메뉴 건너뛰기




Volumn 6, Issue 7, 2014, Pages 757-774

From neuraminidase inhibitors to conjugates: A step towards better anti-influenza drugs?

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; ANTI INFLUENZA AGENT; ANTIINFLAMMATORY AGENT; ANTIVIRUS AGENT; ARBIDOL; INFLUENZA VACCINE; LANINAMIVIR; LANINAMIVIR OCTANOATE; OSELTAMIVIR; PERAMIVIR; PROTEIN M2; RIMANTADINE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; ZANAMIVIR; ENZYME INHIBITOR; SIALIDASE;

EID: 84903183021     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.14.30     Document Type: Review
Times cited : (30)

References (120)
  • 1
    • 77951976539 scopus 로고    scopus 로고
    • Structures of influenza A proteins and insights into antiviral drug targets
    • Das K, Aramini JM, Ma LC, Krug RM, Arnold E. Structures of influenza A proteins and insights into antiviral drug targets. Nat. Struct. Mol. Biol. 17, 530-538 (2010
    • (2010) Nat. Struct. Mol. Biol , vol.17 , pp. 530-538
    • Das, K.1    Aramini, J.M.2    Ma, L.C.3    Krug, R.M.4    Arnold, E.5
  • 2
    • 84864228530 scopus 로고    scopus 로고
    • Antivirals targeting influenza A virus
    • Das K. Antivirals targeting influenza A virus. J. Med. Chem. 55, 6263-6277 (2012
    • (2012) J. Med. Chem , vol.55 , pp. 6263-6277
    • Das, K.1
  • 3
    • 84870834635 scopus 로고    scopus 로고
    • Identification of a novel splice variant form of the influenza A virus M2ion channel with an antigenically distinct ectodomain
    • Wise HM, Hutchinson EC, Jagger BW et al. Identification of a novel splice variant form of the influenza A virus M2ion channel with an antigenically distinct ectodomain. PLoS Pathog. 8, e1002998 (2012
    • (2012) PLoS Pathog , vol.8
    • Wise, H.M.1    Hutchinson, E.C.2    Jagger, B.W.3
  • 4
    • 0033783032 scopus 로고    scopus 로고
    • Receptor binding and membrane fusion in virus entry: The influenza hemagglutinin
    • Skehel JJ, Wiley DC. Receptor binding and membrane fusion in virus entry: The influenza hemagglutinin. Annu. Rev. Biochem. 69, 531-569 (2000
    • (2000) Annu. Rev. Biochem , vol.69 , pp. 531-569
    • Skehel, J.J.1    Wiley, D.C.2
  • 5
    • 0023666999 scopus 로고
    • Influenza virus A pathogenicity: The pivotal role of hemagglutinin
    • Webster RG, Rott R. Influenza virus A pathogenicity: The pivotal role of hemagglutinin. Cell 50, 665-666 (1987
    • (1987) Cell , vol.50 , pp. 665-666
    • Webster, R.G.1    Rott, R.2
  • 6
    • 77956639165 scopus 로고    scopus 로고
    • Novel insights into proteolytic cleavage of influenza virus hemagglutinin
    • Bertram S, Glowacka I, Steffen I, Kühl A, Pöhlmann S. Novel insights into proteolytic cleavage of influenza virus hemagglutinin. Rev. Med. Virol. 20, 298-310 (2010
    • (2010) Rev. Med. Virol , vol.20 , pp. 298-310
    • Bertram, S.1    Glowacka, I.2    Steffen, I.3    Kühl, A.4    Pöhlmann, S.5
  • 7
    • 33845991182 scopus 로고    scopus 로고
    • Structure and functions of influenza virus neuraminidase
    • Gong J, Xu W, Zhang J. Structure and functions of influenza virus neuraminidase. Curr. Med. Chem. 14, 113-122 (2007
    • (2007) Curr. Med. Chem , vol.14 , pp. 113-122
    • Gong, J.1    Xu, W.2    Zhang, J.3
  • 8
    • 33750286032 scopus 로고    scopus 로고
    • Vaccines for seasonal and pandemic influenza
    • Nichol KL, Treanor JJ. Vaccines for seasonal and pandemic influenza. J. Infect. Dis. 194, S111-S118 (2006
    • (2006) J. Infect. Dis , vol.194
    • Nichol, K.L.1    Treanor, J.J.2
  • 9
    • 33947590474 scopus 로고    scopus 로고
    • Scientific barriers to developing vaccines against avian influenza viruses
    • Subbarao K, Joseph T. Scientific barriers to developing vaccines against avian influenza viruses. Nat. Rev. Immunol. 7, 267-278 (2007
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 267-278
    • Subbarao, K.1    Joseph, T.2
  • 10
    • 51449110453 scopus 로고    scopus 로고
    • Correlates of protection: Novel generations of influenza vaccines
    • Rimmelzwaan GF, McElhaney JE. Correlates of protection: Novel generations of influenza vaccines. Vaccine 26S, D41-D44 (2008
    • (2008) Vaccine , vol.26 S
    • Rimmelzwaan, G.F.1    McElhaney, J.E.2
  • 11
    • 78549241668 scopus 로고    scopus 로고
    • Influenza vaccines for the future
    • Lambert LC, Fauci AS. Influenza vaccines for the future. N. Engl. J. Med. 363, 2036-2044 (2010
    • (2010) N. Engl. J. Med , vol.363 , pp. 2036-2044
    • Lambert, L.C.1    Fauci, A.S.2
  • 12
    • 58249083139 scopus 로고    scopus 로고
    • Characteristics of arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol
    • Leneva IA, Russell RJ, Boriskin YS, Hay AJ. Characteristics of arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol. Antivir. Res. 81, 132-140 (2009
    • (2009) Antivir. Res , vol.81 , pp. 132-140
    • Leneva, I.A.1    Russell, R.J.2    Boriskin, Y.S.3    Hay, A.J.4
  • 14
    • 0001055177 scopus 로고
    • Antiviral activity of 1-Adamantanamine (amantadine
    • Davies WL, Grunert RR, Haff RF et al. Antiviral activity of 1-Adamantanamine (amantadine). Science 144, 862-863 (1964
    • (1964) Science , vol.144 , pp. 862-863
    • Davies, W.L.1    Grunert, R.R.2    Haff, R.F.3
  • 15
    • 38749151911 scopus 로고    scopus 로고
    • Structural basis for the function and inhibition of an influenza virus proton channel
    • Stouffer AL, Acharya R, Salom D et al. Structural basis for the function and inhibition of an influenza virus proton channel. Nature 451, 596-599 (2008
    • (2008) Nature , vol.451 , pp. 596-599
    • Stouffer, A.L.1    Acharya, R.2    Salom, D.3
  • 16
    • 38749106195 scopus 로고    scopus 로고
    • Structure and mechanism of the M2 proton channel of influenza A virus
    • Schnell JR, Chou JJ. Structure and mechanism of the M2 proton channel of influenza A virus. Nature 451, 591-595 (2008
