-
1
-
-
77951976539
-
Structures of influenza A proteins and insights into antiviral drug targets
-
Das K, Aramini JM, Ma LC, Krug RM, Arnold E. Structures of influenza A proteins and insights into antiviral drug targets. Nat. Struct. Mol. Biol. 17, 530-538 (2010
-
(2010)
Nat. Struct. Mol. Biol
, vol.17
, pp. 530-538
-
-
Das, K.1
Aramini, J.M.2
Ma, L.C.3
Krug, R.M.4
Arnold, E.5
-
2
-
-
84864228530
-
Antivirals targeting influenza A virus
-
Das K. Antivirals targeting influenza A virus. J. Med. Chem. 55, 6263-6277 (2012
-
(2012)
J. Med. Chem
, vol.55
, pp. 6263-6277
-
-
Das, K.1
-
3
-
-
84870834635
-
Identification of a novel splice variant form of the influenza A virus M2ion channel with an antigenically distinct ectodomain
-
Wise HM, Hutchinson EC, Jagger BW et al. Identification of a novel splice variant form of the influenza A virus M2ion channel with an antigenically distinct ectodomain. PLoS Pathog. 8, e1002998 (2012
-
(2012)
PLoS Pathog
, vol.8
-
-
Wise, H.M.1
Hutchinson, E.C.2
Jagger, B.W.3
-
4
-
-
0033783032
-
Receptor binding and membrane fusion in virus entry: The influenza hemagglutinin
-
Skehel JJ, Wiley DC. Receptor binding and membrane fusion in virus entry: The influenza hemagglutinin. Annu. Rev. Biochem. 69, 531-569 (2000
-
(2000)
Annu. Rev. Biochem
, vol.69
, pp. 531-569
-
-
Skehel, J.J.1
Wiley, D.C.2
-
5
-
-
0023666999
-
Influenza virus A pathogenicity: The pivotal role of hemagglutinin
-
Webster RG, Rott R. Influenza virus A pathogenicity: The pivotal role of hemagglutinin. Cell 50, 665-666 (1987
-
(1987)
Cell
, vol.50
, pp. 665-666
-
-
Webster, R.G.1
Rott, R.2
-
6
-
-
77956639165
-
Novel insights into proteolytic cleavage of influenza virus hemagglutinin
-
Bertram S, Glowacka I, Steffen I, Kühl A, Pöhlmann S. Novel insights into proteolytic cleavage of influenza virus hemagglutinin. Rev. Med. Virol. 20, 298-310 (2010
-
(2010)
Rev. Med. Virol
, vol.20
, pp. 298-310
-
-
Bertram, S.1
Glowacka, I.2
Steffen, I.3
Kühl, A.4
Pöhlmann, S.5
-
7
-
-
33845991182
-
Structure and functions of influenza virus neuraminidase
-
Gong J, Xu W, Zhang J. Structure and functions of influenza virus neuraminidase. Curr. Med. Chem. 14, 113-122 (2007
-
(2007)
Curr. Med. Chem
, vol.14
, pp. 113-122
-
-
Gong, J.1
Xu, W.2
Zhang, J.3
-
8
-
-
33750286032
-
Vaccines for seasonal and pandemic influenza
-
Nichol KL, Treanor JJ. Vaccines for seasonal and pandemic influenza. J. Infect. Dis. 194, S111-S118 (2006
-
(2006)
J. Infect. Dis
, vol.194
-
-
Nichol, K.L.1
Treanor, J.J.2
-
9
-
-
33947590474
-
Scientific barriers to developing vaccines against avian influenza viruses
-
Subbarao K, Joseph T. Scientific barriers to developing vaccines against avian influenza viruses. Nat. Rev. Immunol. 7, 267-278 (2007
-
(2007)
Nat. Rev. Immunol
, vol.7
, pp. 267-278
-
-
Subbarao, K.1
Joseph, T.2
-
10
-
-
51449110453
-
Correlates of protection: Novel generations of influenza vaccines
-
Rimmelzwaan GF, McElhaney JE. Correlates of protection: Novel generations of influenza vaccines. Vaccine 26S, D41-D44 (2008
-
(2008)
Vaccine
, vol.26 S
-
-
Rimmelzwaan, G.F.1
McElhaney, J.E.2
-
11
-
-
78549241668
-
Influenza vaccines for the future
-
Lambert LC, Fauci AS. Influenza vaccines for the future. N. Engl. J. Med. 363, 2036-2044 (2010
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 2036-2044
-
-
Lambert, L.C.1
Fauci, A.S.2
-
12
-
-
58249083139
-
Characteristics of arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol
-
Leneva IA, Russell RJ, Boriskin YS, Hay AJ. Characteristics of arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol. Antivir. Res. 81, 132-140 (2009
-
(2009)
Antivir. Res
, vol.81
, pp. 132-140
-
-
Leneva, I.A.1
Russell, R.J.2
Boriskin, Y.S.3
Hay, A.J.4
-
13
-
-
65649130806
-
Synthetic and natural immunomodulators acting as interferon inducers
-
Silin DS, Lyubomska OV, Ershov FI, Frolov VM, Kutsyna GA. Synthetic and natural immunomodulators acting as interferon inducers. Curr. Pharm. Des. 15, 1238-1247 (2009
-
(2009)
Curr. Pharm. Des
, vol.15
, pp. 1238-1247
-
-
Silin, D.S.1
Lyubomska, O.V.2
Ershov, F.I.3
Frolov, V.M.4
Kutsyna, G.A.5
-
14
-
-
0001055177
-
Antiviral activity of 1-Adamantanamine (amantadine
-
Davies WL, Grunert RR, Haff RF et al. Antiviral activity of 1-Adamantanamine (amantadine). Science 144, 862-863 (1964
-
(1964)
Science
, vol.144
, pp. 862-863
-
-
Davies, W.L.1
Grunert, R.R.2
Haff, R.F.3
-
15
-
-
38749151911
-
Structural basis for the function and inhibition of an influenza virus proton channel
-
Stouffer AL, Acharya R, Salom D et al. Structural basis for the function and inhibition of an influenza virus proton channel. Nature 451, 596-599 (2008
-
(2008)
Nature
, vol.451
, pp. 596-599
-
-
Stouffer, A.L.1
Acharya, R.2
Salom, D.3
-
16
-
-
38749106195
-
Structure and mechanism of the M2 proton channel of influenza A virus
-
Schnell JR, Chou JJ. Structure and mechanism of the M2 proton channel of influenza A virus. Nature 451, 591-595 (2008
-
(2008)
Nature
, vol.451
, pp. 591-595
-
-
Schnell, J.R.1
Chou, J.J.2
-
17
-
-
0020629047
-
Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution
-
Varghese JN, Laver WG, Colman PM. Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution. Nature 303, 35-40 (1983
-
(1983)
Nature
, vol.303
, pp. 35-40
-
-
Varghese, J.N.1
Laver, W.G.2
Colman, P.M.3
-
18
-
-
0027287506
-
Rational design of potent sialidase-based inhibitors of influenza virus replication
-
von Itzstein M, Wu WT, Kok GB et al. Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 363, 418-423 (1993
-
(1993)
Nature
, vol.363
, pp. 418-423
-
-
Von Itzstein, M.1
Wu, W.T.2
Kok, G.B.3
-
19
-
-
0034084227
-
Discovery and development of GS 4104 (oseltamivir): An orally active influenza neuraminidase inhibitor
-
Lew W, Chen X, Kim CU. Discovery and development of GS 4104 (oseltamivir): An orally active influenza neuraminidase inhibitor. Curr. Med. Chem. 7, 663-672 (2000
-
(2000)
Curr. Med. Chem
, vol.7
, pp. 663-672
-
-
Lew, W.1
Chen, X.2
Kim, C.U.3
-
20
-
-
25444501243
-
Neuraminidase inhibitors for influenza
-
Moscona A. Neuraminidase inhibitors for influenza. N. Engl. J. Med. 353, 1363-1373 (2005
-
(2005)
N. Engl. J. Med
, vol.353
, pp. 1363-1373
-
-
Moscona, A.1
-
21
-
-
33748437791
-
