Polymorphism of brain derived neurotrophic factor influences β amyloid load in cognitively intact apolipoprotein e ε4 carriers

NeuroImage: Clinical

Volumn 2, Issue 1, 2013, Pages 512-520

  Adamczuk, Katarzyna ^a   De Weer, An Sofie ^a   Nelissen, Natalie ^a   Chen, Kewei ^b,c,d   Sleegers, Kristel ^f,g   Bettens, Karolien ^f,g   Van Broeckhoven, Christine ^f,g   Vandenbulcke, Mathieu ^h   Thiyyagura, Pradeep ^b,c   Dupont, Patrick ^a   Van Laere, Koen ^h   Reiman, Eric M ^b,c,e   Vandenberghe, Rik ^a,i  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b BANNER ALZHEIMER S INSTITUTE   (United States)

^c ARIZONA ALZHEIMER S CONSORTIUM   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

^e UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^f DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^g UNIVERSITY OF ANTWERP   (Belgium)

^h UNIVERSITY HOSPITALS LEUVEN   (Belgium)

ⁱ Neurology Department   (Belgium)

Author keywords

Alzheimer; Amyloid PET; APOE; BDNF; Flutemetamol

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E4; BRAIN DERIVED NEUROTROPHIC FACTOR; FLUTEMETAMOL F 18;

ADULT; AGE DISTRIBUTION; AGED; ALLELE; ARTICLE; BRAIN REGION; CODON; COGNITION; EPISODIC MEMORY; FEMALE; GENETIC POLYMORPHISM; GYRUS RECTUS; HETEROZYGOTE; HUMAN; HYPOTHESIS; IMAGE ANALYSIS; MALE; NORMAL HUMAN; ORBITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRECUNEUS; PREFRONTAL CORTEX; PRIORITY JOURNAL; SEX DIFFERENCE; ALZHEIMER DISEASE; CLINICAL ARTICLE; INSULA; PROTEIN LOCALIZATION; SINGLE NUCLEOTIDE POLYMORPHISM; TEMPORAL CORTEX;

EID: 84876933724     PISSN: None     EISSN: 22131582     Source Type: Journal    
DOI: 10.1016/j.nicl.2013.04.001     Document Type: Article

References (77)

