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Volumn 21, Issue 14, 2014, Pages 1569-1582

Histopathological determinants of tumor resistance: A special look to the immunohistochemical expression of carbonic anhydrase ix in human cancers

Author keywords

CA IX Carbonic anhydrase; Clinical pathological features and biological outcome; Hypoxia; Immunohistochemistry; Solid human cancers; Stem cells markers; Targeted therapy

Indexed keywords

CARBONATE DEHYDRATASE IX; HERMES ANTIGEN; NESTIN; CARBONATE DEHYDRATASE;

EID: 84899859103     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/09298673113209990227     Document Type: Review
Times cited : (35)

References (168)
  • 1
    • 84880472975 scopus 로고    scopus 로고
    • Precision oncology: An overview
    • Garraway, L.A.; Verwey, J.; Ballman, K. Precision Oncology: An Overview. J. Clin. Oncol., 2013, 31(15), 1803-1805.
    • (2013) J. Clin. Oncol. , vol.31 , Issue.15 , pp. 1803-1805
    • Garraway, L.A.1    Verwey, J.2    Ballman, K.3
  • 2
    • 84864367909 scopus 로고    scopus 로고
    • Global cancer transitions according to the Human Development Index (2008-2030): A population-based study
    • Bray, F.; Jemal, A.; Grey, N.; Ferlay, J.; Forman, D. Global cancer transitions according to the Human Development Index (2008-2030): a population-based study. Lancet Oncol., 2012, 13(8), 790-801.
    • (2012) Lancet Oncol. , vol.13 , Issue.8 , pp. 790-801
    • Bray, F.1    Jemal, A.2    Grey, N.3    Ferlay, J.4    Forman, D.5
  • 3
    • 67449152488 scopus 로고    scopus 로고
    • Cancer genome sequencing-an interim analysis
    • Fox, E.J.; Salk, J.J.; Loeb, L.A. Cancer genome sequencing-an interim analysis. Cancer Res., 2009, 69(12), 4948-4950.
    • (2009) Cancer Res. , vol.69 , Issue.12 , pp. 4948-4950
    • Fox, E.J.1    Salk, J.J.2    Loeb, L.A.3
  • 4
    • 77958014613 scopus 로고    scopus 로고
    • How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine
    • Gerlinger, M.; Swanton, C. How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine. Brit. J. Cancer, 2010, 103(8), 1139-1143.
    • (2010) Brit. J. Cancer , vol.103 , Issue.8 , pp. 1139-1143
    • Gerlinger, M.1    Swanton, C.2
  • 5
    • 33845309647 scopus 로고    scopus 로고
    • Random mutations, selected mutations: A PIN opens the door to new genetic landscapes
    • Klein, C.A. Random mutations, selected mutations: A PIN opens the door to new genetic landscapes. Proc. Natl. Acad. Sci. USA., 2006, 103(48), 18033-18034.
    • (2006) Proc. Natl. Acad. Sci. USA. , vol.103 , Issue.48 , pp. 18033-18034
    • Klein, C.A.1
  • 7
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta, P.B.; Fillmore, C.M.; Jiang, G.; Shapira, S.D.; Tao, K.; Kuperwasser, C.; Lander, E.S. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell, 2011, 146(4), 633-644.
    • (2011) Cell , vol.146 , Issue.4 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4    Tao, K.5    Kuperwasser, C.6    Lander, E.S.7
  • 9
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman, M.M.; Fojo, T.; Bates, S.E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer, 2002, 2(1), 48-58.
    • (2002) Nat. Rev. Cancer , vol.2 , Issue.1 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 10
    • 84858003666 scopus 로고    scopus 로고
    • ABC transporters and their role in nucleoside and nucleotide drug resistance
    • Fukuda, Y.; Schuetz, J.D. ABC transporters and their role in nucleoside and nucleotide drug resistance. Biochem. Pharmacol., 2012, 83(8), 1073-1083.
    • (2012) Biochem. Pharmacol. , vol.83 , Issue.8 , pp. 1073-1083
    • Fukuda, Y.1    Schuetz, J.D.2
  • 12
    • 68149112387 scopus 로고    scopus 로고
    • Mimicking the BH3 domain to kill cancer cells
    • Ni Chonghaile, T.; Letai, A. Mimicking the BH3 domain to kill cancer cells. Oncogene, 2008, 27 Suppl 1, S149-S157.
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Ni Chonghaile, T.1    Letai, A.2
  • 13
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman, J.A. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat. Rev. Cancer, 2009, 9(8), 550-562.
