Potential therapeutic effects of neurotrophins for acute and chronic neurological diseases

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Cai, Junying ^a   Hua, Fuzhou ^a   Yuan, Linhui ^a   Tang, Wei ^a   Lu, Jun ^a   Yu, Shuchun ^a   Wang, Xifeng ^a   Hu, Yanhui ^a  

^a NANCHANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; ANTIINFLAMMATORY AGENT; ATORVASTATIN; BAICALIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE 3; CILOSTAZOL; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUTAMATE RECEPTOR; INTERLEUKIN 10; MESSENGER RNA; NEUROTROPHIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINIC ACID; NITRIC OXIDE SYNTHASE; SCATTER FACTOR; SILDENAFIL; SOMATOMEDIN C; TRANSFERRIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; VASCULOTROPIN A; NERVE GROWTH FACTOR; NEUROPROTECTIVE AGENT;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ASTROCYTE; BRAIN CELL; BRAIN INFARCTION; CALCIUM CELL LEVEL; CELL MIGRATION; CELL THERAPY; CELL TRANSPLANTATION; CEREBROVASCULAR ACCIDENT; CHOROID PLEXUS; COGNITIVE DEFECT; DEGENERATIVE DISEASE; DRUG EFFICACY; GLIA; HEART STROKE VOLUME; HIPPOCAMPAL CA1 REGION; HUMAN; HUNTINGTON CHOREA; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR PERFORMANCE; NERVE FIBER; NERVE INJURY; NERVOUS SYSTEM DEVELOPMENT; NEUROFIBRILLARY TANGLE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PYRAMIDAL NERVE CELL; REVIEW; SPREADING CORTICAL DEPRESSION; SYNAPTOSOME; UPREGULATION; ACUTE DISEASE; ANIMAL; CHRONIC DISEASE; NERVOUS SYSTEM DISEASES; NEURODEGENERATIVE DISEASES;

ACUTE DISEASE; ANIMALS; CHRONIC DISEASE; HUMANS; NERVE GROWTH FACTORS; NERVOUS SYSTEM DISEASES; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS;

EID: 84900026321     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/601084     Document Type: Review

References (123)

1. Numakawa T., Matsumoto T., Numakawa Y., Richards M., Yamawaki S., Kunugi H., Protective action of neurotrophic factors and estrogen against oxidative stress-mediated neurodegeneration. Journal of Toxicology 2011 2011 12 2-s2.0-80051797370 10.1155/2011/405194 405194
2. Dasuri K., Zhang L., Keller J. N., Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis. Free Radical Biology and Medicine 2013 62 170 185
3. Rodrigo R., Fernandez-Gajardo R., Gutierrez R., Matamala J. M., Carrasco R., Miranda-Merchak A., Feuerhake W., Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities. CNS & Neurological Disorders Drug Targets 2013 12 5 698 714
4. Mattson M. P., Glutamate and neurotrophic factors in neuronal plasticity and disease. Annals of the New York Academy of Sciences 2008 1144 97 112 2-s2.0-56649124807 10.1196/annals.1418.005
5. Lakhan S. E., Kirchgessner A., Hofer M., Inflammatory mechanisms in ischemic stroke: therapeutic approaches. Journal of Translational Medicine 2009 7, article 97 2-s2.0-71049180369 10.1186/1479-5876-7-97
6. Reichardt L. F., Neurotrophin-regulated signalling pathways. Philosophical Transactions of the Royal Society B: Biological Sciences 2006 361 1473 1545 1564 2-s2.0-33749010358 10.1098/rstb.2006.1894
7. Nagahara A. H., Tuszynski M. H., Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nature Reviews Drug Discovery 2011 10 3 209 219 2-s2.0-79952182383 10.1038/nrd3366
8. Stankowski J. N., Gupta R., Therapeutic targets for neuroprotection in acute ischemic stroke: lost in translation? Antioxidants and Redox Signaling 2011 14 10 1841 1851 2-s2.0-79954571076 10.1089/ars.2010.3292
9. Webster N. J. G., Pirrung M. C., Small molecule activators of the Trk receptors for neuroprotection. BMC Neuroscience 2008 9 2, article S1 2-s2.0-57449088366 10.1186/1471-2202-9-S2-S1
10. Wu D., Neuroprotection in experimental stroke with targeted neurotrophins. NeuroRx 2005 2 1 120 128 2-s2.0-12344336804 10.1602/neurorx.2.1. 120
11. Schäbitz W.-R., Schwab S., Spranger M., Hacke W., Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. Journal of Cerebral Blood Flow and Metabolism 1997 17 5 500 506 2-s2.0-0030951213
12. Yamashita K., Wiessner C., Lindholm D., Thoenen H., Hossmann K.-A., Post-occlusion treatment with BDNF reduces infarct size in a model of permanent occlusion of the middle cerebral artery in rat. Metabolic Brain Disease 1997 12 4 271 280 2-s2.0-0031415298 10.1023/A:1022322025000