1. H.J. Aizenstein, R.D. Nebes, J.A. Saxton, J.C. Price, C.A. Mathis, N.D. Tsopelas, S.K. Ziolko, J.A. James, B.E. Snitz, P.R. Houck, W. Bi, A.D. Cohen, B.J. Lopresti, S.T. DeKosky, E.M. Halligan, and W.E. Klunk Frequent amyloid deposition without significant cognitive impairment among the elderly Archives of Neurology 65 2008 1509 1517
2. T. Arendt Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease International Journal of Developmental Neuroscience 19 2001 231 245
3. J.W. Ashford, and L. Jarvik Alzheimer's disease: does neuron plasticity predispose to axonal neurofibrillary degeneration? The New England Journal of Medicine 313 1985 388 389
4. H. Braak, and E. Braak Neuropathological stageing of Alzheimer-related changes Acta Neuropathologica 82 1991 239 259
5. R.L. Buckner, J. Sepulcre, T. Talukdar, F.M. Krienen, H. Liu, T. Hedden, J.R. Andrews-Hanna, R.A. Sperling, and K.A. Johnson Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease Journal of Neuroscience 29 2009 1860 1873
6. J.A. Bueller, M. Aftab, S. Sen, D. Gomez-Hassan, M. Burmeister, and J.-K. Zubieta BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects Biological Psychiatry 59 2006 812 815
7. B. Cheeran, P. Talelli, F. Mori, G. Koch, A. Suppa, M. Edwards, H. Houlden, K. Bhatia, R. Greenwood, and J.C. Rothwell A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS The Journal of Physiology 586 2008 5717 5725
8. Z.-Y. Chen, P.D. Patel, G. Sant, C.-X. Meng, K.K. Teng, B.L. Hempstead, and F.S. Lee Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons Journal of Neuroscience 24 2004 4401 4411
9. G. Chételat, V.L. Villemagne, P. Bourgeat, K.E. Pike, G. Jones, D. Ames, K.A. Ellis, C. Szoeke, R.N. Martins, G.J. O'Keefe, O. Salvado, C.L. Masters, and C.C. Rowe Relationship between atrophy and beta-amyloid deposition in Alzheimer disease Annals of Neurology 67 2010 317 324
10. G. Chételat, V.L. Villemagne, K.E. Pike, K.A. Ellis, P. Bourgeat, G. Jones, G.J. O'Keefe, O. Salvado, C. Szoeke, R.N. Martins, D. Ames, C.L. Masters, and C.C. Rowe and the Australian Imaging Biomarkers and Lifestyle Study of Ageing (AIBL) Research Group L.S. Independent contribution of temporal beta-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease Brain 134 2011 798 807
11. M.-C. Chiang, C. Avedissian, M. Barysheva, A.W. Toga, K.L. McMahon, G.I. de Zubicaray, M.J. Wright, and P.M. Thompson Extending genetic linkage analysis to diffusion tensor images to map single gene effects on brain fiber architecture Medical Image Computing and Computer Assisted Intervention 12 2009 506 513
12. R. Christensen, A.B. Marcussen, G. Wörtwein, G.M. Knudsen, and S. Aznar Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels Experimental Neurology 210 2008 164 171
13. B. Connor, D. Young, Q. Yan, R.L. Faull, B. Synek, and M. Dragunow Brain-derived neurotrophic factor is reduced in Alzheimer's disease Molecular Brain Research 49 1997 71 81
14. H.J. Cordell Detecting gene-gene interactions that underlie human diseases Nature Reviews Genetics 10 2009 392 404
15. E.H. Corder, A.M. Saunders, W.J. Strittmatter, D.E. Schmechel, P.C. Gaskell, G.W. Small, A.D. Roses, J.L. Haines, and M.A. Pericak-Vance Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 261 1993 921 923
16. N.A. Dennis, R. Cabeza, A.C. Need, S. Waters-Metenier, D.B. Goldstein, and K.S. LaBar Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks Hippocampus 21 2011 980 989
