Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino- 4H-pyran-6-carboxamides

Journal of Medicinal Chemistry

Volumn 41, Issue 6, 1998, Pages 787-797

  Smith, Paul W ^a   Sollis, Steven L ^a   Howes, Peter D ^a   Cherry, Peter C ^a   Starkey, Ian D ^a   Cobley, Kevin N ^a   Weston, Helen ^a   Scicinski, Jan ^a   Merritt, Andrew ^a   Whittington, Andrew ^a   Wyatt, Paul ^a   Taylor, Neil ^a   Green, Darren ^a   Bethell, Richard ^a   Madar, Safia ^a   Fenton, Robert J ^a   Morley, Peter J ^a   Pateman, Tony ^a   Beresford, Alan ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 (ACETYLAMINO) 4 GUANIDINO 6 (METHYLPROPYLCARBAMOYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID TRIFLUOROACETATE; ALKYL GROUP; AMIDE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS SIALIDASE; ZANAMIVIR; ZANAMIVIR DERIVATIVE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; INFLUENZA; INFLUENZA VIRUS; INTRANASAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIVIRAL AGENTS; ENZYME INHIBITORS; GUANIDINES; INFLUENZA A VIRUS; INFLUENZA B VIRUS; INJECTIONS, INTRAPERITONEAL; MICE; NEURAMINIDASE; ORTHOMYXOVIRIDAE INFECTIONS; PYRANS; SIALIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; ZANAMIVIR;

EID: 15644379365     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970374b     Document Type: Article

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