메뉴 건너뛰기




Volumn 2, Issue 1, 2005, Pages 120-128

Neuroprotection in experimental stroke with targeted neurotrophins

Author keywords

Blood brain barrier; Drug targeting; Ischemic stroke; Neuroprotection; Neurotrophins; Transferrin receptor

Indexed keywords

ANTIBODY; ANTIBODY CONJUGATE; AVIDIN; BASIC FIBROBLAST GROWTH FACTOR; BIOTIN; BRAIN DERIVED NEUROTROPHIC FACTOR; INSULIN RECEPTOR ANTIBODY; MACROGOL 2000; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY OX 26; NERVE GROWTH FACTOR; NEUROTROPHIN; PEPTIDE; PROUROKINASE; STREPTAVIDIN; TISSUE PLASMINOGEN ACTIVATOR; TRANSFERRIN; TRANSFERRIN RECEPTOR ANTIBODY; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE;

EID: 12344336804     PISSN: 15455343     EISSN: 15455351     Source Type: Journal    
DOI: 10.1602/neurorx.2.1.120     Document Type: Article
Times cited : (133)

References (67)
  • 1
    • 0346095478 scopus 로고    scopus 로고
    • Feinberg Lecture: Stroke therapy in the year 2025. Burden, breakthroughs, and barriers to progress
    • Broderick JP. William M. Feinberg Lecture: stroke therapy in the year 2025. Burden, breakthroughs, and barriers to progress. Stroke 35:205-211, 2004.
    • (2004) Stroke , vol.35 , pp. 205-211
    • Broderick, J.P.1    William, M.2
  • 2
    • 0024334873 scopus 로고
    • Clinical and instrumental evaluation of patients with ischemic stroke within the first six hours
    • Fieschi C, Argentino C, Lenzi GL, Sacchetti ML, Toni D, Bozzao L. Clinical and instrumental evaluation of patients with ischemic stroke within the first six hours. J Neurol Sci 91:311-322, 1989.
    • (1989) J Neurol Sci , vol.91 , pp. 311-322
    • Fieschi, C.1    Argentino, C.2    Lenzi, G.L.3    Sacchetti, M.L.4    Toni, D.5    Bozzao, L.6
  • 3
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke
    • The National Institute of Neurological Disorder and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581-1587, 1995.
    • (1995) N Engl J Med , vol.333 , pp. 1581-1587
  • 4
    • 0033486107 scopus 로고    scopus 로고
    • Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: A randomized controlled trial. Prolyse in acute ischemic cerebral thromboembolism
    • Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in acute ischemic cerebral thromboembolism. JAMA 282:2003-2011, 1999.
    • (1999) JAMA , vol.282 , pp. 2003-2011
    • Furlan, A.1    Higashida, R.2    Wechsler, L.3    Gent, M.4    Rowley, H.5    Kase, C.6
  • 6
    • 0032744573 scopus 로고    scopus 로고
    • Thrombolysis in acute ischemic stroke: Controlled trials and clinical experience
    • Hacke W, Brott T, Caplan LR, Meier D, Fieschi C, von Kummer R, et al. Thrombolysis in acute ischemic stroke: controlled trials and clinical experience. Neurology 53[Suppl]:S3-S14, 1999.
    • (1999) Neurology , vol.53 , Issue.SUPPL.
    • Hacke, W.1    Brott, T.2    Caplan, L.R.3    Meier, D.4    Fieschi, C.5    Von Kummer, R.6
  • 7
    • 0038266172 scopus 로고    scopus 로고
    • Neuroprotection for ischemic stroke
    • Hinkle JL, Bowman L. Neuroprotection for ischemic stroke. J Neurosci Nurs 35:114-118, 2003.
