Carbocycles related to oseltamivir as influenza virus group-1-specific neuraminidase inhibitors. Binding to N1 enzymes in the context of virus-like particles

Journal of Medicinal Chemistry

Volumn 53, Issue 20, 2010, Pages 7377-7391

  Mohan, Sankar ^a   McAtamney, Sarah ^b   Haselhorst, Thomas ^b   Von Itzstein, Mark ^b   Pinto, Brian Mario ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b GRIFFITH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

4 ACETAMIDO 3 AMINO 5 (1 ETHYLPROPOXY)CYCLOHEX 1 ENE 1 CARBOXYLIC ACID; 4 ACETAMIDO 3 AZIDO 5 (1 ETHYLPROPOXY)CYCLOHEX 1 ENE 1 CARBOXYLIC ACID; 4 ACETAMIDO 3 [4 [(17ALPHA) ESTRA 1,3,5(10) TRIENE 3,17 DIHYDROXY 17 YL][1,2,3]TRIAZOL 1 YL] 5 (1 ETHYLPROPOXY)CYCLOHEX 1 ENE 1 CARBOXYLIC ACID; 4 ACETAMIDO 5 (1 ETHYLPROPOXY) 3 GUANIDINOCYCLOHEX 1 ENE 1 CARBOXYLIC ACID; 4 ACETAMIDO 5 (1 ETHYLPROPOXY) 3 [4 (1 HYDROXY1 METHYLETHYL)[1,2,3]TRIAZOL 1 YL]CYCLOHEX 1 ENE 1 CARBOXYLIC ACID; 4 ACETAMIDO 5 (1 ETHYLPROPOXY) 3 [4 (1 HYDROXYCYCLOPENTYL)[1,2,3]TRIAZOL 1 YL]CYCLOHEX 1 ENE 1 CARBOXYLIC ACID; 4 ACETAMIDO 5 (1 ETHYLPROPOXY) 3 [4 (1 HYDROXYPROPYL)[1,2,3]TRIAZOL 1 YL]CYCLOHEX 1 ENE 1 CARBOXYLIC ACID; 4 ACETAMIDO 5 (1 ETHYLPROPOXY) 3 [4 (3 HYDROXYPROPYL 1,2,3]TRIAZOL 1 YL]CYCLOHEX 1 ENE 1 CARBOXYLIC ACID; AMINO ACID; GUANIDINE; METHYL 3 AZIDO 5 (1 ETHYLPROPOXY) 4 HYDROXYCYCLOHEX 1 ENE 1 CARBOXYLATE; METHYL 3 CHLORO 5 (1 ETHYLPROPOXY) 4 HYDROXYCYCLOHEX 1 ENE 1 CARBOXYLATE; METHYL 3,4 (ACETYLEPIMINO) 5 (1 ETHYLPROPOXY)CYCLOHEX 1 ENE 1 CARBOXYLATE; METHYL 3,4 EPOXY 5 (1 ETHYLPROPOXY)CYCLOHEX 1 ENE 1 CARBOXYLATE; METHYL 4 ACETAMIDO 3 AMINO 5 (1 ETHYLPROPOXY)CYCLOHEX 1 ENE 1 CARBOXYLATE; METHYL 4 ACETAMIDO 3 [2,3 BIS(TERT BUTOXYCARBONYL)GUANIDINO] 5 (1 ETHYLPROPOXY)CYCLOHEX 1 ENE 1 CARBOXYLATE; METHYL 4 ACETAMIDO 3 [4[(17ALPHA) ESTRA 1,3,5(10) TRIENE 3,17 DIHYDROXY 17 YL][1,2,3]TRIAZOL 1 YL] 5 (1 ETHYLPROPOXY)CYCLOHEX 1 ENE 1 CARBOXYLATE; METHYL 4 ACETAMIDO 5 (1 ETHYLPROPOXY) 3 [4 (1 HYDROXYCYCLOHEXYL)[1,2,3]TRIAZOL 1 YL]CYCLOHEX-1 ENE 1 CARBOXYLATE; METHYL 4 ACETAMIDO 5 (1 ETHYLPROPOXY) 3 [4 (1 HYDROXYCYCLOPENTYL)[1,2,3]TRIAZOL 1 YL]CYCLOHEX 1 ENE 1 CARBOXYLATE; METHYL 4 ACETAMIDO 5 (1 ETHYLPROPOXY) 3 [4 PHENETHYL[1,2,3]TRIAZOL 1 YL]CYCLOHEX 1 ENE 1 CARBOXYLATE; METHYL 4,5 O ISOPENTYLIDENE 3 DEHYDRO 4 EPISHIKIMATE; METHYL 4,5 O ISOPENTYLIDENE 3 O (METHANESULFONYL) 3,4,5 TRIHYDROXYCYCLOHEX 1 ENE 1 CARBOXYLATE; METHYL 4,5 O ISOPENTYLIDENE 3,4,5 TRIHYDROXYCYCLOHEXENE 1 CARBOXYLATE; METHYL 5 (1 ETHYLPROPOXY) 4 HYDROXY 3 (METHASULFONYLOXY)CYCLOHEX 1 ENE 1 CARBOXYLATE; OSELTAMIVIR; SHIKIMIC ACID; SIALIDASE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZANAMIVIR; ANTIVIRUS AGENT; PROTEIN BINDING; TRIAZOLE DERIVATIVE;

ARTICLE; DRUG DESIGN; DRUG TRANSPORT; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; INFLUENZA VIRUS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYLOGENETIC TREE; PROTEIN FUNCTION; PROTON NUCLEAR MAGNETIC RESONANCE; SATURATION TRANSFER DIFFERENCE; THIN LAYER CHROMATOGRAPHY; VIRUS LIKE AGENT; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; INFLUENZA VIRUS A; STEREOISOMERISM; SYNTHESIS; VIRION;

ANTIVIRAL AGENTS; CATALYTIC DOMAIN; INFLUENZA A VIRUS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NEURAMINIDASE; OSELTAMIVIR; PROTEIN BINDING; STEREOISOMERISM; TRIAZOLES; VIRION;

EID: 77958509160     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100822f     Document Type: Article

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