Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors

Journal of Medicinal Chemistry

Volumn 56, Issue 3, 2013, Pages 671-684

  Feng, Enguang ^a   Shin, Woo Jin ^b   Zhu, Xuelian ^a   Li, Jian ^a   Ye, Deju ^a   Wang, Jiang ^a   Zheng, Mingyue ^a   Zuo, Jian Ping ^a   No, Kyoung Tai ^b   Liu, Xian ^a   Zhu, Weiliang ^a   Tang, Wei ^a   Seong, Baik Lin ^b   Jiang, Hualiang ^a   Liu, Hong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3 ACETAMIDO N (3 FLUOROBENZYL) 4 GUANIDINO 2 (1,2,3 TRIHYDROXYPROPYL) 3,4 DIHYDRO 2H PYRAN 6 CARBOXAMIDE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; ZANAMIVIR;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; DRUG HALF LIFE; DRUG POTENCY; DRUG STRUCTURE; HYDROGEN BOND; IC 50; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; INFLUENZA VIRUS A H5N1; MALE; MAXIMUM PLASMA CONCENTRATION; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANTIVIRAL AGENTS; DRUG DESIGN; ENZYME INHIBITORS; MODELS, MOLECULAR; NEURAMINIDASE; ZANAMIVIR;

EID: 84873916093     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3009713     Document Type: Article

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