    • (2003) J Neurosci Nurs , vol.35 , pp. 114-118
    • Hinkle, J.L.1    Bowman, L.2
  • 9
    • 0346787871 scopus 로고    scopus 로고
    • Neuroprotection in cerebral ischemia: Facts and fancies - The need for new approaches
    • Wahlgren NG, Ahmed N. Neuroprotection in cerebral ischemia: Facts and fancies - the need for new approaches. Cerebrovascular Dis 17[Suppl I]:153-166, 2004.
    • (2004) Cerebrovascular Dis , vol.17 , Issue.1 SUPPL. , pp. 153-166
    • Wahlgren, N.G.1    Ahmed, N.2
  • 10
    • 0027463404 scopus 로고
    • Contributions of ions and albumin to the formation and resolution of ischemic brain edema
    • Menzies SA, Betz AL, Hoff JT. Contributions of ions and albumin to the formation and resolution of ischemic brain edema. J Neurosurg 78:257-266, 1993.
    • (1993) J Neurosurg , vol.78 , pp. 257-266
    • Menzies, S.A.1    Betz, A.L.2    Hoff, J.T.3
  • 11
    • 0034982436 scopus 로고    scopus 로고
    • Editorial comment
    • Keep RF. Editorial comment. Stroke 32:1381-1382, 2001.
    • (2001) Stroke , vol.32 , pp. 1381-1382
    • Keep, R.F.1
  • 12
    • 0030928225 scopus 로고    scopus 로고
    • Pharmacology of neurotrophic factors
    • Hefti F. Pharmacology of neurotrophic factors. Annu Rev Pharmacol Toxicol 37:239-267, 1997.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 239-267
    • Hefti, F.1
  • 13
    • 1842314053 scopus 로고
    • Role of nerve growth factor in the central nervous system
    • Ferrendelli JA, Collins RC, Johnson EM, eds, Norwell, MA: Kluwer Academic Publishers
    • Hefti F, Hartikka JA, Montero CN, Junard EO. Role of nerve growth factor in the central nervous system. In: Neurobiology of amino acid, peptides, and trophic factors (Ferrendelli JA, Collins RC, Johnson EM, eds), pp 127-138. Norwell, MA: Kluwer Academic Publishers, 1988.
    • (1988) Neurobiology of Amino Acid, Peptides, and Trophic Factors , pp. 127-138
    • Hefti, F.1    Hartikka, J.A.2    Montero, C.N.3    Junard, E.O.4
  • 15
    • 0022486717 scopus 로고
    • Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transactions
    • Hefti F. Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transactions. J Neurosci 6:2155-2162, 1986.
    • (1986) J Neurosci , vol.6 , pp. 2155-2162
    • Hefti, F.1
  • 16
    • 0022245786 scopus 로고
    • Behavioral and neurochemical effects of chronic intravenous injection of nerve growth factor in adult rats with fimbria lesions
    • Will B, Hefti F. Behavioral and neurochemical effects of chronic intravenous injection of nerve growth factor in adult rats with fimbria lesions. Behav Brain Res 17:17-24, 1985.
    • (1985) Behav Brain Res , vol.17 , pp. 17-24
    • Will, B.1    Hefti, F.2
  • 17
    • 0001641539 scopus 로고
    • Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection
    • William L, Varon S, Peterson G, Wictorin K, Bjorklund A, Gage F. Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection. Proc Natl Acad Sci USA 33:9231-9235, 1986.
    • (1986) Proc Natl Acad Sci USA , vol.33 , pp. 9231-9235
    • William, L.1    Varon, S.2    Peterson, G.3    Wictorin, K.4    Bjorklund, A.5    Gage, F.6
  • 18
    • 0025885723 scopus 로고
    • Amelioration of delayed neuronal death in the hippocampus by nerve growth factor
    • Shigeno T, Mima T, Takakura K, Graham DI, Kato G, et al. Amelioration of delayed neuronal death in the hippocampus by nerve growth factor. J Neurosci 11:2914-2919, 1991.
