Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-Guanidino-Neu5Ac2en (Zanamivir) modified in the glycerol side-chain

European Journal of Medicinal Chemistry

Volumn 34, Issue 7-8, 1999, Pages 563-574

  Andrews, David M ^a   Cherry, Peter C ^a   Humber, David C ^a   Jones, Paul S ^a   Keeling, Steven P ^a   Martin, Paul F ^a   Shaw, Caroline D ^a   Swanson, Stephen ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Antiviral activity; Influenza virus sialidase neuraminidase Zanamivir

Indexed keywords

5 ACETYLAMINO 6 [(6 AMINOHEXYL)CARBAMOYLOXY] 3 DIHYDROXYPROPYL 4 GUANIDINO 5,6 DIHYDRO PYRAN 2 CARBOXYLIC ACID; 5 ACETYLAMINO 6 [HEPTYLCARBAMOYLOXY] 3 DIHYDROXYPROPYL 4 GUANIDINO 5,6 DIHYDRO PYRAN 2 CARBOXYLIC ACID; ENZYME INHIBITOR; SIALIDASE; UNCLASSIFIED DRUG; ZANAMIVIR;

ANTIVIRAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROLYSIS; INFLUENZA VIRUS; LIPOPHILICITY; PROTEIN SYNTHESIS INHIBITION; X RAY CRYSTALLOGRAPHY;

EID: 0032710063     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)80026-4     Document Type: Article

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