Polyphenols and Low Iron Bioavailability

Polyphenols in Human Health and Disease

Volumn 1, Issue , 2013, Pages 311-322

  Petry, Nicolai ^a  

^a GroundWork LLC   (Switzerland)

Author keywords

Caco 2 cells; Iron bioavailability; Iron isotope studies; Iron EDTA; Polyphenols complex; Vitamin C

Indexed keywords

EID: 84902571319     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-398456-2.00024-4     Document Type: Chapter

References (95)

1. Naczk M., Oickle D., Pink D., Shahidi F. Protein precipitating capacity of crude canola tannins: effect of pH, tannin, and protein concentrations. J Agric Food Chem 1996, 44(8):2144-2148.
2. Naczk M., Amarowicz R., Zadernowski R., Shahidi F. Protein-precipitating capacity of crude condensed tannins of canola and rapeseed hulls. J Am Oil Chem Soc 2001, 78(12):1173-1178.
3. Barahona R., Lascano C.E., Cochran R., Morrill J., Titgemeyer E.C. Intake, digestion, and nitrogen utilization by sheep fed tropical legumes with contrasting tannin concentration and astringency. J Anim Sci 1997, 75(6):1633-1640.
4. McDonald M., Mila I., Scalbert A. Precipitation of metal ions by plant polyphenols: optimal conditions and origin of precipitation. J Agric Food Chem 1996, 44(2):599-606.
5. Carpenter C.E., Mahoney A.W. Contributions of heme and nonheme iron to human-nutrition. Crit Rev Food Sci Nutr 1992, 31(4):333-367.
6. Hunt J.R. Moving toward a plant-based diet: are iron and zinc at risk?. Nutri Rev 2002, 60(5):127-134.
7. Donangelo C.M., Woodhouse L.R., King S.M., Toffolo G., Shames D.M., Viteri F.E., et al. Iron and zinc absorption from two bean (Phaseolus vulgaris L.) genotypes in young women. J Agric Food Chem 2003, 51(17):5137-5143.
8. McLean E., Cogswell M., Egli I., Wojdyla D., de Benoist B. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005. Public Health Nutr 2009, 12(4):444-454.
9. Scrimshaw N.S. Functional significance of iron deficiency: an overview. Functional significance of iron deficiency. Annual Nutrition workshop series 1990, vol. III:1-13. Meharry Medical College, Center for Nutrition, Nashville, Tenn, USA.
10. Brabin B.J., Premji Z., Verhoeff F. An analysis of anemia and child mortality. J Nutr 2001, 131(2S-2):636S-645S. discussion 46S-48S.
11. Haas B. Marginal iron deficiency without anemia impairs aerobic adaptation among previously untrained women. Am J Clin Nutr 2001, 75(4):734-742.
12. Merhav H., Amitai Y., Palti H., Godfrey S. Tea drinking and microcytic anemia in infants. Am J Clin Nutr 1985, 41(6):1210-1213.
13. Gibson S.A. Iron intake and iron status of preschool children: associations with breakfast cereals, vitamin C and meat. Public Health Nutr 1999, 2(4):521-528.
14. van Acker S.A.B.E., van Balen G.P., van den Berg D.J., Bast A., van der Vijgh W.J.F. Influence of iron chelation on the antioxidant activity of flavonoids. Biochem Pharmacol 1998, 56(8):935-943.
15. Perron N.R., Brumaghim J.L. A review of the antioxidant mechanisms of polyphenol compounds related to iron binding. Cell Biochem Biophys 2009, 53(2):75-100.
16. Dai J., Mumper R.J. Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules 2010, 15(10):7313-7352.
17. Sesso H.D., Gaziano J.M., Buring J.E., Hennekens C.H. Coffee and tea intake and the risk of myocardial infarction. Am J Epidemiol 1999, 149(2):162-167.
18. Mukamal K.J., Maclure M., Muller J.E., Sherwood J.B., Mittleman M.A. Tea consumption and myocardial mortality after acute infarction. Circulation 2002, 105(21):2476-2481.