    • (1991) J Neurosci , vol.11 , pp. 2914-2919
    • Shigeno, T.1    Mima, T.2    Takakura, K.3    Graham, D.I.4    Kato, G.5
  • 19
    • 0026512910 scopus 로고
    • Nerve growth factor affects C-11 nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (case report)
    • Olson L, Nordberg A, von Holst H, Backman L, Ebendal T, Alafuzoff I, et al. Nerve growth factor affects C-11 nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (case report). J Neural Transm 4:79-95, 1992.
    • (1992) J Neural Transm , vol.4 , pp. 79-95
    • Olson, L.1    Nordberg, A.2    Von Holst, H.3    Backman, L.4    Ebendal, T.5    Alafuzoff, I.6
  • 21
    • 0027318116 scopus 로고
    • Neurotrophins promote motor neuron survival and are present in embryonic limb bud
    • Henderson CE, Camu W, Mettling C, Gouin A, Poulsen K, Karihaloo M, et al. Neurotrophins promote motor neuron survival and are present in embryonic limb bud. Nature 363:266-270, 1993.
    • (1993) Nature , vol.363 , pp. 266-270
    • Henderson, C.E.1    Camu, W.2    Mettling, C.3    Gouin, A.4    Poulsen, K.5    Karihaloo, M.6
  • 22
    • 0002733502 scopus 로고
    • Brain-derived neurotrophic factor: An NGF related neurotrophin
    • Fallon JH, Loughlin SE, eds, New York: Academic Press
    • Lindsay RM. Brain-derived neurotrophic factor: an NGF related neurotrophin. In: Neurotrophic factors (Fallon JH, Loughlin SE, eds), pp 257-284. New York: Academic Press, 1993.
    • (1993) Neurotrophic Factors , pp. 257-284
    • Lindsay, R.M.1
  • 24
    • 0027067035 scopus 로고
    • Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death
    • Yan Q, Elliott J, Snider WD. Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death. Nature 360:753-755, 1992.
    • (1992) Nature , vol.360 , pp. 753-755
    • Yan, Q.1    Elliott, J.2    Snider, W.D.3
  • 25
    • 0028040062 scopus 로고
    • The role of brain-derived neurotrophic factor in transient forebrain ischemia in the rat brain
    • Tsukahara T, Yonekawa MD, Tanaka K, Ohara O, Watanabe S, et al. The role of brain-derived neurotrophic factor in transient forebrain ischemia in the rat brain. Neurosurgery 34:323, 1994.
    • (1994) Neurosurgery , vol.34 , pp. 323
    • Tsukahara, T.1    Yonekawa, M.D.2    Tanaka, K.3    Ohara, O.4    Watanabe, S.5
  • 26
    • 0000337980 scopus 로고
    • A phase I/II study of recombinant brain-derived neurotrophic factor in patients with ALS
    • Bradley WG. A phase I/II study of recombinant brain-derived neurotrophic factor in patients with ALS. Ann Neurol 38:971, 1995.
    • (1995) Ann Neurol , vol.38 , pp. 971
    • Bradley, W.G.1
  • 27
    • 0344076149 scopus 로고    scopus 로고
    • A controlled trial of recombinant methionyl human BDNF in ALS
    • The BDNF Study Group (Phase III). A controlled trial of recombinant methionyl human BDNF in ALS. Neurology 52:1427-1433, 1999.
    • (1999) Neurology , vol.52 , pp. 1427-1433
  • 28
    • 0034208461 scopus 로고    scopus 로고
    • A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administrated by intrathecal infusion to patients with amyotrophic lateral sclerosis
    • Ochs G, Penn RD, York M, Giess R, Beck M, Tonn J, et al. A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administrated by intrathecal infusion to patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1:201-206, 2000.
    • (2000) Amyotroph Lateral Scler Other Motor Neuron Disord , vol.1 , pp. 201-206
    • Ochs, G.1    Penn, R.D.2    York, M.3    Giess, R.4    Beck, M.5    Tonn, J.6
  • 29
    • 0028279458 scopus 로고
    • Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery
    • Pardridge WM, Kang Y-S, Buciak JL. Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery. Pharma Res 11:738-746, 1994.