13. Yanamoto H., Nagata I., Sakata M., Zhang Z., Tohnai N., Sakai H., Kikuchi H., Infarct tolerance induced by intra-cerebral infusion of recombinant brain-derived neurotrophic factor. Brain Research 2000 859 2 240 248 2-s2.0-0034708551 10.1016/S0006-8993(00)01966-1
14. Schabitz W.-R., Sommer C., Zoder W., Kiessling M., Schwaninger M., Schwab S., Finklestein S. P., Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia. Stroke 2000 31 9 2212 2217 2-s2.0-0033811469
15. Shirakura M., Inoue M., Fujikawa S., Washizawa K., Komaba S., Maeda M., Watabe K., Yoshikawa Y., Hasegawa M., Postischemic administration of Sendai virus vector carrying neurotrophic factor genes prevents delayed neuronal death in gerbils. Gene Therapy 2004 11 9 784 790 2-s2.0-2442685359 10.1038/sj.gt.3302224
16. Chen J., Li Y., Chopp M., Intracerebral transplantation of bone marrow with BDNF after MCAo in rat. Neuropharmacology 2000 39 5 711 716 2-s2.0-0033974706 10.1016/S0028-3908(00)00006-X
17. Berger C., Schabitz W.-R., Wolf M., Mueller H., Sommer C., Schwab S., Hypothermia and brain-derived neurotrophic factor reduce glutamate synergistically in acute stroke. Experimental Neurology 2004 185 2 305 312 2-s2.0-0347003761 10.1016/j.expneurol.2003.10.008
18. Borlongan C. V., Skinner S. J. M., Geaney M., Vasconcellos A. V., Elliott R. B., Emerich D. F., Intracerebral transplantation of porcine choroid plexus provides structural and functional neuroprotection in a rodent model of stroke. Stroke 2004 35 9 2206 2210 2-s2.0-4344679545 10.1161/01.STR.0000138954.25825.0b
19. Mochizuki N., Takagi N., Kurokawa K., Onozato C., Moriyama Y., Tanonaka K., Takeo S., Injection of neural progenitor cells improved learning and memory dysfunction after cerebral ischemia. Experimental Neurology 2008 211 1 194 202 2-s2.0-42749090554 10.1016/j.expneurol.2008.01.027
20. Hasegawa Y., Suzuki H., Altay O., Zhang J. H., Preservation of tropomyosin-related kinase B (TrkB) signaling by sodium orthovanadate attenuates early brain injury after subarachnoid hemorrhage in rats. Stroke 2011 42 2 477 483 2-s2.0-79251609536 10.1161/STROKEAHA.110.597344
21. Zhu J. M., Zhao Y. Y., Chen S. D., Zhang W. H., Lou L., Jin X., Functional recovery after transplantation of neural stem cells modified by brain-derived neurotrophic factor in rats with cerebral ischaemia. Journal of International Medical Research 2011 39 2 488 498 2-s2.0-79955663786
22. Sato Y., Chin Y., Kato T., Tanaka Y., Tozuka Y., Mase M., Ageyama N., Ono F., Terao K., Yoshikawa Y., Hisatsune T., White matter activated glial cells produce BDNF in a stroke model of monkeys. Neuroscience Research 2009 65 1 71 78 2-s2.0-67650457934 10.1016/j.neures.2009.05.010
23. Schäbitz W.-R., Berger C., Kollmar R., Seitz M., Tanay E., Kiessling M., Schwab S., Sommer C., Effect of brain-derived neurotrophic factor treatment and forced arm use on functional motor recovery after small cortical ischemia. Stroke 2004 35 4 992 997 2-s2.0-1842575785 10.1161/01.STR.0000119754.85848.0D
24. Endres M., Fan G., Hirt L., Fujii M., Matsushita K., Liu X., Jaenisch R., Moskowitz M. A., Ischemic brain damage in mice after selectively modifying BDNF or NT4 gene expression. Journal of Cerebral Blood Flow and Metabolism 2000 20 1 139 144 2-s2.0-0033962050
25. Saarelainen T., Lukkarinen J. A., Koponen S., Gröhn O. H. J., Jolkkonen J., Koponen E., Haapasalo A., Alhonen L., Wong G., Koistinaho J., Kauppinen R. A., Castrén E., Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia. Molecular and Cellular Neurosciences 2000 16 2 87 96 2-s2.0-0033840707
26. Ploughman M., Windle V., MacLellan C. L., White N., Doré J. J., Corbett D., Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats. Stroke 2009 40 4 1490 1495 2-s2.0-65249126363 10.1161/STROKEAHA.108.531806
27. Gustafsson E., Andsberg G., Darsalia V., Mohapel P., Mandel R. J., Kirik D., Lindvall O., Kokaia Z., Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke. European Journal of Neuroscience 2003 17 12 2667 2678 2-s2.0-0038684215 10.1046/j.1460-9568.2003.02713.x
28. Kurozumi K., Nakamura K., Tamiya T., Kawano Y., Ishii K., Kobune M., Hirai S., Uchida H., Sasaki K., Ito Y., Kato K., Honmou O., Houkin K., Date I., Hamada H., Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model. Molecular Therapy 2005 11 1 96 104 2-s2.0-19944406772 10.1016/j.ymthe.2004.09.020
