The TrkB-positive dopaminergic neurons are less sensitive to MPTP insult in the substantia nigra of adult C57/BL mice

Neurochemical Research

Volumn 36, Issue 10, 2011, Pages 1759-1766

  Ding, Yin Xiu ^a,b   Xia, Yi ^a   Jiao, Xi Ying ^a   Duan, Li ^a   Yu, Jun ^b   Wang, Xi ^a   Chen, Liang Wei ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

Neuroprotection; Neurotrophic factors; Parkinson's disease; Substantia nigra; Tyrosine kinase receptors

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CASPASE 3; NEUROTROPHIN 3 RECEPTOR; TYROSINE 3 MONOOXYGENASE;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MEMBRANE; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DOPAMINERGIC NERVE CELL; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STAINING; SUBSTANTIA NIGRA;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; DISEASE MODELS, ANIMAL; DOPAMINE AGENTS; DOPAMINERGIC NEURONS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MPTP POISONING; NEUROTOXINS; PARKINSON DISEASE; RANDOM ALLOCATION; RECEPTOR, TRKB; RECEPTOR, TRKC; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE;

MUS;

EID: 80555150819     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-011-0491-5     Document Type: Article

References (54)

1. Amino S, Itakura M, Ohnishi H, Tsujimura J, Koizumi S, Takei N, TakahashiM(2002) Nerve growth factor enhances neurotransmitter release fromPC12 cells by increasing Ca(2?)-responsible secretory vesicles through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. J Biochem 131:887-894 (Pubitemid 34717594)
2. Bian GL, Wei LC, Shi M, Wang YQ, Cao R, Chen LW (2007) Fluoro-Jade C can specifically stain the degenerative neurons in the substantia nigra of the MPTP-treated C57BL/6 mice. Brain Res 1150:55-61 (Pubitemid 46702124)
3. Blöchl A, Sirrenberg C (1996) Neurotrophins stimulate the release of dopamine from rat mesencephalic neurons via Trk and p75Lntr receptors. J Biol Chem 271:21100-21107 (Pubitemid 26292960)
4. Canudas AM, Pezzi S, Canals JM, Pallàs M, Alberch J (2005) Endogenous brain-derived neurotrophic factor protects dopaminergic nigral neurons against transneuronal degeneration induced by striatal excitotoxic injury. Brain Res Mol Brain Res 134: 147-154 (Pubitemid 40403646)
5. Cass WA, Peters LE, Harned ME, Seroogy KB (2006) Protection by GDNF and other trophic factors against the dopaminedepleting effects of neurotoxic doses of methamphetamine. Ann N Y Acad Sci 1074:272-281 (Pubitemid 44532830)
6. Chaisuksunt V, Campbell G, Zhang Y, Schachner M, Lieberman AR, Anderson PN (2003) Expression of regeneration-related molecules in injured and regenerating striatal and nigral neurons. J Neurocytol 32:161-183 (Pubitemid 38019308)
7. Chen LW, Hu HJ, Liu HL, Yung KK, Chan YS (2004) Identification of brain-derived neurotrophic factor in nestin-expressing astroglial cells in the neostriatum of 1-methyl-4-phenyl-1, 2, 3, 6- tetrahydropyridine-treated mice. Neuroscience 126:941-953 (Pubitemid 38780898)
8. Chen LW, Yung KK, Chan YS, Shum DK, Bolam JP (2008) The proNGF-p75NTR-sortilin signalling complex as new target for the therapeutic treatment of Parkinson's disease. CNS Neurol Disord Drug Targets 7:512-523
9. Chen LW, Zhang JP, Kwok-Yan Shum D, Chan YS (2006) Localization of nerve growth factor, neurotrophin-3, and glial cell line-derived neurotrophic factor in nestin-expressing reactive astrocytes in the caudate-putamen of MPTP-treated C57/Bl mice. J Comp Neurol 497:898-909
10. Conti G, Gale K, Kondratyev A (2009) Immunohistochemical evaluation of the protein expression of nerve growth factor and its TrkA receptor in rat limbic regions following electroshock seizures. Neurosci Res 65:201-209
11. Deierborg T, Soulet D, Roybon L, Hall V, Brundin P (2008) Emerging restorative treatments for Parkinson's disease. Prog Neurobiol 85:407-432
12. Du Y, Li X, Yang D, Zhang X, Chen S, Huang K, Le W (2008) Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo. Exp Biol Med (Maywood) 233:881-890
13. Erickson J, Brosenitsch T, Katz D (2001) Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor are required simultaneously for survival of dopaminergic primary sensory neurons in vivo. J Neurosci 21:581-589 (Pubitemid 32107447)
