ER stress modulates cellular metabolism

Biochemical Journal

Volumn 435, Issue 1, 2011, Pages 285-296

  Wang, Xiaoli ^a,b   Eno, Colins O ^a,b   Altman, Brian J ^c   Zhu, Yanglong ^a,b   Zhao, Guoping ^a,b   Olberding, Kristen E ^a,b   Rathmell, Jeffrey C ^c   Li, Chi ^a,b  

^a UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

^b University of Louisville School of Medicine   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Akt; Autophagy; Bcl 2 protein family; Endoplasmic reticulum (ER); Glucose; Metabolism

Indexed keywords

CARBON 13; GLUCOSE TRANSPORTER 1; INTERLEUKIN 3; PROTEIN BAX; TUNICAMYCIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CYCLE G1 PHASE; CELL DEATH; CELL METABOLISM; CELL SURFACE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENERGY YIELD; GLUCOSE TRANSPORT; HEMATOPOIETIC CELL; METABOLOMICS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

ANIMALS; AUTOPHAGY; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; ENDOPLASMIC RETICULUM; G1 PHASE; GLUCOSE TRANSPORTER TYPE 1; MAGNETIC RESONANCE IMAGING; MEMBRANE POTENTIAL, MITOCHONDRIAL; METABOLOME; MICE; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TUNICAMYCIN;

EID: 79952845160     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101864     Document Type: Article

References (38)