29. Ding Y., Li J., Luan X., Ding Y. H., Lai Q., Rafols J. A., Phillis J. W., Clark J. C., Diaz F. G., Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin. Neuroscience 2004 124 3 583 591 2-s2.0-1342343120 10.1016/j.neuroscience.2003.12.029
30. Kiprianova I., Schindowski K., Von Bohlen Und Halbach O., Krause S., Dono R., Schwaninger M., Unsicker K., Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2. Experimental Neurology 2004 189 2 252 260 2-s2.0-4544267683 10.1016/j.expneurol.2004.06.004
31. Yanamoto H., Xue J.-H., Miyamoto S., Nagata I., Nakano Y., Murao K., Kikuchi H., Spreading depression induces long-lasting brain protection against infarcted lesion development via BDNF gene-dependent mechanism. Brain Research 2004 1019 1-2 178 188 2-s2.0-4143147483 10.1016/j.brainres.2004.05.105
32. Xu J., Zhang Q.-G., Li C., Zhang G.-Y., Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and calmodulin-mediated PI-3K/Akt pathway activation. Hippocampus 2007 17 7 525 537 2-s2.0-34447527799 10.1002/hipo.20289
33. Chuang D.-M., Neuroprotective and neurotrophic actions of the mood stabilizer lithium: can it be used to treat neurodegenerative diseases? Critical Reviews in Neurobiology 2004 16 1-2 83 90 2-s2.0-9744238838 10.1615/CritRevNeurobiol.v16.i12.90
34. Chuang D. M., Wang Z., Chiu C. T., GSK-3 as a target for lithium-induced neuroprotection against excitotoxicity in neuronal cultures and animal models of ischemic stroke. Frontiers in Molecular Neuroscience 2011 4 15
35. Chen J., Zhang C., Jiang H., Li Y., Zhang L., Robin A., Katakowski M., Lu M., Chopp M., Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice. Journal of Cerebral Blood Flow and Metabolism 2005 25 2 281 290 2-s2.0-12844260208 10.1038/sj.jcbfm.9600034
36. Krikov M., Thone-Reineke C., Müller S., Villringer A., Unger T., Candesartan but not ramipril pretreatment improves outcome after stroke and stimulates neurotrophin BNDF/TrkB system in rats. Journal of Hypertension 2008 26 3 544 552 2-s2.0-39849108925 10.1097/HJH.0b013e3282f2dac9
37. Chen J., Zacharek A., Zhang C., Jiang H., Li Y., Roberts C., Lu M., Kapke A., Chopp M., Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice. Journal of Neuroscience 2005 25 9 2366 2375 2-s2.0-14644444482 10.1523/JNEUROSCI.5071-04. 2005
38. Kim M.-W., Bang M.-S., Han T.-R., Ko Y.-J., Yoon B.-W., Kim J.-H., Kang L.-M., Lee K.-M., Kim M.-H., Exercise increased BDNF and trkB in the contralateral hemisphere of the ischemic rat brain. Brain Research 2005 1052 1 16 21 2-s2.0-23644450397 10.1016/j.brainres.2005.05.070
39. Ke Z., Yip S. P., Li L., Zheng X.-X., Tong K.-Y., The effects of voluntary, involuntary, and forced exercises on brain-derived neurotrophic factor and motor function recovery: a rat brain ischemia model. PLoS ONE 2011 6 2 2-s2.0-79951570562 10.1371/journal.pone.0016643 e16643
40. Clarkson A. N., Overman J. J., Zhong S., Mueller R., Lynch G., Carmichael S. T., AMPA receptor-induced local brain-derived neurotrophic factor signaling mediates motor recovery after stroke. Journal of Neuroscience 2011 31 10 3766 3775 2-s2.0-79952429724 10.1523/JNEUROSCI.5780-10.2011
41. Pera J., Zawadzka M., Kaminska B., Szczudlik A., Neurotrophic factor expression after focal brain ischemia preceded by different preconditioning strategies. Cerebrovascular Diseases 2005 19 4 247 252 2-s2.0-17844395230 10.1159/000084088
42. +/- mice is associated with enhanced recovery of motor performance and increased neuroblast number following experimental stroke. Journal of Neuroscience Research 2006 84 3 626 631 2-s2.0-33747020589 10.1002/jnr.20956
43. Hirata K., Kuge Y., Yokota C., Harada A., Kokame K., Inoue H., Kawashima H., Hanzawa H., Shono Y., Saji H., Minematsu K., Tamaki N., Gene and protein analysis of brain derived neurotrophic factor expression in relation to neurological recovery induced by an enriched environment in a rat stroke model. Neuroscience Letters 2011 495 3 210 215 2-s2.0-79955619815 10.1016/j.neulet. 2011.03.068