    • (2009) Nat. Rev. Cancer , vol.9 , Issue.8 , pp. 550-562
    • Engelman, J.A.1
  • 15
    • 64249086885 scopus 로고    scopus 로고
    • Acute and chronic in vivo therapeutic resistance
    • Teicher, B.A. Acute and chronic in vivo therapeutic resistance. Biochem. Pharmacol., 2009, 77(11), 1665-1673.
    • (2009) Biochem. Pharmacol. , vol.77 , Issue.11 , pp. 1665-1673
    • Teicher, B.A.1
  • 16
    • 77952107920 scopus 로고    scopus 로고
    • Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis
    • Jubb, A.M.; Buffa, F.M.; Harris, A.L. Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis. J. Cell. Mol. Med., 2010, 14(1-2), 18-29.
    • (2010) J. Cell. Mol. Med. , vol.14 , Issue.1-2 , pp. 18-29
    • Jubb, A.M.1    Buffa, F.M.2    Harris, A.L.3
  • 17
    • 55249126800 scopus 로고    scopus 로고
    • The role of endothelial-tomesenchymal transition in cancer progression
    • Potenta, S.; Zeisberg, E.; Kalluri, R. The role of endothelial- tomesenchymal transition in cancer progression. Brit. J. Cancer, 2008, 99(9), 1375-1379.
    • (2008) Brit. J. Cancer , vol.99 , Issue.9 , pp. 1375-1379
    • Potenta, S.1    Zeisberg, E.2    Kalluri, R.3
  • 18
    • 38949119423 scopus 로고    scopus 로고
    • Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3
    • Azad, M.B.; Chen, Y.; Henson, E.S.; Cizeau, J.; McMillan-Ward, E.; Israels, S.J.; Gibson, S.B. Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3. Autophagy, 2008, 4(2), 195-204.
    • (2008) Autophagy , vol.4 , Issue.2 , pp. 195-204
    • Azad, M.B.1    Chen, Y.2    Henson, E.S.3    Cizeau, J.4    McMillan-Ward, E.5    Israels, S.J.6    Gibson, S.B.7
  • 19
    • 84864886919 scopus 로고    scopus 로고
    • Hypoxia-induced tumor cell autophagy mediates resistance to anti-angiogenic therapy
    • Hu, Y.L.; Jahangiri, A.; De Lay, M.; Aghi, M.K. Hypoxia-induced tumor cell autophagy mediates resistance to anti-angiogenic therapy. Autophagy, 2012, 8(6), 979-981.
    • (2012) Autophagy , vol.8 , Issue.6 , pp. 979-981
    • Hu, Y.L.1    Jahangiri, A.2    De Lay, M.3    Aghi, M.K.4
  • 20
    • 34547130302 scopus 로고    scopus 로고
    • Effects of hypoxia on tumor metabolism
    • Kim, J.W.; Gao, P.; Dang, C.V. Effects of hypoxia on tumor metabolism. Cancer Metast. Rev., 2007, 26(2), 291-298.
    • (2007) Cancer Metast. Rev. , vol.26 , Issue.2 , pp. 291-298
    • Kim, J.W.1    Gao, P.2    Dang, C.V.3
  • 21
    • 35448961939 scopus 로고    scopus 로고
    • The Warburg effect and its cancer therapeutic implications
    • Chen, Z.; Lu, W.; Garcia-Prieto, C.; Huang, P. The Warburg effect and its cancer therapeutic implications. J. Bioenerget. Biomembr., 2007, 39(3), 267-274.
    • (2007) J. Bioenerget. Biomembr. , vol.39 , Issue.3 , pp. 267-274
    • Chen, Z.1    Lu, W.2    Garcia-Prieto, C.3    Huang, P.4
  • 22
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: Significance and impact on clinical outcome
    • Vaupel, P.; Mayer, A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metast. Rev., 2007, 26(2), 225-239.
    • (2007) Cancer Metast. Rev. , vol.26 , Issue.2 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 23
    • 39449090004 scopus 로고    scopus 로고
    • Detection and specific targeting of hypoxic regions within solid tumors: Current preclinical and clinical strategies
    • Bache, M.; Kappler, M.; Said, H.M.; Staab, A.; Vordermark, D. Detection and specific targeting of hypoxic regions within solid tumors: current preclinical and clinical strategies. Curr. Med. Chem., 2008, 15(4), 322-338.