1. Schroder, M. and Kaufman, R. J. (2005) The mammalian unfolded protein response. Annu. Rev. Biochem. 74, 739-789
2. Ron, D. and Walter, P. (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8, 519-529
3. Ogata, M., Hino, S., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K. et al. (2006) Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol. Cell. Biol. 26, 9220-9231
4. Heath-Engel, H. M., Chang, N. C. and Shore, G. C. (2008) The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family. Oncogene 27, 6419-6433
5. He, C. and Klionsky, D. J. (2009) Regulation mechanisms and signaling pathways of autophagy. Annu. Rev. Genet. 43, 67-93
6. Yorimitsu, T., Nair, U., Yang, Z. and Klionsky, D. J. (2006) Endoplasmic reticulum stress triggers autophagy. J. Biol. Chem. 281, 30299-30304
7. Li, J., Ni, M., Lee, B., Barron, E., Hinton, D. R. and Lee, A. S. (2008) The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death Differ. 15, 1460-1471
8. Ding, W. X., Ni, H. M., Gao, W., Hou, Y. F., Melan, M. A., Chen, X., Stolz, D. B., Shao, Z. M. and Yin, X. M. (2007) Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J. Biol. Chem. 282, 4702-4710
9. Buttgereit, F. and Brand, M. D. (1995) A hierarchy of ATP-consuming processes in mammalian cells. Biochem. J. 312, 163-167
10. Schmid, D., Burmester, G. R., Tripmacher, R., Kuhnke, A. and Buttgereit, F. (2000) Bioenergetics of human peripheral blood mononuclear cell metabolism in quiescent, activated, and glucocorticoid-treated states. Biosci. Rep. 20, 289-302
11. Wang, X., Olberding, K. E., White, C. and Li, C. (2011) Bcl-2 proteins regulate ER membrane permeability to luminal proteins during ER stress-induced apoptosis. Cell Death Differ. 18, 38-47
12. Olberding, K. E., Wang, X., Zhu, Y., Pan, J., Rai, S. N. and Li, C. (2010) Actinomycin D synergistically enhances the efficacy of the BH3 mimetic ABT-737 by downregulating Mcl-1 expression. Cancer Biol. Ther. 10, 918-929
13. Li, C., Wang, X., Vais, H., Thompson, C. B., Foskett, J. K. and White, C. (2007) Apoptosis regulation by Bcl-xL modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating. Proc. Natl. Acad. Sci. U.S.A. 104, 12565-12570
14. Lum, J. J., Bauer, D. E., Kong, M., Harris, M. H., Li, C., Lindsten, T. and Thompson, C. B. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120, 237-248
15. 13C stable isotope-resolved metabolomics (SIRM). Mol. Cancer 8, 41
16. Fan, T. W., Kucia, M., Jankowski, K., Higashi, R. M., Ratajczak, J., Ratajczak, M. Z. and Lane, A. N. (2008) Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes. Mol. Cancer 7, 79
17. Lane, A. N., Fan, T. W. and Higashi, R. M. (2008) Isotopomer-based metabolomic analysis by NMR and mass spectrometry. Methods Cell Biol. 84, 541-588
18. Lane, A. N., Fan, T. W. and Higashi, R. M. (2008) Stable isotope-assisted metabolomics in cancer research. IUBMB Life 60, 124-129
19. Kim, I., Xu, W. and Reed, J. C. (2008) Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat. Rev. Drug Discovery 7, 1013-1030
20. Dorner, A. J., Wasley, L. C., Raney, P., Haugejorden, S., Green, M. and Kaufman, R. J. (1990) The stress response in Chinese hamster ovary cells: regulation of ERp72 and protein disulfide isomerase expression and secretion. J. Biol. Chem. 265, 22029-22034
21. Scheepers, A., Joost, H. G. and Schurmann, A. (2004) The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. JPEN J. Parenter. Enteral Nutr. 28, 364-371
22. Zhao, F. Q. and Keating, A. F. (2007) Functional properties and genomics of glucose transporters. Curr. Genomics 8, 113-128
23. Rathmell, J. C., Vander Heiden, M. G., Harris, M. H., Frauwirth, K. A. and Thompson, C. B. (2000) In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol. Cell 6, 683-692
24. Frauwirth, K. A. and Thompson, C. B. (2004) Regulation of T lymphocyte metabolism. J. Immunol. 172, 4661-4665
25. Wieman, H. L., Wofford, J. A. and Rathmell, J. C. (2007) Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol. Biol. Cell 18, 1437-1446
26. Wieman, H. L., Horn, S. R., Jacobs, S. R., Altman, B. J., Kornbluth, S. and Rathmell, J. C. (2009) An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. Biochem. J. 418, 345-367
27. Maciver, N. J., Jacobs, S. R., Wieman, H. L., Wofford, J. A., Coloff, J. L. and Rathmell, J. C. (2008) Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J. Leukocyte Biol. 84, 949-957
28. Zhao, Y., Wieman, H. L., Jacobs, S. R. and Rathmell, J. C. (2008) Mechanisms and methods in glucose metabolism and cell death. Methods Enzymol. 442, 439-457
29. Vander Heiden, M. G., Plas, D. R., Rathmell, J. C., Fox, C. J., Harris, M. H. and Thompson, C. B. (2001) Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol. Cell. Biol. 21, 5899-5912
30. Blokhina, O., Virolainen, E. and Fagerstedt, K. V. (2003) Antioxidants, oxidative damage and oxygen deprivation stress: a review. Ann. Bot. 91, 179-194
31. Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N., Nakano, K., Bartrons, R., Gottlieb, E. and Vousden, K. H. (2006) TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126, 107-120
32. Nutt, L. K., Margolis, S. S., Jensen, M., Herman, C. E., Dunphy, W. G., Rathmell, J. C. and Kornbluth, S. (2005) Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell 123, 89-103 (Pubitemid 41414531)
33. Zhou, R., Vander Heiden, M. G. and Rudin, C. M. (2002) Genotoxic exposure is associated with alterations in glucose uptake and metabolism. Cancer Res. 62, 3515-3520
34. Altman, B. J., Wofford, J. A., Zhao, Y., Coloff, J. L., Ferguson, E. C., Wieman, H. L., Day, A. E., Ilkayeva, O. and Rathmell, J. C. (2009) Autophagy provides nutrients but can lead to CHOP-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis. Mol. Biol. Cell 20, 1180-1191
35. Lin, Y., Wang, Z., Liu, L. and Chen, L (2011) Akt is the downstream target of GRP78 in mediating cisplatin resistance in ER stress-tolerant human lung cancer cells. Lung Cancer 71, 291-297
36. Qin, L., Wang, Z., Tao, L. and Wang, Y. (2010) ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy. Autophagy 6, 239-247
37. Pfaffenbach, K. T. and Lee, A. S. (2010) The critical role of GRP78 in physiologic and pathologic stress. Curr. Opin. Cell Biol., doi:10.1016/j.ceb. 2010.09.007
38. Fang, M., Shen, Z., Huang, S., Zhao, L., Chen, S., Mak, T. W. and Wang, X. (2010) The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell 143, 711-724