    • (2008) Nature , vol.451 , pp. 591-595
    • Schnell, J.R.1    Chou, J.J.2
  • 17
    • 0020629047 scopus 로고
    • Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution
    • Varghese JN, Laver WG, Colman PM. Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution. Nature 303, 35-40 (1983
    • (1983) Nature , vol.303 , pp. 35-40
    • Varghese, J.N.1    Laver, W.G.2    Colman, P.M.3
  • 18
    • 0027287506 scopus 로고
    • Rational design of potent sialidase-based inhibitors of influenza virus replication
    • von Itzstein M, Wu WT, Kok GB et al. Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 363, 418-423 (1993
    • (1993) Nature , vol.363 , pp. 418-423
    • Von Itzstein, M.1    Wu, W.T.2    Kok, G.B.3
  • 19
    • 0034084227 scopus 로고    scopus 로고
    • Discovery and development of GS 4104 (oseltamivir): An orally active influenza neuraminidase inhibitor
    • Lew W, Chen X, Kim CU. Discovery and development of GS 4104 (oseltamivir): An orally active influenza neuraminidase inhibitor. Curr. Med. Chem. 7, 663-672 (2000
    • (2000) Curr. Med. Chem , vol.7 , pp. 663-672
    • Lew, W.1    Chen, X.2    Kim, C.U.3
  • 20
    • 25444501243 scopus 로고    scopus 로고
    • Neuraminidase inhibitors for influenza
    • Moscona A. Neuraminidase inhibitors for influenza. N. Engl. J. Med. 353, 1363-1373 (2005
    • (2005) N. Engl. J. Med , vol.353 , pp. 1363-1373
    • Moscona, A.1
  • 21
    • 33748437791 scopus 로고    scopus 로고
    • The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design
    • Russell RJ, Haire LF, Stevens DJ et al. The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature 443, 45-49 (2006
    • (2006) Nature , vol.443 , pp. 45-49
    • Russell, R.J.1    Haire, L.F.2    Stevens, D.J.3
  • 22
    • 36749056771 scopus 로고    scopus 로고
    • The war against influenza: Discovery and development of sialidase inhibitor
    • von Itzstein M. The war against influenza: Discovery and development of sialidase inhibitor. Nat. Rev. Drug. Discov. 6, 967-974 (2007
    • (2007) Nat. Rev. Drug. Discov , vol.6 , pp. 967-974
    • Von Itzstein, M.1
  • 23
    • 0026755388 scopus 로고
    • Evidence for a sialosyl cation transition-state complex in the reaction of sialidase from influenza virus
    • Chong AKJ, Pegg MS, Taylor NR, von Itzstein M. Evidence for a sialosyl cation transition-state complex in the reaction of sialidase from influenza virus. Eur. J. Biochem. 207, 335-343 (1992
    • (1992) Eur. J. Biochem , vol.207 , pp. 335-343
    • Chong, A.K.J.1    Pegg, M.S.2    Taylor, N.R.3    Von Itzstein, M.4
  • 24
    • 0028325249 scopus 로고
    • Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis
    • Taylor NR, von Itzstein M. Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis. J. Med. Chem. 37, 616-624 (1994
    • (1994) J. Med. Chem , vol.37 , pp. 616-624
    • Taylor, N.R.1    Von Itzstein, M.2
  • 25
    • 0027930960 scopus 로고
    • Structure of influenza virus neuraminidase B/Lee/40 complexed with sialic acid and a dehydro analog at 1.8-Å resolution: Implications for the catalytic mechanism
    • Janakiraman MN, White CL, Laver WG, Air GM, Luo M. Structure of influenza virus neuraminidase B/Lee/40 complexed with sialic acid and a dehydro analog at 1.8-Å resolution: Implications for the catalytic mechanism. Biochemistry 33, 8172-8179 (1994
    • (1994) Biochemistry , vol.33 , pp. 8172-8179
    • Janakiraman, M.N.1    White, C.L.2    Laver, W.G.3    Air, G.M.4    Luo, M.5
  • 26
    • 0027162942 scopus 로고
    • 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-Acetyl neuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro
    • Woods JM, Bethell RC, Coates JA et al. 4-Guanidino-2,4-dideoxy-2,3- dehydro-N-Acetyl neuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro. Antimicrob. Agents Chemother. 37, 1473-1479 (1993
    • (1993) Antimicrob. Agents Chemother , vol.37 , pp. 1473-1479
    • Woods, J.M.1    Bethell, R.C.2    Coates, J.A.3
  • 27
    • 0032710055 scopus 로고    scopus 로고
    • Zanamivir, a review of its use in influenza
    • Dunn CJ, Goa KL. Zanamivir, a review of its use in influenza. Drugs 58, 761-784 (1999
    • (1999) Drugs , vol.58 , pp. 761-784
    • Dunn, C.J.1    Goa, K.L.2
  • 28
    • 0036183659 scopus 로고    scopus 로고
    • Zanamivir, an update of its use in influenza
    • Cheer SM, Wagstaff AJ. Zanamivir, an update of its use in influenza. Drugs 62, 71-106 (2002
    • (2002) Drugs , vol.62 , pp. 71-106
    • Cheer, S.M.1    Wagstaff, A.J.2
  • 29
    • 0031048319 scopus 로고    scopus 로고
    • Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, syn thesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity
    • Kim CU, Lew W, Williams MA et al. Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J. Am. Chem. Soc. 119, 681-690 (1997
    • (1997) J. Am. Chem. Soc , vol.119 , pp. 681-690
    • Kim, C.U.1    Lew, W.2    Williams, M.A.3
  • 30
    • 15444353753 scopus 로고    scopus 로고
    • Structure-Activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors
    • Kim CU, Lew W, Williams MA et al. Structure-Activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors. J. Med. Chem. 41, 2451-2460 (1998
    • (1998) J. Med. Chem , vol.41 , pp. 2451-2460
    • Kim, C.U.1    Lew, W.2    Williams, M.A.3
  • 31
    • 0035096415 scopus 로고    scopus 로고
    • Oseltamivir, a review of its use in influenza
    • McClellan K, Perry CM. Oseltamivir, a review of its use in influenza. Drugs 61, 263-283 (2001
    • (2001) Drugs , vol.61 , pp. 263-283
    • McClellan, K.1    Perry, C.M.2
  • 32
    • 0029003145 scopus 로고
    • Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase
    • Varghese JN, Epa VC, Colman PM. Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase. Protein Sci. 4, 1081-1087 (1995
