Sendai virus vector-mediated brain-derived neurotrophic factor expression ameliorates memory deficits and synaptic degeneration in a transgenic mouse model of Alzheimer's disease

Journal of Neuroscience Research

Volumn 90, Issue 5, 2012, Pages 981-989

  Iwasaki, Yuki ^a,b   Negishi, Takayuki ^c   Inoue, Makoto ^d   Tashiro, Tomoko ^c   Tabira, Takeshi ^e   Kimura, Nobuyuki ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c AOYAMA GAKUIN UNIVERSITY   (Japan)

^d DNAVEC Research Inc   (Japan)

^e JUNTENDO UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; BDNF; Gene therapy; Sendai virus vector

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; SENDAI VIRUS VECTOR; UNCLASSIFIED DRUG; VIRUS VECTOR;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN NERVE CELL; COGNITION; CONTROLLED STUDY; HIPPOCAMPUS; IN VIVO STUDY; MALE; MEMORY DISORDER; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNAPTIC DEGENERATION; WHITE MATTER;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HUMANS; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; NERVE DEGENERATION; NEURONS; PEPTIDE FRAGMENTS; SENDAI VIRUS; SYNAPSES;

EID: 84858006948     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22830     Document Type: Article

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