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design
-
Russell RJ, Haire LF, Stevens DJ et al. The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature 443, 45-49 (2006
-
(2006)
Nature
, vol.443
, pp. 45-49
-
-
Russell, R.J.1
Haire, L.F.2
Stevens, D.J.3
-
22
-
-
36749056771
-
The war against influenza: Discovery and development of sialidase inhibitor
-
von Itzstein M. The war against influenza: Discovery and development of sialidase inhibitor. Nat. Rev. Drug. Discov. 6, 967-974 (2007
-
(2007)
Nat. Rev. Drug. Discov
, vol.6
, pp. 967-974
-
-
Von Itzstein, M.1
-
23
-
-
0026755388
-
Evidence for a sialosyl cation transition-state complex in the reaction of sialidase from influenza virus
-
Chong AKJ, Pegg MS, Taylor NR, von Itzstein M. Evidence for a sialosyl cation transition-state complex in the reaction of sialidase from influenza virus. Eur. J. Biochem. 207, 335-343 (1992
-
(1992)
Eur. J. Biochem
, vol.207
, pp. 335-343
-
-
Chong, A.K.J.1
Pegg, M.S.2
Taylor, N.R.3
Von Itzstein, M.4
-
24
-
-
0028325249
-
Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis
-
Taylor NR, von Itzstein M. Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis. J. Med. Chem. 37, 616-624 (1994
-
(1994)
J. Med. Chem
, vol.37
, pp. 616-624
-
-
Taylor, N.R.1
Von Itzstein, M.2
-
25
-
-
0027930960
-
Structure of influenza virus neuraminidase B/Lee/40 complexed with sialic acid and a dehydro analog at 1.8-Å resolution: Implications for the catalytic mechanism
-
Janakiraman MN, White CL, Laver WG, Air GM, Luo M. Structure of influenza virus neuraminidase B/Lee/40 complexed with sialic acid and a dehydro analog at 1.8-Å resolution: Implications for the catalytic mechanism. Biochemistry 33, 8172-8179 (1994
-
(1994)
Biochemistry
, vol.33
, pp. 8172-8179
-
-
Janakiraman, M.N.1
White, C.L.2
Laver, W.G.3
Air, G.M.4
Luo, M.5
-
26
-
-
0027162942
-
4-Guanidino-2,4-dideoxy-2,3-dehydro-N-Acetyl neuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro
-
Woods JM, Bethell RC, Coates JA et al. 4-Guanidino-2,4-dideoxy-2,3- dehydro-N-Acetyl neuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro. Antimicrob. Agents Chemother. 37, 1473-1479 (1993
-
(1993)
Antimicrob. Agents Chemother
, vol.37
, pp. 1473-1479
-
-
Woods, J.M.1
Bethell, R.C.2
Coates, J.A.3
-
27
-
-
0032710055
-
Zanamivir, a review of its use in influenza
-
Dunn CJ, Goa KL. Zanamivir, a review of its use in influenza. Drugs 58, 761-784 (1999
-
(1999)
Drugs
, vol.58
, pp. 761-784
-
-
Dunn, C.J.1
Goa, K.L.2
-
28
-
-
0036183659
-
Zanamivir, an update of its use in influenza
-
Cheer SM, Wagstaff AJ. Zanamivir, an update of its use in influenza. Drugs 62, 71-106 (2002
-
(2002)
Drugs
, vol.62
, pp. 71-106
-
-
Cheer, S.M.1
Wagstaff, A.J.2
-
29
-
-
0031048319
-
Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, syn thesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity
-
Kim CU, Lew W, Williams MA et al. Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J. Am. Chem. Soc. 119, 681-690 (1997
-
(1997)
J. Am. Chem. Soc
, vol.119
, pp. 681-690
-
-
Kim, C.U.1
Lew, W.2
Williams, M.A.3
-
30
-
-
15444353753
-
Structure-Activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors
-
Kim CU, Lew W, Williams MA et al. Structure-Activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors. J. Med. Chem. 41, 2451-2460 (1998
-
(1998)
J. Med. Chem
, vol.41
, pp. 2451-2460
-
-
Kim, C.U.1
Lew, W.2
Williams, M.A.3
-
31
-
-
0035096415
-
Oseltamivir, a review of its use in influenza
-
McClellan K, Perry CM. Oseltamivir, a review of its use in influenza. Drugs 61, 263-283 (2001
-
(2001)
Drugs
, vol.61
, pp. 263-283
-
-
McClellan, K.1
Perry, C.M.2
-
32
-
-
0029003145
-
Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase
-
Varghese JN, Epa VC, Colman PM. Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase. Protein Sci. 4, 1081-1087 (1995
-
(1995)
Protein Sci
, vol.4
, pp. 1081-1087
-
-
Varghese, J.N.1
Epa, V.C.2
Colman, P.M.3
-
33
-
-
84876313858
-
Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity
-
Kim J-H, Resende R, Wennekes T et al. Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity. Science 340, 71-75 (2013
-
(2013)
Science
, vol.340
, pp. 71-75
-
-
Kim, J.-H.1
Resende, R.2
Wennekes, T.3
-
34
-
-
84874604902
-
Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors
-
Vavrickal CJ, Liu Y, Kiyota H et al. Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors. Nat. Commun. 4, 1491 (2013
-
(2013)
Nat. Commun
, vol.4
, Issue.1491
-
-
Vavrickal, C.J.1
Liu, Y.2
Kiyota, H.3
-
35
-
-
0032996541
-
Pharmacokinetics of zanamivir after intravenous, oral, inhaled or intranasal administration to healthy volunteers
-
Cass LMR, Efthymiopoulos C, Bye A. Pharmacokinetics of zanamivir after intravenous, oral, inhaled or intranasal administration to healthy volunteers. Clin. Pharmacokinet. 36, 1-11 (1999
-
(1999)
Clin. Pharmacokinet
, vol.36
, pp. 1-11
-
-
Cass, L.M.R.1
Efthymiopoulos, C.2
Bye, A.3
-
36
-
-
68649115290
-
Prescription of antiinfluenza drugs for healthy adults: A systematic review and meta-Analysis
-
Burch J, Corbett M, Stock C et al. Prescription of antiinfluenza drugs for healthy adults: A systematic review and meta-Analysis. Lancet Infect. Dis. 9, 537-545 (2009
-
(2009)
Lancet Infect. Dis
, vol.9
, pp. 537-545
-
-
Burch, J.1
Corbett, M.2
Stock, C.3
-
37
-
-
61849118968
-
Global transmission of oseltamivir-resistant influenza
-
Moscona A. Global transmission of oseltamivir-resistant influenza. N. Engl. J. Med. 360, 953-956 (2009
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 953-956
-
-
Moscona, A.1
-
38
-
-
62149112223
-
The evolution of influenza resistance and treatment
-
Weinstock DM, Zuccotti G. The evolution of influenza resistance and treatment. J. Am. Med. Assoc. 301, 1066-1069 (2009
-
(2009)
J. Am. Med. Assoc
, vol.301
, pp. 1066-1069
-
-
Weinstock, D.M.1
Zuccotti, G.2
-
39
-
-
0036016097
-
Peramivir (BCX-1812, RWJ-270201): Potential new therapy for influenza
-
Smee DF, Sidwell RW. Peramivir (BCX-1812, RWJ-270201): Potential new therapy for influenza. Expert Opin. Invest. Drugs 11, 859-869 (2002
-
(2002)
Expert Opin. Invest. Drugs
, vol.11
, pp. 859-869
-
-
Smee, D.F.1
Sidwell, R.W.2
-
40
-
-
79953756895
-
Peramivir: Another tool for influenza treatment?
