Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 12, 2004, Pages 4542-4549

  Macdonald, Simon J F ^a   Watson, Keith G ^b,c   Cameron, Rachel ^b   Chalmers, David K ^b   Demaine, Derek A ^a   Fenton, Rob J ^a   Gower, David ^a   Hamblin, J Nicole ^a   Hamilton, Stephanie ^b   Hart, Graham J ^a   Inglis, Graham G A ^a   Jin, Betty ^b   Jones, Haydn T ^a   McConnell, Darryl B ^b,d   Mason, Andy M ^a   Nguyen, Van ^b   Owens, Ian J ^a   Parry, Nigel ^a   Reece, Phillip A ^b   Shanahan, Stephen E ^a   Smith, Donna ^a   Wu, Wen Yang ^b   Tucker, Simon P ^b   more..

^a GLAXOSMITHKLINE   (United Kingdom)

^b Biota Holdings Limited   (Australia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d BOEHRINGER INGELHEIM RCV GMBH AND CO KG   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; SIALIDASE INHIBITOR; TETRAMER; ZANAMIVIR;

ANIMAL CELL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSIMETRY; DRUG EFFICACY; DRUG POTENCY; INFLUENZA; INFLUENZA VIRUS; ISOLATION PROCEDURE; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VIRION; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CHROMATOGRAPHY, GEL; CYTOPATHOGENIC EFFECT, VIRAL; DOGS; ENZYME INHIBITORS; GUANIDINES; INDICATORS AND REAGENTS; KINETICS; LUNG; MALE; MICE; MICROSCOPY, ELECTRON; NEURAMINIDASE; ORTHOMYXOVIRIDAE; ORTHOMYXOVIRIDAE INFECTIONS; PLAQUE ASSAY; PYRANS; RATS; RATS, SPRAGUE-DAWLEY; SIALIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION; ZANAMIVIR;

EID: 9644275467     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.12.4542-4549.2004     Document Type: Article

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