Impact of nitric oxide on metabolism in health and age-related disease

Diabetes, Obesity and Metabolism

Volumn 12, Issue SUPPL. 2, 2010, Pages 126-133

  Knott, A B ^a   Bossy Wetzel, E ^a  

^a UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Mitochondrial biogenesis; Mitochondrial fission and fusion; Nitric oxide; PGC1 ; Sirtuins

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SIRTUIN;

ADIPOSE TISSUE; ARTICLE; BIOGENESIS; ENERGY EXPENDITURE; EXERCISE; HEALTH; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LIPID COMPOSITION; METABOLISM; MITOCHONDRION; NERVE DEGENERATION; NERVE INJURY; NITROSATIVE STRESS; NONHUMAN; PATHOPHYSIOLOGY; PREVALENCE;

EID: 77957320216     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2010.01267.x     Document Type: Article

References (87)

1. Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet 2005, 39:359-407..
2. Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature 2006, 444:868-874..
3. Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 2010, 5:253-295..
4. Knowles RG, Moncada S. Nitric oxide synthases in mammals. Biochem J 1994, 298:249-258..
5. Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from l-arginine. Nature 1988, 333:664-666..
6. Knott AB, Bossy-Wetzel E. Nitric oxide in health and disease of the nervous system. Antioxid Redox Signal 2009, 11:541-554..
7. Ghafourifar P, Cadenas E. Mitochondrial nitric oxide synthase. Trends Pharmacol Sci 2005, 26:190-195..
8. Ghafourifar P, Richter C. Nitric oxide synthase activity in mitochondria. FEBS Lett 1997, 418:291-296..
9. Moncada S, Bolanos JP. Nitric oxide, cell bioenergetics and neurodegeneration. J Neurochem 2006, 97:1676-1689..
10. Merrill JE, Murphy SP, Mitrovic B. Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes. J Neurosci Res 1997, 48:372-384..
11. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987, 84:9265-9269..
12. Snyder SH. Nitric oxide: first in a new class of neurotransmitters. Science 1992, 257:494-496..
13. Bredt DS, Glatt CE, Hwang PM, Fotuhi M, Dawson TM, Snyder SH. Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron 1991, 7:615-624..
14. Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 1991, 351:714-718..
15. Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH. Nitric oxide: a physiologic mediator of penile erection. Science 1992, 257:401-403..
16. Choi YB, Tenneti L, Le DA. Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation. Nat Neurosci 2000, 3:15-21..
17. Kim WK, Choi YB, Rayudu PV. Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO. Neuron 1999, 24:461-469..
18. Hibbs JB, Taintor RR, Vavrin Z, Rachlin EM. Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 1988, 157:87-94..
19. Nelson EJ, Connolly J, McArthur P. Nitric oxide and S-nitrosylation: excitotoxic and cell signaling mechanism. Biol Cell 2003, 95:3-8..
20. Ghafourifar P, Schenk U, Klein SD, Richter C. Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation. J Biol Chem 1999, 274:31185-31188..
21. Stamler JS, Lamas S, Fang FC. Nitrosylation: the prototypic redox-based signaling mechanism. Cell 2001, 106:675-683..
22. Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci USA 1991, 88:6368-6371..
23. Nisoli E, Carruba MO. Nitric oxide and mitochondrial biogenesis. J Cell Sci 2006, 119:2855-2862..
24. Nisoli E, Clementi E, Paolucci C. Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 2003, 299:896-899..
25. Kelly DP, Scarpulla RC. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev 2004, 18:357-368..
26. Nisoli E, Falcone S, Tonello C. Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals. Proc Natl Acad Sci USA 2004, 101:16507-16512..
27. Baar K, Wende AR, Jones TE. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. Faseb J 2002, 16:1879-1886..
28. Wadley GD, McConell GK. Effect of nitric oxide synthase inhibition on mitochondrial biogenesis in rat skeletal muscle. J Appl Physiol 2007, 102:314-320..
