Non-invasive UPR monitoring system and its applications in CHO production cultures

Biotechnology and Bioengineering

Volumn 110, Issue 8, 2013, Pages 2184-2194

  Du, Zhimei ^a   Treiber, David ^a   Mccoy, Rebecca E ^a   Miller, Amanda K ^a   Han, Mei ^a   He, Feng ^a   Domnitz, Sarah ^a   Heath, Carole ^a   Reddy, Pranhitha ^a  

^a AMGEN INC   (United States)

Author keywords

Cell culture; Cell line development; ER stress; Production process

Indexed keywords

CELL LINES; ER STRESS; INTRACELLULAR SIGNALING PATHWAYS; PRODUCTION PROCESS; RECOMBINANT PROTEIN PRODUCTIONS; RECOMBINANT PROTEIN SECRETION; TRANSCRIPTIONAL ACTIVATIONS; UNFOLDED PROTEIN RESPONSE;

CELL MEMBRANES; CLONE CELLS; CLONING; MONITORING; PRODUCTION ENGINEERING; RECOMBINANT PROTEINS; SIGNALING;

CELL CULTURE;

RECOMBINANT PROTEIN;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CELL CULTURE; CELL GROWTH; CELL SURVIVAL; CELL VIABILITY; CHO CELL; CONTROLLED STUDY; CULTURE MEDIUM; FEMALE; FLUORESCENCE; INTRACELLULAR SIGNALING; MOLECULAR CLONING; NON INVASIVE PROCEDURE; NONHUMAN; OSMOLARITY; PHENOTYPE; TRANSCRIPTION INITIATION; UNFOLDED PROTEIN RESPONSE;

ANIMALS; BIOSENSING TECHNIQUES; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETULUS; FLUORESCENCE; GENES, REPORTER; STRESS, PHYSIOLOGICAL; UNFOLDED PROTEIN RESPONSE;

MAMMALIA;

EID: 84879600520     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24877     Document Type: Article

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