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Volumn 40, Issue 2, 2014, Pages 245-256

Inhibitors of mitochondrial fission as a therapeutic strategy for diseases with oxidative stress and mitochondrial dysfunction

Author keywords

Alzheimer's disease; fission inhibitors; free radical production; mitochondrial dynamics; mitochondrial dysfunction; oxidative stress

Indexed keywords

AGENTS AFFECTING METABOLISM; CENTRAL NERVOUS SYSTEM AGENTS; DYNASORE; MDIVI; P 110; UNCLASSIFIED DRUG; 3-(2,4-DICHLORO-5-METHOXYPHENYL)-2-SULFANYL-4(3H)-QUINAZOLINONE; 9-DEOXY-DELTA-9-PROSTAGLANDIN D2; HYDRAZONE DERIVATIVE; MITOCHONDRIAL PROTEIN; N'-(3,4-DIHYDROXYBENZYLIDENE)-3-HYDROXY-2-NAPHTHAHYDRAZIDE; PROSTAGLANDIN D2; QUINAZOLINONE DERIVATIVE;

EID: 84901948619     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-132060     Document Type: Review
Times cited : (120)

References (85)
  • 1
    • 33750445482 scopus 로고    scopus 로고
    • Mitochondrial fusion and fission in mammals
    • Chan DC (2006) Mitochondrial fusion and fission in mammals. Annu Rev Cell Dev Biol 22, 79-99.
    • (2006) Annu Rev Cell Dev Biol , vol.22 , pp. 79-99
    • Chan, D.C.1
  • 2
    • 77951096150 scopus 로고    scopus 로고
    • Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases
    • Chen H, Chan DC (2009) Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases. Hum Mol Genet 18, R169-R176.
    • (2009) Hum Mol Genet , vol.18
    • Chen, H.1    Chan, D.C.2
  • 3
    • 58049218922 scopus 로고    scopus 로고
    • Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
    • Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X (2008) Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci U S A 105, 19318-19323.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19318-19323
    • Wang, X.1    Su, B.2    Siedlak, S.L.3    Moreira, P.I.4    Fujioka, H.5    Wang, Y.6    Casadesus, G.7    Zhu, X.8
  • 4
    • 67650732998 scopus 로고    scopus 로고
    • Impaired balance of mitochondrial fission and fusion in Alzheimer's disease
    • Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, Zhu X (2009) Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 29, 9090-9103.
    • (2009) J Neurosci , vol.29 , pp. 9090-9103
    • Wang, X.1    Su, B.2    Lee, H.G.3    Li, X.4    Perry, G.5    Smith, M.A.6    Zhu, X.7
  • 6
    • 79958721260 scopus 로고    scopus 로고
    • Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: Implications for neuronal damage
    • Manczak M, Calkins MJ, Reddy PH (2011) Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: Implications for neuronal damage. Hum Mol Genet 20, 2495-2509.
    • (2011) Hum Mol Genet , vol.20 , pp. 2495-2509
    • Manczak, M.1    Calkins, M.J.2    Reddy, P.H.3
  • 7
    • 81255190781 scopus 로고    scopus 로고
    • Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease
    • Calkins MJ, Manczak M, Mao P, Shirendeb U, Reddy PH (2011) Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease. Hum Mol Genet 20, 4515-4529.
    • (2011) Hum Mol Genet , vol.20 , pp. 4515-4529
    • Calkins, M.J.1    Manczak, M.2    Mao, P.3    Shirendeb, U.4    Reddy, P.H.5
  • 10
    • 67650556426 scopus 로고    scopus 로고
    • Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: Implications for the pathogenesis of Alzheimer disease
    • Quintanilla RA, Matthews-Roberson TA, Dolan PJ, Johnson GV (2009) Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: Implications for the pathogenesis of Alzheimer disease. J Biol Chem 284, 18754-18766.