44. Geral C., Angelova A., Lesieur S., From molecular to nanotechnology strategies for delivery of neurotrophins: emphasis on brain-derived neurotrophic factor (BDNF). Pharmaceutics 2013 5 1 127 167
45. Zhang Y., Pardridge W. M., Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system. Stroke 2001 32 6 1378 1383 2-s2.0-0034988984
46. Zhang Y., Pardridge W. M., Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion. Brain Research 2006 1111 1 227 229 2-s2.0-33748438120 10.1016/j.brainres.2006.07.005
47. Yanamoto H., Miyamoto S., Nakajo Y., Nakano Y., Hori T., Naritomi H., Kikuchi H., Repeated application of an electric field increases BDNF in the brain, enhances spatial learning, and induces infarct tolerance. Brain Research 2008 1212 79 88 2-s2.0-43549105602 10.1016/j.brainres.2008.03.011
48. Han Q., Li B., Feng H., Xiao Z., Chen B., Zhao Y., Huang J., Dai J., The promotion of cerebral ischemia recovery in rats by laminin-binding BDNF. Biomaterials 2011 32 22 5077 5085 2-s2.0-79956084656 10.1016/j.biomaterials. 2011.03.072
49. Jiang Y., Wei N., Lu T., Zhu J., Xu G., Liu X., Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience 2011 172 398 405 2-s2.0-78650748359 10.1016/j.neuroscience.2010.10.054
50. Jang S.-W., Liu X., Yepes M., Shepherd K. R., Miller G. W., Liu Y., Wilson W. D., Xiao G., Blanchi B., Sun Y. E., Ye K., A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proceedings of the National Academy of Sciences of the United States of America 2010 107 6 2687 2692 2-s2.0-77249168715 10.1073/pnas.0913572107
51. Zhang Z.-J., Li P., Wang Z., Li P.-T., Zhang W.-S., Sun Z.-H., Zhang X.-J., Wang Y.-Y., A comparative study on the individual and combined effects of baicalin and jasminoidin on focal cerebral ischemia-reperfusion injury. Brain Research 2006 1123 1 188 195 2-s2.0-33751292170 10.1016/j.brainres.2006.09.063
52. Cui X., Chopp M., Zacharek A., Roberts C., Buller B., Ion M., Chen J., Niacin treatment of stroke increases synaptic plasticity and axon growth in rats. Stroke 2010 41 9 2044 2049 2-s2.0-77956402483 10.1161/STROKEAHA.110.589333
53. Qu W.-S., Wang Y.-H., Wang J.-P., Tang Y.-X., Zhang Q., Tian D.-S., Yu Z.-Y., Xie M.-J., Wang W., Galectin-1 enhances astrocytic BDNF production and improves functional outcome in rats following ischemia. Neurochemical Research 2010 35 11 1716 1724 2-s2.0-78449279872 10.1007/s11064-010-0234-z
54. Kam K.-Y., Yu S. J., Jeong N., Hong J. H., Jalin A. M. A. A., Lee S., Choi Y. W., Lee C. K., Kang S. G., p-hydroxybenzyl alcohol prevents brain injury and behavioral impairment by activating Nrf2, PDI, and neurotrophic factor genes in a rat model of brain ischemia. Molecules and Cells 2011 31 3 209 215 2-s2.0-79959976451 10.1007/s10059-011-0028-4
55. Rothman S. M., Mattson M. P., Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan. Neuroscience 2013 239 228 240
56. Markham A., Cameron I., Bains R., Franklin P., Kiss J. P., Schwendimann L., Gressens P., Spedding M., Brain-derived neurotrophic factor-mediated effects on mitochondrial respiratory coupling and neuroprotection share the same molecular signalling pathways. European Journal of Neuroscience 2012 35 3 366 374 2-s2.0-84856467949 10.1111/j.1460-9568.2011.07965.x
57. Schäbitz W.-R., Steigleder T., Cooper-Kuhn C. M., Schwab S., Sommer C., Schneider A., Kuhn H. G., Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis. Stroke 2007 38 7 2165 2172 2-s2.0-34347354314 10.1161/STROKEAHA.106.477331
58. Keiner S., Witte O. W., Redecker C., Immunocytochemical detection of newly generated neurons in the perilesional area of cortical infarcts after intraventricular application of brain-derived neurotrophic factor. Journal of Neuropathology and Experimental Neurology 2009 68 1 83 93 2-s2.0-64049089692 10.1097/NEN.0b013e31819308e9
59. Li B., Piao C.-S., Liu X.-Y., Guo W.-P., Xue Y.-Q., Duan W.-M., Gonzalez-Toledo M. E., Zhao L.-R., Brain self-protection: the role of endogenous neural progenitor cells in adult brain after cerebral cortical ischemia. Brain Research 2010 1327 91 102 2-s2.0-77950355854 10.1016/j.brainres.2010.02.030
60. Bao X., Wei J., Feng M., Lu S., Li G., Dou W., Ma W., Ma S., An Y., Qin C., Zhao R. C., Wang R., Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats. Brain Research 2011 1367 103 113 2-s2.0-78650517407 10.1016/j.brainres.2010.10.063