    • (1995) Protein Sci , vol.4 , pp. 1081-1087
    • Varghese, J.N.1    Epa, V.C.2    Colman, P.M.3
  • 33
    • 84876313858 scopus 로고    scopus 로고
    • Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity
    • Kim J-H, Resende R, Wennekes T et al. Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity. Science 340, 71-75 (2013
    • (2013) Science , vol.340 , pp. 71-75
    • Kim, J.-H.1    Resende, R.2    Wennekes, T.3
  • 34
    • 84874604902 scopus 로고    scopus 로고
    • Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors
    • Vavrickal CJ, Liu Y, Kiyota H et al. Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors. Nat. Commun. 4, 1491 (2013
    • (2013) Nat. Commun , vol.4 , Issue.1491
    • Vavrickal, C.J.1    Liu, Y.2    Kiyota, H.3
  • 35
    • 0032996541 scopus 로고    scopus 로고
    • Pharmacokinetics of zanamivir after intravenous, oral, inhaled or intranasal administration to healthy volunteers
    • Cass LMR, Efthymiopoulos C, Bye A. Pharmacokinetics of zanamivir after intravenous, oral, inhaled or intranasal administration to healthy volunteers. Clin. Pharmacokinet. 36, 1-11 (1999
    • (1999) Clin. Pharmacokinet , vol.36 , pp. 1-11
    • Cass, L.M.R.1    Efthymiopoulos, C.2    Bye, A.3
  • 36
    • 68649115290 scopus 로고    scopus 로고
    • Prescription of antiinfluenza drugs for healthy adults: A systematic review and meta-Analysis
    • Burch J, Corbett M, Stock C et al. Prescription of antiinfluenza drugs for healthy adults: A systematic review and meta-Analysis. Lancet Infect. Dis. 9, 537-545 (2009
    • (2009) Lancet Infect. Dis , vol.9 , pp. 537-545
    • Burch, J.1    Corbett, M.2    Stock, C.3
  • 37
    • 61849118968 scopus 로고    scopus 로고
    • Global transmission of oseltamivir-resistant influenza
    • Moscona A. Global transmission of oseltamivir-resistant influenza. N. Engl. J. Med. 360, 953-956 (2009
    • (2009) N. Engl. J. Med , vol.360 , pp. 953-956
    • Moscona, A.1
  • 38
    • 62149112223 scopus 로고    scopus 로고
    • The evolution of influenza resistance and treatment
    • Weinstock DM, Zuccotti G. The evolution of influenza resistance and treatment. J. Am. Med. Assoc. 301, 1066-1069 (2009
    • (2009) J. Am. Med. Assoc , vol.301 , pp. 1066-1069
    • Weinstock, D.M.1    Zuccotti, G.2
  • 39
    • 0036016097 scopus 로고    scopus 로고
    • Peramivir (BCX-1812, RWJ-270201): Potential new therapy for influenza
    • Smee DF, Sidwell RW. Peramivir (BCX-1812, RWJ-270201): Potential new therapy for influenza. Expert Opin. Invest. Drugs 11, 859-869 (2002
    • (2002) Expert Opin. Invest. Drugs , vol.11 , pp. 859-869
    • Smee, D.F.1    Sidwell, R.W.2
  • 40
    • 79953756895 scopus 로고    scopus 로고
    • Peramivir: Another tool for influenza treatment?
    • Jain S, Fry AM. Peramivir: Another tool for influenza treatment?. Clin. Infect. Dis. 52, 707-709 (2011
    • (2011) Clin. Infect. Dis , vol.52 , pp. 707-709
    • Jain, S.1    Fry, A.M.2
  • 41
    • 73349121665 scopus 로고    scopus 로고
    • The emergency use authorization of peramivir for treatment of 2009 H1N1 influenza
    • Birnkrant D, Cox E. The emergency use authorization of peramivir for treatment of 2009 H1N1 influenza. N. Engl. J. Med. 361, 2204-2207 (2009
    • (2009) N. Engl. J. Med , vol.361 , pp. 2204-2207
    • Birnkrant, D.1    Cox, E.2
  • 42
    • 59749091876 scopus 로고    scopus 로고
    • CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-Acting anti-influenza virus activity
    • Yamashita M, Tomozawa T, Kakuta M, Tokumitsu A, Nasu H, Kubo S. CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-Acting anti-influenza virus activity. Antimicrob. Agents Chemother. 53, 186-192 (2009
    • (2009) Antimicrob. Agents Chemother , vol.53 , pp. 186-192
    • Yamashita, M.1    Tomozawa, T.2    Kakuta, M.3    Tokumitsu, A.4    Nasu, H.5    Kubo, S.6
  • 43
    • 70350328007 scopus 로고    scopus 로고
    • CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract
    • Koyama K, Takahashi M, Oitate M et al. CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract. Antimicrob. Agents Chemother. 53, 4845-4851 (2009
    • (2009) Antimicrob. Agents Chemother , vol.53 , pp. 4845-4851
    • Koyama, K.1    Takahashi, M.2    Oitate, M.3
  • 44
    • 65149099661 scopus 로고    scopus 로고
    • Synthesis and in vivo influenza virus-inhibitory effect of ester prodrug of 4-guanidino-7-O-methyl-Neu5Ac2en
    • Honda T, Kubo S, Masuda T, Arai M, Kobayashi Y, Yamashita M. Synthesis and in vivo influenza virus-inhibitory effect of ester prodrug of 4-guanidino-7-O-methyl-Neu5Ac2en. Bioorg. Med. Chem. Lett. 19, 2938-2940 (2009
    • (2009) Bioorg. Med. Chem. Lett , vol.19 , pp. 2938-2940
    • Honda, T.1    Kubo, S.2    Masuda, T.3    Arai, M.4    Kobayashi, Y.5    Yamashita, M.6
  • 45
    • 77149156604 scopus 로고    scopus 로고
    • Laninamivir prodrug CS-8958, a long-Acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration
    • Kubo S, Tomozawa T, Kakuta M, Tokumitsu A, Yamashita M. Laninamivir prodrug CS-8958, a long-Acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration. Antimicrob. Agents Chemother. 54, 1256-1264 (2010
    • (2010) Antimicrob. Agents Chemother , vol.54 , pp. 1256-1264
    • Kubo, S.1    Tomozawa, T.2    Kakuta, M.3    Tokumitsu, A.4    Yamashita, M.5
  • 46
    • 80053637254 scopus 로고    scopus 로고
    • Unique characteristics of long-Acting neuraminidase inhibitor laninamivir octanoate (CS-8958 that explains its long-lasting activity
    • Yamashita M, Hirai T, Kubota K, Kubo S. Unique characteristics of long-Acting neuraminidase inhibitor laninamivir octanoate (CS-8958) that explains its long-lasting activity. Influenza Other Respir. Viruses 5(Suppl. 1), 90-123 (2011
