Mutant Huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

Human Molecular Genetics

Volumn 21, Issue 2, 2012, Pages 406-420

  Shirendeb, Ulziibat P ^a   Calkins, Marcus J ^a   Manczak, Maria ^a   Anekonda, Vishwanath ^a   Dufour, Brett ^a   McBride, Jodi L ^a   Mao, Peizhong ^a   Reddy, P Hemachandra ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; HUNTINGTIN; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL PROTEIN DRP1; OLIGOMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BIOGENESIS; BRAIN; BRAIN CELL; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; MITOCHONDRION; MOUSE; NERVE CELL; NERVE CELL DEGENERATION; NERVE FIBER TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN INTERACTION; SYNAPSE;

ANIMALS; AXONS; GTP PHOSPHOHYDROLASES; HUMANS; HUNTINGTON DISEASE; MICE; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING; SYNAPSES;

MUS;

EID: 84855395163     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr475     Document Type: Article

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