17. M.F. Egan, M. Kojima, J.H. Callicott, T.E. Goldberg, B.S. Kolachana, A. Bertolino, E. Zaitsev, B. Gold, D. Goldman, M. Dean, B. Lu, and D.R. Weinberger The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function Cell 112 2003 257 269
18. K.I. Erickson, R.S. Prakash, M.W. Voss, L. Chaddock, S. Heo, M. McLaren, B.D. Pence, S.A. Martin, V.J. Vieira, J.A. Woods, E. McAuley, and A.F. Kramer Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume Journal of Neuroscience 30 2010 5368 5375
19. K.I. Erickson, M.W. Voss, R.S. Prakash, C. Basak, A. Szabo, L. Chaddock, J.S. Kim, S. Heo, H. Alves, S.M. White, T.R. Wojcicki, E. Mailey, V.J. Vieira, S.A. Martin, B.D. Pence, J.A. Woods, E. McAuley, and A.F. Kramer Exercise training increases size of hippocampus and improves memory Proceedings of the National Academy of Sciences of the United States of America 108 2011 3017 3022
20. I. Ferrer, C. Marín, M.J. Rey, T. Ribalta, E. Goutan, R. Blanco, E. Tolosa, and E. Martí BDNF and full-length and truncated TrkB expression in Alzheimer disease. implications in therapeutic strategies Journal of Neuropathology and Experimental Neurology 58 1999 729 739
21. A.S. Fleisher, K. Chen, X. Liu, A. Roontiva, P. Thiyyagura, N. Ayutyanont, A.D. Joshi, C.M. Clark, M.A. Mintun, M.J. Pontecorvo, P.M. Doraiswamy, K.A. Johnson, D.M. Skovronsky, and E.M. Reiman Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease Archives of Neurology 68 2011 1404 1411
22. A.S. Fleisher, K. Chen, X. Liu, N. Ayutyanont, A. Roontiva, P. Thiyyagura, H. Protas, A.D. Joshi, M. Sabbagh, C.H. Sadowsky, R.A. Sperling, C.M. Clark, M.A. Mintun, M.J. Pontecorvo, R.E. Coleman, P.M. Doraiswamy, K.A. Johnson, A.P. Carpenter, D.M. Skovronsky, and E.M. Reiman Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease Neurobiology of Aging 34 2013 1 12
23. M.F. Folstein, S.E. Folstein, and P.R. McHugh Mini-mental state. A practical method for grading the cognitive state of patients for the clinician Journal of Psychiatry Research 12 1975 189 198
24. J.A. Gorski, S.R. Zeiler, S. Tamowski, and K.R. Jones Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites Journal of Neuroscience 23 2003 6856 6865
25. T. Hajek, M. Kopecek, and C. Höschl Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor val66met polymorphism: meta-analysis The World Journal of Biological Psychiatry 13 2012 178 187
26. A.R. Hariri, T.E. Goldberg, V.S. Mattay, B.S. Kolachana, J.H. Callicott, M.F. Egan, and D.R. Weinberger Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance Journal of Neuroscience 23 2003 6690 6694
27. K. Herholz, E. Salmon, D. Perani, J.C. Baron, V. Holthoff, L. Frlich, P. Schnknecht, K. Ito, R. Mielke, E. Kalbe, G. ZÃÂndorf, X. Delbeuck, O. Pelati, D. Anchisi, F. Fazio, N. Kerrouche, B. Desgranges, F. Eustache, B. Beuthien-Baumann, C. Menzel, J. SchrÃder, T. Kato, Y. Arahata, M. Henze, and W.D. Heiss Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET NeuroImage 17 2002 302 316
28. C. Hock, K. Heese, C. Hulette, C. Rosenberg, and U. Otten Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas Archives of Neurology 57 2000 846 851
29. R.M. Holsinger, J. Schnarr, P. Henry, V.T. Castelo, and M. Fahnestock Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease Brain Research. Molecular Brain Research 76 2000 347 354
30. R. Huang, J. Huang, H. Cathcart, S. Smith, and S.E. Poduslo Genetic variants in brain-derived neurotrophic factor associated with Alzheimer's disease Journal of Medical Genetics 44 2007 e66
31. 18F-GE067: a radioligand for in vivo brain amyloid imaging Journal of Nuclear Medicine 50 2009 818 822