    • (1994) Pharma Res , vol.11 , pp. 738-746
    • Pardridge, W.M.1    Kang, Y.-S.2    Buciak, J.L.3
  • 30
    • 0027344852 scopus 로고
    • Structural and functional diversity in the FGF receptor multigene family
    • Johnson DE, Williams LT. Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res 60:1-41, 1993.
    • (1993) Adv Cancer Res , vol.60 , pp. 1-41
    • Johnson, D.E.1    Williams, L.T.2
  • 33
    • 0032892598 scopus 로고    scopus 로고
    • Potential usefulness of basic fibroblast growth factor as a treatment for stroke
    • Ay H, Ay I, Joroshetz WJ, Finklestein SP. Potential usefulness of basic fibroblast growth factor as a treatment for stroke. Cerebrovascular Dis 9:131-135, 1999.
    • (1999) Cerebrovascular Dis , vol.9 , pp. 131-135
    • Ay, H.1    Ay, I.2    Joroshetz, W.J.3    Finklestein, S.P.4
  • 35
    • 0000543835 scopus 로고    scopus 로고
    • Clinical safety of intravenous bFGF in acute stroke
    • The FIBLAST Safety Study Group. Clinical safety of intravenous bFGF in acute stroke. Stroke 29:287, 1998.
    • (1998) Stroke , vol.29 , pp. 287
  • 36
    • 0036968150 scopus 로고    scopus 로고
    • Fiblast (trafermin) in acute stroke: Results of the European-Australian phase II/III safety and efficacy trial
    • Bogousslavsky J, Victor SJ, Salinas EO, Pallay A, Donnan GA, Fieschi C, et al. Fiblast (trafermin) in acute stroke: results of the European-Australian phase II/III safety and efficacy trial. Cerebrovas Dis 14:239-251, 2002.
    • (2002) Cerebrovas Dis , vol.14 , pp. 239-251
    • Bogousslavsky, J.1    Victor, S.J.2    Salinas, E.O.3    Pallay, A.4    Donnan, G.A.5    Fieschi, C.6
  • 38
    • 0036942233 scopus 로고    scopus 로고
    • Blood-brain barrier drug targeting enables neuroprotection in brain ischemia following delayed intravenous administration of neurotrophins
    • Pardridge WM. Blood-brain barrier drug targeting enables neuroprotection in brain ischemia following delayed intravenous administration of neurotrophins. Adv Exp Med Biol 513:397-430, 2002.
    • (2002) Adv Exp Med Biol , vol.513 , pp. 397-430
    • Pardridge, W.M.1
  • 39
    • 0030426639 scopus 로고    scopus 로고
    • Central nervous system pharmacologic effect in conscious rats after intravenous injection of a biotinylated vasoactive intestinal peptide analog coupled to a blood-brain barrier drug delivery system
    • Wu D, Pardridge WM. Central nervous system pharmacologic effect in conscious rats after intravenous injection of a biotinylated vasoactive intestinal peptide analog coupled to a blood-brain barrier drug delivery system. J Pharmacol Exper Ther 279:77-83, 1996.
    • (1996) J Pharmacol Exper Ther , vol.279 , pp. 77-83
    • Wu, D.1    Pardridge, W.M.2
  • 40
    • 0033524392 scopus 로고    scopus 로고
    • Neuroprotection with noninvasive neurotrophin delivery to the brain
    • Wu D, Pardridge WM. Neuroprotection with noninvasive neurotrophin delivery to the brain. Proc Natl Acad Sci USA 96:254-259, 1999.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 254-259
    • Wu, D.1    Pardridge, W.M.2
  • 41
    • 0036245040 scopus 로고    scopus 로고
    • Pharmacokinetics and brain uptake of biotinylated basic fibroblast growth factor conjugated to a blood-brain barrier drug delivery system
    • Wu D, Song B-W, Vinters HV, Pardridge WM. Pharmacokinetics and brain uptake of biotinylated basic fibroblast growth factor conjugated to a blood-brain barrier drug delivery system. J Drug Target 10:239-245, 2002.
