Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 50, 2012, Pages 20385-20390

  Lee, Chia Min ^a,b   Weight, Alisha K ^b   Haldar, Jayanta ^b   Wang, Ling ^b   Klibanov, Alexander M ^a,b   Chen, Jianzhu ^b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

IC50; Inhibition constant; Mode of drug action; Polymeric inhibitor; Viral trafficking

Indexed keywords

POLYMER; VIRUS SIALIDASE; ZANAMIVIR;

ANTIVIRAL ACTIVITY; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DRUG BINDING; DRUG POTENCY; ENDOCYTOSIS; ENDOSOME; INFLUENZA; INFLUENZA VIRUS; NONHUMAN; PRIORITY JOURNAL; VIRUS ATTACHMENT; VIRUS INHIBITION; VIRUS PARTICLE;

ANIMALS; ANTIVIRAL AGENTS; DOGS; DRUG SYNERGISM; ENDOCYTOSIS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MADIN DARBY CANINE KIDNEY CELLS; MICROSCOPY, ELECTRON, TRANSMISSION; NEURAMINIDASE; ORTHOMYXOVIRIDAE INFECTIONS; PEPTIDES; ZANAMIVIR;

ORTHOMYXOVIRIDAE;

EID: 84870912652     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219155109     Document Type: Article

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