    • (2008) Curr. Med. Chem. , vol.15 , Issue.4 , pp. 322-338
    • Bache, M.1    Kappler, M.2    Said, H.M.3    Staab, A.4    Vordermark, D.5
  • 24
    • 70450223507 scopus 로고    scopus 로고
    • Generating specificity and diversity in the transcriptional response to hypoxia
    • Lendahl, U.; Lee, K.L.; Yang, H.; Poellinger, L. Generating specificity and diversity in the transcriptional response to hypoxia. Nat. Rev. Genet., 2009, 10(12), 821-832.
    • (2009) Nat. Rev. Genet. , vol.10 , Issue.12 , pp. 821-832
    • Lendahl, U.1    Lee, K.L.2    Yang, H.3    Poellinger, L.4
  • 25
    • 0028111173 scopus 로고
    • Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment
    • Pastorek, J.; Pastorekova, S.; Callebaut, I.; Mornon, J.P.; Zelnik, V.; Opavsky, R.; Zat'ovicova, M.; Liao, S.; Portetelle, D.; Stanbridge, E.J.; et al. Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment. Oncogene, 1994, 9(10), 2877-2888.
    • (1994) Oncogene , vol.9 , Issue.10 , pp. 2877-2888
    • Pastorek, J.1    Pastorekova, S.2    Callebaut, I.3    Mornon, J.P.4    Zelnik, V.5    Opavsky, R.6    Zat'Ovicova, M.7    Liao, S.8    Portetelle, D.9    Stanbridge, E.J.10
  • 26
    • 74449091486 scopus 로고    scopus 로고
    • Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target
    • De Simone, G.; Supuran, C.T. Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target. Biochim. Biophys. Acta, 2010, 1804(2), 404-409.
    • (2010) Biochim. Biophys. Acta , vol.1804 , Issue.2 , pp. 404-409
    • De Simone, G.1    Supuran, C.T.2
  • 27
    • 38849143765 scopus 로고    scopus 로고
    • Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators
    • Supuran, C.T. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat. Rev. Drug Discov., 2008, 7(2), 168-181.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , Issue.2 , pp. 168-181
    • Supuran, C.T.1
  • 28
    • 67749145635 scopus 로고    scopus 로고
    • The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths
    • Swietach, P.; Patiar, S.; Supuran, C.T.; Harris, A.L.; Vaughan-Jones, R.D. The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths. J. Biol. Chem., 2009, 284(30), 20299-20310.
    • (2009) J. Biol. Chem. , vol.284 , Issue.30 , pp. 20299-20310
    • Swietach, P.1    Patiar, S.2    Supuran, C.T.3    Harris, A.L.4    Vaughan-Jones, R.D.5
  • 29
    • 80053563164 scopus 로고    scopus 로고
    • Interfering with pH regulation in tumours as a therapeutic strategy
    • Neri, D.; Supuran, C.T. Interfering with pH regulation in tumours as a therapeutic strategy. Nat. Rev. Drug Discov., 2011, 10(10), 767-777.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , Issue.10 , pp. 767-777
    • Neri, D.1    Supuran, C.T.2
  • 30
    • 48349111944 scopus 로고    scopus 로고
    • Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression
    • Fang, J.S.; Gillies, R.D.; Gatenby, R.A. Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Semin. Cancer Biol., 2008, 18(5), 330-337.
    • (2008) Semin. Cancer Biol. , vol.18 , Issue.5 , pp. 330-337
    • Fang, J.S.1    Gillies, R.D.2    Gatenby, R.A.3
  • 31
    • 37549013776 scopus 로고    scopus 로고
    • A microenvironmental model of carcinogenesis
    • Gatenby, R.A.; Gillies, R.J. A microenvironmental model of carcinogenesis. Nat. Rev. Cancer, 2008, 8(1), 56-61.
    • (2008) Nat. Rev. Cancer , vol.8 , Issue.1 , pp. 56-61
    • Gatenby, R.A.1    Gillies, R.J.2
  • 32
    • 34547124566 scopus 로고    scopus 로고
    • Hypoxia and adaptive landscapes in the evolution of carcinogenesis
    • Gillies, R.J.; Gatenby, R.A. Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metast. Rev., 2007, 26(2), 311-317.
    • (2007) Cancer Metast. Rev. , vol.26 , Issue.2 , pp. 311-317
    • Gillies, R.J.1    Gatenby, R.A.2
  • 33
    • 0032514685 scopus 로고    scopus 로고
    • Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
    • Ivanov, S.V.; Kuzmin, I.; Wei, M.H.; Pack, S.; Geil, L.; Johnson, B.E.; Stanbridge, E.J.; Lerman, M.I. Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Proc. Natl. Acad. Sci. USA., 1998, 95(21), 12596-12601.
