β-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons

Journal of Neuroscience

Volumn 24, Issue 30, 2004, Pages 6799-6809

  Tong, Liqi ^a   Balazs, Robert ^a   Thornton, Phillip L ^a   Cotman, Carl W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

amyloid; BDNF; Cortical neurons; CREB; MAPK; PI3 K

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DOCKING PROTEIN; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSCRIPTION FACTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN CELL; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; EFFECTOR CELL; ENZYME ACTIVATION; NERVE CELL CULTURE; NERVE CELL PLASTICITY; NERVE DEGENERATION; NERVE FUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; SERUM RESPONSIVE ELEMENT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; CEREBRAL CORTEX; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ETS-DOMAIN PROTEIN ELK-1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLYCOGEN SYNTHASE KINASE 3; MAP KINASE SIGNALING SYSTEM; NERVE TISSUE PROTEINS; NEURONS; ONCOGENE PROTEIN P21(RAS); PEPTIDE FRAGMENTS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, TRKB; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 3342908640     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5463-03.2004     Document Type: Article

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