61. Tanaka Y., Tanaka R., Liu M., Hattori N., Urabe T., Cilostazol attenuates ischemic brain injury and enhances neurogenesis in the subventricular zone of adult mice after transient focal cerebral ischemia. Neuroscience 2010 171 4 1367 1376 2-s2.0-78650172130 10.1016/j.neuroscience.2010.10.008
62. Qu R., Li Y., Gao Q., Shen L., Zhang J., Liu Z., Chen X., Chopp M., Neurotrophic and growth factor gene expression profiling of mouse bone marrow stromal cells induced by ischemic brain extracts. Neuropathology 2007 27 4 355 363 2-s2.0-34447325950 10.1111/j.1440-1789.2007.00792.x
63. Guo S., Kim W. J., Lok J., Lee S.-R., Besancon E., Luo B.-H., Stins M. F., Wang X., Dedhar S., Lo E. H., Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons. Proceedings of the National Academy of Sciences of the United States of America 2008 105 21 7582 7587 2-s2.0-44949103395 10.1073/pnas.0801105105
64. Choi Y. J., Li W. Y., Moon G. J., Lee P. H., Ahn Y. H., Lee G., Bang O. Y., Enhancing trophic support of mesenchymal stem cells by ex vivo treatment with trophic factors. Journal of the Neurological Sciences 2010 298 1-2 28 34 2-s2.0-77958152038 10.1016/j.jns.2010.09.003
65. Madinier A., Bertrand N., Mossiat C., Prigent-Tessier A., Beley A., Marie C., Garnier P., Microglial involvement in neuroplastic changes following focal brain ischemia in rats. PloS one 2009 4 12 e8101 2-s2.0-77949496119
66. Narantuya D., Nagai A., Abdullah M., Masuda J., Kobayashi S., Yamaguchi S., Kim S. U., Human microglia transplanted in rat focal ischemia brain induce neuroprotection and behavioral improvement. PLoS ONE 2010 5 7 2-s2.0-77955363785 10.1371/journal.pone.0011746 e11746
67. Arancibia S., Silhol M., Moulière F., Meffre J., Höllinger I., Maurice T., Tapia-Arancibia L., Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats. Neurobiology of Disease 2008 31 3 316 326 2-s2.0-49349113732 10.1016/j.nbd.2008.05.012
68. Nagahara A. H., Merrill D. A., Coppola G., Tsukada S., Schroeder B. E., Shaked G. M., Wang L., Blesch A., Kim A., Conner J. M., Rockenstein E., Chao M. V., Koo E. H., Geschwind D., Masliah E., Chiba A. A., Tuszynski M. H., Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nature Medicine 2009 15 3 331 337 2-s2.0-62049083420 10.1038/nm.1912
69. Iwasaki Y., Negishi T., Inoue M., Tashiro T., Tabira T., Kimura N., Sendai virus vector-mediated brain-derived neurotrophic factor expression ameliorates memory deficits and synaptic degeneration in a transgenic mouse model of Alzheimer's disease. Journal of Neuroscience Research 2012 90 5 981 989 2-s2.0-84858006948 10.1002/jnr.22830
70. Rohe M., Synowitz M., Glass R., Paul S. M., Nykjaer A., Willnow T. E., Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. Journal of Neuroscience 2009 29 49 15472 15478 2-s2.0-71849109591 10.1523/JNEUROSCI.3960-09.2009
71. Blurton-Jones M., Kitazawa M., Martinez-Coria H., Castello N. A., Müller F.-J., Loring J. F., Yamasaki T. R., Poon W. W., Green K. N., LaFerla F. M., Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America 2009 106 32 13594 13599 2-s2.0-69449091994 10.1073/pnas.0901402106
72. Kitiyanant N., Kitiyanant Y., Svendsen C. N., Thangnipon W., BDNF-, IGF-1- and GDNF-secreting human neural progenitor cells rescue amyloid β -induced toxicity in cultured rat septal neurons. Neurochemical Research 2012 37 1 143 152 2-s2.0-84856279659 10.1007/s11064-011-0592-1
73. Gil-Bea F. J., Solas M., Mateos L., Winblad B., Ramírez M. J., Cedazo-Mínguez A., Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF down regulation. Hippocampus 2011 21 9 999 1009 2-s2.0-79955580737 10.1002/hipo.20812
74. Nagahara A. H., Mateling M., Kovacs I., Wang L., Eggert S., Rockenstein E., Koo E. H., Masliah E., Tuszynski M. H., Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. Journal of Neuroscience 2013 33 39 15596 15602
75. Elliott E., Atlas R., Lange A., Ginzburg I., Brain-derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI-3Kinase signalling mechanism. European Journal of Neuroscience 2005 22 5 1081 1089 2-s2.0-25844490528 10.1111/j.1460-9568.2005.04290.x
76. Devi L., Ohno M., 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of alzheimer's disease. Neuropsychopharmacology 2012 37 2 434 444 2-s2.0-84856059838 10.1038/npp.2011.191
