A selective inhibitor of Drp1, Mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 5, 2011, Pages 2837-2843

  Park, Sang Woo ^a,b   Kim, Keun Young ^c   Lindsey, James D ^a   Dai, Yi ^a   Heo, Hwan ^b   Nguyen, Duy H ^a   Ellisman, Mark H ^c   Weinreb, Robert N ^a   Ju, Won Kyu ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Chonnam National University Medical School   (South Korea)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYNAMIN; DYNAMIN RELATED PROTEIN 1; GLIAL FIBRILLARY ACIDIC PROTEIN; MITOCHONDRIAL DIVISION INHIBITOR 1; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME LOCALIZATION; IMMUNOREACTIVITY; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA GANGLION CELL; RETINA ISCHEMIA;

ACUTE DISEASE; ANIMALS; APOPTOSIS; BLOOD PRESSURE; BLOTTING, WESTERN; BODY WEIGHT; CELL COUNT; CELL SURVIVAL; GTP PHOSPHOHYDROLASES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INTRAOCULAR PRESSURE; MICE; MICE, INBRED C57BL; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; OCULAR HYPERTENSION; QUINAZOLINONES; REPERFUSION INJURY; RETINAL DISEASES; RETINAL GANGLION CELLS; RETINAL VESSELS;

EID: 79956048283     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-5010     Document Type: Article

References (23)

1. Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet. 2004;363:1711-1720.
2. Ju WK, Kim KY, Lindsey JD, et al. Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve. Invest Ophthalmol Vis Sci. 2008;49:4903-4911.
3. Ju WK, Kim KY, Lindsey JD, et al. Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells. Mol Vis. 2009;15:120-134.
4. Ju WK, Lindsey JD, Angert M, Patel A, Weinreb RN. Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina. Mol Vis. 2008;14:2629-2638.
5. Karbowski M, Youle RJ. Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death Differ. 2003;10: 870-880.
6. Okamoto K, Shaw JM. Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. Annu Rev Genet. 2005;39:503-536.
7. Chen H, Chan DC. Emerging functions of mammalian mitochondrial fusion and fission. Hum Mol Genet. 2005;1:R283-R289.
8. Bossy-Wetzel E, Barsoum MJ, Godzik A, Schwarzenbacher R, Lipton SA. Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr Opin Cell Biol. 2003;15:706-716.
9. Labrousse AM, Zappaterra MD, Rube DA, van der Bliek AM. C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol Cell. 1999;4:815-826.
10. Cassidy-Stone A, Chipuk JE, Ingerman E, et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bakdependent mitochondrial outer membrane permeabilization. Dev Cell. 2008;14:193-204.
11. Tanaka A, Youle RJ. A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol Cell. 2008;29:409-410.
12. Frank S, Gaume B, Bergmann-Leitner ES, et al. The role of dynaminrelated protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell. 2001;1:515-525.
13. Lee YJ, Jeong SY, Karbowski M, Smith CL, Youle RJ. Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol Cell. 2004;15:5001-5011.
14. Jagasia R, Grote P, Westermann B, Conradt B. DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans. Nature. 2005;433:754-760.
15. Brooks C, Wei Q, Cho SG, Dong Z. Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest. 2009;119:1275-1285.
16. Ju WK, Misaka T, Kushnareva Y, et al. OPA1 expression in the normal rat retina and optic nerve. J Comp Neurol. 2005;488:1-10.
17. Ju WK, Liu Q, Kim KY, et al. Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells. Invest Ophthalmol Vis Sci. 2007;48: 2145-2151.
18. Yaffe MP. Dynamic mitochondria. Nat Cell Biol. 1999;1:E149-E150.
19. Youle RJ, Karbowski M. Mitochondrial fission in apoptosis. Nat Rev Mol Cell Biol. 2005;6:657-663.
20. Martinou JC, Youle RJ. Which came first, the cytochrome c release or the mitochondrial fission? Cell Death Differ. 2006;13:1291-1295.
21. Karbowski M, Lee YJ, Gaume B, et al. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J Cell Biol. 2002;159:931-938.
22. Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006;10:839-850.
23. Ju WK, Kim KY, Angert M, et al. Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina. Invest Ophthalmol Vis Sci. 2009;50: 707-716.