29. Nisoli E. Really different knockout strains in movement? J Physiol 2008, 586:913..
30. Wadley GD, Choate J, McConell GK. Authors' reply to letter from Nisoli. J Physiol 2008, 586:915-916..
31. Wadley GD, Choate J, McConell GK. NOS isoform-specific regulation of basal but not exercise-induced mitochondrial biogenesis in mouse skeletal muscle. J Physiol 2007, 585:253-262..
32. Mattson MP. Perspective: Does brown fat protect against diseases of aging? Ageing Res Rev 2010, 9:69-76..
33. Seale P, Kajimura S, Spiegelman BM. Transcriptional control of brown adipocyte development and physiological function-of mice and men. Genes Dev 2009, 23:788-797..
34. Nisoli E, Clementi E, Tonello C, Sciorati C, Briscini L, Carruba MO. Effects of nitric oxide on proliferation and differentiation of rat brown adipocytes in primary cultures. Br J Pharmacol 1998, 125:888-894..
35. Petrovic V, Korac A, Buzadzic B, Korac B. The effects of l-arginine and l-NAME supplementation on redox-regulation and thermogenesis in interscapular brown adipose tissue. J Exp Biol 2005, 208:4263-4271..
36. Haas B, Mayer P, Jennissen K. Protein kinase G controls brown fat cell differentiation and mitochondrial biogenesis. Sci Signal 2009, 2:ra78..
37. Xiao XQ, Williams SM, Grayson BE. Excess weight gain during the early postnatal period is associated with permanent reprogramming of brown adipose tissue adaptive thermogenesis. Endocrinology 2007, 148:4150-4159..
38. Ogden CL, Carroll MD, Curtin LR, Lamb MM, Flegal KM. Prevalence of high body mass index in US children and adolescents, 2007-2008. J Am Med Assoc 2010, 303:242-249..
39. Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140:900-917..
40. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006, 444:860-867..
41. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91..
42. Gotoh T, Mori M. Nitric oxide and endoplasmic reticulum stress. Arterioscler Thromb Vasc Biol 2006, 26:1439-1446..
43. Uehara T, Nakamura T, Yao D. S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature 2006, 441:513-517..
44. Kaneki M, Shimizu N, Yamada D, Chang K. Nitrosative stress and pathogenesis of insulin resistance. Antioxid Redox Signal 2007, 9:319-329..
45. Perreault M, Marette A. Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 2001, 7:1138-1143..
46. Cohen HY, Miller C, Bitterman KJ. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004, 305:390-392..
47. Taylor DM, Maxwell MM, Luthi-Carter R, Kazantsev AG. Biological and potential therapeutic roles of sirtuin deacetylases. Cell Mol Life Sci 2008, 65:4000-4018..
48. Hirschey MD, Shimazu T, Goetzman E. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 2010, 464:121-125..
49. Rodgers JT, Lerin C, Gerhart-Hines Z, Puigserver P. Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS Lett 2008, 582:46-53..
50. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005, 434:113-118..
51. Wareski P, Vaarmann A, Choubey V. PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. J Biol Chem 2009, 284:21379-21385..
52. Nemoto S, Fergusson MM, Finkel T. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem 2005, 280:16456-16460..
53. Nisoli E, Tonello C, Cardile A. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 2005, 310:314-317..
54. Labrousse AM, Zappaterra MD, Rube DA, van der Bliek AM. C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol Cell 1999, 4:815-826..
55. Smirnova E, Griparic L, Shurland DL, van der Bliek AM. Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol Biol Cell 2001, 12:2245-2256..
56. Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser SE, Chan DC. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 2003, 160:189-200..
57. Ishihara N, Eura Y, Mihara K. Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity. J Cell Sci 2004, 117:6535-6546..
58. Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L. OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci USA 2004, 101:15927-15932..