77. Chen Q., Prior M., Dargusch R., Roberts A., Riek R., Eichmann C., Chiruta C., Akaishi T., Abe K., Maher P., Schubert D., A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS ONE 2011 6 12 2-s2.0-83355173051 10.1371/journal.pone.0027865 e27865
78. Prior M., Dargusch R., Ehren J. L., Chiruta C., Schubert D., The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimer's Research & Therapy 2013 5 3 25
79. Zheng Z., Sabirzhanov B., Keifer J., Oligomeric amyloid- β inhibits the proteolytic conversion of brain-derived neurotrophic factor (BDNF), AMPA receptor trafficking, and classical conditioning. Journal of Biological Chemistry 2010 285 45 34708 34717 2-s2.0-78049404433 10.1074/jbc.M110.150821
80. Cuadrado-Tejedor M., Hervias I., Ricobaraza A., Puerta E., Pérez-Roldán J. M., García-Barroso C., Franco R., Aguirre N., García-Osta A., Sildenafil restores cognitive function without affecting β -amyloid burden in a mouse model of Alzheimer's disease. British Journal of Pharmacology 2011 164 8 2029 2041 2-s2.0-81855203432 10.1111/j.1476-5381.2011.01517.x
81. Croce N., Dinallo V., Ricci V., Federici G., Caltagirone C., Bernardini S., Angelucci F., Neuroprotective effect of neuropeptide Y against beta-amyloid 25-35 toxicity in SH-SY5Y neuroblastoma cells is associated with increased neurotrophin production. Neurodegenerative Diseases 2011 8 5 300 309 2-s2.0-79958785450 10.1159/000323468
82. Chadwick W., Mitchell N., Caroll J., Zhou Y., Park S.-S., Wang L., Becker K. G., Zhang Y., Lehrmann E., Wood W. H. III, Martin B., Maudsley S., Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity. PLoS ONE 2011 6 6 2-s2.0-79959602251 10.1371/journal.pone.0021660 e21660
83. Doi Y., Takeuchi H., Horiuchi H., Hanyu T., Kawanokuchi J., Jin S., Parajuli B., Sonobe Y., Mizuno T., Suzumura A., Fingolimod phosphate attenuates oligomeric amyloid beta-induced neurotoxicity via increased brain-derived neurotrophic factor expression in neurons. PloS ONE 8 4 e61988
84. Shin M. K., Kim H. G., Baek S. H., Jung W. R., Park D. I., Park J. S., Jo D. G., Kim K. L., Neuropep-1 ameliorates learning and memory deficits in an Alzheimer's disease mouse model, increases brain-derived neurotrophic factor expression in the brain, and causes reduction of amyloid beta plaques. Neurobiology of Aging 2014 35 5 990 1001
85. Corbett G. T., Roy A., Pahan K., Sodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): implications for Alzheimer disease therapy. Journal of Biological Chemistry 2013 288 12 8299 8312
86. Tsukahara T., Takeda M., Shimohama S., Ohara O., Hashimoto N., Bakay R. A. E., Redmond D. E., Effects of brain-derived neurotrophic factor on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in monkeys. Neurosurgery 1995 37 4 733 741 2-s2.0-0029103262
87. Wang Z. H., Ji Y., Shan W., Zeng B., Raksadawan N., Pastores G. M., Wisniewski T., Kolodny E. H., Therapeutic effects of astrocytes expressing both tyrosine hydroxylase and brain-derived neurotrophic factor on a rat model of Parkinson's disease. Neuroscience 2002 113 3 629 640 2-s2.0-0037008876 10.1016/S0306-4522(02)00204-X
88. Klein R. L., Lewis M. H., Muzyczka N., Meyer E. M., Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer. Brain Research 1999 847 2 314 320 2-s2.0-0032704605 10.1016/S0006-8993(99)02116- 2
89. Frim D. M., Uhler T. A., Galpern W. R., Beal M. F., Breakefield X. O., Isacson O., Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat. Proceedings of the National Academy of Sciences of the United States of America 1994 91 11 5104 5108 2-s2.0-0028276809 10.1073/pnas.91.11.5104
90. Lee J. Y., Kim S. H., Ko A. R., Lee J. S., Yu J. H., Seo J. H., Cho B. P., Cho S. R., Therapeutic effects of repetitive transcranial magnetic stimulation in an animal model of Parkinson's disease. Brain Research 2013 1537 290 302
91. Real C. C., Ferreira A. F., Chaves-Kirsten G. P., Torrao A. S., Pires R. S., Britto L. R., BDNF receptor blockade hinders the beneficial effects of exercise in a rat model of Parkinson's disease. Neuroscience 2013 237 118 129
92. Wu S.-Y., Wang T.-F., Yu L., Jen C. J., Chuang J.-I., Wu F.-S., Wu C.-W., Kuo Y.-M., Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain, Behavior, and Immunity 2011 25 1 135 146 2-s2.0-78649318267 10.1016/j.bbi.2010.09.006