    • (2011) Influenza Other Respir. Viruses , vol.5 , Issue.SUPPL. 1 , pp. 90-123
    • Yamashita, M.1    Hirai, T.2    Kubota, K.3    Kubo, S.4
  • 47
    • 80053629582 scopus 로고    scopus 로고
    • Laninamivir octanoate: A new longacting neuraminidase inhibitor for the treatment of influenza
    • Ikematsu H, Kawai N. Laninamivir octanoate: A new longacting neuraminidase inhibitor for the treatment of influenza. Expert Rev. Anti-Infect. Ther. 9, 851-857 (2011
    • (2011) Expert Rev. Anti-Infect. Ther , vol.9 , pp. 851-857
    • Ikematsu, H.1    Kawai, N.2
  • 49
    • 0036894107 scopus 로고    scopus 로고
    • Mechanism by which mutations at His274 alter sensitivity of influenza A Virus N1 neuraminidase to oseltamivir carboxylate and zanamivir
    • Wang MZ, Tai CY, Mendel DB. Mechanism by which mutations at His274 alter sensitivity of influenza A Virus N1 neuraminidase to oseltamivir carboxylate and zanamivir. Antimicrob. Agents Chemother. 46, 3809-3816 (2002
    • (2002) Antimicrob. Agents Chemother , vol.46 , pp. 3809-3816
    • Wang, M.Z.1    Tai, C.Y.2    Mendel, D.B.3
  • 50
    • 46249111790 scopus 로고    scopus 로고
    • Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
    • Collins PJ, Haire LF, Lin YP et al. Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature 453, 1258-1262 (2008
    • (2008) Nature , vol.453 , pp. 1258-1262
    • Collins, P.J.1    Haire, L.F.2    Lin, Y.P.3
  • 51
    • 0033897803 scopus 로고    scopus 로고
    • Resistance of influenza viruses to neuraminidase inhibitors-A review
    • McKimm-Breschkin JL. Resistance of influenza viruses to neuraminidase inhibitors-A review. Antiviral Res. 47, 1-17 (2000
    • (2000) Antiviral Res , vol.47 , pp. 1-17
    • McKimm-Breschkin, J.L.1
  • 52
    • 78650045655 scopus 로고    scopus 로고
    • Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase
    • Rudrawar S, Dyason JC, Rameix-Welti MA et al. Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase. Nat. Commun. 1, 113 (2010
    • (2010) Nat. Commun , vol.1 , Issue.113
    • Rudrawar, S.1    Dyason, J.C.2    Rameix-Welti, M.A.3
  • 54
    • 34347230817 scopus 로고    scopus 로고
    • Remarkable loop flexibility in avian influenza N1 and its implications for antiviral drug design
    • Amaro RE, Minh DDL, Cheng LS et al. Remarkable loop flexibility in avian influenza N1 and its implications for antiviral drug design. J. Am. Chem. Soc. 129, 7764-7765 (2007
    • (2007) J. Am. Chem. Soc , vol.129 , pp. 7764-7765
    • Amaro, R.E.1    Minh, D.D.L.2    Cheng, L.S.3
  • 55
    • 67949124553 scopus 로고    scopus 로고
    • Characterizing loop dynamics and ligand recognition in human-And avian-Type influenza neuraminidases via generalized born molecular dynamics and end-point free energy calculations
    • Amaro RE, Cheng X, Ivanov I, Xu D, McCammon JA. Characterizing loop dynamics and ligand recognition in human-And avian-Type influenza neuraminidases via generalized born molecular dynamics and end-point free energy calculations. J. Am. Chem. Soc. 131, 4702-4709 (2009
    • (2009) J. Am. Chem. Soc , vol.131 , pp. 4702-4709
    • Amaro, R.E.1    Cheng, X.2    Ivanov, I.3    Xu, D.4    McCammon, J.A.5
  • 56
    • 84873916093 scopus 로고    scopus 로고
    • Structure-based design and synthesis of C-1-And C-4-modified analogs of zanamivir as neuraminidase inhibitors
    • Feng E, Shin W-J, Zhu X et al. Structure-based design and synthesis of C-1-And C-4-modified analogs of zanamivir as neuraminidase inhibitors. J. Med. Chem. 56, 671-684 (2013
    • (2013) J. Med. Chem , vol.56 , pp. 671-684
    • Feng, E.1    Shin, W.-J.2    Zhu, X.3
  • 57
    • 34547527847 scopus 로고    scopus 로고
    • Synthesis and anti-influenza activities of carboxyl alkoxyalkyl esters of 4-guanidino-Neu5Ac2en (zanamivir)
    • Liu Z-y, Wang B, Zhao L-x et al. Synthesis and anti-influenza activities of carboxyl alkoxyalkyl esters of 4-guanidino-Neu5Ac2en (zanamivir). Bioorg. Med. Chem. Lett. 17, 4851-4854 (2007
    • (2007) Bioorg. Med. Chem. Lett , vol.17 , pp. 4851-4854
    • Liu, Z.-Y.1    Wang, B.2    Zhao, L.-X.3
  • 58
    • 82955173045 scopus 로고    scopus 로고
    • Enhancing the intestinal membrane permeability of zanamivir: A carrier mediated prodrug approach
    • Gupta SV, Gupta D, Sun J et al. Enhancing the intestinal membrane permeability of zanamivir: A carrier mediated prodrug approach. Mol. Pharm. 8, 2358-2367 (2011
    • (2011) Mol. Pharm , vol.8 , pp. 2358-2367
    • Gupta, S.V.1    Gupta, D.2    Sun, J.3
  • 59
    • 80455129357 scopus 로고    scopus 로고
    • A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity
    • Shie JJ, Fang JM, Lai PT et al. A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity. J. Am. Chem. Soc. 133, 17959-17965 (2011
    • (2011) J. Am. Chem. Soc , vol.133 , pp. 17959-17965
    • Shie, J.J.1    Fang, J.M.2    Lai, P.T.3
  • 60
    • 13344250452 scopus 로고    scopus 로고
    • Noncovalent binding between guanidinium and anionic groups: Focus on biological-And synthetic-based arginine/guanidinium interactions with phosph[on]ate and sulf[on]ate residues
    • Schug KA, Lindner W. Noncovalent binding between guanidinium and anionic groups: Focus on biological-And synthetic-based arginine/guanidinium interactions with phosph[on]ate and sulf[on]ate residues. Chem. Rev. 105, 67-114 (2005
    • (2005) Chem. Rev , vol.105 , pp. 67-114
    • Schug, K.A.1    Lindner, W.2
  • 61
    • 54549127383 scopus 로고    scopus 로고
    • Phosphate coordination and movement of DNA in the Tn5 synaptic complex: Role of the (R)YREK motif
    • Klenchin VA, Czyz A, Goryshin IY et al. Phosphate coordination and movement of DNA in the Tn5 synaptic complex: Role of the (R)YREK motif. Nucl. Acids Res. 36, 5855-5862 (2008
    • (2008) Nucl. Acids Res , vol.36 , pp. 5855-5862
