Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cell

Biotechnology Progress

Volumn 29, Issue 4, 2013, Pages 980-985

  Hu, Zhilan ^a   Guo, Donglin ^a,b   Yip, Shirley S M ^a   Zhan, Dejin ^a   Misaghi, Shahram ^a   Joly, John C ^a   Snedecor, Bradley R ^a   Shen, Amy Y ^a  

^a GENENTECH INC   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Antibody; CHO cells; CHOK1; DUXB11

Indexed keywords

CHINESE HAMSTER OVARY; CHINESE HAMSTER OVARY CELLS; CHO CELL; CHOK1; DIHYDROFOLATE REDUCTASE; DUXB11; ENDOPLASMIC RETICULUM; THERAPEUTIC MONOCLONAL ANTIBODIES;

ANTIBODIES; BOTTLES; CELL CULTURE; CELL MEMBRANES; CLONING; MONOCLONAL ANTIBODIES; PROTEINS;

CLONE CELLS;

CRICETULUS GRISEUS;

ANTIBODY; DIHYDROFOLATE REDUCTASE; MONOCLONAL ANTIBODY;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHO CELL LINE; CHOK1; CRICETULUS; DUXB11; ENDOPLASMIC RETICULUM; FLOW CYTOMETRY; GENETICS; METABOLISM; MITOCHONDRION;

ANTIBODY; CHO CELLS; CHOK1; DUXB11;

ANIMALS; ANTIBODIES, MONOCLONAL; CELLS, CULTURED; CHO CELLS; CRICETULUS; ENDOPLASMIC RETICULUM; FLOW CYTOMETRY; MITOCHONDRIA; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84881617305     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1730     Document Type: Article

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