32. C. Laske, E. Stransky, T. Leyhe, G.W. Eschweiler, A. Wittorf, E. Richartz, M. Bartels, G. Buchkremer, and K. Schott Stage-dependent BDNF serum concentrations in Alzheimer's disease Journal of Neural Transmission 113 2006 1217 1224
33. Y. Li, B.W. Luikart, S. Birnbaum, J. Chen, C.-H. Kwon, S.G. Kernie, R. Bassel-Duby, and L.F. Parada Trkb regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment Neuron 59 2008 399 412
34. T.W. McAllister, A.L. Tyler, L.A. Flashman, C.H. Rhodes, B.C. McDonald, A.J. Saykin, T.D. Tosteson, G.J. Tsongalis, and J.H. Moore Polymorphisms in the brain-derived neurotrophic factor gene influence memory and processing speed one month after brain injury Journal of Neurotrauma 29 2012 1111 1118
35. M.M. Mesulam Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles Neuron 24 1999 521 529
36. M.M. Mesulam A plasticity-based theory of the pathogenesis of Alzheimer's disease Annals of the New York Academy of Sciences 924 2000 42 52
37. M.M. Mesulam, G.W. Van Hoesen, D.N. Pandya, and N. Geschwind Limbic and sensory connections of the inferior parietal lobule (area PG) in the rhesus monkey: a study with a new method for horseradish peroxidase histochemistry Brain Research 136 1977 393 414
38. M.A. Mintun, G.N. Larossa, Y.I. Sheline, C.S. Dence, S.Y. Lee, R.H. Mach, W.E. Klunk, C.A. Mathis, S.T. DeKosky, and J.C. Morris [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease Neurology 67 2006 446 452
39. F. Miyajima, W. Ollier, A. Mayes, A. Jackson, N. Thacker, P. Rabbitt, N. Pendleton, M. Horan, and A. Payton Brain-derived neurotrophic factor polymorphism Val66Met influences cognitive abilities in the elderly Genes, Brain, and Behavior 7 2008 411 417
40. C. Montag, B. Weber, K. Fliessbach, C. Elger, and M. Reuter The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression Psychological Medicine 39 2009 1831 1839
41. E.C. Mormino, J.T. Kluth, C.M. Madison, G.D. Rabinovici, S.L. Baker, B.L. Miller, R.A. Koeppe, C.A. Mathis, M.W. Weiner, and W.J. Jagust Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects Brain 132 2009 1310 1323
42. E.C. Mormino, A. Smiljic, A.O. Hayenga, S.H. Onami, M.D. Greicius, G.D. Rabinovici, M. Janabi, S.L. Baker, I.V. Yen, C.M. Madison, B.L. Miller, and W.J. Jagust Relationships between beta-amyloid and functional connectivity in different components of the default mode network in aging Cerebral Cortex 21 2011 2399 2407
43. J.C. Morris, C. Ernesto, K. Schafer, M. Coats, S. Leon, M. Sano, L.J. Thal, and P. Woodbury Clinical dementia rating training and reliability in multicenter studies: the Alzheimer's Disease Cooperative Study experience Neurology 48 1997 1508 1510
44. J.C. Morris, C.M. Roe, C. Xiong, A.M. Fagan, A.M. Goate, D.M. Holtzman, and M.A. Mintun APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging Annals of Neurology 67 2010 122 131
45. H.W. Müller-Gärtner, J.M. Links, J.L. Prince, R.N. Bryan, E. McVeigh, J.P. Leal, C. Davatzikos, and J.J. Frost Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects Journal of Cerebral Blood Flow and Metabolism 12 1992 571 583
46. A.H. Nagahara, D.A. Merrill, G. Coppola, S. Tsukada, B.E. Schroeder, G.M. Shaked, L. Wang, A. Blesch, A. Kim, J.M. Conner, E. Rockenstein, M.V. Chao, E.H. Koo, D. Geschwind, E. Masliah, A.A. Chiba, and M.H. Tuszynski Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease Nature Medicine 15 2009 331 337
47. N. Nelissen, M. Vandenbulcke, K. Fannes, A. Verbruggen, R. Peeters, P. Dupont, K. Van Laere, G. Bormans, and R. Vandenberghe Abeta amyloid deposition in the language system and how the brain responds Brain 130 2007 2055 2069