-
Jain S, Fry AM. Peramivir: Another tool for influenza treatment?. Clin. Infect. Dis. 52, 707-709 (2011
-
(2011)
Clin. Infect. Dis
, vol.52
, pp. 707-709
-
-
Jain, S.1
Fry, A.M.2
-
41
-
-
73349121665
-
The emergency use authorization of peramivir for treatment of 2009 H1N1 influenza
-
Birnkrant D, Cox E. The emergency use authorization of peramivir for treatment of 2009 H1N1 influenza. N. Engl. J. Med. 361, 2204-2207 (2009
-
(2009)
N. Engl. J. Med
, vol.361
, pp. 2204-2207
-
-
Birnkrant, D.1
Cox, E.2
-
42
-
-
59749091876
-
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-Acting anti-influenza virus activity
-
Yamashita M, Tomozawa T, Kakuta M, Tokumitsu A, Nasu H, Kubo S. CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-Acting anti-influenza virus activity. Antimicrob. Agents Chemother. 53, 186-192 (2009
-
(2009)
Antimicrob. Agents Chemother
, vol.53
, pp. 186-192
-
-
Yamashita, M.1
Tomozawa, T.2
Kakuta, M.3
Tokumitsu, A.4
Nasu, H.5
Kubo, S.6
-
43
-
-
70350328007
-
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract
-
Koyama K, Takahashi M, Oitate M et al. CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract. Antimicrob. Agents Chemother. 53, 4845-4851 (2009
-
(2009)
Antimicrob. Agents Chemother
, vol.53
, pp. 4845-4851
-
-
Koyama, K.1
Takahashi, M.2
Oitate, M.3
-
44
-
-
65149099661
-
Synthesis and in vivo influenza virus-inhibitory effect of ester prodrug of 4-guanidino-7-O-methyl-Neu5Ac2en
-
Honda T, Kubo S, Masuda T, Arai M, Kobayashi Y, Yamashita M. Synthesis and in vivo influenza virus-inhibitory effect of ester prodrug of 4-guanidino-7-O-methyl-Neu5Ac2en. Bioorg. Med. Chem. Lett. 19, 2938-2940 (2009
-
(2009)
Bioorg. Med. Chem. Lett
, vol.19
, pp. 2938-2940
-
-
Honda, T.1
Kubo, S.2
Masuda, T.3
Arai, M.4
Kobayashi, Y.5
Yamashita, M.6
-
45
-
-
77149156604
-
Laninamivir prodrug CS-8958, a long-Acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration
-
Kubo S, Tomozawa T, Kakuta M, Tokumitsu A, Yamashita M. Laninamivir prodrug CS-8958, a long-Acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration. Antimicrob. Agents Chemother. 54, 1256-1264 (2010
-
(2010)
Antimicrob. Agents Chemother
, vol.54
, pp. 1256-1264
-
-
Kubo, S.1
Tomozawa, T.2
Kakuta, M.3
Tokumitsu, A.4
Yamashita, M.5
-
46
-
-
80053637254
-
Unique characteristics of long-Acting neuraminidase inhibitor laninamivir octanoate (CS-8958 that explains its long-lasting activity
-
Yamashita M, Hirai T, Kubota K, Kubo S. Unique characteristics of long-Acting neuraminidase inhibitor laninamivir octanoate (CS-8958) that explains its long-lasting activity. Influenza Other Respir. Viruses 5(Suppl. 1), 90-123 (2011
-
(2011)
Influenza Other Respir. Viruses
, vol.5
, Issue.SUPPL. 1
, pp. 90-123
-
-
Yamashita, M.1
Hirai, T.2
Kubota, K.3
Kubo, S.4
-
47
-
-
80053629582
-
Laninamivir octanoate: A new longacting neuraminidase inhibitor for the treatment of influenza
-
Ikematsu H, Kawai N. Laninamivir octanoate: A new longacting neuraminidase inhibitor for the treatment of influenza. Expert Rev. Anti-Infect. Ther. 9, 851-857 (2011
-
(2011)
Expert Rev. Anti-Infect. Ther
, vol.9
, pp. 851-857
-
-
Ikematsu, H.1
Kawai, N.2
-
48
-
-
77957711113
-
Oseltamivir in seasonal, avian H5N1 and pandemic 2009 A/H1N1 influenza
-
Widmer N, Meylan P, Ivanyuk A, Aouri M, Decosterd LA, Buclin T. Oseltamivir in seasonal, avian H5N1 and pandemic 2009 A/H1N1 influenza. Clin. Pharmacokinet. 49, 741-765 (2010
-
(2010)
Clin. Pharmacokinet
, vol.49
, pp. 741-765
-
-
Widmer, N.1
Meylan, P.2
Ivanyuk, A.3
Aouri, M.4
Decosterd, L.A.5
Buclin, T.6
-
49
-
-
0036894107
-
Mechanism by which mutations at His274 alter sensitivity of influenza A Virus N1 neuraminidase to oseltamivir carboxylate and zanamivir
-
Wang MZ, Tai CY, Mendel DB. Mechanism by which mutations at His274 alter sensitivity of influenza A Virus N1 neuraminidase to oseltamivir carboxylate and zanamivir. Antimicrob. Agents Chemother. 46, 3809-3816 (2002
-
(2002)
Antimicrob. Agents Chemother
, vol.46
, pp. 3809-3816
-
-
Wang, M.Z.1
Tai, C.Y.2
Mendel, D.B.3
-
50
-
-
46249111790
-
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
-
Collins PJ, Haire LF, Lin YP et al. Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature 453, 1258-1262 (2008
-
(2008)
Nature
, vol.453
, pp. 1258-1262
-
-
Collins, P.J.1
Haire, L.F.2
Lin, Y.P.3
-
51
-
-
0033897803
-
Resistance of influenza viruses to neuraminidase inhibitors-A review
-
McKimm-Breschkin JL. Resistance of influenza viruses to neuraminidase inhibitors-A review. Antiviral Res. 47, 1-17 (2000
-
(2000)
Antiviral Res
, vol.47
, pp. 1-17
-
-
McKimm-Breschkin, J.L.1
-
52
-
-
78650045655
-
Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase
-
Rudrawar S, Dyason JC, Rameix-Welti MA et al. Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase. Nat. Commun. 1, 113 (2010
-
(2010)
Nat. Commun
, vol.1
, Issue.113
-
-
Rudrawar, S.1
Dyason, J.C.2
Rameix-Welti, M.A.3
-
53
-
-
79960337244
-
Mechanism of 150-cavity formation in influenza neuraminidase
-
Amaro RE, Swift RV, Votapka L, Li WW, Walker RC, Bush, RM. Mechanism of 150-cavity formation in influenza neuraminidase. Nat. Commun. 2, 388 (2011
-
(2011)
Nat. Commun
, vol.2
, pp. 388
-