19. Taubert D., Berkels R., Roesen R., Klaus W. Chocolate and blood pressure in elderly individuals with isolated systolic hypertension. JAMA 2003, 290(8):1029-1030.
20. Rein D., Paglieroni T.G., Wun T., Pearson D.A., Schmitz H.H., Gosselin R., et al. Cocoa inhibits platelet activation and function. Am J Clin Nutr 2000, 72(1):30-35.
21. Heiss C., Dejam A., Kleinbongard P., Schewe T., Sies H., Kelm M. Vascular effects of cocoa rich in flavan-3-ols. JAMA 2003, 290(8):1030-1031.
22. Grassi D., Desideri G., Croce G., Tiberti S., Aggio A., Ferri C. Flavonoids, vascular function and cardiovascular protection. Curr Pharm Design 2009, 15(10):1072-1084.
23. Di Castelnuovo A., Rotondo S., Iacoviello L., Donati M.B., de Gaetano G. Meta-analysis of wine and beer consumption in relation to vascular risk. Circulation 2002, 105(24):2836-2844.
24. Yoshino M., Murakami K. Interaction of iron with polyphenolic compounds: application to antioxidant characterization. Anal Biochem 1998, 257(1):40-44.
25. Chaudhary P., Shukla S.K., Kumar I.P., Namita I., Afrin F., Sharma R.K. Radioprotective properties of apple polyphenols: an in vitro study. Mol Cell Biochem 2006, 288(1-2):37-46.
26. Grinberg L.N., Newmark H., Kitrossky N., Rahamim E., Chevion M., Rachmilewitz E.A. Protective effects of tea polyphenols against oxidative damage to red blood cells. Biochem Pharmacol 1997, 54(9):973-978.
27. Lopes G.K.B., Schulman H.M., Hermes-Lima M. Polyphenol tannic acid inhibits hydroxyl radical formation from Fenton reaction by complexing ferrous ions. Biochim Biophys Acta 1999, 1472(1-2):142-152.
28. Cook J.D., Dassenko S.A., Lynch S.R. Assessment of the role of nonheme-iron availability in iron balance. Am J Clin Nutr 1991, 54(4):717-722.
29. Tidehag P., Hallmans G., Wing K., Sjostrom R., Agren G., Lundin E., et al. A comparison of iron absorption from single meals and daily diets using radioFe (Fe-55,Fe-59). Br J Nutr 1996, 75(2):281-289.
30. Cook J.D., Reddy M.B. Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet. Am J Clin Nutr 2001, 73(1):93-98.
31. Cook J.D., Watson S.S., Simpson K.M., Lipschitz D.A., Skikne B.S. The effect of high ascorbic acid supplementation on body iron stores. Blood 1984, 64(3):721-726.
32. Hunt J.R., Gallagher S.K., Johnson L.K. Effect of ascorbic acid on apparent iron absorption by women with low iron stores. Am J Clin Nutr 1994, 59(6):1381-1385.
33. Reddy M.B., Hurrell R.F., Cook J.D. Estimation of nonheme-iron bioavailability from meal composition. Am J Clin Nutr 2000, 71(4):937-943.
34. Hunt J.R., Roughead Z.K. Adaptation of iron absorption in men consuming diets with high or low iron bioavailability. Am J Clin Nutr 2000, 71(1):94-102.
35. Hunt J.R. High-, but not low-bioavailability diets enable substantial control of women's iron absorption in relation to body iron stores, with minimal adaptation within several weeks. Am J Clin Nutr 2003, 78(6):1168-1177.
36. Disler P.B., Lynch S.R., Charlton R.W., Torrance J.D., Bothwell T.H., Walker R.B., et al. Effect of tea on iron absorption. Gut 1975, 16(3):193-200.
37. Hurrell R.F., Reddy M., Cook J.D. Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages. Br J Nutr 1999, 81(4):289-295.
38. Cook J.D., Reddy M.B., Hurrell R.F. The effect of red and white wines on nonheme-iron absorption in humans. Am J Clin Nutr 1995, 61(4):800-804.