48. 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease Journal of Nuclear Medicine 50 2009 1251 1259
49. K. Nemoto, T. Ohnishi, T. Mori, Y. Moriguchi, R. Hashimoto, T. Asada, and H. Kunugi The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology Neuroscience Letters 397 2006 25 29
50. H. Okuno, W. Tokuyama, Y.X. Li, T. Hashimoto, and Y. Miyashita Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito-temporo-hippocampal pathway in adult macaque monkeys The Journal of Comparative Neurology 408 1999 378 398
51. T. Osada, Y. Adachi, H.M. Kimura, and Y. Miyashita Towards understanding of the cortical network underlying associative memory Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 363 2008 2187 2199
52. L. Pezawas, B.A. Verchinski, V.S. Mattay, J.H. Callicott, B.S. Kolachana, R.E. Straub, M.F. Egan, A. Meyer-Lindenberg, and D.R. Weinberger The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology Journal of Neuroscience 24 2004 10099 10102
53. H.S. Phillips, J.M. Hains, M. Armanini, G.R. Laramee, S.A. Johnson, and J.W. Winslow BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease Neuron 7 1991 695 702
54. K.E. Pike, G. Savage, V.L. Villemagne, S. Ng, S.A. Moss, P. Maruff, C.A. Mathis, W.E. Klunk, C.L. Masters, and C.C. Rowe Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease Brain 130 2007 2837 2844
55. G.W. Rebeck, J.S. Reiter, D.K. Strickland, and B.T. Hyman Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions Neuron 11 1993 575 580
56. E.M. Reiman, K. Chen, X. Liu, D. Bandy, M. Yu, W. Lee, N. Ayutyanont, J. Keppler, S.A. Reeder, J.B.S. Langbaum, G.E. Alexander, W.E. Klunk, C.A. Mathis, J.C. Price, H.J. Aizenstein, S.T. DeKosky, and R.J. Caselli Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 106 2009 6820 6825
57. D.M. Rentz, J.J. Locascio, J.A. Becker, E.K. Moran, E. Eng, R.L. Buckner, R.A. Sperling, and K.A. Johnson Cognition, reserve, and amyloid deposition in normal aging Annals of Neurology 67 2010 353 364
58. S.M. Resnick, J. Sojkova, Y. Zhou, Y. An, W. Ye, D.P. Holt, R.F. Dannals, C.A. Mathis, W.E. Klunk, L. Ferrucci, M.A. Kraut, and D.F. Wong Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB Neurology 74 2010 807 815
59. C.C. Rowe, S. Ng, U. Ackermann, S.J. Gong, K. Pike, G. Savage, T.F. Cowie, K.L. Dickinson, P. Maruff, D. Darby, C. Smith, M. Woodward, J. Merory, H. Tochon-Danguy, G. O'Keefe, W.E. Klunk, C.A. Mathis, J.C. Price, C.L. Masters, and V.L. Villemagne Imaging beta-amyloid burden in aging and dementia Neurology 68 2007 1718 1725
60. C.C. Rowe, K.A. Ellis, M. Rimajova, P. Bourgeat, K.E. Pike, G. Jones, J. Fripp, H. Tochon-Danguy, L. Morandeau, G. O'Keefe, R. Price, P. Raniga, P. Robins, O. Acosta, N. Lenzo, C. Szoeke, O. Salvado, R. Head, R. Martins, C.L. Masters, D. Ames, and V.L. Villemagne Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging Neurobiology of Aging 31 2010 1275 1283
61. B. Seltzer, and D.N. Pandya Parietal, temporal, and occipital projections to cortex of the superior temporal sulcus in the rhesus monkey: a retrograde tracer study The Journal of Comparative Neurology 343 1994 445 463
62. R.A. Sperling, P.S. Aisen, L.A. Beckett, D.A. Bennett, S. Craft, A.M. Fagan, T. Iwatsubo, C.R. Jack Jr., J. Kaye, T.J. Montine, D.C. Park, E.M. Reiman, C.C. Rowe, E. Siemers, Y. Stern, K. Yaffe, M.C. Carrillo, B. Thies, M. Morrison-Bogorad, M.V. Wagster, and C.H. Phelps Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Alzheimer's & Dementia 7 2011 280 292