    • (2009) J Biol Chem , vol.284 , pp. 18754-18766
    • Quintanilla, R.A.1    Matthews-Roberson, T.A.2    Dolan, P.J.3    Johnson, G.V.4
  • 11
    • 84855761078 scopus 로고    scopus 로고
    • Truncated tau and A cooperatively impair mitochondria in primary neurons
    • Quintanilla RA, Dolan PJ, Jin YN, Johnson GV (2012) Truncated tau and A- cooperatively impair mitochondria in primary neurons. Neurobiol Aging 33, 619.e25-35.
    • (2012) Neurobiol Aging , vol.33
    • Quintanilla, R.A.1    Dolan, P.J.2    Jin, Y.N.3    Johnson, G.V.4
  • 14
    • 84865352799 scopus 로고    scopus 로고
    • Tau promotes neurodegeneration via DRP1 mislocalization in vivo
    • DuBoff B, G?otz J, Feany MB (2012) Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron 75, 618-632.
    • (2012) Neuron , vol.75 , pp. 618-632
    • Duboff, B.1    Gotz, J.2    Feany, M.B.3
  • 15
    • 58949099388 scopus 로고    scopus 로고
    • Effects of overexpression of huntingtin proteins on mitochondrial integrity
    • Wang H, Lim PJ, Karbowski M, Monteiro MJ (2009) Effects of overexpression of huntingtin proteins on mitochondrial integrity. Hum Mol Genet 18, 737-752.
    • (2009) Hum Mol Genet , vol.18 , pp. 737-752
    • Wang, H.1    Lim, P.J.2    Karbowski, M.3    Monteiro, M.J.4
  • 18
    • 79952585486 scopus 로고    scopus 로고
    • Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: Implications for selective neuronal damage
    • Shirendeb U, Reddy AP, Manczak M, Calkins MJ, Mao P, TagleDA, ReddyPH(2011) Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: Implications for selective neuronal damage. Hum Mol Genet 20, 1438-1455.
    • (2011) Hum Mol Genet , vol.20 , pp. 1438-1455
    • Shirendeb, U.1    Reddy, A.P.2    Manczak, M.3    Calkins, M.J.4    Mao, P.5    Tagle, D.A.6    Reddy, P.H.7
  • 19
    • 84855395163 scopus 로고    scopus 로고
    • Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease
    • Shirendeb UP, Calkins MJ,Manczak M, Anekonda V, Dufour B, McBride JL, Mao P, Reddy PH (2012) Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease. Hum Mol Genet 21, 406-420.
    • (2012) Hum Mol Genet , vol.21 , pp. 406-420
    • Shirendeb, U.P.1    Calkins, M.J.2    Manczak, M.3    Anekonda, V.4    Dufour, B.5    McBride, J.L.6    Mao, P.7    Reddy, P.H.8
  • 21
    • 84872683148 scopus 로고    scopus 로고
    • Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: Neuroprotection by SIRT3 and PGC-1
    • SongW, Song Y, Kincaid B, Bossy B, Bossy-Wetzel E (2013) Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: Neuroprotection by SIRT3 and PGC-1-. Neurobiol Dis 51, 72-81.
    • (2013) Neurobiol Dis , vol.51 , pp. 72-81
    • Song, W.1    Song, Y.2    Kincaid, B.3    Bossy, B.4    Bossy-Wetzel, E.5
  • 22
    • 84855931735 scopus 로고    scopus 로고
    • Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons
    • Magrané J, SahawnehMA, Przedborski S, Este'vez Á G,Manfredi G (2012) Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons. J Neurosci 32, 229-242.
    • (2012) J Neurosci , vol.32 , pp. 229-242
    • Magrané, J.1    Sahawneh, M.A.2    Przedborski, S.3    Este'Vez, Á.G.4    Manfredi, G.5
  • 24
    • 84860539187 scopus 로고    scopus 로고
    • Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction
    • Wang X, Petrie TG, Liu Y, Liu J, Fujioka H, Zhu X (2012) Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction. J Neurochem 121, 830-839.
    • (2012) J Neurochem , vol.121 , pp. 830-839
    • Wang, X.1    Petrie, T.G.2    Liu, Y.3    Liu, J.4    Fujioka, H.5    Zhu, X.6
  • 26
    • 0034662806 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis
    • Lu F, Selak M, O'Connor J, Croul S, Lorenzana C, Butunoi C, Kalman B (2000) Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis. J Neurol Sci 177, 95-103.