39. Hallberg L., Rossander L. Effect of different drinks on the absorption of non-heme iron from composite meals. Hum Nutr Appl Nutr 1982, 36(2):116-123.
40. Tuntawiroon M., Sritongkul N., Brune M., Rossanderhulten L., Pleehachinda R., Suwanik R., et al. Dose-dependent inhibitory effect of phenolic compounds in foods on nonheme-iron absorption in men. Am J Clin Nutr 1991, 53(2):554-557.
41. Gillooly M., Bothwell T.H., Torrance J.D., Macphail A.P., Derman D.P., Bezwoda W.R., et al. The effects of organic acids, phytates and polyphenols on the absorption of iron from vegetables. Br J Nutr 1983, 49(3):331-342.
42. Hurrell R.F., Reddy M.B., Juillerat M.A., Cook J.D. Degradation of phytic acid in cereal porridges improves iron absorption by human subjects. Am J Clin Nutr 2003, 77(5):1213-1219.
43. Gillooly M., Bothwell T.H., Charlton R.W., Torrance J.D., Bezwoda W.R., Macphail A.P., et al. Factors affecting the absorption of iron from cereals. Br J Nutr 1984, 51(1):37-46.
44. Petry N., Egli I., Zeder C., Walczyk T., Hurrell R. Polyphenols and phytic acid contribute to the low iron bioavailability from common beans in young women. J Nutr 2010, 140(11):1977-1982.
45. Petry N., Egli I., Gahutu J.B., Tugirimana P.L., Boy E., Hurrell R. Stable iron isotope studies in Rwandese women indicate that the common bean has limited potential as a vehicle for iron biofortification. J Nutr 2012, 142(3):492-497.
46. Tuntipopipat S., Judprasong K., Zeder C., Wasantwisut E., Winichagoon P., Charoenkiatkul S., et al. Chili, but not turmeric, inhibits iron absorption in young women from an iron-fortified composite meal. J Nutr 2006, 136(12):2970-2974.
47. Brune M., Rossander L., Hallberg L. Iron absorption and phenolic compounds: importance of different phenolic structures. Eur J Clin Nutr 1989, 43(8):547-558.
48. Samman S., Sandstrom B., Toft M.B., Bukhave K., Jensen M., Sorensen S.S., et al. Green tea or rosemary extract added to foods reduces nonheme-iron absorption. Am J Clin Nutr 2001, 73(3):607-612.
49. Drynan J.W., Clifford M.N., Obuchowicz J., Kuhnert N. The chemistry of low molecular weight black tea polyphenols. Nat Prod Rep 2010, 27(3):417-462.
50. Hallfors D., Cho H., Sanchez V., Khatapoush S., Kim H.M., Bauer D. Efficacy vs effectiveness trial results of an indicated "model" substance abuse program: implications for public health. Am J Public Health 2006, 96(12):2254-2259.
51. Flay B.R. Efficacy and effectiveness trials (and other phases of research) in the development of health promotion programs. Prev Med 1986, 15(5):451-474.
52. Flay B., Biglan A., Boruch R., Castro F., Gottfredson D., Kellam S., et al. Standards of evidence: criteria for efficacy, effectiveness and dissemination. Prev Sci 2005, 6(3):151-175.
53. Glasgow R.E., Lichtenstein E., Marcus A.C. Why don't we see more translation of health promotion research to practice? Rethinking the efficacy-to-effectiveness transition. Am J Public Health 2003, 93(8):1261-1267.
54. Kim E.Y., Ham S.K., Shigenaga M.K., Han O. Bioactive dietary polyphenolic compounds reduce nonheme iron transport across human intestinal cell monolayers. J Nutr 2008, 138(9):1647-1651.
55. Ma Q., Kim E.Y., Han O. Bioactive dietary polyphenols decrease heme iron absorption by decreasing basolateral iron release in human intestinal Caco-2 cells. J Nutr 2010, 140(6):1117-1121.
