Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 16, 2011, Pages 4796-4802

  Liu, Kung Cheng ^a   Lee, Pei Shan ^a   Wang, Shi Yun ^b   Cheng, Yih Shyun E ^b   Fang, Jim Min ^a,b   Wong, Chi Huey ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b GENOMICS RESEARCH CENTER   (Taiwan)

Author keywords

Influenza; Intramolecular ion pair; Neuraminidase inhibitor; Prodrug

Indexed keywords

1 (2 PROPENOXY) 2 NAPHTHOIC ACID; 1 HYDROXY 2 NAPHTHOIC ACID; 2 NAPHTHOIC ACID; 3 HYDROXYPROPYL 4 ACETAMIDO 5 [N2,N3 BIS(TERT BUTOXYCARBONYL)GUANIDO] 3 (1 ETHYLPROPOXY) 1CYCLOHEXENE 1 CARBOXYLATE; 5 ACETYLAMINO 4 [N2,N3 BIS(TERT BUTOXYCARBONYL)GUANIDO] 6 [(2,2 DIMETHYL 1,3 DIOXOLAN 4 YL) HYDROXY METHYL] 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID 3 HYDROXYPROPYL ESTER; 5 ACETYLAMINO 4 [N2,N3 BIS(TERT BUTOXYCARBONYL)GUANIDO] 6 [(2,2 DIMETHYL 1,3 DIOXOLAN 4 YL) HYDROXY METHYL] 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID ETHYL ESTER; GUANIDINO OSELTAMIVIR; GUANIDINO OSELTAMIVIR HYDROXYNAPHTHOATE; OSELTAMIVIR; PRODRUG; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; ZANAMIVIR; ZANAMIVIR HYDROXYNAPHTHOATE;

ANIMAL CELL; ANTIINFLUENZA ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; INFLUENZA; INFLUENZA VIRUS; LIPOPHILICITY; NONHUMAN;

ADMINISTRATION, ORAL; ANTIVIRAL AGENTS; CARBON DIOXIDE; CELL LINE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ESTERS; GUANIDINE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; IONS; MOLECULAR STRUCTURE; NAPHTHOLS; NEURAMINIDASE; OSELTAMIVIR; PRODRUGS; ZANAMIVIR;

EID: 79961172983     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.080     Document Type: Article

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