ENDOPLASMIC RETICULUM; HETEROLOGOUS PROTEINS; MULTI-GRAM QUANTITIES; OXIDOREDUCTASES; TRANSIENT GENE EXPRESSIONS; TRANSIENT PROTEIN EXPRESSION;

EID: 84879256909     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1693     Document Type: Article
Times cited : (78)

References (30)
  • 1
    • 56649099058 scopus 로고    scopus 로고
    • Coexpression of acidic fibroblast growth factor enhances specific productivity and antibody titers in transiently transfected HEK293 cells
    • Backliwal G, Hildinger M, Chenuet S, Dejesus M, Wurm FM. Coexpression of acidic fibroblast growth factor enhances specific productivity and antibody titers in transiently transfected HEK293 cells. N Biotechnol. 2008;25:162-166.
    • (2008) N Biotechnol , vol.25 , pp. 162-166
    • Backliwal, G.1    Hildinger, M.2    Chenuet, S.3    Dejesus, M.4    Wurm, F.M.5
  • 2
    • 79955536348 scopus 로고    scopus 로고
    • A simple high-yielding process for transient gene expression in CHO cells
    • Rajendra Y, Kiseljak D, Baldi L, Hacker DL, Wurm FM. A simple high-yielding process for transient gene expression in CHO cells. J Biotechnol. 2011;153:22-26.
    • (2011) J Biotechnol , vol.153 , pp. 22-26
    • Rajendra, Y.1    Kiseljak, D.2    Baldi, L.3    Hacker, D.L.4    Wurm, F.M.5
  • 3
    • 8344271026 scopus 로고    scopus 로고
    • Production of recombinant protein therapeutics in cultivated mammalian cells
    • Wurm FM. Production of recombinant protein therapeutics in cultivated mammalian cells. Nat Biotechnol. 2004;22:1393-1398.
    • (2004) Nat Biotechnol , vol.22 , pp. 1393-1398
    • Wurm, F.M.1
  • 4
    • 34147125994 scopus 로고    scopus 로고
    • Recombinant protein production by large-scale transient gene expression in mammalian cells: state of the art and future perspectives
    • Baldi L, Hacker DL, Adam M, Wurm FM. Recombinant protein production by large-scale transient gene expression in mammalian cells: state of the art and future perspectives. Biotechnol Lett. 2007;29:677-684.
    • (2007) Biotechnol Lett , vol.29 , pp. 677-684
    • Baldi, L.1    Hacker, D.L.2    Adam, M.3    Wurm, F.M.4
  • 5
    • 71549154680 scopus 로고    scopus 로고
    • Recombinat protein production by transient gene transfer into mammalian cells
    • Geisse S, Fux C. Recombinat protein production by transient gene transfer into mammalian cells. Methods Enzymol. 2009;463:233-238.
    • (2009) Methods Enzymol , vol.463 , pp. 233-238
    • Geisse, S.1    Fux, C.2
  • 6
    • 33845935849 scopus 로고    scopus 로고
    • Large-scale transfections of mammalian cells for fast production of recombinant protein
    • Pham PL, Kamen A, Durocher Y. Large-scale transfections of mammalian cells for fast production of recombinant protein. Mol Biotechnol. 2006;34:225-237.
    • (2006) Mol Biotechnol , vol.34 , pp. 225-237
    • Pham, P.L.1    Kamen, A.2    Durocher, Y.3
  • 8
    • 77954458920 scopus 로고    scopus 로고
    • Valproic acid enhances recombinat mRNA and protein levels in transiently transfected Chinese Hamster Ovary cells
    • Wulhfard S, Baldi L, Hacker DL, Wurm F. Valproic acid enhances recombinat mRNA and protein levels in transiently transfected Chinese Hamster Ovary cells. J Biotechnol. 2010;148:128-132.
    • (2010) J Biotechnol , vol.148 , pp. 128-132
    • Wulhfard, S.1    Baldi, L.2    Hacker, D.L.3    Wurm, F.4
  • 9
    • 79955788202 scopus 로고    scopus 로고
    • Manufacturing recombinant proteins in kg-ton quantities using animal cells in bioreactors
    • De Jesus M, Wurm FM. Manufacturing recombinant proteins in kg-ton quantities using animal cells in bioreactors. Eur J Pharm Biopharm. 2011;78:184-188.
    • (2011) Eur J Pharm Biopharm , vol.78 , pp. 184-188
    • De Jesus, M.1    Wurm, F.M.2
  • 10
    • 84862192605 scopus 로고    scopus 로고
    • Identifying bottlenecks in transient and stable production of recombinant monoclonal-antibody sequence variants in Chinese hamster ovary cells
    • Mason M, Sweeney B, Cain K, Stephens P, Shaftstein S. Identifying bottlenecks in transient and stable production of recombinant monoclonal-antibody sequence variants in Chinese hamster ovary cells. Biotechnol Prog. 2012;28:846-855.