    • Klenchin, V.A.1    Czyz, A.2    Goryshin, I.Y.3
  • 62
    • 34848839869 scopus 로고    scopus 로고
    • Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity
    • Shie JJ, Fang JM, Wang SY et al. Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity. J. Am. Chem. Soc. 129, 11892-11893 (2007
    • (2007) J. Am. Chem. Soc , vol.129 , pp. 11892-11893
    • Shie, J.J.1    Fang, J.M.2    Wang, S.Y.3
  • 63
    • 84867750793 scopus 로고    scopus 로고
    • Development of oseltamivir phosphonate congeners as antiinfluenza agents
    • Cheng TJR, Weinheimer S, Tarbet EB et al. Development of oseltamivir phosphonate congeners as antiinfluenza agents. J. Med. Chem. 55, 8657-8670 (2012
    • (2012) J. Med. Chem , vol.55 , pp. 8657-8670
    • Cheng, T.J.R.1    Weinheimer, S.2    Tarbet, E.B.3
  • 64
    • 84867566248 scopus 로고    scopus 로고
    • Synthesis and evaluation of novel 3-C-Alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility
    • Rudrawar S, Kerry PS, Rameix-Welti MA et al. Synthesis and evaluation of novel 3-C-Alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility. Org. Biomol. Chem. 10, 8628-8639 (2012
    • (2012) Org. Biomol. Chem , vol.10 , pp. 8628-8639
    • Rudrawar, S.1    Kerry, P.S.2    Rameix-Welti, M.A.3
  • 65
    • 84880574055 scopus 로고    scopus 로고
    • Novel 3,4-disubstituted-Neu5Ac2en derivatives as probes to investigate flexibility of the influenza virus sialidase 150-loop
    • Rudrawar S, Dyason JC, Maggioni A, Thomson RJ, von Itzstein M. Novel 3,4-disubstituted-Neu5Ac2en derivatives as probes to investigate flexibility of the influenza virus sialidase 150-loop. Bioorg. Med. Chem. 21, 4820-4830 (2013
    • (2013) Bioorg. Med. Chem , vol.21 , pp. 4820-4830
    • Rudrawar, S.1    Dyason, J.C.2    Maggioni, A.3    Thomson, R.J.4    Von Itzstein, M.5
  • 66
    • 77953138513 scopus 로고    scopus 로고
    • Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses
    • Wen WH, Wang SY, Tsai KC et al. Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses. Bioorg. Med. Chem. 18, 4074-4084 (2010
    • (2010) Bioorg. Med. Chem , vol.18 , pp. 4074-4084
    • Wen, W.H.1    Wang, S.Y.2    Tsai, K.C.3
  • 67
    • 84878683463 scopus 로고    scopus 로고
    • Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-Activities
    • Lin CH, Chang TC, Das A et al. Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-Activities. Org. Biomol. Chem. 11, 3943-3948 (2013
    • (2013) Org. Biomol. Chem , vol.11 , pp. 3943-3948
    • Lin, C.H.1    Chang, T.C.2    Das, A.3
  • 68
    • 77955235031 scopus 로고    scopus 로고
    • Enabling the intestinal absorption of highly polar antiviral agents: Ion-pair facilitated membrane permeation of zanamivir heptyl ester and guanidino oseltamivir
    • Miller JM, Dahan A, Gupta D, Varghese S, Amidon GL. Enabling the intestinal absorption of highly polar antiviral agents: Ion-pair facilitated membrane permeation of zanamivir heptyl ester and guanidino oseltamivir. Mol. Pharm. 7, 1223-1234 (2010
    • (2010) Mol. Pharm , vol.7 , pp. 1223-1234
    • Miller, J.M.1    Dahan, A.2    Gupta, D.3    Varghese, S.4    Amidon, G.L.5
  • 69
    • 0023032232 scopus 로고
    • Salt selection for basic drugs
    • Gould PL. Salt selection for basic drugs. Int. J. Pharm. 33, 201-217 (1986
    • (1986) Int. J. Pharm , vol.33 , pp. 201-217
    • Gould, P.L.1
  • 72
    • 0029998956 scopus 로고    scopus 로고
    • Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-guanidino-Neu5Ac2en (GG167) with modified 5-substituents
    • Smith PW, Starkey ID, Howes PD et al. Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-guanidino-Neu5Ac2en (GG167) with modified 5-substituents. Eur. J. Med. Chem. 31, 143-150 (1996
    • (1996) Eur. J. Med. Chem , vol.31 , pp. 143-150
    • Smith, P.W.1    Starkey, I.D.2    Howes, P.D.3
  • 73
    • 0035848405 scopus 로고    scopus 로고
    • Sialidase inhibitors related to zanamivir Further SAR studies of 4-Amino-4H-pyran-2-carboxylic acid-6-propylamides
    • Wyatt PG, Coomber BA, Evans DN et al. Sialidase inhibitors related to zanamivir. Further SAR studies of 4-Amino-4H-pyran-2-carboxylic acid-6-propylamides. Bioorg. Med. Chem. Lett. 11, 669-673 (2001
    • (2001) Bioorg. Med. Chem. Lett , vol.11 , pp. 669-673
    • Wyatt, P.G.1    Coomber, B.A.2    Evans, D.N.3
  • 74
    • 0030572487 scopus 로고    scopus 로고
    • Novel inhibitors of influenza sialidase related to GG167 Synthesis of 4-Amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza A virus sialidase
    • Sollis SL, Smith PW, Howes PD, Cherry PC, Bethell RC. Novel inhibitors of influenza sialidase related to GG167. Synthesis of 4-Amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza A virus sialidase. Bioorg. Med. Chem. Lett. 6, 1805-1808 (1996
    • (1996) Bioorg. Med. Chem. Lett , vol.6 , pp. 1805-1808
    • Sollis, S.L.1    Smith, P.W.2    Howes, P.D.3    Cherry, P.C.4    Bethell, R.C.5
  • 75
    • 15644379365 scopus 로고    scopus 로고
    • Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 1 Discovery, syn thesis, biological activity, and structureactivity relationships of 4-guanidino-And 4-Amino-4Hpyran-6- carboxamides
    • Smith PW, Sollis SL, Howes PD et al. Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structureactivity relationships of 4-guanidino-And 4-Amino-4Hpyran-6-carboxamides. J. Med. Chem. 41, 787-797 (1998
    • (1998) J. Med. Chem , vol.41 , pp. 787-797
    • Smith, P.W.1    Sollis, S.L.2    Howes, P.D.3
  • 76
    • 0030591866 scopus 로고    scopus 로고
    • Novel inhibitors of influenza sialidases related to GG167 structure-Activity, crystallographic and molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides
    • Smith PW, Sollis SL, Howes PD et al. Novel inhibitors of influenza sialidases related to GG167 structure-Activity, crystallographic and molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides. Bioorg. Med. Chem. Lett. 6, 2931-2936 (1996
    • (1996) Bioorg. Med. Chem. Lett , vol.6 , pp. 2931-2936
    • Smith, P.W.1    Sollis, S.L.2    Howes, P.D.3
  • 77
    • 0032510373 scopus 로고    scopus 로고
    • Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 2 Crystallographic and molecular modeling study of complexes of 4-Amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B
    • Taylor NR, Cleasby A, Singh O et al. Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-Amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B. J. Med. Chem. 41, 798-807 (1998
    • (1998) J. Med. Chem , vol.41 , pp. 798-807
    • Taylor, N.R.1    Cleasby, A.2    Singh, O.3
  • 78
    • 0037025440 scopus 로고    scopus 로고
    • Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives
    • Honda T, Masuda T, Yoshida S, Arai M, Kobayashi Y, Yamashita M. Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives. Bioorg. Med. Chem. Lett. 12, 1921-1924 (2002
    • (2002) Bioorg. Med. Chem. Lett , vol.12 , pp. 1921-1924
    • Honda, T.1    Masuda, T.2    Yoshida, S.3    Arai, M.4    Kobayashi, Y.5    Yamashita, M.6
  • 79
    • 0037025439 scopus 로고    scopus 로고
    • Synthesis and anti-influenza virus activity of 7-O-Alkylated derivatives related to zanamivir
    • Honda T, Masuda T, Yoshida S, Arai M, Kaneko S, Yamashita M. Synthesis and anti-influenza virus activity of 7-O-Alkylated derivatives related to zanamivir. Bioorg. Med. Chem. Lett. 12, 1925-1928 (2002
    • (2002) Bioorg. Med. Chem. Lett , vol.12 , pp. 1925-1928
    • Honda, T.1    Masuda, T.2    Yoshida, S.3    Arai, M.4    Kaneko, S.5    Yamashita, M.6
  • 80
    • 0037293018 scopus 로고    scopus 로고
    • Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir
    • Masuda T, Shibuya S, Arai M et al. Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir. Bioorg. Med. Chem. Lett. 13, 669-673 (2003
    • (2003) Bioorg. Med. Chem. Lett , vol.13 , pp. 669-673
    • Masuda, T.1    Shibuya, S.2    Arai, M.3
  • 81
    • 0032710063 scopus 로고    scopus 로고
    • Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-guanidino-Neu5Ac2en (zanamivir) modified in the glycerol side-chain
    • Andrews DM, Cherry PC, Humber DC et al. Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-guanidino-Neu5Ac2en (zanamivir) modified in the glycerol side-chain. Eur. J. Med. Chem. 34, 563-574 (1999
    • (1999) Eur. J. Med. Chem , vol.34 , pp. 563-574
    • Andrews, D.M.1    Cherry, P.C.2    Humber, D.C.3
  • 82
    • 78751692669 scopus 로고    scopus 로고
    • Laninamivir and its prodrug CS-8958: Long-Acting neuraminidase inhibitors for the treatment of influenza
    • Yamashita M. Laninamivir and its prodrug, CS-8958: Long-Acting neuraminidase inhibitors for the treatment of influenza. Antivir. Chem. Chemother. 21, 71-84 (2010
    • (2010) Antivir. Chem. Chemother , vol.21 , pp. 71-84
    • Yamashita, M.1
  • 83
    • 77955448761 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of laninamivir, a novel long-Acting neuraminidase inhibitor, after single and multiple inhaled doses of its prodrug, CS-8958, in healthy male volunteers
    • Ishizuka H, Yoshiba S, Okabe H, Yoshihara K. Clinical pharmacokinetics of laninamivir, a novel long-Acting neuraminidase inhibitor, after single and multiple inhaled doses of its prodrug, CS-8958, in healthy male volunteers. J. Clin. Pharmacol. 50, 1319-1329 (2010
    • (2010) J. Clin. Pharmacol , vol.50 , pp. 1319-1329
    • Ishizuka, H.1    Yoshiba, S.2    Okabe, H.3    Yoshihara, K.4
  • 84
    • 0000358206 scopus 로고
    • Carbohydrate-protein interactions: Basis of glycobiology
    • Lee YC, Lee RT. Carbohydrate-protein interactions: Basis of glycobiology. Acc. Chem. Res. 28, 321-327 (1995
    • (1995) Acc. Chem. Res , vol.28 , pp. 321-327
    • Lee, Y.C.1    Lee, R.T.2
  • 85
    • 0028805760 scopus 로고
    • Effective inhibitors of hemagglutination by influenza virus synthesized from polymers having active ester groups Insight into mechanism of inhibition
    • Mammen M, Dahmann G, Whitesides GM. Effective inhibitors of hemagglutination by influenza virus synthesized from polymers having active ester groups. Insight into mechanism of inhibition. J. Med. Chem. 38, 4179-4190 (1995
    • (1995) J. Med. Chem , vol.38 , pp. 4179-4190
    • Mammen, M.1    Dahmann, G.2    Whitesides, G.M.3
  • 86
    • 0032476812 scopus 로고    scopus 로고
    • Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors
    • Mammen M, Choi SK, Whitesides GM. Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors. Angew. Chem. Int. Ed. 37, 2754-2794 (1998
    • (1998) Angew. Chem. Int. E.d. , vol.37 , pp. 2754-2794
    • Mammen, M.1    Choi, S.K.2    Whitesides, G.M.3
  • 87
    • 0036462602 scopus 로고    scopus 로고
    • The cluster glycoside effect
    • Lundquist JJ, Toone EJ. The cluster glycoside effect. Chem. Rev. 102, 555-578 (2002
    • (2002) Chem. Rev , vol.102 , pp. 555-578
    • Lundquist, J.J.1    Toone, E.J.2
  • 88
    • 9644275467 scopus 로고    scopus 로고
    • Potent and long-Acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen
    • Macdonald SJF, Watson KG, Cameron R et al. Potent and long-Acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen. Antimicrob. Agents Chemother. 48, 4542-4549 (2004
    • (2004) Antimicrob. Agents Chemother , vol.48 , pp. 4542-4549
    • Macdonald, S.J.F.1    Watson, K.G.2    Cameron, R.3
  • 89
    • 10744221268 scopus 로고    scopus 로고
    • Highly potent and long-Acting trimeric and tetrameric inhibitors of influenza virus neuraminidase
    • Watson KG, Cameron R, Fenton RJ et al. Highly potent and long-Acting trimeric and tetrameric inhibitors of influenza virus neuraminidase. Bioorg. Med. Chem. Lett. 14, 1589-1592 (2004