    • (2000) J Neurol Sci , vol.177 , pp. 95-103
    • Lu, F.1    Selak, M.2    O'Connor, J.3    Croul, S.4    Lorenzana, C.5    Butunoi, C.6    Kalman, B.7
  • 27
    • 0041825345 scopus 로고    scopus 로고
    • A mitochondrial component of neurodegeneration in multiple sclerosis
    • Kalman B, Leist TP (2003) A mitochondrial component of neurodegeneration in multiple sclerosis. Neuromolecular Med 3, 147-158.
    • (2003) Neuromolecular Med , vol.3 , pp. 147-158
    • Kalman, B.1    Leist, T.P.2
  • 28
    • 84880031119 scopus 로고    scopus 로고
    • 2-Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte-derive dendritic cells
    • Singh V, Prajeeth CK, Gudi V, B́enardais K, Voss EV, Stangel M (2013) 2-Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte-derive dendritic cells. Clin Exp Immunol 173, 288-297.
    • (2013) Clin Exp Immunol , vol.173 , pp. 288-297
    • Singh, V.1    Prajeeth, C.K.2    Gudi, V.3    B́enardais, K.4    Voss, E.V.5    Stangel, M.6
  • 29
    • 71849083196 scopus 로고    scopus 로고
    • Is multiple sclerosis a mitochondrial disease?
    • Mao P, Reddy PH (2010) Is multiple sclerosis a mitochondrial disease? Biochim Biophys Acta 1802, 66-79.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 66-79
    • Mao, P.1    Reddy, P.H.2
  • 32
    • 84888378078 scopus 로고    scopus 로고
    • Cytoplasmic irradiation results in mitochondrial dysfunction and DRP1-dependent mitochondrial fission
    • Zhang B, Davidson MM, Zhou H, Wang C, Walker WF, Hei TK (2013) Cytoplasmic irradiation results in mitochondrial dysfunction and DRP1-dependent mitochondrial fission. Cancer Res 73, 6700-6710.
    • (2013) Cancer Res , vol.73 , pp. 6700-6710
    • Zhang, B.1    Davidson, M.M.2    Zhou, H.3    Wang, C.4    Walker, W.F.5    Hei, T.K.6
  • 33
    • 84883626428 scopus 로고    scopus 로고
    • An improved quantitative approach for the assessment of mitochondrial fragmentation in chemoresistant ovarian cancer cells
    • Farrand L, Kim JY, Im-Aram A, Suh JY, Lee HJ, Tsang BK (2013) An improved quantitative approach for the assessment of mitochondrial fragmentation in chemoresistant ovarian cancer cells. PLoS One 8, e74008.
    • (2013) PLoS One , vol.8
    • Farrand, L.1    Kim, J.Y.2    Im-Aram, A.3    Suh, J.Y.4    Lee, H.J.5    Tsang, B.K.6
  • 36
    • 0032425350 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations and age
    • DOI 10.1111/j.1749-6632.1998.tb09898.x
    • Ozawa T (1998) Mitochondrial DNA mutations and age. Ann N Y Acad Sci 854, 128-154. (Pubitemid 29022798)
    • (1998) Annals of the New York Academy of Sciences , vol.854 , pp. 128-154
    • Ozawa, T.1
  • 38
    • 78649905092 scopus 로고    scopus 로고
    • Mitochondrial biogenesis and fragmentation as regulators of muscle protein degradation
    • Romanello V, SandriM(2010) Mitochondrial biogenesis and fragmentation as regulators of muscle protein degradation. Curr Hypertens Rep 12, 433-439.
    • (2010) Curr Hypertens Rep , vol.12 , pp. 433-439
    • Romanello, V.1    Sandri, M.2
  • 39
    • 84864774722 scopus 로고    scopus 로고
    • Mitochondrial function in vascular endothelial cell in diabetes
    • Pangare M, Makino A (2012) Mitochondrial function in vascular endothelial cell in diabetes. J Smooth Muscle Res 48, 1-26.