-
Amaro, R.E.1
Swift, R.V.2
Votapka, L.3
Li, W.W.4
Walker, R.C.5
Bush, R.M.6
-
54
-
-
34347230817
-
Remarkable loop flexibility in avian influenza N1 and its implications for antiviral drug design
-
Amaro RE, Minh DDL, Cheng LS et al. Remarkable loop flexibility in avian influenza N1 and its implications for antiviral drug design. J. Am. Chem. Soc. 129, 7764-7765 (2007
-
(2007)
J. Am. Chem. Soc
, vol.129
, pp. 7764-7765
-
-
Amaro, R.E.1
Minh, D.D.L.2
Cheng, L.S.3
-
55
-
-
67949124553
-
Characterizing loop dynamics and ligand recognition in human-And avian-Type influenza neuraminidases via generalized born molecular dynamics and end-point free energy calculations
-
Amaro RE, Cheng X, Ivanov I, Xu D, McCammon JA. Characterizing loop dynamics and ligand recognition in human-And avian-Type influenza neuraminidases via generalized born molecular dynamics and end-point free energy calculations. J. Am. Chem. Soc. 131, 4702-4709 (2009
-
(2009)
J. Am. Chem. Soc
, vol.131
, pp. 4702-4709
-
-
Amaro, R.E.1
Cheng, X.2
Ivanov, I.3
Xu, D.4
McCammon, J.A.5
-
56
-
-
84873916093
-
Structure-based design and synthesis of C-1-And C-4-modified analogs of zanamivir as neuraminidase inhibitors
-
Feng E, Shin W-J, Zhu X et al. Structure-based design and synthesis of C-1-And C-4-modified analogs of zanamivir as neuraminidase inhibitors. J. Med. Chem. 56, 671-684 (2013
-
(2013)
J. Med. Chem
, vol.56
, pp. 671-684
-
-
Feng, E.1
Shin, W.-J.2
Zhu, X.3
-
57
-
-
34547527847
-
Synthesis and anti-influenza activities of carboxyl alkoxyalkyl esters of 4-guanidino-Neu5Ac2en (zanamivir)
-
Liu Z-y, Wang B, Zhao L-x et al. Synthesis and anti-influenza activities of carboxyl alkoxyalkyl esters of 4-guanidino-Neu5Ac2en (zanamivir). Bioorg. Med. Chem. Lett. 17, 4851-4854 (2007
-
(2007)
Bioorg. Med. Chem. Lett
, vol.17
, pp. 4851-4854
-
-
Liu, Z.-Y.1
Wang, B.2
Zhao, L.-X.3
-
58
-
-
82955173045
-
Enhancing the intestinal membrane permeability of zanamivir: A carrier mediated prodrug approach
-
Gupta SV, Gupta D, Sun J et al. Enhancing the intestinal membrane permeability of zanamivir: A carrier mediated prodrug approach. Mol. Pharm. 8, 2358-2367 (2011
-
(2011)
Mol. Pharm
, vol.8
, pp. 2358-2367
-
-
Gupta, S.V.1
Gupta, D.2
Sun, J.3
-
59
-
-
80455129357
-
A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity
-
Shie JJ, Fang JM, Lai PT et al. A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity. J. Am. Chem. Soc. 133, 17959-17965 (2011
-
(2011)
J. Am. Chem. Soc
, vol.133
, pp. 17959-17965
-
-
Shie, J.J.1
Fang, J.M.2
Lai, P.T.3
-
60
-
-
13344250452
-
Noncovalent binding between guanidinium and anionic groups: Focus on biological-And synthetic-based arginine/guanidinium interactions with phosph[on]ate and sulf[on]ate residues
-
Schug KA, Lindner W. Noncovalent binding between guanidinium and anionic groups: Focus on biological-And synthetic-based arginine/guanidinium interactions with phosph[on]ate and sulf[on]ate residues. Chem. Rev. 105, 67-114 (2005
-
(2005)
Chem. Rev
, vol.105
, pp. 67-114
-
-
Schug, K.A.1
Lindner, W.2
-
61
-
-
54549127383
-
Phosphate coordination and movement of DNA in the Tn5 synaptic complex: Role of the (R)YREK motif
-
Klenchin VA, Czyz A, Goryshin IY et al. Phosphate coordination and movement of DNA in the Tn5 synaptic complex: Role of the (R)YREK motif. Nucl. Acids Res. 36, 5855-5862 (2008
-
(2008)
Nucl. Acids Res
, vol.36
, pp. 5855-5862
-
-
Klenchin, V.A.1
Czyz, A.2
Goryshin, I.Y.3
-
62
-
-
34848839869
-
Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity
-
Shie JJ, Fang JM, Wang SY et al. Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity. J. Am. Chem. Soc. 129, 11892-11893 (2007
-
(2007)
J. Am. Chem. Soc
, vol.129
, pp. 11892-11893
-
-
Shie, J.J.1
Fang, J.M.2
Wang, S.Y.3
-
63
-
-
84867750793
-
Development of oseltamivir phosphonate congeners as antiinfluenza agents
-
Cheng TJR, Weinheimer S, Tarbet EB et al. Development of oseltamivir phosphonate congeners as antiinfluenza agents. J. Med. Chem. 55, 8657-8670 (2012
-
(2012)
J. Med. Chem
, vol.55
, pp. 8657-8670
-
-
Cheng, T.J.R.1
Weinheimer, S.2
Tarbet, E.B.3
-
64
-
-
84867566248
-
Synthesis and evaluation of novel 3-C-Alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility
-
Rudrawar S, Kerry PS, Rameix-Welti MA et al. Synthesis and evaluation of novel 3-C-Alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility. Org. Biomol. Chem. 10, 8628-8639 (2012
-
(2012)
Org. Biomol. Chem
, vol.10
, pp. 8628-8639
-
-
Rudrawar, S.1
Kerry, P.S.2
Rameix-Welti, M.A.3
-
65
-
-
84880574055
-
Novel 3,4-disubstituted-Neu5Ac2en derivatives as probes to investigate flexibility of the influenza virus sialidase 150-loop
-
Rudrawar S, Dyason JC, Maggioni A, Thomson RJ, von Itzstein M. Novel 3,4-disubstituted-Neu5Ac2en derivatives as probes to investigate flexibility of the influenza virus sialidase 150-loop. Bioorg. Med. Chem. 21, 4820-4830 (2013
-
(2013)
Bioorg. Med. Chem
, vol.21
, pp. 4820-4830
-
-
Rudrawar, S.1
Dyason, J.C.2
Maggioni, A.3
Thomson, R.J.4
Von Itzstein, M.5
-
66
-
-
77953138513
-
Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses
-
Wen WH, Wang SY, Tsai KC et al. Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses. Bioorg. Med. Chem. 18, 4074-4084 (2010
