Sodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): Implications for alzheimer disease therapy

Journal of Biological Chemistry

Volumn 288, Issue 12, 2013, Pages 8299-8312

  Corbett, Grant T ^a   Roy, Avik ^a   Pahan, Kalipada ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; BRAIN-DERIVED NEUROTROPHIC FACTORS; CAMP-RESPONSE ELEMENT-BINDING PROTEINS; HIPPOCAMPAL NEURONS; NEUROTROPHIC FACTORS; ORAL ADMINISTRATION; THERAPEUTIC TARGETS; TRANSCRIPTIONAL ACTIVATIONS;

BRAIN; ENZYME INHIBITION; NEURODEGENERATIVE DISEASES; NEURONS; PROTEINS; SODIUM;

BIOSYNTHESIS;

4 PHENYLBUTYRIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; NEUROTROPHIN 3; PROTEIN KINASE C; RECEPTOR ANTIBODY; SERINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; HUMAN CELL; MACROGLIA; MALE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SPATIAL LEARNING; SPATIAL MEMORY; SYNAPSE; TRANSCRIPTION INITIATION; TREATMENT RESPONSE; UPREGULATION;

ADMINISTRATION, ORAL; ALZHEIMER DISEASE; ANIMALS; ASTROCYTES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SHAPE; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FORMATES; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; HUMANS; MALE; MEMORY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; NEUROTROPHIN 3; PHENYLBUTYRATES; PHOSPHORYLATION; PRIMARY CELL CULTURE; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, NERVE GROWTH FACTOR; UP-REGULATION;

EID: 84875441025     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.426536     Document Type: Article

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