Gender-related association of brain-derived neurotrophic factor gene 196A/G polymorphism with Alzheimer's disease--a meta-analysis including 6854 cases and 6868 controls

International Journal of Neuroscience

Volumn 124, Issue 10, 2014, Pages 724-733

  Chen, Jia ^a   Liang, Xiaomin ^a   Li, Binghu ^a   Jiang, Xiaojiang ^a   Xu, Zhiqiang ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Brain derived neurotrophic factor; Gene polymorphism; Meta analysis

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ALZHEIMER DISEASE; ARTICLE; CASE CONTROL STUDY; CENTRAL NERVOUS SYSTEM; DNA POLYMORPHISM; DSM-IV; EMBASE; GENETIC RISK; HUMAN; MEDLINE; META ANALYSIS; PUBLICATION; QUALITY CONTROL; SAMPLE SIZE; SYSTEMATIC REVIEW; WEB OF SCIENCE; BIBLIOGRAPHIC DATABASE; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICS AND NUMERICAL DATA;

ALZHEIMER DISEASE; BRAIN-DERIVED NEUROTROPHIC FACTOR; DATABASES, BIBLIOGRAPHIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX FACTORS;

EID: 84900028987     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207454.2013.869594     Document Type: Article

References (53)

1. Ritchie K, Lovestone S. The dementias. The Lancet 2002; 360:1759-66.
2. Brookmeyer R, Johnson E, Ziegler-Graham K, et al. Forecasting the global burden of Alzheimers disease. Alzheimers Dement 2007;3:186-91.
3. Duyckaerts C, Delatour B, Potier M-C. Classification and basic pathology of Alzheimer disease. Acta Neuropathol 2009;118:5-36.
4. Phillips HS, Hains JM, Armanini M, et al. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimers disease. Neuron 1991;7:695-702.
5. Connor B, Young D, Yan Q, et al. Brain-derived neurotrophic factor is reduced in Alzheimers disease. Mol Brain Res 1997;49:71-81.
6. Holsinger RM, Schnarr J, Henry P, et al. Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimers disease. Mol Brain Res 2000;76:347-54.
7. Bertram L, Lill CM, Tanzi RE. The genetics of Alzheimer disease: back to the future. Neuron 2010;68:270-81.
8. Egan MF, Kojima M, Callicott JH, et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003;112:257-69.
9. Bath KG, Lee FS. Variant BDNF (Val66Met) impact on brain structure and function. Cogn Affect Behav Ne 2006;6:79-85.
10. Lewin GR, Barde Y-A. Physiology of the neurotrophins. Ann Rev Neurosci 1996;19:289-317.
11. Maisonpierre PC, Le Beau MM, Espinosa Iii R, et al. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Genomics 1991;10:558-68.
12. Fukumoto N, Fujii T, Combarros O, et al. Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimers disease: New data and meta-analysis. Am J Med Genet B 2010;153:235-42.
13. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009;151:264-9.
14. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimers disease report of the NINCDS-ADRDA Work Group∗ under the auspices of department of health and human services task force on Alzheimers Disease. Neurology 1984;34:939-44.
15. Mirra SS, Heyman A, McKeel D, et al. The Consortium to Establish a Registry for Alzheimers Disease (CERAD) Part II. Standardization of the neuropathologic assessment of Alzheimers disease. Neurology 1991;41:479-86.
16. Guo SW, Thompson EA. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics 1992:361-72.
17. Wells GA, Shea B, Oconnell D, et al. 2000. The Newcastle- Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses.
18. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. The Challenge of Epidemiology: Issues and Selected Readings 2004;1:533-53.
19. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88.
20. Cochran WG. The combination of estimates from different experiments. Biometrics 1954;10:101-29.
21. Higgins J, Thompson SG. Quantifying heterogeneity in a metaanalysis. Stat Med 2002;21:1539-58.
22. Sim J, Wright CC. The kappa statistic in reliability studies: use, interpretation, and sample size requirements. Phys Ther 2005;85:257-68.
23. Egger M, Smith GD, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-34.
24. Sonali N, Tripathi M, Sagar R, et al. Val66Met polymorphism and BDNF levels in Alzheimers disease patients in North Indian population. Int J Neurosci 2013;123:409-16.
25. Hashimoto R, Hirata Y, Asada T, et al. Effect of the brainderived neurotrophic factor and the apolipoprotein E polymorphisms on disease progression in preclinical Alzheimers disease. Genes Brain Behav 2009;8:43-52.
26. Voineskos AN, Lerch JP, Felsky D, et al. The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease. Arch Gen Psychiat 2011;68:198-206.