-
(2010)
Bioorg. Med. Chem
, vol.18
, pp. 4074-4084
-
-
Wen, W.H.1
Wang, S.Y.2
Tsai, K.C.3
-
67
-
-
84878683463
-
Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-Activities
-
Lin CH, Chang TC, Das A et al. Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-Activities. Org. Biomol. Chem. 11, 3943-3948 (2013
-
(2013)
Org. Biomol. Chem
, vol.11
, pp. 3943-3948
-
-
Lin, C.H.1
Chang, T.C.2
Das, A.3
-
68
-
-
77955235031
-
Enabling the intestinal absorption of highly polar antiviral agents: Ion-pair facilitated membrane permeation of zanamivir heptyl ester and guanidino oseltamivir
-
Miller JM, Dahan A, Gupta D, Varghese S, Amidon GL. Enabling the intestinal absorption of highly polar antiviral agents: Ion-pair facilitated membrane permeation of zanamivir heptyl ester and guanidino oseltamivir. Mol. Pharm. 7, 1223-1234 (2010
-
(2010)
Mol. Pharm
, vol.7
, pp. 1223-1234
-
-
Miller, J.M.1
Dahan, A.2
Gupta, D.3
Varghese, S.4
Amidon, G.L.5
-
69
-
-
0023032232
-
Salt selection for basic drugs
-
Gould PL. Salt selection for basic drugs. Int. J. Pharm. 33, 201-217 (1986
-
(1986)
Int. J. Pharm
, vol.33
, pp. 201-217
-
-
Gould, P.L.1
-
71
-
-
79961172983
-
Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir
-
Liu KC, Lee PS, Wang SY, Cheng YSE, Fang JM, Wong CH. Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir. Bioorg. Med. Chem. 19, 4796-4802 (2011
-
(2011)
Bioorg. Med. Chem
, vol.19
, pp. 4796-4802
-
-
Liu, K.C.1
Lee, P.S.2
Wang, S.Y.3
Cheng, Y.S.E.4
Fang, J.M.5
Wong, C.H.6
-
72
-
-
0029998956
-
Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-guanidino-Neu5Ac2en (GG167) with modified 5-substituents
-
Smith PW, Starkey ID, Howes PD et al. Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-guanidino-Neu5Ac2en (GG167) with modified 5-substituents. Eur. J. Med. Chem. 31, 143-150 (1996
-
(1996)
Eur. J. Med. Chem
, vol.31
, pp. 143-150
-
-
Smith, P.W.1
Starkey, I.D.2
Howes, P.D.3
-
73
-
-
0035848405
-
Sialidase inhibitors related to zanamivir Further SAR studies of 4-Amino-4H-pyran-2-carboxylic acid-6-propylamides
-
Wyatt PG, Coomber BA, Evans DN et al. Sialidase inhibitors related to zanamivir. Further SAR studies of 4-Amino-4H-pyran-2-carboxylic acid-6-propylamides. Bioorg. Med. Chem. Lett. 11, 669-673 (2001
-
(2001)
Bioorg. Med. Chem. Lett
, vol.11
, pp. 669-673
-
-
Wyatt, P.G.1
Coomber, B.A.2
Evans, D.N.3
-
74
-
-
0030572487
-
Novel inhibitors of influenza sialidase related to GG167 Synthesis of 4-Amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza A virus sialidase
-
Sollis SL, Smith PW, Howes PD, Cherry PC, Bethell RC. Novel inhibitors of influenza sialidase related to GG167. Synthesis of 4-Amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza A virus sialidase. Bioorg. Med. Chem. Lett. 6, 1805-1808 (1996
-
(1996)
Bioorg. Med. Chem. Lett
, vol.6
, pp. 1805-1808
-
-
Sollis, S.L.1
Smith, P.W.2
Howes, P.D.3
Cherry, P.C.4
Bethell, R.C.5
-
75
-
-
15644379365
-
Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 1 Discovery, syn thesis, biological activity, and structureactivity relationships of 4-guanidino-And 4-Amino-4Hpyran-6- carboxamides
-
Smith PW, Sollis SL, Howes PD et al. Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structureactivity relationships of 4-guanidino-And 4-Amino-4Hpyran-6-carboxamides. J. Med. Chem. 41, 787-797 (1998
-
(1998)
J. Med. Chem
, vol.41
, pp. 787-797
-
-
Smith, P.W.1
Sollis, S.L.2
Howes, P.D.3
-
76
-
-
0030591866
-
Novel inhibitors of influenza sialidases related to GG167 structure-Activity, crystallographic and molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides
-
Smith PW, Sollis SL, Howes PD et al. Novel inhibitors of influenza sialidases related to GG167 structure-Activity, crystallographic and molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides. Bioorg. Med. Chem. Lett. 6, 2931-2936 (1996
-
(1996)
Bioorg. Med. Chem. Lett
, vol.6
, pp. 2931-2936
-
-
Smith, P.W.1
Sollis, S.L.2
Howes, P.D.3
-
77
-
-
0032510373
-
Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 2 Crystallographic and molecular modeling study of complexes of 4-Amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B
-
Taylor NR, Cleasby A, Singh O et al. Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-Amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B. J. Med. Chem. 41, 798-807 (1998
-
(1998)
J. Med. Chem
, vol.41
, pp. 798-807
-
-
Taylor, N.R.1
Cleasby, A.2
Singh, O.3
-
78
-
-
0037025440
-
Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives
-
Honda T, Masuda T, Yoshida S, Arai M, Kobayashi Y, Yamashita M. Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives. Bioorg. Med. Chem. Lett. 12, 1921-1924 (2002
-
(2002)
Bioorg. Med. Chem. Lett
, vol.12
, pp. 1921-1924
-
-
Honda, T.1
Masuda, T.2
Yoshida, S.3
Arai, M.4
Kobayashi, Y.5
Yamashita, M.6
-
79
-
-
0037025439
-
Synthesis and anti-influenza virus activity of 7-O-Alkylated derivatives related to zanamivir
-
Honda T, Masuda T, Yoshida S, Arai M, Kaneko S, Yamashita M. Synthesis and anti-influenza virus activity of 7-O-Alkylated derivatives related to zanamivir. Bioorg. Med. Chem. Lett. 12, 1925-1928 (2002
-
(2002)