63. M.E. Sublette, E. Baca-Garcia, R.V. Parsey, M.A. Oquendo, S.M. Rodrigues, H. Galfalvy, Y.-Y. Huang, V. Arango, and J.J. Mann Effect of BDNF val66met polymorphism on age-related amygdala volume changes in healthy subjects Progress in Neuropsychopharmacology and Biological Psychiatry 32 2008 1652 1655
64. P.R. Szeszko, R. Lipsky, C. Mentschel, D. Robinson, H. Gunduz-Bruce, S. Sevy, M. Ashtari, B. Napolitano, R.M. Bilder, J.M. Kane, D. Goldman, and A.K. Malhotra Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation Molecular Psychiatry 10 2005 631 636
65. B. Teter ApoE-dependent plasticity in Alzheimer's disease Journal of Molecular Neuroscience 23 2004 167 179
66. M. Thambisetty, Y. An, M. Nalls, J. Sojkova, S. Swaminathan, Y. Zhou, A.B. Singleton, D.F. Wong, L. Ferrucci, A.J. Saykin, S.M. Resnick, for the Baltimore Longitudinal Study of Aging and, and the Alzheimer's Disease Neuroimaging Initiative Effect of Complement CR1 on brain amyloid burden during aging and its modification by APOE genotype Biological Psychiatry 73 2012 422 428
67. H. Thöni Testing the difference between two coefficients of correlation Biometrical Journal 19 1977 355 359
68. N. Tzourio-Mazoyer, B. Landeau, D. Papathanassiou, F. Crivello, O. Etard, N. Delcroix, B. Mazoyer, and M. Joliot Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain NeuroImage 15 2002 273 289
69. 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial Annals of Neurology 68 2010 319 329
70. R. Vandenberghe, N. Nelissen, E. Salmon, A. Ivanoiu, S. Hasselbalch, A. Andersen, A. Korner, L. Minthon, D.J. Brooks, K. Van Laere, and P. Dupont Binary classification of (18)F-flutemetamol PET using machine learning: comparison with visual reads and structural MRI NeuroImage 64 2013 517 525
71. P. Vemuri, H.J. Wiste, S.D. Weigand, D.S. Knopman, L.M. Shaw, J.Q. Trojanowski, P.S. Aisen, M. Weiner, R.C. Petersen, and C.R. Jack Jr. Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease Annals of Neurology 67 2010 308 316
72. V.L. Villemagne, K.E. Pike, G. Chételat, K.A. Ellis, R.S. Mulligan, P. Bourgeat, U. Ackermann, G. Jones, C. Szoeke, O. Salvado, R. Martins, G. O'Keefe, C.A. Mathis, W.E. Klunk, D. Ames, C.L. Masters, and C.C. Rowe Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease Annals of Neurology 69 2011 181 192
73. A.N. Voineskos, J.P. Lerch, D. Felsky, S. Shaikh, T.K. Rajji, D. Miranda, N.J. Lobaugh, B.H. Mulsant, B.G. Pollock, and J.L. Kennedy The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease Archives of General Psychiatry 68 2011 198 206
74. M.J. Webster, M.M. Herman, J.E. Kleinman, and C. Shannon Weickert BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan Gene Expression Patterns 6 2006 941 951
75. C. Xiong, C.M. Roe, V. Buckles, A. Fagan, D. Holtzman, D. Balota, J. Duchek, M. Storandt, M. Mintun, E. Grant, A.Z. Snyder, D. Head, T.L.S. Benzinger, J. Mettenburg, J. Csernansky, and J.C. Morris Role of family history for Alzheimer biomarker abnormalities in the adult children study Archives of Neurology 68 2011 1313 1319
76. C. Xu, Z. Wang, M. Fan, B. Liu, M. Song, X. Zhen, T. Jiang and Alzheimer's Disease Neuroimaging Initiative Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease NeuroReport 21 2010 802 807
77. X. Yang, P. Liu, J. Sun, G. Wang, F. Zeng, K. Yuan, J. Liu, M. Dong, K.M. von Deneen, W. Qin, and J. Tian Impact of brain-derived neurotrophic factor val66met polymorphism on cortical thickness and voxel-based morphometry in healthy chinese young adults PLoS One 7 2012 e37777