Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity

Journal of the American Chemical Society

Volumn 119, Issue 4, 1997, Pages 681-690

  Kim, Choung U ^a   Lew, Willard ^a   Williams, Matthew A ^a   Liu, Hongtao ^a   Zhang, Lijun ^a   Swaminathan, S ^a   Bischofberger, Norbert ^a   Chen, Ming S ^a   Mendel, Dirk B ^a   Tai, Chun Y ^a   Laver, W Graeme ^b   Stevens, Raymond C ^c  

^a GILEAD SCIENCES   (United States)

^b Biology and Environment   (Australia)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; ENZYME INHIBITOR; SIALIDASE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; IN VITRO STUDY; INFLUENZA; LIPOPHILICITY; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ACETAMIDES; ANIMALS; ANTIVIRAL AGENTS; BINDING SITES; CARBOXYLIC ACIDS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANES; CYCLOHEXENES; DISEASE MODELS, ANIMAL; DRUG DESIGN; ENZYME INHIBITORS; HYDROPHOBICITY; INFLUENZA A VIRUS; NEURAMINIDASE; PLAQUE ASSAY; QUINIC ACID; SIALIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031048319     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja963036t     Document Type: Article

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