    • (2002) J Drug Target , vol.10 , pp. 239-245
    • Wu, D.1    Song, B.-W.2    Vinters, H.V.3    Pardridge, W.M.4
  • 42
    • 0035910336 scopus 로고    scopus 로고
    • Conjugation of brain-derived neurotrophic factor (BDNF) to a blood-brain barrier targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin
    • Zhang Y, Pardridge WM. Conjugation of brain-derived neurotrophic factor (BDNF) to a blood-brain barrier targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin. Brain Res 889:49-56, 2001.
    • (2001) Brain Res , vol.889 , pp. 49-56
    • Zhang, Y.1    Pardridge, W.M.2
  • 43
    • 0034988984 scopus 로고    scopus 로고
    • Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system
    • Zhang Y, Pardridge WM. Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system. Stroke 32:1378-1384, 2001.
    • (2001) Stroke , vol.32 , pp. 1378-1384
    • Zhang, Y.1    Pardridge, W.M.2
  • 44
    • 0014954352 scopus 로고
    • Polypeptide with broad biological activity. Isolation from small intestine
    • Said SI, Mutt V. Polypeptide with broad biological activity. Isolation from small intestine. Science 169:1217-1218, 1970.
    • (1970) Science , vol.169 , pp. 1217-1218
    • Said, S.I.1    Mutt, V.2
  • 45
    • 0021720862 scopus 로고
    • Characterization of relaxant effects of vasoactive intestinal peptide (VIP) and PHI on isolated brain arteries
    • Suzuki Y, McMaster D, Lederis K, Rorstad OP. Characterization of relaxant effects of vasoactive intestinal peptide (VIP) and PHI on isolated brain arteries. Brain Res 322:9-16, 1984.
    • (1984) Brain Res , vol.322 , pp. 9-16
    • Suzuki, Y.1    McMaster, D.2    Lederis, K.3    Rorstad, O.P.4
  • 46
    • 0023214752 scopus 로고
    • Cortical vasodilatation produced by vasoactive intestinal peptide (VIP) and by physiological stimuli in the rat
    • Yaksh TL, Wang J-Y, Go VLW. Cortical vasodilatation produced by vasoactive intestinal peptide (VIP) and by physiological stimuli in the rat. J Cereb Blood Flow Metab 7:315-326, 1987.
    • (1987) J Cereb Blood Flow Metab , vol.7 , pp. 315-326
    • Yaksh, T.L.1    Wang, J.-Y.2    Go, V.L.W.3
  • 47
    • 0029883129 scopus 로고    scopus 로고
    • A femtomolar-acting neuroprotective peptide
    • Brenneman DE, Gozes I. A femtomolar-acting neuroprotective peptide. J Clin Invest 97:2299-2307, 1996.
    • (1996) J Clin Invest , vol.97 , pp. 2299-2307
    • Brenneman, D.E.1    Gozes, I.2
  • 48
    • 0023786731 scopus 로고
    • Neuronal cell killing by the envelope protein HIV and its prevention by vasoactive intestinal peptide
    • Brenneman DE, Westbrook GL, Fitzgerald SP, Ennist DL, Elkins KL, Ruff MR, et al. Neuronal cell killing by the envelope protein HIV and its prevention by vasoactive intestinal peptide. Nature 335:639-642, 1988.
    • (1988) Nature , vol.335 , pp. 639-642
    • Brenneman, D.E.1    Westbrook, G.L.2    Fitzgerald, S.P.3    Ennist, D.L.4    Elkins, K.L.5    Ruff, M.R.6
  • 50
    • 0019000169 scopus 로고
    • Cerebral circulatory and metabolic effects of vasoactive intestinal polypeptide
    • McCulloch J, Edvinsson L. Cerebral circulatory and metabolic effects of vasoactive intestinal polypeptide. Am J Physiol (Lond) 238:H449-H456, 1980.