14. Falk T, Zhang S, Sherman SJ (2009) Pigment epithelium derived factor (PEDF) is neuroprotective in two in vitro models of Parkinson's disease. Neurosci Lett 458:49-52
15. Gall CM, Gold SJ, Isackson PJ, Seroogy KB (1992) Brainderived neurotrophic factor and neurotrophin-3 mRNAs are expressed in ventral midbrain regions containing dopaminergic neurons. Mol Cell Neurosci 3:56-63
16. Gibrat C, Bousquet M, Saint-Pierre M, Lévesque D, Calon F, Rouillard C, Cicchetti F (2010) Cystamine prevents MPTPinduced toxicity in young adult mice via the up-regulation of the brain-derived neurotrophic factor. Prog Neuropsychopharmacol Biol Psychiatry 34:193-203
17. Granholm AC, Sanders LA, Crnic LS (2000) Loss of cholinergic phenotype in basalforebrain coincides with cognitive decline in a mouse model of Down's syndrome. Exp Neurol 161:647-663 (Pubitemid 30137022)
18. Gyárfás T, Knuuttila J, Lindholm P, Rantamäki T, Castrén E (2010) Regulation of brain-derived neurotrophic factor (BDNF) and cerebral dopamine neurotrophic factor (CDNF) by anti-parkinsonian drug therapy in vivo. Cell Mol Neurobiol 30:361-368
19. Hagg T (1998) Neurotrophins prevent death and differentially affect tyrosine hydroxylase of adult rat nigrostriatal neurons in vivo. Exp Neurol 149:183-192 (Pubitemid 28091027)
20. Hirata Y, Meguro T, Kiuchi K (2006) Differential effect of nerve growth factor on dopaminergic neurotoxin-induced apoptosis. J Neurochem 99:416-425 (Pubitemid 44477199)
21. Hyman C, Hofer M, Barde YA, Juhasz M, Yancopoulos GD, Squinto SP, Lindsay RM (1991) BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350: 230-232 (Pubitemid 21912205)
22. Hyman C, Juhasz M, Jackson C, Wright P, Ip NY, Lindsay RM (1994) Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon. J Neurosci 14:335-347
23. Katsuki H, Kurimoto E, Takemori S, Kurauchi Y, Hisatsune A, Isohama Y, Izumi Y, Kume T, Shudo K, Akaike A (2009) Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling. J Neurochem 110:707-718
24. Longo FM, Massa SM (2004) Neurotrophin-based strategies for neuroprotection. J Alzheimers Dis 6(Suppl):S13-S17 (Pubitemid 40202537)
25. Mandel SA, Sagi Y, Amit T (2007) Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTPinduced parkinsonism via activation of tyrosine kinase receptor signaling pathway. Neurochem Res 32:1694-1699 (Pubitemid 47428857)
26. Melchior B, Nerrière-Daguin V, Laplaud DA, Rémy S, Wiertlewski S, Neveu I, Naveilhan P, Meakin SO, Brachet P (2003) Ectopic expression of the TrkA receptor in adult dopaminergic mesencephalic neurons promotes retrograde axonal NGF transport and NGF-dependent neuroprotection. Exp Neurol 183:367-378 (Pubitemid 37205079)
27. Mufson EJ, Ginsberg SD, Ikonomovic MD, DeKosky ST (2003) Human cholinergic basal forebrain: Chemoanatomy and neurologic dysfunction. J Chem Neuroanat 26:233-242 (Pubitemid 38077147)
28. Nagatsu T, Mogi M, Ichinose H, Togari A (2000) Changes in cytokines and neurotrophins in Parkinson's disease. J Neural Transm Suppl 60:277-290 (Pubitemid 32037200)
29. Nagatsu T (2002) Parkinson's disease: Changes in apoptosisrelated factors suggesting possible gene therapy. J Neural Transm 109:731-745 (Pubitemid 34810770)
30. Nishio T, Furukawa S, Akiguchi I, Sunohara N (1998) Medial nigral dopamine neurons have rich neurotrophin support in humans. Neuroreport 9:2847-2851 (Pubitemid 28435175)
31. Numan S, Seroogy KB (1999) Expression of trkB and trkC mRNAs by adult midbrain dopamine neurons: A double-label in situ hybridization study. J Comp Neurol 403:295-308 (Pubitemid 29006214)
32. Paredes D, Granholm AC, Bickford PC (2007) Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat. Brain Res 1141:56-64 (Pubitemid 46365646)
33. Park HJ, Lim S, Joo WS, Yin CS, Lee HS, Lee HJ, Seo JC, Leem K, Son YS, Kim YJ, Kim CJ, Kim YS, Chung JH (2003) Acupuncture prevents 6-hydroxydopamine-induced neuronal death in the nigrostriatal dopaminergic system in the rat Parkinson's disease model. Exp Neurol 180:93-98
34. Porritt MJ, Batchelor PE, Howells DW (2005) Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons. Exp Neurol 192:226-234 (Pubitemid 40208556)