56. Kim B., Ham S.K., Bradke D., Ma Q.Y., Han O. Ascorbic acid offsets the inhibitory effect of bioactive dietary polyphenolic compounds on transepithelial iron transport in Caco-2 intestinal cells. J Nutr 2011, 141(5):828-834.
57. Hurrell R.F. Bioavailability of iron. Eur J Clin Nutr 1997, 51:S4-S8.
58. Kim E., Ham S., Bradke D., Ma Q.Y., Han O. Ascorbic acid offsets the inhibitory effect of bioactive dietary polyphenolic compounds on transepithelial iron transport in Caco-2 intestinal cells. J Nutr 2011, 141(5):828-834.
59. Hider R.C., Liu Z.D., Khodr H.H. Metal chelation of polyphenols. Method Enzymol 2001, 335:190-203.
60. Purawatt S., Siripinyanond A., Shiowatana J. Flow field-flow fractionation-inductively coupled optical emission spectrometric investigation of the size-based distribution of iron complexed to phytic and tannic acids in a food suspension: implications for iron availability. Anal Bioanal Chem 2007, 389(3):733-742.
61. Jovanovic S.V., Simic M.G., Steenken S., Hara Y. Iron complexes of gallocatechins. Antioxidant action or iron regulation?. J Chem Soc Perk T 2 1998, 11:2365-2369.
62. Crozier A., Jaganath I.B., Clifford M.N. Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 2009, 26(8):1001-1043.
63. Carando S., Teissedre P.L., Pascual-Martinez L., Cabanis J.C. Levels of flavan-3-ols in French wines. J Agric Food Chem 1999, 47(10):4161-4166.
64. Fazary A.E., Taha M., Ju Y.H. Iron complexation studies of gallic acid. J Chem Eng Data 2009, 54(1):35-42.
65. Aherne S.A., O'Brien N.M. Dietary flavonols: chemistry, food content, and metabolism. Nutrition 2002, 18(1):75-81.
66. Bohm H., Boeing H., Hempel J., Raab B., Kroke A. Flavonols, flavones and anthocyanins as native antioxidants of food and their possible role in the prevention of chronic diseases. Z Ernahrungswiss 1998, 37(2):147-163.
67. Ryan P., Hynes M.J. The kinetics and mechanisms of the reactions of iron(III) with quercetin and morin. J Inorg Biochem 2008, 102(1):127-136.
68. Hynes M.J., Coinceanainn M.O. The kinetics and mechanisms of the reaction of iron(III) with gallic acid, gallic acid methyl ester and catechin. J Inorg Biochem 2001, 85(2-3):131-142.
69. Ribera A.E., Reyes-Diaz M., Alberdi M., Zuniga G.E., Mora M.L. Antioxidant compounds in skin and pulp of fruits change among genotypes and maturity stages in highbush blueberry (Vaccinium corymbosum L.) grown in southern Chile. J Soil Sci Plant Nut 2010, 10(4):509-536.
70. Kawabata T., Schepkin V., Haramaki N., Phadke R.S., Packer L. Iron coordination by catechol derivative antioxidants. Biochem Pharmacol 1996, 51(11):1569-1577.
71. Powell H.K.J., Taylor M.C. Interactions of iron(II) and iron(III) with gallic acid and its homologues: a potentiometric and spectrophotometric study. Aust J Chem 1982, 35(4):739-756.
72. Cooper S.R., Mcardle J.V., Raymond K.N. Siderophore electrochemistry - relation to intracellular iron release mechanism. Proc Natl Acad Sci USA 1978, 75(8):3551-3554.
73. Perron N.R., Wang H.C., DeGuire S.N., Jenkins M., Lawson M., Brumaghim J.L. Kinetics of iron oxidation upon polyphenol binding. Dalton Trans 2010, 39(41):9982-9987.
74. Chvatalova K., Slaninova I., Brezinova L., Slanina J. Influence of dietary phenolic acids on redox status of iron: ferrous iron autoxidation and ferric iron reduction. Food Chem 2008, 106(2):650-660.
75. Stumm W., Lee G.F. Oxygenation of ferrous iron. Ind Eng Chem 1961, 53(2):143-146.