    • (2012) Biotechnol Prog , vol.28 , pp. 846-855
    • Mason, M.1    Sweeney, B.2    Cain, K.3    Stephens, P.4    Shaftstein, S.5
  • 11
    • 13544249755 scopus 로고    scopus 로고
    • Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line
    • Borth N, Mattanovich D, Kunert R, Katinger H. Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line. Biotechnol Prog. 2005;21:106-111.
    • (2005) Biotechnol Prog , vol.21 , pp. 106-111
    • Borth, N.1    Mattanovich, D.2    Kunert, R.3    Katinger, H.4
  • 12
    • 78149250499 scopus 로고    scopus 로고
    • Effect of inducible co-overexpression of protein disulfide isomerase and endoplasmic reticulum oxidoreductase on the specific antibody productivity of recombinant Chinese hamster ovary cells
    • Mohan C, Lee GM. Effect of inducible co-overexpression of protein disulfide isomerase and endoplasmic reticulum oxidoreductase on the specific antibody productivity of recombinant Chinese hamster ovary cells. Biotechnol Bioeng. 2010;107:337-346.
    • (2010) Biotechnol Bioeng , vol.107 , pp. 337-346
    • Mohan, C.1    Lee, G.M.2
  • 13
    • 33646078130 scopus 로고    scopus 로고
    • Xbp1-based engineering of secretory capacity enhances the productivity of Chinese hamster ovary cells
    • Tigges M, Fussenegger M. Xbp1-based engineering of secretory capacity enhances the productivity of Chinese hamster ovary cells. Metab Eng. 2006;8:264-272.
    • (2006) Metab Eng , vol.8 , pp. 264-272
    • Tigges, M.1    Fussenegger, M.2
  • 14
    • 44149115663 scopus 로고    scopus 로고
    • An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes
    • Becker E, Florin L, Pfizenmaier K, Kaufmann H. An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes. J Biotechnol. 2008;135:217-223.
    • (2008) J Biotechnol , vol.135 , pp. 217-223
    • Becker, E.1    Florin, L.2    Pfizenmaier, K.3    Kaufmann, H.4
  • 15
    • 53549124125 scopus 로고    scopus 로고
    • Enhancement of transient gene expression and culture viability using Chinese hamster ovary cells overexpressing Bcl-xL
    • Majors BS, Betenbaug MJ, Pederson NE, Chiang GG. Enhancement of transient gene expression and culture viability using Chinese hamster ovary cells overexpressing Bcl-xL. Biotechnol Bioeng. 2008;1001:567-578.
    • (2008) Biotechnol Bioeng , vol.1001 , pp. 567-578
    • Majors, B.S.1    Betenbaug, M.J.2    Pederson, N.E.3    Chiang, G.G.4
  • 16
    • 69149086474 scopus 로고    scopus 로고
    • Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells
    • Majors BS, Betenbaug MJ, Pederson NE, Chiang GG. Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells. Biotechnol Prog. 2009;25:1161-1168.
    • (2009) Biotechnol Prog , vol.25 , pp. 1161-1168
    • Majors, B.S.1    Betenbaug, M.J.2    Pederson, N.E.3    Chiang, G.G.4
  • 17
    • 0142059951 scopus 로고    scopus 로고
    • XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
    • Lee AH, Iwakoshi NN, Glimcher LH. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol. 2003;23:7448-7459.
    • (2003) Mol Cell Biol , vol.23 , pp. 7448-7459
    • Lee, A.H.1    Iwakoshi, N.N.2    Glimcher, L.H.3
  • 18
    • 37549030190 scopus 로고    scopus 로고
    • Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cells
    • Ku SC, Ng DT, Yap MG, Chao SH. Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cells. Biotechnol Bioeng. 2008;99:155-164.
    • (2008) Biotechnol Bioeng , vol.99 , pp. 155-164
    • Ku, S.C.1    Ng, D.T.2    Yap, M.G.3    Chao, S.H.4
  • 19
    • 77950950835 scopus 로고    scopus 로고
    • Regulation of XBP-1 signalling during transient and stable recombinant protein production in CHO cells
    • Ku SCY, Toh PC, Lee YY, Chusainow J, Yap MGS, Chao S. Regulation of XBP-1 signalling during transient and stable recombinant protein production in CHO cells. Biotechnol Prog. 2010;26:517-526.