93. Frazzitta G., Bertotti G., Riboldazzi G., Turla M., Uccellini D., Boveri N., Guaglio G., Perini M., Comi C., Balbi P., Maestri R., Effectiveness of intensive inpatient rehabilitation treatment on disease progression in parkinsonian patients: a randomized controlled trial with 1-year follow-up. Neurorehabilitation and Neural Repair 2012 26 2 144 150 2-s2.0-84856327636 10.1177/1545968311416990
94. Spieles-Engemann A. L., Steece-Collier K., Behbehani M. M., Collier T. J., Wohlgenant S. L., Kemp C. J., Cole-Strauss A., Levine N. D., Gombash S. E., Thompson V. B., Lipton J. W., Sortwell C. E., Subthalamic nucleus stimulation increases brain derived neurotrophic factor in the nigrostriatal system and primary motor cortex. Journal of Parkinson's Disease 2011 1 1 123 136 2-s2.0-79958208175 10.3233/JPD-2011-11008
95. Bousquet M., Gibrat C., Saint-Pierre M., Julien C., Calon F., Cicchetti F., Modulation of brain-derived neurotrophic factor as a potential neuroprotective mechanism of action of omega-3 fatty acids in a parkinsonian animal model. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2009 33 8 1401 1408 2-s2.0-71549124927 10.1016/j.pnpbp.2009.07.018
96. Jourdi H., Hamo L., Oka T., Seegan A., Baudry M., BDNF mediates the neuroprotective effects of positive AMPA receptor modulators against MPP+-induced toxicity in cultured hippocampal and mesencephalic slices. Neuropharmacology 2009 56 5 876 885 2-s2.0-63049099414 10.1016/j.neuropharm. 2009.01.015
97. + in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease. FASEB Journal 2008 22 7 2488 2497 2-s2.0-46749109164 10.1096/fj.07-095398
98. Zuccato C., Cattaneo E., Role of brain-derived neurotrophic factor in Huntington's disease. Progress in Neurobiology 2007 81 5-6 294 330 2-s2.0-34047130812 10.1016/j.pneurobio.2007.01.003
99. Weinstein G., Beiser A. S., Choi S. H., Preis S. R., Chen T. C., Vorgas D., Au R., Pikula A., Wolf P. A., Destefano A. L., Vasan R. S., Seshadri S., Serum brain-derived neurotrophic factor and the risk for dementia: the framingham heart study. JAMA Neurology 2014 71 1 55 61
100. Rantamaki T., Kemppainen S., Autio H., Staven S., Koivisto H., Kojima M., Antila H., Miettinen P. O., Karkkainen E., Karpova N., Vesa L., Lindemann L., Hoener M. C., Tanila H., Castren E., The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease. PloS ONE 2013 8 7 e68722
101. Peng S., Garzon D. J., Marchese M., Klein W., Ginsberg S. D., Francis B. M., Mount H. T. J., Mufson E. J., Salehi A., Fahnestock M., Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. Journal of Neuroscience 2009 29 29 9321 9329 2-s2.0-67651171367 10.1523/JNEUROSCI.4736-08.2009
102. Burbach G. J., Hellweg R., Haas C. A., Del Turco D., Deicke U., Abramowski D., Jucker M., Staufenbiel M., Deller T., Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice. Journal of Neuroscience 2004 24 10 2421 2430 2-s2.0-1542327619 10.1523/JNEUROSCI.5599-03.2004
103. Wong J., Higgins M., Halliday G., Garner B., Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer's disease. Neuroscience 2012 210 363 374 2-s2.0-84858992625 10.1016/j.neuroscience.2012.02.037
104. Tong L., Balazs R., Thornton P. L., Cotman C. W., β -amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons. Journal of Neuroscience 2004 24 30 6799 6809 2-s2.0-3342908640 10.1523/JNEUROSCI.5463-03.2004
105. Kemppainen S., Rantamäki T., Jerónimo-Santos A., Lavasseur G., Autio H., Karpova N., Kärkkäinen E., Stavén S., Miranda H. V., Outeiro T. F., Diógenes M. J., Laroche S., Davis S., Sebastião A. M., Castrén E., Tanila H., Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice. Neurobiology of Aging 2012 33 6 1122.e23 1122.e39 2-s2.0-84859486324 10.1016/j.neurobiolaging.2011.11.006
106. Barthet G., Dunys J., Shao Z., Xuan Z., Ren Y., Xu J., Arbez N., Mauger G., Bruban J., Georgakopoulos A., Shioi J., Robakis N. K., Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors. Neurobiology of Aging 2012 34 2 499 510 2-s2.0-84859119707 10.1016/j.neurobiolaging.2012.02.024
107. Caccamo A., Maldonado M. A., Bokov A. F., Majumder S., Oddo S., CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America 2010 107 52 22687 22692 2-s2.0-78651072485 10.1073/pnas.1012851108