Bioorg. Med. Chem. Lett
, vol.12
, pp. 1925-1928
-
-
Honda, T.1
Masuda, T.2
Yoshida, S.3
Arai, M.4
Kaneko, S.5
Yamashita, M.6
-
80
-
-
0037293018
-
Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir
-
Masuda T, Shibuya S, Arai M et al. Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir. Bioorg. Med. Chem. Lett. 13, 669-673 (2003
-
(2003)
Bioorg. Med. Chem. Lett
, vol.13
, pp. 669-673
-
-
Masuda, T.1
Shibuya, S.2
Arai, M.3
-
81
-
-
0032710063
-
Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-guanidino-Neu5Ac2en (zanamivir) modified in the glycerol side-chain
-
Andrews DM, Cherry PC, Humber DC et al. Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-guanidino-Neu5Ac2en (zanamivir) modified in the glycerol side-chain. Eur. J. Med. Chem. 34, 563-574 (1999
-
(1999)
Eur. J. Med. Chem
, vol.34
, pp. 563-574
-
-
Andrews, D.M.1
Cherry, P.C.2
Humber, D.C.3
-
82
-
-
78751692669
-
Laninamivir and its prodrug CS-8958: Long-Acting neuraminidase inhibitors for the treatment of influenza
-
Yamashita M. Laninamivir and its prodrug, CS-8958: Long-Acting neuraminidase inhibitors for the treatment of influenza. Antivir. Chem. Chemother. 21, 71-84 (2010
-
(2010)
Antivir. Chem. Chemother
, vol.21
, pp. 71-84
-
-
Yamashita, M.1
-
83
-
-
77955448761
-
Clinical pharmacokinetics of laninamivir, a novel long-Acting neuraminidase inhibitor, after single and multiple inhaled doses of its prodrug, CS-8958, in healthy male volunteers
-
Ishizuka H, Yoshiba S, Okabe H, Yoshihara K. Clinical pharmacokinetics of laninamivir, a novel long-Acting neuraminidase inhibitor, after single and multiple inhaled doses of its prodrug, CS-8958, in healthy male volunteers. J. Clin. Pharmacol. 50, 1319-1329 (2010
-
(2010)
J. Clin. Pharmacol
, vol.50
, pp. 1319-1329
-
-
Ishizuka, H.1
Yoshiba, S.2
Okabe, H.3
Yoshihara, K.4
-
84
-
-
0000358206
-
Carbohydrate-protein interactions: Basis of glycobiology
-
Lee YC, Lee RT. Carbohydrate-protein interactions: Basis of glycobiology. Acc. Chem. Res. 28, 321-327 (1995
-
(1995)
Acc. Chem. Res
, vol.28
, pp. 321-327
-
-
Lee, Y.C.1
Lee, R.T.2
-
85
-
-
0028805760
-
Effective inhibitors of hemagglutination by influenza virus synthesized from polymers having active ester groups Insight into mechanism of inhibition
-
Mammen M, Dahmann G, Whitesides GM. Effective inhibitors of hemagglutination by influenza virus synthesized from polymers having active ester groups. Insight into mechanism of inhibition. J. Med. Chem. 38, 4179-4190 (1995
-
(1995)
J. Med. Chem
, vol.38
, pp. 4179-4190
-
-
Mammen, M.1
Dahmann, G.2
Whitesides, G.M.3
-
86
-
-
0032476812
-
Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors
-
Mammen M, Choi SK, Whitesides GM. Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors. Angew. Chem. Int. Ed. 37, 2754-2794 (1998
-
(1998)
Angew. Chem. Int. E.d.
, vol.37
, pp. 2754-2794
-
-
Mammen, M.1
Choi, S.K.2
Whitesides, G.M.3
-
87
-
-
0036462602
-
The cluster glycoside effect
-
Lundquist JJ, Toone EJ. The cluster glycoside effect. Chem. Rev. 102, 555-578 (2002
-
(2002)
Chem. Rev
, vol.102
, pp. 555-578
-
-
Lundquist, J.J.1
Toone, E.J.2
-
88
-
-
9644275467
-
Potent and long-Acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen
-
Macdonald SJF, Watson KG, Cameron R et al. Potent and long-Acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen. Antimicrob. Agents Chemother. 48, 4542-4549 (2004
-
(2004)
Antimicrob. Agents Chemother
, vol.48
, pp. 4542-4549
-
-
Macdonald, S.J.F.1
Watson, K.G.2
Cameron, R.3
-
89
-
-
10744221268
-
Highly potent and long-Acting trimeric and tetrameric inhibitors of influenza virus neuraminidase
-
Watson KG, Cameron R, Fenton RJ et al. Highly potent and long-Acting trimeric and tetrameric inhibitors of influenza virus neuraminidase. Bioorg. Med. Chem. Lett. 14, 1589-1592 (2004
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 1589-1592
-
-
Watson, K.G.1
Cameron, R.2
Fenton, R.J.3
-
90
-
-
20944450978
-
Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza
-
Macdonald SJF, Cameron R, Demaine DA et al. Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza. J. Med. Chem. 48, 2964-2971 (2005
-
(2005)
J. Med. Chem
, vol.48
, pp. 2964-2971
-
-
Macdonald, S.J.F.1
Cameron, R.2
Demaine, D.A.3
-
91
-
-
84876708005
-
Synthesis of 1,4-Triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B
-
Fraser BH, Hamilton S, Krause-Heuer AM et al. Synthesis of 1,4-Triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B. Med. Chem. Commun. 4, 383-386. (2013
-
(2013)
Med. Chem. Commun
, vol.4
, pp. 383-386
-
-
Fraser, B.H.1
Hamilton, S.2
Krause-Heuer, A.M.3
-
92
-
-
0037025441
-
Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives
-
Honda T, Yoshida S, Arai M, Masuda T, Yamashita M. Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives. Bioorg. Med. Chem. Lett. 12, 1929-1932 (2002
-
(2002)
Bioorg. Med. Chem. Lett
, vol.12
, pp. 1929-1932
-
-
Honda, T.1
Yoshida, S.2
Arai, M.3
Masuda, T.4
Yamashita, M.5
-
93
-
-
79251571764
-
Attaching zanamivir to a polymer markedly enhances its activity against drug-resistant strains of influenza A virus
-
Weight AK, Haldar J, Álvarez de Cienfuegos L et al. Attaching zanamivir to a polymer markedly enhances its activity against drug-resistant strains of influenza A virus. J. Pharm. Sci. 100, 831-835 (2011