    • (1998) Proc. Natl. Acad. Sci. USA. , vol.95 , Issue.21 , pp. 12596-12601
    • Ivanov, S.V.1    Kuzmin, I.2    Wei, M.H.3    Pack, S.4    Geil, L.5    Johnson, B.E.6    Stanbridge, E.J.7    Lerman, M.I.8
  • 34
    • 78649659788 scopus 로고    scopus 로고
    • PH control mechanisms of tumor survival and growth
    • Parks, S.K.; Chiche, J.; Pouyssegur, J. pH control mechanisms of tumor survival and growth. J. Cell. Physiol., 2011, 226(2), 299-308.
    • (2011) J. Cell. Physiol. , vol.226 , Issue.2 , pp. 299-308
    • Parks, S.K.1    Chiche, J.2    Pouyssegur, J.3
  • 35
    • 78650308850 scopus 로고    scopus 로고
    • New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
    • Swietach, P.; Hulikova, A.; Vaughan-Jones, R.D.; Harris, A.L. New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation. Oncogene, 2010, 29(50), 6509-6521.
    • (2010) Oncogene , vol.29 , Issue.50 , pp. 6509-6521
    • Swietach, P.1    Hulikova, A.2    Vaughan-Jones, R.D.3    Harris, A.L.4
  • 36
    • 0033986761 scopus 로고    scopus 로고
    • Causes and consequences of tumour acidity and implications for treatment
    • Stubbs, M.; McSheehy, P.M.; Griffiths, J.R.; Bashford, C.L. Causes and consequences of tumour acidity and implications for treatment. Mol. Med. Today, 2000, 6(1), 15-19.
    • (2000) Mol. Med. Today , vol.6 , Issue.1 , pp. 15-19
    • Stubbs, M.1    McSheehy, P.M.2    Griffiths, J.R.3    Bashford, C.L.4
  • 37
    • 0035881307 scopus 로고    scopus 로고
    • Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    • Fukumura, D.; Xu, L.; Chen, Y.; Gohongi, T.; Seed, B.; Jain, R.K. Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res., 2001, 61(16), 6020-6024.
    • (2001) Cancer Res. , vol.61 , Issue.16 , pp. 6020-6024
    • Fukumura, D.1    Xu, L.2    Chen, Y.3    Gohongi, T.4    Seed, B.5    Jain, R.K.6
  • 38
    • 0026667311 scopus 로고
    • Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines
    • Kato, Y.; Nakayama, Y.; Umeda, M.; Miyazaki, K. Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines. J. Biol. Chem., 1992, 267(16), 11424-11430.
    • (1992) J. Biol. Chem. , vol.267 , Issue.16 , pp. 11424-11430
    • Kato, Y.1    Nakayama, Y.2    Umeda, M.3    Miyazaki, K.4
  • 40
    • 0033848896 scopus 로고    scopus 로고
    • Acidic pH inhibits non-MHC-restricted killer cell functions
    • Fischer, B.; Muller, B.; Fischer, K.G.; Baur, N.; Kreutz, W. Acidic pH inhibits non-MHC-restricted killer cell functions. Clin. Immunol., 2000, 96(3), 252-263.
    • (2000) Clin. Immunol. , vol.96 , Issue.3 , pp. 252-263
    • Fischer, B.1    Muller, B.2    Fischer, K.G.3    Baur, N.4    Kreutz, W.5
  • 41
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • Chiche, J.; Ilc, K.; Laferriere, J.; Trottier, E.; Dayan, F.; Mazure, N.M.; Brahimi-Horn, M.C.; Pouyssegur, J. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res., 2009, 69(1), 358-368.
    • (2009) Cancer Res. , vol.69 , Issue.1 , pp. 358-368
    • Chiche, J.1    Ilc, K.2    Laferriere, J.3    Trottier, E.4    Dayan, F.5    Mazure, N.M.6    Brahimi-Horn, M.C.7    Pouyssegur, J.8
  • 42
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes -bipolar effects of the tumour stroma in cancer
    • Mueller, M.M.; Fusenig, N.E. Friends or foes -bipolar effects of the tumour stroma in cancer. Nat. Rev. Cancer, 2004, 4(11), 839-849.
    • (2004) Nat. Rev. Cancer , vol.4 , Issue.11 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 43
    • 0142121458 scopus 로고    scopus 로고
    • Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin
    • Svastova, E.; Zilka, N.; Zat'ovicova, M.; Gibadulinova, A.; Ciampor, F.; Pastorek, J.; Pastorekova, S. Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin. Exp. Cell Res., 2003, 290(2), 332-345.
