Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 9, 2011, Pages 2817-2822

  Albohy, Amgad ^a   Mohan, Sankar ^b   Zheng, Ruixiang Blake ^a   Pinto, B Mario ^b   Cairo, Christopher W ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b SIMON FRASER UNIVERSITY   (Canada)

Author keywords

Antiviral; Enzyme inhibitor; Glycosidase; Human neuraminidase; NEU1; NEU2; NEU3; NEU4; Oseltamivir; Sialidase; Viral neuraminidase; Zanamivir

Indexed keywords

2' (4 METHYLUMBELLIFERYL)ALPHA N ACETYLNEURAMINIC ACID; N ACETYL 2,3 DIDEHYDRO 2 DEOXYNEURAMINIC ACID; OSELTAMIVIR; RECOMBINANT NEURAMINIDASE 3; RECOMBINANT NEURAMINIDASE 4; SIALIDASE; UNCLASSIFIED DRUG; VIRUS SIALIDASE; VIRUS SIALIDASE 1; VIRUS SIALIDASE 4; VIRUS SIALIDASE 8;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; DRUG TRANSFORMATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBUNIT; INFLUENZA VIRUS;

ANTIVIRAL AGENTS; CATALYTIC DOMAIN; ENZYME INHIBITORS; HUMANS; INFLUENZA A VIRUS; NEURAMINIDASE; OSELTAMIVIR; PROTEIN ISOFORMS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

EID: 79955471904     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.039     Document Type: Article

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