Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development

Diabetes

Volumn 62, Issue 10, 2013, Pages 3488-3499

  Supale, Sachin ^a   Thorel, Fabrizio ^a   Merkwirth, Carsten ^b,c   Gjinovci, Asllan ^a,d   Herrera, Pedro L ^a   Scorrano, Luca ^a,e   Meda, Paolo ^a   Langer, Thomas ^b   Maechler, Pierre ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b UNIVERSITY OF COLOGNE   (Germany)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; MITOCHONDRIAL DNA; PROHIBITIN; GUANOSINE TRIPHOSPHATASE; OPA1 PROTEIN (GTPASE), MOUSE; REPRESSOR PROTEIN; GLUCOSE BLOOD LEVEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CELL SURVIVAL; DIABETES MELLITUS; DISEASE COURSE; GLUCOSE HOMEOSTASIS; INSULIN RELEASE; MITOCHONDRIAL DNA DISORDER; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY CHAIN; ANIMAL; FEMALE; GENE DELETION; GENETICS; GLUCOSE BLOOD LEVEL; HUMAN; KNOCKOUT MOUSE; MALE; METABOLISM; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; SECRETION (PROCESS);

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; CELL PROLIFERATION; CELL SURVIVAL; DIABETES MELLITUS, TYPE 2; DISEASE PROGRESSION; DNA, MITOCHONDRIAL; FEMALE; GENE DELETION; GTP PHOSPHOHYDROLASES; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIA; REPRESSOR PROTEINS;

EID: 84891549568     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0152     Document Type: Article

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