Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-guanidino-Neu5Ac2en (GG167) with modified 5-substituents

European Journal of Medicinal Chemistry

Volumn 31, Issue 2, 1996, Pages 143-150

  Smith, P W ^a   Starkey, I D ^a   Howes, P D ^a   Sollis, S L ^a   Keeling, S P ^a   Cherry, P C ^a   Von Itzstein, M ^b   Wu, W Y ^b   Jin, B ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Antiviral activity; Influenza virus sialidase neuraminidase GG167

Indexed keywords

4 GUANIDINO 5 (2,2,2 TRIFLUOROACETAMIDO) 6 (1,2,3 TRIHYDROXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID; ANTIVIRUS AGENT; ENZYME INHIBITOR; NEURAMINIC ACID DERIVATIVE; SIALIDASE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; ZANAMIVIR;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; INFLUENZA VIRUS A; INFLUENZA VIRUS B; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 0029998956     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/0223-5234(96)80447-8     Document Type: Article

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