Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors

Journal of Medicinal Chemistry

Volumn 41, Issue 14, 1998, Pages 2451-2460

  Kim, Choung U ^a   Lew, Willard ^a   Williams, Matthew A ^a   Wu, Huiwei ^a   Zhang, Lijun ^a   Chen, Xiaowu ^a   Escarpe, Paul A ^a   Mendel, Dirk B ^a   Laver, W Graeme ^b   Stevens, Raymond C ^c  

^a GILEAD SCIENCES   (United States)

^b Biology and Environment   (Australia)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYCLOHEXENONE; 4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; ETHYL 4 ACETAMIDO 5 AZIDO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLATE PHOSPHATE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS ENZYME; ZANAMIVIR;

AMINO ACID SEQUENCE; ARTICLE; DRUG EFFICACY; ENANTIOMER; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; HYDROPHOBICITY; INFLUENZA; INFLUENZA VIRUS A; LIPOPHILICITY; ORAL DRUG ADMINISTRATION; PROPHYLAXIS; STRUCTURE ACTIVITY RELATION; VIRUS INFECTION; X RAY CRYSTALLOGRAPHY;

ACETAMIDES; ANTIVIRAL AGENTS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; INFLUENZA A VIRUS; INFLUENZA B VIRUS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEURAMINIDASE; OSELTAMIVIR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15444353753     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980162u     Document Type: Article

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