    • (1980) Am J Physiol (Lond) , vol.238
    • McCulloch, J.1    Edvinsson, L.2
  • 52
    • 0028211211 scopus 로고
    • Use of neutral-avidin improves pharmacokinetics and brain delivery of biotin bound to an avidin-monoclonal antibody conjugate
    • Kang Y-S, Pardridge WM. Use of neutral-avidin improves pharmacokinetics and brain delivery of biotin bound to an avidin-monoclonal antibody conjugate. J Pharmacol Exper Ther 269: 344-350, 1994.
    • (1994) J Pharmacol Exper Ther , vol.269 , pp. 344-350
    • Kang, Y.-S.1    Pardridge, W.M.2
  • 53
    • 0028989728 scopus 로고
    • Pharmacokinetics of [3H]biotin bound to different avidin analogues
    • Kang Y-S, Saito Y, Pardridge WM. Pharmacokinetics of [3H]biotin bound to different avidin analogues. J Drug Target 3:159-165, 1995.
    • (1995) J Drug Target , vol.3 , pp. 159-165
    • Kang, Y.-S.1    Saito, Y.2    Pardridge, W.M.3
  • 54
    • 0031901771 scopus 로고    scopus 로고
    • Combined use of carboxyl-directed protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration
    • Pardridge WM, Wu D, Sakane T. Combined use of carboxyl-directed protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration. Pharma Res 15:576-582, 1998.
    • (1998) Pharma Res , vol.15 , pp. 576-582
    • Pardridge, W.M.1    Wu, D.2    Sakane, T.3
  • 55
    • 0033811469 scopus 로고    scopus 로고
    • Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia
    • Schabitz W-R, Sommer C, Zoder W, Kiessling M, Schwaninger M, Schwab S. Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia. Stroke 31:2212-2217, 2000.
    • (2000) Stroke , vol.31 , pp. 2212-2217
    • Schabitz, W.-R.1    Sommer, C.2    Zoder, W.3    Kiessling, M.4    Schwaninger, M.5    Schwab, S.6
  • 56
    • 0036228917 scopus 로고    scopus 로고
    • Enhanced neuroprotective effects of basic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector
    • Song B-W, Vinters HV, Wu D, Pardridge WM. Enhanced neuroprotective effects of basic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector. J Pharmacol Exper Ther 301:605-610, 2002.
    • (2002) J Pharmacol Exper Ther , vol.301 , pp. 605-610
    • Song, B.-W.1    Vinters, H.V.2    Wu, D.3    Pardridge, W.M.4
  • 57
    • 0036317353 scopus 로고    scopus 로고
    • Therapeutic applications of monoclonal antibodies
    • Berger M, Shankar V, Vafai A. Therapeutic applications of monoclonal antibodies. Am J Med Sci 324:14-30, 2002.
    • (2002) Am J Med Sci , vol.324 , pp. 14-30
    • Berger, M.1    Shankar, V.2    Vafai, A.3
  • 58
    • 0031570025 scopus 로고    scopus 로고
    • Functional and pharmacokinetic properties of antibody-avidin fusion proteins
    • Shin SU, Wu D, Ramanathan R, Pardridge WM, Morrison SL. Functional and pharmacokinetic properties of antibody-avidin fusion proteins. J Immunol 158:4797-4804, 1997.
    • (1997) J Immunol , vol.158 , pp. 4797-4804
    • Shin, S.U.1    Wu, D.2    Ramanathan, R.3    Pardridge, W.M.4    Morrison, S.L.5
  • 60
    • 0030930364 scopus 로고    scopus 로고
    • Drug targeting of a peptide radiopharmaceutical through the primary blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor
    • Wu D, Yang J, Pardridge WM. Drug targeting of a peptide radiopharmaceutical through the primary blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor. J Clin Invest 100:1804-1812, 1997.