    • (2012) J Smooth Muscle Res , vol.48 , pp. 1-26
    • Pangare, M.1    Makino, A.2
  • 40
    • 77957320216 scopus 로고    scopus 로고
    • Impact of nitric oxide on metabolism in health and age-related disease
    • Knott AB, Bossy-Wetzel E (2010) Impact of nitric oxide on metabolism in health and age-related disease. Diabetes Obes Metab Suppl 2, 126-133.
    • (2010) Diabetes Obes Metab Suppl , vol.2 , pp. 126-133
    • Knott, A.B.1    Bossy-Wetzel, E.2
  • 41
    • 84891549568 scopus 로고    scopus 로고
    • Loss of prohibitin induces mitochondrial damages altering -cell function and survival and is responsible for gradual diabetes development
    • Supale S, Thorel F, Merkwirth C, Gjinovci A, Herrera PL, Scorrano L, Meda P, Langer T, Maechler P (2013) Loss of prohibitin induces mitochondrial damages altering -cell function and survival and is responsible for gradual diabetes development. Diabetes 62, 3488-3499.
    • (2013) Diabetes , vol.62 , pp. 3488-3499
    • Supale, S.1    Thorel, F.2    Merkwirth, C.3    Gjinovci, A.4    Herrera, P.L.5    Scorrano, L.6    Meda, P.7    Langer, T.8    Maechler, P.9
  • 43
    • 80054872790 scopus 로고    scopus 로고
    • Alcoholic liver disease: Pathogenesis and new therapeutic targets
    • Gao B, Bataller R (2011) Alcoholic liver disease: Pathogenesis and new therapeutic targets. Gastroenterology 141, 1572-1585.
    • (2011) Gastroenterology , vol.141 , pp. 1572-1585
    • Gao, B.1    Bataller, R.2
  • 44
    • 0036137559 scopus 로고    scopus 로고
    • Contribution of mitochondria to oxidative stress associated with alcoholic liver disease
    • DOI 10.1016/S0891-5849(01)00769-9, PII S0891584901007699
    • Bailey SM, Cunningham CC (2002) Contribution of mitochondria to oxidative stress associated with alcoholic liver disease. Free Radic Biol Med 32, 11-16. (Pubitemid 34045132)
    • (2002) Free Radical Biology and Medicine , vol.32 , Issue.1 , pp. 11-16
    • Bailey, S.M.1    Cunningham, C.C.2
  • 45
    • 0036083422 scopus 로고    scopus 로고
    • Alcohol and mitochondria: A dysfunctional relationship
    • Hoek JB, Cahill A, Pastorino JG (2002) Alcohol and mitochondria: A dysfunctional relationship. Gastroenterology 122, 2049-2063. (Pubitemid 34651446)
    • (2002) Gastroenterology , vol.122 , Issue.7 , pp. 2049-2063
    • Hoek, J.B.1    Cahill, A.2    Pastorino, J.G.3
  • 46
    • 0036017180 scopus 로고    scopus 로고
    • Ethanol, oxidative stress, and cytokine-induced liver cell injury
    • DOI 10.1016/S0741-8329(02)00215-X, PII S074183290200215X
    • Hoek JB, Pastorino JG (2002) Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol 27, 63-68. (Pubitemid 34626486)
    • (2002) Alcohol , vol.27 , Issue.1 , pp. 63-68
    • Hoek, J.B.1    Pastorino, J.G.2
  • 47
    • 34648834538 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in aging and Alzheimer's disease: Strategies to protect neurons
    • DOI 10.1089/ars.2007.1754
    • Reddy PH (2007) Mitochondrial dysfunction in aging and Alzheimer's disease: Strategies to protect neurons. Antioxid Redox Signal 9, 1647-1658. (Pubitemid 47462968)
    • (2007) Antioxidants and Redox Signaling , vol.9 , Issue.10 , pp. 1647-1658
    • Reddy, P.H.1
  • 48
    • 60349108806 scopus 로고    scopus 로고
    • Mitochondrial medicine for aging and neurodegenerative diseases
    • Reddy PH (2008) Mitochondrial medicine for aging and neurodegenerative diseases. Neuromolecular Med 10, 291-315.
