Neuroprotective and neurotrophic actions of the mood stabilizer lithium: Can it be used to treat neurodegenerative diseases?

Critical Reviews in Neurobiology

Volumn 16, Issue 1-2, 2004, Pages 83-90

  Chuang, De Maw ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Bcl 2; Excitotoxiciy; Heat shock protein; Huntington's disease; Ischemia; Lithium; MAP kinases; Neurodegeneration; Neurogenesis; Neuroprotection

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CASPASE 3; CHAPERONE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUTAMIC ACID; HEAT SHOCK PROTEIN 70; LITHIUM; MITOGEN ACTIVATED PROTEIN KINASE P38; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; BIPOLAR DISORDER; BRAIN INFARCTION; BRAIN INJURY; CALCIUM CURRENT; CONTROLLED STUDY; CYTOTOXICITY; DEGENERATIVE DISEASE; DRUG EFFECT; ENZYME ACTIVATION; HUNTINGTON CHOREA; LONG TERM CARE; MACROGLIA; NEUROPROTECTION; NONHUMAN; RAT; REVIEW; STROKE;

ANIMALS; CELLS, CULTURED; CEREBROVASCULAR ACCIDENT; HUMANS; HUNTINGTON DISEASE; LITHIUM; MICE; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; NOOTROPIC AGENTS; RATS;

EID: 9744238838     PISSN: 08920915     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevNeurobiol.v16.i12.90     Document Type: Review

References (32)

1. Jope RS. Anti-bipolar therapy: mechanism of action of lithium. Mol Psychiatry 1999; 4:117-128.
2. Nonaka S, Hough C, Chuang D-M. Chronic lithium treatment robustly protects CNS neurons against excitotoxicity by inhibiting NMDA receptor-mediated calcium influx. Proc Natl Acad Sci USA 1998; 95:2642-2647.
3. Chen R-W, Chuang D-M. Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression: a prominent role in neuroprotection against excitotoxicity. J Biol Chem (Commun) 1999; 274:6039-6042.
4. Chen G, Zeng W-Z, Yuan P-X, Huang L-D, Jiang Y-M, Zhao Z-H, Manji HK. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. J Neurochem 1999; 72:879-882.
5. Chalecka-Franaszek E, Chuang D-M. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc Natl Acad Sci USA 1999; 96: 8745-8750.
6. Klein PS, Melton DA. A molecular mechanism for die effect of lithium on development. Proc Natl Acad Sci USA 1996; 93:8455-8459.
7. Finkbeiner, S. CREB couples neurotrophin signals to survival messages. Neuron 2000; 25:11-14.
8. Kopnisky KL, Chalecka-Franaszek E, Gonzalez-Zulueta M, Chuang D-M. Chronic lithium treatment antogonizes glutamine-induced decrease of phosphorylated CREB in neurons by reducing PP1 and increasing MEK activities. Neurosci 2003; 116: 425-435.
9. Mielke K, Herdegen T. JNK and p38 stresskinases-degenerative effectors of signal-transduction-cascades in the nervous system. Prog Neurobiol 2000; 61:45-60.
10. Chen R-W, Qin Z-H, Ren M, Kani H, Chalecka-Franaszek E, Leeds P, Chuang D-M. Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitation and lithium neuroprotection. J Neurochem 2003; 84:566-575.
11. Drevets, W.C. Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders. Curr Opin Neurobiol 2001; 11:240-249.
12. Manji HK, Quiroz JA, Sporn J, Payne JL, Denicoff K, Gray NA, et al. Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression. Biol Psychiatry 2003; 53:707-742.
13. Hashimoto R, Hough C, Nakazawa T, Yamamoto T, Chuang D-M. Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation. J Neurochem 2002; 80:589-597.
14. Takasu MA, Dalva MB, Zigmond RE, Greenberg ME. Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors. Science 2002; 295:491-495.
15. Hashimoto R, Fujimaki K, Jeong M-R, Chuang D-M. Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity. FEBS Lett 2003; 538: 145-148.
16. Patapoutian A, Reichardt LF. Trk receptors: mediators of neurotrophin action. Curr Opin Neurol 2001; 11:272-80.
17. Hashimoto R, Takei N, Shimazu K, Christ L, Lu B, Chuang D-M. Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity. Neuropharmacology 2002; 43:1173-1179.
18. Yasuda S, Chuang D-M. Lithium activates promoter III of brain-derived neurotrophic factor (BDNF) gene in rat cortical neurons. 33nd Annual Meeting, Society for Neuroscience 2003; Abstract no. 458.2.
19. Chuang D-M, Chen R-W, Chalecka-Franaszek E, Ren M, Hashimoto R, Senatorov V, Kanai H, Hough C, Hiroi T, Leeds P. Neuroprotective effects of lithium in cultured cells and animal models of diseases. Bipol Disord 2002; 4:129-136.
20. Gage FH. Mammalian neural stem cells. Science 2000; 287:1433-1438.
21. Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 2000; 20:9104-9110.
22. Fukumoto T, Morinobu S, Okamoto Y, Kagaya A, Yamawaki S. Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain. Psychopharmacology 2001; 158: 100-106.
23. Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, Manji HK. Enhancement of hippocampal neurogenesis by lithium. J Neurochem 2000; 75:1729-1734.
24. Hashimoto R, Senatorov W, Kanai H, Leeds P, Chuang D-M. Lithium stimulates progenitor proliferation in cultured brain neurons. Neuroscience 2003; 117:55-61.
25. Nonaka S, Chuang D-M. Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats. Neuro Report 1998; 9:2081-2084.
26. Ren M, Senatorov W, Chen R-W, Chuang D-M. Post-insult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model. Proc Natl Acad Sci USA 2003; 100:6210-6215.
27. Ren M, Leng Y, Jeong MR, Leeds P, Chuang D-M. Valproate protects against brain injury in a transient focal ischemia model of rats. J Neurochem 2004; 18: 1358-1367.
28. Wei H, Qin Z-H, Senatorov V, Wei W, Wang Y, Qian Y, Chuang D-M. Lithium suppresses excitotoxicity-induced striatal lesions in a rat model of Huntington's disease. Neurosci 2001; 106:603-612.
29. Senatorov W, Ren M, Kanai H, Wei H, Chuang D-M. Short-term lithium treatment promotes neuronal survival and proliferation in rat striatum infused with quinolinic acid, a model of Huntington's disease. Mol Psychiatry 2004; 9:301-385.
30. Moore GJ, Bebchuk JM, Wilds IB, Chen G, Manji HK. Lithium-induced increase in human brain grey matter. Lancet 2000; 356:1241-1242.
31. Moore GJ, Bebchuk JM, Hasanat K, Chen G, Seraji-Bozorgzad N, Wilds IB, et al. Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2's neurotrophic effects? Biol Psychiatry 2000; 48:1-8.
32. Drevets WC. Neuroimaging studies of major depression. In: Morihisa J, editor. Advances In Brain Imaging of the American Psychiatric Press Annual Review of Psychiatry (Oldham JM, Series editor). Washington DC: American Psychiatric Press, 2001.