    • (1997) J Clin Invest , vol.100 , pp. 1804-1812
    • Wu, D.1    Yang, J.2    Pardridge, W.M.3
  • 61
    • 0033996507 scopus 로고    scopus 로고
    • Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor
    • Coloma MJ, Lee HJ, Kurihara A, Landaw EM, Boado RJ, Morrison SL, Pardridge WM. Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor. Pharm Res 17:266-274, 2000.
    • (2000) Pharm Res , vol.17 , pp. 266-274
    • Coloma, M.J.1    Lee, H.J.2    Kurihara, A.3    Landaw, E.M.4    Boado, R.J.5    Morrison, S.L.6    Pardridge, W.M.7
  • 62
    • 0842291436 scopus 로고    scopus 로고
    • The effects of citicoline and lamotrigine alone and in combination following permanent middle cerebral artery occlusion in rats
    • Ataus SA, Onal MZ, Ozdem SS, Locke KW, Balkan S. The effects of citicoline and lamotrigine alone and in combination following permanent middle cerebral artery occlusion in rats. Int J Neurosci. 114:183-196, 2004.
    • (2004) Int J Neurosci. , vol.114 , pp. 183-196
    • Ataus, S.A.1    Onal, M.Z.2    Ozdem, S.S.3    Locke, K.W.4    Balkan, S.5
  • 63
    • 2342517614 scopus 로고    scopus 로고
    • New perspectives on the pharmacotherapy of ischemic stroke
    • Bradberry JC, Fagan SC, Gray DR, Moon YS. New perspectives on the pharmacotherapy of ischemic stroke. J Am Pharm Assoc 44[2 Suppl 1]:S46-S56, 2004.
    • (2004) J Am Pharm Assoc , vol.44 , Issue.2 SUPPL. 1
    • Bradberry, J.C.1    Fagan, S.C.2    Gray, D.R.3    Moon, Y.S.4
  • 64
    • 0036399717 scopus 로고    scopus 로고
    • Combination therapy for ischemic stroke: Potential of neuroprotectants plus thrombolytics
    • Chen SD, Lee JM, Yang DI, Nassief A, Hsu CY. Combination therapy for ischemic stroke: potential of neuroprotectants plus thrombolytics. Am J Cardiovasc Drugs 2:303-313, 2002.
    • (2002) Am J Cardiovasc Drugs , vol.2 , pp. 303-313
    • Chen, S.D.1    Lee, J.M.2    Yang, D.I.3    Nassief, A.4    Hsu, C.Y.5
  • 65
    • 0037466232 scopus 로고    scopus 로고
    • Combined nimodipine and citicoline reduce infarct size, attenuation apoptosis and increase bcl-2 expression after focal cerebral ischemia
    • Sobrado M, Lopez MG, Carceller F, Garcia AG, Roda JM. Combined nimodipine and citicoline reduce infarct size, attenuation apoptosis and increase bcl-2 expression after focal cerebral ischemia. Neuroscience 118:107-113, 2003.
    • (2003) Neuroscience , vol.118 , pp. 107-113
    • Sobrado, M.1    Lopez, M.G.2    Carceller, F.3    Garcia, A.G.4    Roda, J.M.5
  • 66
    • 0037106173 scopus 로고    scopus 로고
    • Dual antiplatelet therapy for prevention of recurrent ischemic events
    • Nappi J, Talbert R. Dual antiplatelet therapy for prevention of recurrent ischemic events. Am J Health Syst Pharm 59:1723-1735, 2002.
    • (2002) Am J Health Syst Pharm , vol.59 , pp. 1723-1735
    • Nappi, J.1    Talbert, R.2
  • 67
    • 0345561549 scopus 로고    scopus 로고
    • Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia
    • Schabitz WR, Li F, Irie K, Sandage BW Jr, Locke KW, Fisher M. Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia. Stroke 30:427-431, 1999.
    • (1999) Stroke , vol.30 , pp. 427-431
    • Schabitz, W.R.1    Li, F.2    Irie, K.3    Sandage Jr., B.W.4    Locke, K.W.5    Fisher, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.