    • (2008) Neuromolecular Med , vol.10 , pp. 291-315
    • Reddy, P.H.1
  • 51
    • 78650167618 scopus 로고    scopus 로고
    • Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
    • Otera H,Wang C, Cleland MM, Setoguchi K,Yokota S,Youle RJ, Mihara K (2010) Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol 191, 1141-1158.
    • (2010) J Cell Biol , vol.191 , pp. 1141-1158
    • Otera, H.1    Wang, C.2    Cleland, M.M.3    Setoguchi, K.4    Yokota, S.5    Youle, R.J.6    Mihara, K.7
  • 53
    • 79957937433 scopus 로고    scopus 로고
    • Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases
    • Reddy PH, Reddy TP,Manczak M, Calkins MJ, Shirendeb U, Mao P (2011) Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases. Brain Res Rev 67, 103-118.
    • (2011) Brain Res Rev , vol.67 , pp. 103-118
    • Reddy, P.H.1    Reddy, T.P.2    Manczak, M.3    Calkins, M.J.4    Shirendeb, U.5    Mao, P.6
  • 54
    • 84861130196 scopus 로고    scopus 로고
    • Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: Implications for mitochondrial dysfunction and neuronal damage
    • Manczak M, Reddy PH (2012) Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: Implications for mitochondrial dysfunction and neuronal damage. Hum Mol Genet 21, 2538-2547.
    • (2012) Hum Mol Genet , vol.21 , pp. 2538-2547
    • Manczak, M.1    Reddy, P.H.2
  • 57
    • 67349120572 scopus 로고    scopus 로고
    • Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway
    • Liot G, Bossy B, Lubitz S, Kushnareva Y, Sejbuk N, Bossy- Wetzel E (2009) Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway. Cell Death Differ 16, 899-909.
    • (2009) Cell Death Differ , vol.16 , pp. 899-909
    • Liot, G.1    Bossy, B.2    Lubitz, S.3    Kushnareva, Y.4    Sejbuk, N.5    Bossy- Wetzel, E.6
  • 58
    • 80052794422 scopus 로고    scopus 로고
    • DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4- phenylpyridinium toxicity in neurons: Implications for Parkinson's disease
    • Wang X, Su B, Liu W, He X, Gao Y, Castellani RJ, Perry G, Smith MA, Zhu X (2011) DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4- phenylpyridinium toxicity in neurons: Implications for Parkinson's disease. Aging Cell 10, 807-823.
    • (2011) Aging Cell , vol.10 , pp. 807-823
    • Wang, X.1    Su, B.2    Liu, W.3    He, X.4    Gao, Y.5    Castellani, R.J.6    Perry, G.7    Smith, M.A.8    Zhu, X.9
  • 59
    • 33644552417 scopus 로고    scopus 로고
    • Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
    • Yu T, Robotham JL, Yoon Y (2006) Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A 103, 2653-2658.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2653-2658
    • Yu, T.1    Robotham, J.L.2    Yoon, Y.3
  • 60
    • 33744964144 scopus 로고    scopus 로고
    • 2+ overload than nonsynaptic mitochondria
    • DOI 10.1074/jbc.M510303200
    • Brown MR, Sullivan PG, Geddes JW (2006) Synaptic mitochondria are more susceptible to Ca2+ overload than nonsynaptic mitochondria. J Biol Chem 281, 11658-11668. (Pubitemid 43855423)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.17 , pp. 11658-11668
    • Brown, M.R.1    Sullivan, P.G.2    Geddes, J.W.3
  • 61
    • 64249133725 scopus 로고    scopus 로고
    • S-nitrosylation of Drp1 mediates betaamyloid- related mitochondrial fission and neuronal injury
    • Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton SA (2009) S-nitrosylation of Drp1 mediates betaamyloid- related mitochondrial fission and neuronal injury. Science 324, 102-105.