108. Poon W. W., Blurton-Jones M., Tu C. H., Feinberg L. M., Chabrier M. A., Harris J. W., Jeon N. L., Cotman C. W., β -Amyloid impairs axonal BDNF retrograde trafficking. Neurobiology of Aging 2011 32 5 821 833 2-s2.0-79954593840 10.1016/j.neurobiolaging.2009.05.012
109. Poon W. W., Carlos A. J., Aguilar B. L., Berchtold N. C., Kawano C. K., Zograbyan V., Yaopruke T., Shelanski M., Cotman C. W., beta-amyloid (Abeta) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1. Journal of Biological Chemistry 2013 288 23 16937 16948
110. Hashimoto R., Hirata Y., Asada T., Yamashita F., Nemoto K., Mori T., Moriguchi Y., Kunugi H., Arima K., Ohnishi T., Effect of the brain-derived neurotrophic factor and the apolipoprotein E polymorphisms on disease progression in preclinical Alzheimer's disease. Genes, Brain and Behavior 2009 8 1 43 52 2-s2.0-59149107273 10.1111/j.1601-183X.2008.00440.x
111. Honea R. A., Cruchaga C., Perea R. D., Saykin A. J., Burns J. M., Weinberger D. R., Goate A. M., Characterizing the role of brain derived neurotrophic factor genetic variation in Alzheimer's disease neurodegeneration. PloS ONE 2013 8 9 e76001
112. Adamczuk K., De Weer A. S., Nelissen N., Chen K., Sleegers K., Bettens K., Van Broeckhoven C., Vandenbulcke M., Thiyyagura P., Dupont P., Van Laere K., Reiman E. M., Vandenberghe R., Polymorphism of brain derived neurotrophic factor influences beta amyloid load in cognitively intact apolipoprotein E epsilon4 carriers. NeuroImage: Clinical 2013 2 512 520
113. Chen J., Liang X., Li B., Jiang X., Xu Z., Gender-related association of brain-derived neurotrophic factor gene 196A/G polymorphism with Alzheimer's disease-a meta-analysis including 6854 cases and 6868 controls. International Journal of Neuroscience 2014 10.3109/00207454.2013.869594
114. Lim Y. Y., Villemagne V. L., Laws S. M., Ames D., Pietrzak R. H., Ellis K. A., Harrington K. D., Bourgeat P., Salvado O., Darby D., Snyder P. J., Bush A. I., Martins R. N., Masters C. L., Rowe C. C., Nathan P. J., Maruff B P., BDNF Val66Met, Abeta amyloid, and cognitive decline in preclinical Alzheimer's disease. Neurobiology of Aging 2013 34 11 2457 2464
115. Howells D. W., Porritt M. J., Wong J. Y. F., Batchelor P. E., Kalnins R., Hughes A. J., Donnan G. A., Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra. Experimental Neurology 2000 166 1 127 135 2-s2.0-0033762265 10.1006/exnr.2000.7483
116. Nagatsu T., Sawada M., Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. Journal of Neural Transmission, Supplementa 2007 72 113 120 2-s2.0-38449091547 10.1007/978-3-211-73574-9-14
117. Zuccato C., Cattaneo E., Role of brain-derived neurotrophic factor in Huntington's disease. Progress in Neurobiology 2007 81 5-6 294 330 2-s2.0-34047130812 10.1016/j.pneurobio.2007.01.003
118. Porritt M. J., Batchelor P. E., Howells D. W., Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons. Experimental Neurology 2005 192 1 226 234 2-s2.0-13444273332 10.1016/j.expneurol.2004.11.030
119. Baquet Z. C., Bickford P. C., Jones K. R., Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta. Journal of Neuroscience 2005 25 26 6251 6259 2-s2.0-21544446985 10.1523/JNEUROSCI.4601-04.2005
120. Lau Y.-S., Patki G., Das-Panja K., Le W.-D., Ahmad S. O., Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegeneration. European Journal of Neuroscience 2011 33 7 1264 1274 2-s2.0-79953292347 10.1111/j.1460-9568.2011.07626.x
121. von Bohlen und Halbach O., Minichiello L., Unsicker K., Haploin-sufficiency for trkB and trkC receptors induces cell loss and accumulation of α -synuclein in the substantia nigra. FASEB Journal 2005 19 12 1740 1742 2-s2.0-26444562924 10.1096/fj.05-3845fje
122. Baydyuk M., Nguyen M. T., Xu B., Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degeneration. Experimental Neurology 2011 228 1 118 125 2-s2.0-79851511400 10.1016/j.expneurol.2010.12.018
123. Ding Y.-X., Xia Y., Jiao X.-Y., Duan L., Yu J., Wang X., Chen L.-W., The TrkB-positive dopaminergic neurons are less sensitive to MPTP insult in the substantia nigra of adult C57/BL mice. Neurochemical Research 2011 36 10 1759 1766 2-s2.0-80555150819 10.1007/s11064-011-0491-5