Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B

Journal of Medicinal Chemistry

Volumn 41, Issue 6, 1998, Pages 798-807

  Taylor, Neil R ^a   Cleasby, Anne ^a   Singh, Onkar ^a   Skarzynski, Tadeusz ^a   Wonacott, Alan J ^b   Smith, Paul W ^b   Sollis, Steven L ^c   Howes, Peter D ^c   Cherry, Peter C ^d   Bethell, Richard ^a   Colman, Peter ^a   Varghese, Jose ^b  

^a Department of Biomolecular Structure ^*  (Australia)

^b GLAXOSMITHKLINE   (United Kingdom)

^c CSIRO   (Australia)

^d BASF Bioresearch Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (ACETYLAMINO) 4 AMINO 6 (PHENETHYLPROPYLCARBAMOYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID; AMIDE; HYDROGEN; LIGAND; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS SIALIDASE; ZANAMIVIR; ZANAMIVIR DERIVATIVE;

ARTICLE; BINDING AFFINITY; CALCULATION; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG BINDING; DRUG POTENCY; ENZYME ACTIVE SITE; HYDROGEN BOND; INFLUENZA VIRUS A; INFLUENZA VIRUS B; LIGAND BINDING; MOLECULAR MODEL; X RAY CRYSTALLOGRAPHY;

ACETAMIDES; ANTIVIRAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GUANIDINES; INFLUENZA A VIRUS; INFLUENZA B VIRUS; MODELS, MOLECULAR; NEURAMINIDASE; PROTEIN CONFORMATION; PYRANS; SIALIC ACIDS; ZANAMIVIR;

EID: 0032510373     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9703754     Document Type: Article

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