76. Avdeef A., Sofen S.R., Bregante T.L., Raymond K.N. Coordination chemistry of microbial iron transport compounds. 9. Stability constants for catechol models of enterobactin. J Am Chem Soc 1978, 100(17):5362-5370.
77. Loomis L.D., Raymond K.N. Solution equilibria of enterobactin and metal enterobactin complexes. Inorg Chem 1991, 30(5):906-911.
78. Cheng G.W.W., Crisosto C.H. Iron-polyphenol complex formation and skin discoloration in peaches and nectarines. J Am Soc Hortic Sci 1997, 122(1):95-99.
79. Brune M., Hallberg L., Skanberg A.B. Determination of iron-binding phenolic groups in foods. J Food Sci 1991, 56(1):128-131.
80. Khokhar S., Apenten R.K.O. Iron binding characteristics of phenolic compounds: some tentative structure-activity relations. Food Chem 2003, 81(1):133-140.
81. Siegenberg D., Baynes R.D., Bothwell T.H., Macfarlane B.J., Lamparelli R.D., Car N.G., et al. Ascorbic acid prevents the dose-dependent inhibitory effects of polyphenols and phytates on nonheme-iron absorption. Am J Clin Nutr 1991, 53(2):537-541.
82. South P.K., Miller D.D. Iron binding by tannic acid: effects of selected ligands. Food Chem 1998, 63(2):167-172.
83. Davidsson L., Ziegler E., Zeder C., Walczyk T., Hurrell R. Sodium iron EDTA [NaFe(III)EDTA] as a food fortificant: erythrocyte incorporation of iron and apparent absorption of zinc, copper, calcium, and magnesium from a complementary food based on wheat and soy in healthy infants. Am J Clin Nutr 2005, 81(1):104-109.
84. Macphail A.P., Bothwell T.H., Torrance J.D., Derman D.P., Bezwoda W.R., Charlton R.W., et al. Factors affecting the absorption of iron from Fe(III)EDTA. Br J Nutr 1981, 45(2):215-227.
85. Hurrell R.F., Reddy M.B., Burri J., Cook J.D. An evaluation of EDTA compounds for iron fortification of cereal-based foods. Br J Nutr 2000, 84(6):903-910.
86. Engle-Stone R., Yeung A., Welch R., Glahn R. Meat and ascorbic acid can promote Fe availability from Fe-phytate but not from Fe-tannic acid complexes. J Agric Food Chem 2005, 53(26):10276-10284.
87. Mccloy R.F., Greenberg G.R., Baron J.H. Duodenal pH in health and duodenal-ulcer disease: effect of a meal, Coca-Cola, smoking, and cimetidine. Gut 1984, 25(4):386-392.
88. Lynch S.R., Hurrell R.F., Bothwell T.H., Macphail A.P. Iron EDTA for food fortification 1993, International Nutritional Anemia Consultative Group, p. 54.
89. Hurrell R., Egli I. Iron bioavailability and dietary reference values. Am J Clin Nutr 2010, 91(5):1461s-1467s.
90. Teucher B., Olivares M., Cori H. Enhancers of iron absorption: ascorbic acid and other organic acids. Int J Vitam Nutr Res 2004, 74(6):403-419.
91. Beebe S., Gonzalez A.V., Rengifo J. Research on trace minerals in the common bean. Food Nutr Bull 2000, 21(4):387-391.
92. Mayer A.M. Polyphenol oxidases in plants and fungi: going places? A review. Phytochemistry 2006, 67(21):2318-2331.
93. Amarowicz R., Carle R., Dongowski G., Durazzo A., Galensa R., Kammerer D., et al. Influence of postharvest processing and storage on the content of phenolic acids and flavonoids in foods. Mol Nutr Food Res 2009, 53:S151-S183.
94. Matuschek E., Svanberg U. Oxidation of polyphenols and the effect on in vitro iron accessibility in a model food system. J Food Sci 2002, 67(1):420-424.
95. Shimelis E.A., Rakshit S.K. Effect of processing on antinutrients and in vitro protein digestibility of kidney bean (Phaseolus vulgaris L.) varieties grown in East Africa. Food Chem 2007, 103(1):161-172.