-
(2011)
J. Pharm. Sci
, vol.100
, pp. 831-835
-
-
Weight, A.K.1
Haldar, J.2
Álvarez De Cienfuegos, L.3
-
94
-
-
84870912652
-
Polymer-Attached zanamivir inhibits synergistically both early and late stages of influenza virus infection
-
Lee CM, Weight AK, Haldar J, Wang L, Klibanov AM, Chen J. Polymer-Attached zanamivir inhibits synergistically both early and late stages of influenza virus infection. Proc. Natl Acad. Sci. USA 109, 20385-20390 (2012
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 20385-20390
-
-
Lee, C.M.1
Weight, A.K.2
Haldar, J.3
Wang, L.4
Klibanov, A.M.5
Chen, J.6
-
95
-
-
77949272751
-
Bifunctional polymeric inhibitors of human influenza A viruses
-
Haldar J, Cienfuegos LÁ, Tumpey TM, Gubareva LV, Chen J, Klibanov AM. Bifunctional polymeric inhibitors of human influenza A viruses. Pharm. Res. 27, 259-263 (2010
-
(2010)
Pharm. Res
, vol.27
, pp. 259-263
-
-
Haldar, J.1
Cienfuegos, L.Á.2
Tumpey, T.M.3
Gubareva, L.V.4
Chen, J.5
Klibanov, A.M.6
-
96
-
-
26944484395
-
One-bead-one-inhibitor-onesubstrate screening of neuraminidase activity
-
Ying L, Gervay-Hague J. One-bead-one-inhibitor-onesubstrate screening of neuraminidase activity. ChemBioChem 6, 1857-1865 (2005
-
(2005)
ChemBioChem
, vol.6
, pp. 1857-1865
-
-
Ying, L.1
Gervay-Hague, J.2
-
97
-
-
84871951522
-
Chemical probes for drug-resistance assessment by binding competition (RABC): Oseltamivir susceptibility evaluation
-
Cheng TJR, Wang SY, Wen WH et al. Chemical probes for drug-resistance assessment by binding competition (RABC): Oseltamivir susceptibility evaluation. Angew. Chem. Int. Ed. 52, 366-370 (2013
-
(2013)
Angew. Chem. Int. E.d.
, vol.52
, pp. 366-370
-
-
Cheng, T.J.R.1
Wang, S.Y.2
Wen, W.H.3
-
98
-
-
77958514624
-
Differential receptor binding affinities of influenza hemagglutinins on glycan arrays
-
Liao HY, Hsu CH, Wang SC et al. Differential receptor binding affinities of influenza hemagglutinins on glycan arrays. J. Am. Chem. Soc. 132, 14849-14856 (2010
-
(2010)
J. Am. Chem. Soc
, vol.132
, pp. 14849-14856
-
-
Liao, H.Y.1
Hsu, C.H.2
Wang, S.C.3
-
99
-
-
14744297285
-
Antibody-Targeted photolysis of bacteria in vivo
-
Berthiaume F, Reiken SR, Toner M, Tompkins RG, Yarmush ML. Antibody-Targeted photolysis of bacteria in vivo. Nat. Biotechnol. 12, 703-706 (1994
-
(1994)
Nat. Biotechnol
, vol.12
, pp. 703-706
-
-
Berthiaume, F.1
Reiken, S.R.2
Toner, M.3
Tompkins, R.G.4
Yarmush, M.L.5
-
101
-
-
3042779537
-
Photodynamic therapy a new antimicrobial approach to infectious disease?
-
Hamblin MR, Hasan T. Photodynamic therapy a new antimicrobial approach to infectious disease?. Photochem. Photobiol. Sci. 3, 436-450 (2004
-
(2004)
Photochem. Photobiol. Sci
, vol.3
, pp. 436-450
-
-
Hamblin, M.R.1
Hasan, T.2
-
102
-
-
68549115376
-
Synergistic effect of zanamivir-porphyrin conjugates on inhibition of neuraminidase and inactivation of influenza virus
-
Wen WH, Lin M, Su CY et al. Synergistic effect of zanamivir-porphyrin conjugates on inhibition of neuraminidase and inactivation of influenza virus. J. Med. Chem. 52, 4903-4910 (2009
-
(2009)
J. Med. Chem
, vol.52
, pp. 4903-4910
-
-
Wen, W.H.1
Lin, M.2
Su, C.Y.3
-
103
-
-
84867389246
-
Enhanced anti-influenza agents conjugated with anti-inflammatory activity
-
Liu KC, Fang JM, Jan JT et al. Enhanced anti-influenza agents conjugated with anti-inflammatory activity. J. Med. Chem. 55, 8493-8501 (2012
-
(2012)
J. Med. Chem
, vol.55
, pp. 8493-8501
-
-
Liu, K.C.1
Fang, J.M.2
Jan, J.T.3
-
104
-
-
34547619982
-
Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection
-
Salomon R, Hoffmann E, Webster RG. Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection. Proc. Natl Acad. Sci. USA 104, 12479-12481 (2007
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 12479-12481
-
-
Salomon, R.1
Hoffmann, E.2
Webster, R.G.3
-
105
-
-
67649126476
-
Confronting the next influenza pandemic with anti-inflammatory and immunomodulatory agents: Why they are needed and how they might work
-
Fedson DS. Confronting the next influenza pandemic with anti-inflammatory and immunomodulatory agents: Why they are needed and how they might work. Influenza Other Respir. Viruses 3, 129-142 (2009
-
(2009)
Influenza Other Respir. Viruses
, vol.3
, pp. 129-142
-
-
Fedson, D.S.1
-
106
-
-
0141520652
-
Combination anti-inflammatory and antiviral therapy of influenza in a cotton rat model
-
Ottolini M, Blanco J, Porter D, Peterson L, Curtis S, Prince G. Combination anti-inflammatory and antiviral therapy of influenza in a cotton rat model. Pediatr. Pulmonol. 36, 290-294 (2003
-
(2003)
Pediatr. Pulmonol
, vol.36
, pp. 290-294
-
-
Ottolini, M.1
Blanco, J.2
Porter, D.3
Peterson, L.4
Curtis, S.5
Prince, G.6
-
107
-
-
45849109558
-
Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus
-
Zheng BJ, Chan KW, Lin YP et al. Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus. Proc. Natl Acad. Sci. USA 105, 8091-8096 (2008
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 8091-8096
-
-
Zheng, B.J.1
Chan, K.W.2
Lin, Y.P.3
-
108
-
-
84865584158
-
Recent advances in neuraminidase inhibitor development as anti-influenza drugs