27. BicalhoMAC, Pimenta FA, Bastos-Rodrigues L, et al. Sociodemographic characteristics, clinical factors, and genetic polymorphisms associated with Alzheimers disease. Int J Geriatr Psych 2013;28:640-6.
28. Desai P, Nebes R, DeKosky ST, et al. Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimers disease (AD) and quantitative measures of AD progression. Neurosci Lett 2005;379:229-34.
29. Li Y, Rowland C, Tacey K, et al. The BDNF Val66Met polymorphism is not associated with late onset Alzheimers disease in three case-control samples.Mol Psychiatr 2005;10:809-10.
30. Ventriglia M, Bocchio Chiavetto L, Benussi L, et al. Association between the BDNF 196 A/G polymorphism and sporadic Alzheimers disease. Mol Psychiatr 2002;7:136-7.
31. Bagnoli S, Nacmias B, Tedde A, et al. Brain-derived neurotrophic factor genetic variants are not susceptibility factors to Alzheimers disease in Italy. Ann Neurol 2004;55:447-8.
32. Combarros O, Infante J, Llorca J, et al. Polymorphism at codon 66 of the brain-derived neurotrophic factor gene is not associated with sporadic Alzheimers disease. Dement Geriatr Cogn 2004;18:55-8.
33. Nacmias B, Piccini C, Bagnoli S, et al. Brain-derived neurotrophic factor, apolipoprotein E genetic variants and cognitive performance in Alzheimers disease. Neurosci Lett 2004;367:379-83.
34. Bian JT, Zhang JW, Zhang ZX, et al. Association analysis of brain-derived neurotrophic factor (BDNF) gene 196 A/G polymorphism with Alzheimers disease (AD) in mainland Chinese. Neurosci Lett 2005;387:11-6.
35. Bodner SM, Berrettini W, van Deerlin V, et al. Genetic variation in the brain derived neurotrophic factor gene in Alzheimers disease. Am J Med Genet B 2005;134B:1-5.
36. Lee J, Fukumoto H, Orne J, et al. Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. Exp Neurol 2005;194:91-6.
37. Matsushita S, Arai H, Matsui T, et al. Brain-derived neurotrophic factor gene polymorphisms and Alzheimers disease. J Neural Transm 2005;112:703-11.
38. Vepsalainen S, Castren E, Helisalmi S, et al. Genetic analysis of BDNF and TrkB gene polymorphisms in Alzheimers disease. J Neurol 2005;252:423-8.
39. Akatsu H, Yamagata HD, Kawamata J, et al. Variations in the BDNF gene in autopsy-confirmed Alzheimers disease and dementia with Lewy bodies in Japan. Dement Geriatr Cogn 2006;22:216-22.
40. Forero DA, Benitez B, Arboleda G, et al. Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimers disease in Colombia. Neurosci Res 2006;55:334-41.
41. Saarela MS, Lehtimaki T, Rinne JO, et al. No association between the brain-derived neurotrophic factor 196 G>A or 270 C>T polymorphisms and Alzheimers or Parkinsons disease. Folia Neuropathol 2006;44:12-6.
42. Tsai SJ, Hong CJ, Liu HC, et al. The brain-derived neurotrophic factor gene as a possible susceptibility candidate for Alzheimers disease in a chinese population. Dement Geriatr Cogn 2006;21:139-43.
43. Zhang H, Ozbay F, Lappalainen J, et al. Brain derived neurotrophic factor (BDNF) gene variants and Alzheimers disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence. Am J Med Genet B 2006;141B:387-93.
44. He XM, Zhang ZX, Zhang JW, et al. Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population. Neuropsychobiology 2007;55:151-5.
45. Huang R, Huang J, Cathcart H, et al. Genetic variants in brainderived neurotrophic factor associated with Alzheimers disease. J Med Genet 2007;44:e66.
46. Feher A, Juhasz A, Rimanoczy A, et al. Association between BDNF Val66Met polymorphism and Alzheimer disease, dementia with Lewy bodies, and Pick disease. Alz Dis Assoc Dis 2009;23:224-8.
47. Pivac N, Nikolac M, Nedic G, et al. Brain derived neurotrophic factor Val66Met polymorphism and psychotic symptoms in Alzheimers disease. Prog Neuro-Psychoph 2011;35:356-62.
48. Borroni B, Bianchi M, Premi E, et al. The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced hippocampus perfusion in frontotemporal lobar degeneration. J Alz Dis 2012;31:243-51.
49. Boiocchi C, Maggioli E, Zorzetto M, et al. Brain-derived neurotrophic factor gene variants and Alzheimer disease: an association study in an Alzheimer disease Italian population. Rejuv Res 2013;16:57-66.
50. LeBlanc ES, Janowsky J, Chan BKS, et al. Hormone replacement therapy and cognition. JAMA 2001;285:1489-99.
51. Emmelot-Vonk MH, Verhaar HJJ, Pour HRN, et al. Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men. JAMA 2008;299: 39-52.
52. Miranda RC, Sohrabji F, Toran-Allerand CD. Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions. Proc Natl Acad Sci USA 1993;90(14):6439-43.
53. Sohrabji F, Miranda RC, Toran-Allerand CD. Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor. Proc Natl Acad Sci USA 1995;92(24):11110-4.