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 1589-1592
    • Watson, K.G.1    Cameron, R.2    Fenton, R.J.3
  • 90
    • 20944450978 scopus 로고    scopus 로고
    • Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza
    • Macdonald SJF, Cameron R, Demaine DA et al. Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza. J. Med. Chem. 48, 2964-2971 (2005
    • (2005) J. Med. Chem , vol.48 , pp. 2964-2971
    • Macdonald, S.J.F.1    Cameron, R.2    Demaine, D.A.3
  • 91
    • 84876708005 scopus 로고    scopus 로고
    • Synthesis of 1,4-Triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B
    • Fraser BH, Hamilton S, Krause-Heuer AM et al. Synthesis of 1,4-Triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B. Med. Chem. Commun. 4, 383-386. (2013
    • (2013) Med. Chem. Commun , vol.4 , pp. 383-386
    • Fraser, B.H.1    Hamilton, S.2    Krause-Heuer, A.M.3
  • 92
    • 0037025441 scopus 로고    scopus 로고
    • Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives
    • Honda T, Yoshida S, Arai M, Masuda T, Yamashita M. Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives. Bioorg. Med. Chem. Lett. 12, 1929-1932 (2002
    • (2002) Bioorg. Med. Chem. Lett , vol.12 , pp. 1929-1932
    • Honda, T.1    Yoshida, S.2    Arai, M.3    Masuda, T.4    Yamashita, M.5
  • 93
    • 79251571764 scopus 로고    scopus 로고
    • Attaching zanamivir to a polymer markedly enhances its activity against drug-resistant strains of influenza A virus
    • Weight AK, Haldar J, Álvarez de Cienfuegos L et al. Attaching zanamivir to a polymer markedly enhances its activity against drug-resistant strains of influenza A virus. J. Pharm. Sci. 100, 831-835 (2011
    • (2011) J. Pharm. Sci , vol.100 , pp. 831-835
    • Weight, A.K.1    Haldar, J.2    Álvarez De Cienfuegos, L.3
  • 94
    • 84870912652 scopus 로고    scopus 로고
    • Polymer-Attached zanamivir inhibits synergistically both early and late stages of influenza virus infection
    • Lee CM, Weight AK, Haldar J, Wang L, Klibanov AM, Chen J. Polymer-Attached zanamivir inhibits synergistically both early and late stages of influenza virus infection. Proc. Natl Acad. Sci. USA 109, 20385-20390 (2012
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 20385-20390
    • Lee, C.M.1    Weight, A.K.2    Haldar, J.3    Wang, L.4    Klibanov, A.M.5    Chen, J.6
  • 96
    • 26944484395 scopus 로고    scopus 로고
    • One-bead-one-inhibitor-onesubstrate screening of neuraminidase activity
    • Ying L, Gervay-Hague J. One-bead-one-inhibitor-onesubstrate screening of neuraminidase activity. ChemBioChem 6, 1857-1865 (2005
    • (2005) ChemBioChem , vol.6 , pp. 1857-1865
    • Ying, L.1    Gervay-Hague, J.2
  • 97
    • 84871951522 scopus 로고    scopus 로고
    • Chemical probes for drug-resistance assessment by binding competition (RABC): Oseltamivir susceptibility evaluation
    • Cheng TJR, Wang SY, Wen WH et al. Chemical probes for drug-resistance assessment by binding competition (RABC): Oseltamivir susceptibility evaluation. Angew. Chem. Int. Ed. 52, 366-370 (2013
    • (2013) Angew. Chem. Int. E.d. , vol.52 , pp. 366-370
    • Cheng, T.J.R.1    Wang, S.Y.2    Wen, W.H.3
  • 98
    • 77958514624 scopus 로고    scopus 로고
    • Differential receptor binding affinities of influenza hemagglutinins on glycan arrays
    • Liao HY, Hsu CH, Wang SC et al. Differential receptor binding affinities of influenza hemagglutinins on glycan arrays. J. Am. Chem. Soc. 132, 14849-14856 (2010
    • (2010) J. Am. Chem. Soc , vol.132 , pp. 14849-14856
    • Liao, H.Y.1    Hsu, C.H.2    Wang, S.C.3
  • 100
  • 101
    • 3042779537 scopus 로고    scopus 로고
    • Photodynamic therapy a new antimicrobial approach to infectious disease?
    • Hamblin MR, Hasan T. Photodynamic therapy a new antimicrobial approach to infectious disease?. Photochem. Photobiol. Sci. 3, 436-450 (2004
    • (2004) Photochem. Photobiol. Sci , vol.3 , pp. 436-450
    • Hamblin, M.R.1    Hasan, T.2
  • 102
    • 68549115376 scopus 로고    scopus 로고
    • Synergistic effect of zanamivir-porphyrin conjugates on inhibition of neuraminidase and inactivation of influenza virus
    • Wen WH, Lin M, Su CY et al. Synergistic effect of zanamivir-porphyrin conjugates on inhibition of neuraminidase and inactivation of influenza virus. J. Med. Chem. 52, 4903-4910 (2009
    • (2009) J. Med. Chem , vol.52 , pp. 4903-4910
    • Wen, W.H.1    Lin, M.2    Su, C.Y.3
  • 103
    • 84867389246 scopus 로고    scopus 로고
    • Enhanced anti-influenza agents conjugated with anti-inflammatory activity
    • Liu KC, Fang JM, Jan JT et al. Enhanced anti-influenza agents conjugated with anti-inflammatory activity. J. Med. Chem. 55, 8493-8501 (2012
    • (2012) J. Med. Chem , vol.55 , pp. 8493-8501
    • Liu, K.C.1    Fang, J.M.2    Jan, J.T.3
  • 104
    • 34547619982 scopus 로고    scopus 로고
    • Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection
    • Salomon R, Hoffmann E, Webster RG. Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection. Proc. Natl Acad. Sci. USA 104, 12479-12481 (2007
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 12479-12481
    • Salomon, R.1    Hoffmann, E.2    Webster, R.G.3
  • 105
    • 67649126476 scopus 로고    scopus 로고
    • Confronting the next influenza pandemic with anti-inflammatory and immunomodulatory agents: Why they are needed and how they might work
    • Fedson DS. Confronting the next influenza pandemic with anti-inflammatory and immunomodulatory agents: Why they are needed and how they might work. Influenza Other Respir. Viruses 3, 129-142 (2009
    • (2009) Influenza Other Respir. Viruses , vol.3 , pp. 129-142
    • Fedson, D.S.1
  • 106
  • 107
    • 45849109558 scopus 로고    scopus 로고
    • Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus
    • Zheng BJ, Chan KW, Lin YP et al. Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus. Proc. Natl Acad. Sci. USA 105, 8091-8096 (2008
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 8091-8096
    • Zheng, B.J.1    Chan, K.W.2    Lin, Y.P.3
  • 108
    • 84865584158 scopus 로고    scopus 로고
    • Recent advances in neuraminidase inhibitor development as anti-influenza drugs
    • Feng E, Ye D, Li J et al. Recent advances in neuraminidase inhibitor development as anti-influenza drugs. ChemMedChem 7, 1527-1536 (2012
    • (2012) ChemMedChem , vol.7 , pp. 1527-1536
    • Feng, E.1    Ye, D.2    Li, J.3
  • 109
    • 62749130228 scopus 로고    scopus 로고
    • Efficient synthesis of highly active phospha-isosteres of the influenza neuraminidase inhibitor oseltamivir
    • Carbain B, Collins PJ, Callum L et al. Efficient synthesis of highly active phospha-isosteres of the influenza neuraminidase inhibitor oseltamivir. ChemMedChem 4, 335-337 (2009
    • (2009) ChemMedChem , vol.4 , pp. 335-337
    • Carbain, B.1    Collins, P.J.2    Callum, L.3
  • 110
    • 67650432594 scopus 로고    scopus 로고
    • Galactose-conjugates of the oseltamivir pharmacophore-new tools for the characterization of influenza virus neuraminidases
    • Carbain B, Martin SR, Collins PJ, Hitchcock PB, Streicher H. Galactose-conjugates of the oseltamivir pharmacophore-new tools for the characterization of influenza virus neuraminidases. Org. Biomol. Chem. 7, 2570-2575 (2009
    • (2009) Org. Biomol. Chem , vol.7 , pp. 2570-2575
    • Carbain, B.1    Martin, S.R.2    Collins, P.J.3    Hitchcock, P.B.4    Streicher, H.5
  • 111
    • 79960995604 scopus 로고    scopus 로고
    • Biotin-, fluorescein-And 'clickable' conjugates of phosphaoseltamivir as probes for the influenza virus which utilize selective binding to the neuraminidase
    • Stanley M, Martin SR, Birge M, Carbain B, Streicher H. Biotin-, fluorescein-And 'clickable' conjugates of phosphaoseltamivir as probes for the influenza virus which utilize selective binding to the neuraminidase. Org. Biomol. Chem. 9, 5625-5629 (2011
    • (2011) Org. Biomol. Chem , vol.9 , pp. 5625-5629
    • Stanley, M.1    Martin, S.R.2    Birge, M.3    Carbain, B.4    Streicher, H.5
  • 112
    • 84873325984 scopus 로고    scopus 로고
    • Increasing oral absorption of polar neuraminidase inhibitors: A prodrug transporter approach applied to oseltamivir analogue
    • Gupta D, Varghese Gupta S, Dahan A et al. Increasing oral absorption of polar neuraminidase inhibitors: A prodrug transporter approach applied to oseltamivir analogue. Mol. Pharmacol. 10, 512-522 (2013
    • (2013) Mol. Pharmacol , vol.10 , pp. 512-522
    • Gupta, D.1    Varghese Gupta, S.2    Dahan, A.3
  • 113
    • 84894094139 scopus 로고    scopus 로고
    • Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A
    • Schade D, Kotthaus J, Riebling L et al. Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A. J. Med. Chem. 57, 759-769 (2014
    • (2014) J. Med. Chem , vol.57 , pp. 759-769
    • Schade, D.1    Kotthaus, J.2    Riebling, L.3
  • 114
    • 77958509160 scopus 로고    scopus 로고
    • Carbocycles related to oseltamivir as influenza virus group-1-specific neuraminidase inhibitors Binding to N1 enzymes in the context of virus-like particles
    • Mohan S, McAtamney S, Haselhorst T, von Itzstein M, Pinto BM. Carbocycles related to oseltamivir as influenza virus group-1-specific neuraminidase inhibitors. Binding to N1 enzymes in the context of virus-like particles. J. Med. Chem. 53, 7377-7391 (2010
    • (2010) J. Med. Chem , vol.53 , pp. 7377-7391
    • Mohan, S.1    McAtamney, S.2    Haselhorst, T.3    Von Itzstein, M.4    Pinto, B.M.5
  • 115
    • 79955471904 scopus 로고    scopus 로고
    • Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes
    • Albohy A, Mohan S, Zheng RB, Pinto BM, Cairo CW. Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes. Bioorg. Med. Chem. 19, 2817-2822 (2011
    • (2011) Bioorg. Med. Chem , vol.19 , pp. 2817-2822
    • Albohy, A.1    Mohan, S.2    Zheng, R.B.3    Pinto, B.M.4    Cairo, C.W.5
  • 116
    • 18644382945 scopus 로고    scopus 로고
    • Design, syn thesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm
    • Hanessian S, Wang J, Montgomery D et al. Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm. Bioorg. Med. Chem. Lett. 12, 3425-3429 (2002
    • (2002) Bioorg. Med. Chem. Lett , vol.12 , pp. 3425-3429
    • Hanessian, S.1    Wang, J.2    Montgomery, D.3
  • 117
  • 118
    • 65649103683 scopus 로고    scopus 로고
    • A novel small-molecule inhibitor of the avian influenza H5N1 virus determined through computational screening against the neuraminidase
    • An J, Lee DCW, Law AHY et al. A novel small-molecule inhibitor of the avian influenza H5N1 virus determined through computational screening against the neuraminidase. J. Med. Chem. 52, 2667-2672 (2009
    • (2009) J. Med. Chem , vol.52 , pp. 2667-2672
    • An, J.1    Lee, D.C.W.2    Law, A.H.Y.3
  • 119
    • 42949174825 scopus 로고    scopus 로고
    • Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting
    • Li F, Maag H, Alfredson T. Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting. J. Pharm. Sci. 97, 1109-1134 (2008
    • (2008) J. Pharm. Sci , vol.97 , pp. 1109-1134
    • Li, F.1    Maag, H.2    Alfredson, T.3
  • 120
    • 0032853619 scopus 로고    scopus 로고
    • Intestinal peptide transport systems and oral drug availability
    • Yang CY, Dantzig AH, Pidgeon C. Intestinal peptide transport systems and oral drug availability. Pharm. Res. 16, 1331-1343 (1999.
    • (1999) Pharm. Res , vol.16 , pp. 1331-1343
    • Yang, C.Y.1    Dantzig, A.H.2    Pidgeon, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.