Intracerebral transplantation of porcine choroid plexus provides structural and functional neuroprotection in a rodent model of stroke

Stroke

Volumn 35, Issue 9, 2004, Pages 2206-2210

  Borlongan, Cesar V ^a,b   Skinner, Steve J M ^d   Geaney, Marilyn ^d   Vasconcellos, Alfred V ^c   Elliott, Robert B ^d   Emerich, Dwaine F ^c  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c LCT BioPharma Inc   (United States)

^d Living Cell Technologies NZ Ltd   (New Zealand)

Author keywords

Cerebral ischemia; Neuroprotection; Stroke, acute

Indexed keywords

ALGINIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; TRIPHENYLTETRAZOLIUM;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; BRAIN INFARCTION SIZE; BRAIN NERVE CELL; CHOROID PLEXUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; ENCAPSULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EVALUATION; EXPERIMENTAL MODEL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROCAPSULE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL CULTURE; NEUROPROTECTION; NEWBORN; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; STROKE; SWINE; TISSUE STRUCTURE; TRANSPLANTATION;

ALGINATES; ANIMALS; ANIMALS, NEWBORN; BRAIN TISSUE TRANSPLANTATION; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; CEREBRAL INFARCTION; CHOROID PLEXUS; CULTURE MEDIA, CONDITIONED; DRUG COMPOUNDING; FEMALE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIOSIS; GLUCURONIC ACID; HEXURONIC ACIDS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MOTOR ACTIVITY; NERVE GROWTH FACTOR; NERVE GROWTH FACTORS; NEURONS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SUS SCROFA; TRANSPLANTATION, HETEROLOGOUS; TRANSPLANTATION, HETEROTOPIC;

EID: 4344679545     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000138954.25825.0b     Document Type: Article

References (23)

1. Borlongan CV, Yamamoto M, Takei N, Kumazaki M, Ungsuparkorn C, Hida H, Sanberg PR, Nishino H. Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia. FASEB J. 2000;14:1307-1317.
2. Chiang YH, Lin SZ, Borlongan CV, Hoffer BJ, Morales M, Wang Y. Transplantation of fetal kidney tissue reduces cerebral infarction induced by middle cerebral artery ligation. J Cereb Blood Flow Metab. 1999;19: 1329-1335.
3. Grabowski M, Johansson BB, Brundin P. Fetal neocortical grafts placed in brain infarcts do not improve paw-reaching deficits in adult spontaneously hypertensive rats. Acta Neurochir Suppl (Wien). 1996;66:68-72.
4. Sinden JD, Stroemer P, Grigoryan G, Patel S, French SJ, Hodges H. Functional repair with neural stem cells. Novartis Found Symp. 2000; 231:270-283.
5. Kondziolka D, Wechsler L, Goldstein S, Meltzer C, Thulborn KR, Gebel J, Jannetta P, DeCesare S, Elder EM, McGrogan M, Reitman MA, Bynum L. Transplantation of cultured human neuronal cells for patients with stroke. Neurology. 2000;55:565-569.
6. Hoffer B, Olson L. Treatment strategies for neurodegenerative diseases based on trophic factors and cell transplantation techniques. J Neural Transm Suppl. 1997;49:1-10.
7. Johnston RE, Dillon-Carter O, Freed WJ, Borlongan CV. Trophic factor secreting kidney cell lines: in vitro characterization and functional effects following transplantation in ischemic rats. Brain Res. 2001;900:268-276.
8. Stopa EG, Berzin TM, Kim S, Song P, Kuo-LeBlanc V, Rodriguez-Wolf M, Baird A, Johanson CE. Human choroid plexus growth factors: what are the implications for CSF dynamics in Alzheimer's disease? Exp Neurol. 2001;167:40-47.
9. Ide C, Kitada M, Chakrabortty S, Taketomi M, Matsumoto N, Kikukawa S, Mizoguchi A, Kawaguchi S, Endoh K, Suzuki Y. Grafting of choroid plexus ependymal cells promotes the growth of regenerating axons in the dorsal funiculus of rat spinal cord: a preliminary report. Exp Neural. 2001;167:242-251.
10. Elliott RB, Escobar L, Garkavenko O, Croxson MC, Schroeder BA, McGregor M, Ferguson G, Beckman N, Ferguson S. No evidence of infection with porcine endogenous retrovirus in recipients of encapsulated porcine islet xenografts. Cell Transplant. 2000;9:895-901.
11. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. New York: Academic Press; 1986.
12. Borlongan CV, Sumaya I, Moss D, Kumazaki M, Sakurai T, Hida H, Nishino H. Melatonin-secreting pineal gland: a novel tissue source for neural transplantation therapy in stroke. Cell Transplant. 2003;12: 225-234.
13. Borlongan CV, Tajima Y, Trojanowski JQ, Lee VM, Sanberg PR. Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats. Exp Neurol. 1998;149:310-321.
14. Fukuda A, Deshpande SB, Shimano Y, Nishino H. Astrocytes are more vulnerable than neurons to cellular Ca2+ overload induced by a mitochondrial toxin, 3-nitropropionic acid. Neuroscience. 1998;87:497-507.
15. Emerich DF, Lindner MD, Winn SR, Chen EY, Frydel BR, Kordower JH. Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease. J Neurosci. 1996;16:5168-5181.
16. Joki T, Machluf M, Atala A, Zhu J, Seyfried NT, Dunn IF, Abe T, Carroll RS, Black PM. Continuous release of endostatin from microencapsulated engineered cells for tumor therapy. Nat Biotechnol. 2001;19:35-39.
17. Winn SR, Hammang JP, Emerich DF, Lee A, Palmiter RD, Baetge EE. Polymer-encapsulated cells genetically modified to secrete human nerve growth factor promote the survival of axotomized septal cholinergic neurons. Proc Natl Acad Sci U S A. 1994;91:2324-2328.
18. Aleshire SL, Hajdu I, Bradley CA, Parl FF. Choroid plexus as a barrier to immunoglobulin delivery into cerebrospinal fluid. J Neurosurg. 1985;63: 593-597.
19. Johanson CE, Palm DE, Primiano MJ, McMillan PN, Chan P, Knuckey NW, Stopa EG. Choroid plexus recovery after transient forebrain ischemia: role of growth factors and other repair mechanisms. Cell Mol Neurobiol. 2000;20:197-216.
20. National Institute of Neurological Disorders, and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581-1587.
21. Chen J, Li Y, Katakowski M, Chen X, Wang L, Lu D, Lu M, Gautam SC, Chopp M. Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat. J Neurosci Res. 2003;73:778-786.
22. Wang Y, Lin SZ, Chiou AL, Williams LR, Hoffer BJ. Glial cell line-derived neurotrophic factor protects against ischemia-induced injury in the cerebral cortex. J Neurosci. 1997;17:4341-4348.
23. Rubanyi GM. The future of human gene therapy. Mol Aspects Med. 2001;3:113-142.