59. Meeusen S, DeVay R, Block J. Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1. Cell 2006, 127:383-395..
60. Olichon A, Baricault L, Gas N. Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J Biol Chem 2003, 278:7743-7746..
61. Alexander C, Votruba M, Pesch UE. OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28. Nat Genet 2000, 26:211-215..
62. Delettre C, Lenaers G, Griffoin JM. Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy. Nat Genet 2000, 26:207-210..
63. Kijima K, Numakura C, Izumino H. Mitochondrial GTPase mitofusin 2 mutation in Charcot-Marie-Tooth neuropathy type 2A. Hum Genet 2005, 116:23-27..
64. Zuchner S, Mersiyanova IV, Muglia M. Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Nat Genet 2004, 36:449-451..
65. Barsoum MJ, Yuan H, Gerencser AA. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. Embo J 2006, 25:3900-3911..
66. Yuan H, Gerencser AA, Liot G. Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons. Cell Death Differ 2007, 14:462-471..
67. Wang X, Su B, Siedlak SL. Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci USA 2008, 105:19318-19323..
68. Cho DH, Nakamura T, Fang J. S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 2009, 324:102-105..
69. Ingerman E, Perkins EM, Marino M. Dnm1 forms spirals that are structurally tailored to fit mitochondria. J Cell Biol 2005, 170:1021-1027..
70. Shin HW, Takatsu H, Mukai H, Munekata E, Murakami K, Nakayama K. Intermolecular and interdomain interactions of a dynamin-related GTP-binding protein, Dnm1p/Vps1p-like protein. J Biol Chem 1999, 274:2780-2785..
71. Zhu PP, Patterson A, Stadler J, Seeburg DP, Sheng M, Blackstone C. Intra- and intermolecular domain interactions of the C-terminal GTPase effector domain of the multimeric dynamin-like GTPase Drp1. J Biol Chem 2004, 279:35967-35974..
72. Ban T, Heymann JA, Song Z, Hinshaw JE, Chan DC. OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation. Hum Mol Genet 2010, 19:2113-2122..
73. Mears JA, Hinshaw JE. Visualization of dynamins. Methods Cell Biol 2008, 88:237-256..
74. Bossy B, Petrilli A, Klinglmayr E. S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease. J Alzheimers Dis 2010, 20:S513-526. Suppl. 2
75. Bolanos JP, Peuchen S, Heales SJ, Land JM, Clark JB. Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J Neurochem 1994, 63:910-916..
76. Brown GC, Bolanos JP, Heales SJ, Clark JB. Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration. Neurosci Lett 1995, 193:201-204..
77. Brown GC, Cooper CE. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett 1994, 356:295-298..
78. Radi R, Rodriguez M, Castro L, Telleri R. Inhibition of mitochondrial electron transport by peroxynitrite. Arch Biochem Biophys 1994, 308:89-95..
79. Liot G, Bossy B, Lubitz S, Kushnareva Y, Sejbuk N, Bossy-Wetzel E. Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway. Cell Death Differ 2009, 16:899-909..
80. Rui Y, Tiwari P, Xie Z, Zheng JQ. Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons. J Neurosci 2006, 26:10480-10487..
81. Miglio G, Rosa AC, Rattazzi L, Collino M, Lombardi G, Fantozzi R. PPARgamma stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss. Neurochem Int 2009, 55:496-504..
82. Soriano FX, Liesa M, Bach D, Chan DC, Palacin M, Zorzano A. Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2. Diabetes 2006, 55:1783-1791..
83. Taguchi N, Ishihara N, Jofuku A, Oka T, Mihara K. Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem 2007, 282:11521-11529..
84. Lee HG, Casadesus G, Zhu X. Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease. Neurochem Int 2009, 54:84-88..
85. Bezprozvanny I, Mattson MP. Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci 2008, 31:454-463..
86. Cereghetti GM, Stangherlin A, Martins de Brito O. Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci USA 2008, 105:15803-15808..
87. Cribbs JT, Strack S. Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO Rep 2007, 8:939-944..