7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of alzheimer's disease

Neuropsychopharmacology

Volumn 37, Issue 2, 2012, Pages 434-444

  Devi, Latha ^a   Ohno, Masuo ^a,b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

7,8 dihydroxyflavone; Alzheimer's disease; BACE1; BDNF; learning and memory; TrkB agonist

Indexed keywords

7,8 DIHYDROXYFLAVONE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE 1; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; HIPPOCAMPUS; MALE; MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPATIAL MEMORY; TRANSGENIC MOUSE; TREATMENT DURATION; WILD TYPE; WORKING MEMORY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; FEMALE; FLAVONES; HUMANS; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; PHOSPHORYLATION; RECEPTOR, TRKB; SIGNAL TRANSDUCTION;

EID: 84856059838     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.191     Document Type: Article

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