    • (2009) Science , vol.324 , pp. 102-105
    • Cho, D.H.1    Nakamura, T.2    Fang, J.3    Cieplak, P.4    Godzik, A.5    Gu, Z.6    Lipton, S.A.7
  • 62
    • 84880940047 scopus 로고    scopus 로고
    • S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtininduced mitochondrial fragmentation and neuronal injury in Huntington's disease
    • Haun F, Nakamura T, Shiu AD, Cho DH, Tsunemi T, Holland EA, La Spada AR, Lipton SA (2013) S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtininduced mitochondrial fragmentation and neuronal injury in Huntington's disease. Antioxid Redox Signal 19, 1173-1184.
    • (2013) Antioxid Redox Signal , vol.19 , pp. 1173-1184
    • Haun, F.1    Nakamura, T.2    Shiu, A.D.3    Cho, D.H.4    Tsunemi, T.5    Holland, E.A.6    La Spada, A.R.7    Lipton, S.A.8
  • 64
    • 34848840991 scopus 로고    scopus 로고
    • Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death
    • DOI 10.1038/sj.embor.7401062, PII 7401062
    • Cribbs JT, Strack S (2007) Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death.EMBO Rep 8, 939-944. (Pubitemid 47500477)
    • (2007) EMBO Reports , vol.8 , Issue.10 , pp. 939-944
    • Cribbs, J.T.1    Strack, S.2
  • 65
    • 34547611925 scopus 로고    scopus 로고
    • Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology
    • DOI 10.1074/jbc.C700083200
    • Chang CR, Blackstone C (2007) Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology. J Biol Chem 282, 21583-21587. (Pubitemid 47195725)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.30 , pp. 21583-21587
    • Chang, C.-R.1    Blackstone, C.2
  • 66
    • 34249689057 scopus 로고    scopus 로고
    • Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission
    • DOI 10.1074/jbc.M607279200
    • Taguchi N, Ishihara N, Jofuku A, Oka T, Mihara K (2007) Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem 282, 11521- 11529. (Pubitemid 47100787)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.15 , pp. 11521-11529
    • Taguchi, N.1    Ishihara, N.2    Jofuku, A.3    Oka, T.4    Mihara, K.5
  • 69
    • 79959987510 scopus 로고    scopus 로고
    • Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation
    • Rambold AS, Kostelecky B, Elia N, Lippincott-Schwartz J (2011) Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci U S A 108, 10190-10195.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 10190-10195
    • Rambold, A.S.1    Kostelecky, B.2    Elia, N.3    Lippincott-Schwartz, J.4
  • 71
    • 38849099158 scopus 로고    scopus 로고
    • Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization
    • DOI 10.1016/j.devcel.2007.11.019, PII S1534580707004753
    • Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T, Kurth MJ, Shaw JT, Hinshaw JE, Green DR, Nunnari J (2008) Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell 14, 193-204. (Pubitemid 351189177)
    • (2008) Developmental Cell , vol.14 , Issue.2 , pp. 193-204
    • Cassidy-Stone, A.1    Chipuk, J.E.2    Ingerman, E.3    Song, C.4    Yoo, C.5    Kuwana, T.6    Kurth, M.J.7    Shaw, J.T.8    Hinshaw, J.E.9    Green, D.R.10    Nunnari, J.11
  • 72
    • 84876312885 scopus 로고    scopus 로고
    • A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity
    • Qi X, Qvit N, Su YC, Mochly-Rosen D (2013) A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci 126, 789-802.
    • (2013) J Cell Sci , vol.126 , pp. 789-802
    • Qi, X.1    Qvit, N.2    Su, Y.C.3    Mochly-Rosen, D.4
  • 74
    • 84878556565 scopus 로고    scopus 로고
    • A selective inhibitor of Drp1, mdivi-1, protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats
    • Xie N, Wang C, Lian Y, Zhang H, Wu C, Zhang Q (2013) A selective inhibitor of Drp1, mdivi-1, protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. Neurosci Lett 545, 64-68.
