Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke

European Journal of Neuroscience

Volumn 17, Issue 12, 2003, Pages 2667-2678

  Gustafsson, Elin ^a   Andsberg, Gunnar ^a   Darsalia, Vladimer ^a   Mohapel, Paul ^a   Mandel, Ronald J ^b   Kirik, Deniz ^a   Lindvall, Olle ^a   Kokaia, Zaal ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Anterograde transport; BDNF; BrdU; Focal cerebral ischaemia; GFP; Neurogenesis; Neuroprotection; Substantia nigra

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; 5 BROMO 2' DEOXYURIDINE 5' PHOSPHATE; ADENOVIRUS VECTOR; BIOCHEMICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; BROXURIDINE; DOUBLECORTIN; NEUROPEPTIDE Y; PARVALBUMIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MOVEMENT; BODY POSTURE; CELL SURVIVAL; CHOLINERGIC NERVE; CHOREA; CONTROLLED STUDY; CORPUS STRIATUM; FORELIMB; GENE TRANSFER; GENETIC TRANSDUCTION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOSIS; NERVE CELL; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NEUROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STROKE; SUBSTANTIA NIGRA; VIRAL GENE DELIVERY SYSTEM;

ALPHA-METHYLTYROSINE; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; BROMODEOXYURIDINE; CELL COUNT; CELL DEATH; CELL SIZE; CEREBROVASCULAR ACCIDENT; CHOLINE O-ACETYLTRANSFERASE; CORPUS STRIATUM; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GREEN FLUORESCENT PROTEINS; HOMEODOMAIN PROTEINS; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; LUMINESCENT PROTEINS; MALE; MICROSCOPY, CONFOCAL; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; NEURONS; NEUROPEPTIDE Y; NEUROPEPTIDES; PARVALBUMINS; RADIATION-SENSITIZING AGENTS; RATS; RATS, WISTAR; RNA-BINDING PROTEINS; SUBSTANTIA NIGRA; TRANSDUCTION, GENETIC;

EID: 0038684215     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02713.x     Document Type: Article

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