    • (2010) Biotechnol Prog , vol.26 , pp. 517-526
    • Ku, S.C.Y.1    Toh, P.C.2    Lee, Y.Y.3    Chusainow, J.4    Yap, M.G.S.5    Chao, S.6
  • 20
    • 33745761475 scopus 로고    scopus 로고
    • Disulfide transfer between two conserved cysteine pairs imparts selectivity to protein oxidation by Ero1
    • Sevier CS, Kaiser CA. Disulfide transfer between two conserved cysteine pairs imparts selectivity to protein oxidation by Ero1. Mol Biol Cell. 2006;17:2256-2266.
    • (2006) Mol Biol Cell , vol.17 , pp. 2256-2266
    • Sevier, C.S.1    Kaiser, C.A.2
  • 22
    • 0037517089 scopus 로고    scopus 로고
    • The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha
    • Gess B, Hofbauer KH, Wenger RH, Lohaus C, Meyer H, Kurtz A. The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha. Eur J Biochem. 2003;270:2228-2235.
    • (2003) Eur J Biochem , vol.270 , pp. 2228-2235
    • Gess, B.1    Hofbauer, K.H.2    Wenger, R.H.3    Lohaus, C.4    Meyer, H.5    Kurtz, A.6
  • 23
    • 0034604675 scopus 로고    scopus 로고
    • Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response
    • Pagani M, Fabbri M, Benedetti C, Fassio A, Pilati S, Bulleid NJ, Cabibbo A, Sitia R. Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response. J Biol Chem. 2000;275:23685-23692.
    • (2000) J Biol Chem , vol.275 , pp. 23685-23692
    • Pagani, M.1    Fabbri, M.2    Benedetti, C.3    Fassio, A.4    Pilati, S.5    Bulleid, N.J.6    Cabibbo, A.7    Sitia, R.8
  • 24
    • 0035890070 scopus 로고    scopus 로고
    • Manipulation of oxidative protein folding and PDI redox state in mammalian cells
    • Mezghrani A, Fassio A, Benham A, Simmen T, Braakman I, Sitia R. Manipulation of oxidative protein folding and PDI redox state in mammalian cells. EMBO J. 2001;20:6288-6296.
    • (2001) EMBO J , vol.20 , pp. 6288-6296
    • Mezghrani, A.1    Fassio, A.2    Benham, A.3    Simmen, T.4    Braakman, I.5    Sitia, R.6
  • 25
    • 0019167355 scopus 로고
    • Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
    • Owen WG. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem. 1980;106:207-212.
    • (1980) Anal Biochem , vol.106 , pp. 207-212
    • Owen, W.G.1
  • 26
    • 33845590523 scopus 로고    scopus 로고
    • Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types
    • Kanda Y, Yamada T, Mori K, Okazaki A, Inoue M, Kitajima-Miyama K. Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types. Glycobiology. 2010;17:104-118.
    • (2010) Glycobiology , vol.17 , pp. 104-118
    • Kanda, Y.1    Yamada, T.2    Mori, K.3    Okazaki, A.4    Inoue, M.5    Kitajima-Miyama, K.6
  • 27
    • 77950461287 scopus 로고    scopus 로고
    • Evaluation of a combinatorial cell engineering approach to overcome apoptotic effects in XBP-1(s) expressing cells
    • Becker E, Florin L, Pfizenmaier K, Kaufmann H. Evaluation of a combinatorial cell engineering approach to overcome apoptotic effects in XBP-1(s) expressing cells. J Biotechnol. 2010;146:198-206.
    • (2010) J Biotechnol , vol.146 , pp. 198-206
    • Becker, E.1    Florin, L.2    Pfizenmaier, K.3    Kaufmann, H.4
  • 29
    • 33745038944 scopus 로고    scopus 로고
    • Control of culture environment for improved polyethylenimine-mediated transient production of recombinant monoclonal antibodies by CHO cells
    • Galbraith DJ, Tait AS, Racher AJ, Birch JR, James DC. Control of culture environment for improved polyethylenimine-mediated transient production of recombinant monoclonal antibodies by CHO cells. Biotechnol Prog. 2006;22:753-762.
    • (2006) Biotechnol Prog , vol.22 , pp. 753-762
    • Galbraith, D.J.1    Tait, A.S.2    Racher, A.J.3    Birch, J.R.4    James, D.C.5
  • 30
    • 0032422375 scopus 로고    scopus 로고
    • Optimization of transient gene expression in mammalian cells and potential for scale-up using flow electroporation
    • Parham JH, Iannone Ma, Overton LK, Hutchins JT. Optimization of transient gene expression in mammalian cells and potential for scale-up using flow electroporation. Cytotechnology. 1998;28: 147-155.
    • (1998) Cytotechnology , vol.28 , pp. 147-155
    • Parham, J.H.1    Iannone, M.2    Overton, L.K.3    Hutchins, J.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.