    • (2013) Neurosci Lett , vol.545 , pp. 64-68
    • Xie, N.1    Wang, C.2    Lian, Y.3    Zhang, H.4    Wu, C.5    Zhang, Q.6
  • 75
    • 84878403607 scopus 로고    scopus 로고
    • Role of mitochondrial fission in neuronal injury in pilocarpine-induced epileptic rats
    • Qiu X, Cao L, Yang X, Zhao X, Liu X, Han Y, Xue Y, Jiang H, Chi Z (2013) Role of mitochondrial fission in neuronal injury in pilocarpine-induced epileptic rats. Neuroscience 245, 157- 165.
    • (2013) Neuroscience , vol.245 , pp. 157-165
    • Qiu, X.1    Cao, L.2    Yang, X.3    Zhao, X.4    Liu, X.5    Han, Y.6    Xue, Y.7    Jiang, H.8    Chi, Z.9
  • 76
    • 84873256104 scopus 로고    scopus 로고
    • A selective inhibitor of Drp1, mdivi-1, acts against cerebral ischemia/reperfusion injury via an anti-apoptotic pathway in rats
    • Zhang N, Wang S, Li Y, Che L, Zhao Q (2013) A selective inhibitor of Drp1, mdivi-1, acts against cerebral ischemia/reperfusion injury via an anti-apoptotic pathway in rats. Neurosci Lett 535, 104-109.
    • (2013) Neurosci Lett , vol.535 , pp. 104-109
    • Zhang, N.1    Wang, S.2    Li, Y.3    Che, L.4    Zhao, Q.5
  • 77
    • 84877048945 scopus 로고    scopus 로고
    • Mitochondrial dynamics associated with oxygenglucose deprivation in rat primary neuronal cultures
    • Wappler EA, Institoris A, Dutta S, Katakam PV, Busija DW(2013) Mitochondrial dynamics associated with oxygenglucose deprivation in rat primary neuronal cultures. PLoS One 8, e63206.
    • (2013) PLoS One , vol.8
    • Wappler, E.A.1    Institoris, A.2    Dutta, S.3    Katakam, P.V.4    Busija, D.W.5
  • 78
    • 84889640326 scopus 로고    scopus 로고
    • Amelioration of rhabdomyolysis-induced renal mitochondrial injury and apoptosis through suppression of Drp-1 translocation
    • TangWX,WuWH, QiuHY,BoH, HuangSM(2013) Amelioration of rhabdomyolysis-induced renal mitochondrial injury and apoptosis through suppression of Drp-1 translocation. J Nephrol 26, 1073-1082.
    • (2013) J Nephrol , vol.26 , pp. 1073-1082
    • Tang, W.X.1    Wu, W.H.2    Qiu, H.Y.3    Bo, H.4    Huang, S.M.5
  • 81
    • 84858378920 scopus 로고    scopus 로고
    • Secretion of IL- 1- triggered by dynasore in murine peritoneal macrophages
    • Seil M, El Ouaaliti M, Dehaye JP (2012) Secretion of IL- 1- triggered by dynasore in murine peritoneal macrophages. Innate Immun 18, 241-249.
    • (2012) Innate Immun , vol.18 , pp. 241-249
    • Seil, M.1    El Ouaaliti, M.2    Dehaye, J.P.3
  • 82
    • 84876170176 scopus 로고    scopus 로고
    • Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart
    • Gao D, Zhang L, Dhillon R, Hong TT, Shaw RM, Zhu J (2013) Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PLoS One 8, e60967.
    • (2013) PLoS One , vol.8
    • Gao, D.1    Zhang, L.2    Dhillon, R.3    Hong, T.T.4    Shaw, R.M.5    Zhu, J.6
  • 85
    • 84858984845 scopus 로고    scopus 로고
    • Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies
    • Manczak M, Sesaki H, Kageyama Y, Reddy PH (2012) Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies. Biochim Biophys Acta 1822, 862-874.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 862-874
    • Manczak, M.1    Sesaki, H.2    Kageyama, Y.3    Reddy, P.H.4


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