-
Feng E, Ye D, Li J et al. Recent advances in neuraminidase inhibitor development as anti-influenza drugs. ChemMedChem 7, 1527-1536 (2012
-
(2012)
ChemMedChem
, vol.7
, pp. 1527-1536
-
-
Feng, E.1
Ye, D.2
Li, J.3
-
109
-
-
62749130228
-
Efficient synthesis of highly active phospha-isosteres of the influenza neuraminidase inhibitor oseltamivir
-
Carbain B, Collins PJ, Callum L et al. Efficient synthesis of highly active phospha-isosteres of the influenza neuraminidase inhibitor oseltamivir. ChemMedChem 4, 335-337 (2009
-
(2009)
ChemMedChem
, vol.4
, pp. 335-337
-
-
Carbain, B.1
Collins, P.J.2
Callum, L.3
-
110
-
-
67650432594
-
Galactose-conjugates of the oseltamivir pharmacophore-new tools for the characterization of influenza virus neuraminidases
-
Carbain B, Martin SR, Collins PJ, Hitchcock PB, Streicher H. Galactose-conjugates of the oseltamivir pharmacophore-new tools for the characterization of influenza virus neuraminidases. Org. Biomol. Chem. 7, 2570-2575 (2009
-
(2009)
Org. Biomol. Chem
, vol.7
, pp. 2570-2575
-
-
Carbain, B.1
Martin, S.R.2
Collins, P.J.3
Hitchcock, P.B.4
Streicher, H.5
-
111
-
-
79960995604
-
Biotin-, fluorescein-And 'clickable' conjugates of phosphaoseltamivir as probes for the influenza virus which utilize selective binding to the neuraminidase
-
Stanley M, Martin SR, Birge M, Carbain B, Streicher H. Biotin-, fluorescein-And 'clickable' conjugates of phosphaoseltamivir as probes for the influenza virus which utilize selective binding to the neuraminidase. Org. Biomol. Chem. 9, 5625-5629 (2011
-
(2011)
Org. Biomol. Chem
, vol.9
, pp. 5625-5629
-
-
Stanley, M.1
Martin, S.R.2
Birge, M.3
Carbain, B.4
Streicher, H.5
-
112
-
-
84873325984
-
Increasing oral absorption of polar neuraminidase inhibitors: A prodrug transporter approach applied to oseltamivir analogue
-
Gupta D, Varghese Gupta S, Dahan A et al. Increasing oral absorption of polar neuraminidase inhibitors: A prodrug transporter approach applied to oseltamivir analogue. Mol. Pharmacol. 10, 512-522 (2013
-
(2013)
Mol. Pharmacol
, vol.10
, pp. 512-522
-
-
Gupta, D.1
Varghese Gupta, S.2
Dahan, A.3
-
113
-
-
84894094139
-
Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A
-
Schade D, Kotthaus J, Riebling L et al. Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A. J. Med. Chem. 57, 759-769 (2014
-
(2014)
J. Med. Chem
, vol.57
, pp. 759-769
-
-
Schade, D.1
Kotthaus, J.2
Riebling, L.3
-
114
-
-
77958509160
-
Carbocycles related to oseltamivir as influenza virus group-1-specific neuraminidase inhibitors Binding to N1 enzymes in the context of virus-like particles
-
Mohan S, McAtamney S, Haselhorst T, von Itzstein M, Pinto BM. Carbocycles related to oseltamivir as influenza virus group-1-specific neuraminidase inhibitors. Binding to N1 enzymes in the context of virus-like particles. J. Med. Chem. 53, 7377-7391 (2010
-
(2010)
J. Med. Chem
, vol.53
, pp. 7377-7391
-
-
Mohan, S.1
McAtamney, S.2
Haselhorst, T.3
Von Itzstein, M.4
Pinto, B.M.5
-
115
-
-
79955471904
-
Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes
-
Albohy A, Mohan S, Zheng RB, Pinto BM, Cairo CW. Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes. Bioorg. Med. Chem. 19, 2817-2822 (2011
-
(2011)
Bioorg. Med. Chem
, vol.19
, pp. 2817-2822
-
-
Albohy, A.1
Mohan, S.2
Zheng, R.B.3
Pinto, B.M.4
Cairo, C.W.5
-
116
-
-
18644382945
-
Design, syn thesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm
-
Hanessian S, Wang J, Montgomery D et al. Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm. Bioorg. Med. Chem. Lett. 12, 3425-3429 (2002
-
(2002)
Bioorg. Med. Chem. Lett
, vol.12
, pp. 3425-3429
-
-
Hanessian, S.1
Wang, J.2
Montgomery, D.3
-
117
-
-
65549152349
-
Design and synthesis of immobilized tamiflu analog on resin for affinity chromatography
-
Kimura Y, Yamatsugu K, Kanai M, Echigo N, Kuzuhara T, Shibasaki M. Design and synthesis of immobilized tamiflu analog on resin for affinity chromatography. Tetrahedron Lett. 50, 3205-3208 (2009
-
(2009)
Tetrahedron Lett
, vol.50
, pp. 3205-3208
-
-
Kimura, Y.1
Yamatsugu, K.2
Kanai, M.3
Echigo, N.4
Kuzuhara, T.5
Shibasaki, M.6
-
118
-
-
65649103683
-
A novel small-molecule inhibitor of the avian influenza H5N1 virus determined through computational screening against the neuraminidase
-
An J, Lee DCW, Law AHY et al. A novel small-molecule inhibitor of the avian influenza H5N1 virus determined through computational screening against the neuraminidase. J. Med. Chem. 52, 2667-2672 (2009
-
(2009)
J. Med. Chem
, vol.52
, pp. 2667-2672
-
-
An, J.1
Lee, D.C.W.2
Law, A.H.Y.3
-
119
-
-
42949174825
-
Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting
-
Li F, Maag H, Alfredson T. Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting. J. Pharm. Sci. 97, 1109-1134 (2008
-
(2008)
J. Pharm. Sci
, vol.97
, pp. 1109-1134
-
-
Li, F.1
Maag, H.2
Alfredson, T.3
-
120
-
-
0032853619
-
Intestinal peptide transport systems and oral drug availability
-
Yang CY, Dantzig AH, Pidgeon C. Intestinal peptide transport systems and oral drug availability. Pharm. Res. 16, 1331-1343 (1999.
-
(1999)
Pharm. Res
, vol.16
, pp. 1331-1343
-
-
Yang, C.Y.1
Dantzig, A.H.2
Pidgeon, C.3
|