35. Roussa E, und Halbach O, Krieglstein K (2009) TGF-beta in dopamine neuron development, maintenance and neuroprotection. Adv Exp Med Biol 651:81-90
36. Sadan O, Bahat-Stromza M, Barhum Y, Levy YS, Pisnevsky A, Peretz H, Ilan AB, Bulvik S, Shemesh N, Krepel D, Cohen Y, Melamed E, Offen D (2009) Protective effects of neurotrophic factor-secreting cells in a 6-OHDA rat model of parkinson disease. Stem Cells Dev 18:1179-1190
37. Sagi Y, Mandel S, Amit T, Youdim MB (2007) Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism. Neurobiol Dis 25:35-44 (Pubitemid 44765215)
38. Sauer H, Wong V, Björklund A (1995) Brain-derived neurotrophic factor and neurotrophin-4/5 modify neurotransmitter-related gene expression in the 6-hydroxydopamine-lesioned rat striatum. Neuroscience 65:927-933
39. Saylor AJ, Meredith GE, Vercillo MS, Zahm DS, McGinty JF (2006) BDNF heterozygous mice demonstrate age-related changes in striatal and nigral gene expression. Exp Neurol 199:362-372 (Pubitemid 43928965)
40. Sobreviela T, Clary DO, Reichardt LF, Brandabur MM, Kordower JH, Mufson EJ (1994) TrkA-immunoreactive profiles in the central nervous system: Colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin. J Comp Neurol 350:587-611 (Pubitemid 24372037)
41. Somoza R, Juri C, Baes M, Wyneken U, Rubio FJ (2010) Intranigral transplantation of epigenetically-induced BDNFsecreting human mesenchymal stem cells: Implications for cellbased therapies in parkinson s disease. Biol Blood Marrow Transplant [Epub ahead of print]
42. Studer L, Spenger C, Seiler RW, Altar CA, Lindsay RM, Hyman C (1995) Comparison of the effects of the neurotrophins on the morphological structure of dopaminergic neurons in cultures of rat substantia nigra. Eur J Neurosci 7:223-233
43. Tam SY, Elsworth JD, Sladek JR Jr, Redmond DE Jr, Roth RH (1997) Identification of novel variants of trkC mRNA transcripts in brain of African green monkeys. Exp Neurol 143:172-176 (Pubitemid 27049142)
44. Venero JL, Vizuete ML, Revuelta M, Vargas C, Cano J, Machado A (2000) Upregulation of BDNF mRNA and trkB mRNA in the nigrostriatal system and in the lesion site following unilateral transection of the medial forebrain bundle. Exp Neurol 161:38-48 (Pubitemid 30136528)
45. Volpicelli F, Caiazzo M, Greco D, Consales C, Leone L, Perrone- Capano C, Colucci D'Amato L, di Porzio U (2007) Bdnf gene is a downstream target of Nurr1 transcription factor in rat midbrain neurons in vitro. J Neurochem 102:441-453 (Pubitemid 47000587)
46. und Halbach O, Minichiello L, Unsicker K (2005) Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra. FASEB J 19:1740-1742 (Pubitemid 41429548)
47. Wang YQ, Bian GL, Bai Y, Cao R, Chen LW (2008) Identification and kainic acid-induced up-regulation of low-affinity p75 neurotrophin receptor (p75NTR) in the nigral dopamine neurons of adult rats. Neurochem Int 53:56-62
48. Wang YQ, Bian GL, Wei LC, Cao R, Peng YF, Chen LW (2008) Nigrostriatal neurons in rat express the glial cell line-derived neurotrophic factor receptor subunit c-RET. Anat Rec 291:49-54
49. Wu J, Yu W, Chen Y, Su Y, Ding Z, Ren H, Jiang Y, Wang J (2010) Intrastriatal transplantation of GDNF-engineered BMSCs and its neuroprotection in lactacystin-induced parkinsonian rat model. Neurochem Res 35:495-502
50. Yacoubian TA, Standaert DG (2009) Targets for neuroprotection in Parkinson's disease. Biochim Biophys Acta 1792:676-687
51. Yurek DM, Fletcher-Turner A (2001) Differential expression of GDNF, BDNF, and NT-3 in the aging nigrostriatal system following a neurotoxic lesion. Brain Res 891:228-235 (Pubitemid 32115512)
52. Yurek DM, Seroogy KB (2000) Differential expression of neurotrophin and neurotrophin receptor mRNAs in and adjacent to fetal midbrain grafts implanted into the dopamine-denervated striatum. J Comp Neurol 423:462-473 (Pubitemid 30451679)
53. Zaman V, Nelson ME, Gerhardt GA, Rohrer B (2004) Neurodegenerative alterations in the nigrostriatal system of trkB hypomorphic mice. Exp Neurol 190:337-346 (Pubitemid 39504991)
54. Zhou J, Bradford HF, Stern GM (1997) Influence of BDNF on the expression of the dopaminergic phenotype of tissue used for brain transplants. Brain Res Dev Brain Res 100:43-51 (Pubitemid 27241492)