    • (2003) Exp. Cell Res. , vol.290 , Issue.2 , pp. 332-345
    • Svastova, E.1    Zilka, N.2    Zat'Ovicova, M.3    Gibadulinova, A.4    Ciampor, F.5    Pastorek, J.6    Pastorekova, S.7
  • 44
    • 79953138420 scopus 로고    scopus 로고
    • Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion
    • Shin, H.J.; Rho, S.B.; Jung, D.C.; Han, I.O.; Oh, E.S.; Kim, J.Y. Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion. J. Cell Sci., 2011, 124(Pt 7), 1077-1087.
    • (2011) J. Cell Sci. , vol.124 , Issue.PART. 7 , pp. 1077-1087
    • Shin, H.J.1    Rho, S.B.2    Jung, D.C.3    Han, I.O.4    Oh, E.S.5    Kim, J.Y.6
  • 45
    • 64249126758 scopus 로고    scopus 로고
    • Expression of transmembrane carbonic anhydrases, CAIX and CAXII, in human development
    • Liao, S.Y.; Lerman, M.I.; Stanbridge, E.J. Expression of transmembrane carbonic anhydrases, CAIX and CAXII, in human development. BMC Develop. Biol., 2009, 9, 22.
    • (2009) BMC Develop. Biol. , vol.9 , pp. 22
    • Liao, S.Y.1    Lerman, M.I.2    Stanbridge, E.J.3
  • 48
    • 62749124795 scopus 로고    scopus 로고
    • Transcriptional control of the tumor-and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show? Biochim
    • Kaluz, S.; Kaluzova, M.; Liao, S.Y.; Lerman, M.; Stanbridge, E.J. Transcriptional control of the tumor-and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show? Biochim. Biophys. Acta, 2009, 1795(2), 162-172.
    • (2009) Biophys. Acta , vol.1795 , Issue.2 , pp. 162-172
    • Kaluz, S.1    Kaluzova, M.2    Liao, S.Y.3    Lerman, M.4    Stanbridge, E.J.5
  • 52
    • 0037315252 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer
    • Swinson, D.E.; Jones, J.L.; Richardson, D.; Wykoff, C.; Turley, H.; Pastorek, J.; Taub, N.; Harris, A.L.; O'Byrne, K.J. Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. J. Clin. Oncol., 2003, 21(3), 473-482.
    • (2003) J. Clin. Oncol. , vol.21 , Issue.3 , pp. 473-482
    • Swinson, D.E.1    Jones, J.L.2    Richardson, D.3    Wykoff, C.4    Turley, H.5    Pastorek, J.6    Taub, N.7    Harris, A.L.8    O'Byrne, K.J.9
  • 55
    • 0031819881 scopus 로고    scopus 로고
    • Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation
    • Saarnio, J.; Parkkila, S.; Parkkila, A.K.; Haukipuro, K.; Pastorekova, S.; Pastorek, J.; Kairaluoma, M.I.; Karttunen, T.J. Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am. J. Pathol., 1998, 153(1), 279-285.
    • (1998) Am. J. Pathol. , vol.153 , Issue.1 , pp. 279-285
    • Saarnio, J.1    Parkkila, S.2    Parkkila, A.K.3    Haukipuro, K.4    Pastorekova, S.5    Pastorek, J.6    Kairaluoma, M.I.7    Karttunen, T.J.8
  • 58
    • 33847649279 scopus 로고    scopus 로고
    • HIF-1alpha and CA IX staining in invasive breast carcinomas: Prognosis and treatment outcome
    • Trastour, C.; Benizri, E.; Ettore, F.; Ramaioli, A.; Chamorey, E.; Pouyssegur, J.; Berra, E. HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome. Int. J. Cancer, 2007, 120(7), 1451-1458.
    • (2007) Int. J. Cancer , vol.120 , Issue.7 , pp. 1451-1458
    • Trastour, C.1    Benizri, E.2    Ettore, F.3    Ramaioli, A.4    Chamorey, E.5    Pouyssegur, J.6    Berra, E.7
  • 60
    • 0035418586 scopus 로고    scopus 로고
    • Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
    • Loncaster, J.A.; Harris, A.L.; Davidson, S.E.; Logue, J.P.; Hunter, R.D.; Wycoff, C.C.; Pastorek, J.; Ratcliffe, P.J.; Stratford, I.J.; West, C.M. Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res., 2001, 61(17), 6394-6399.
    • (2001) Cancer Res. , vol.61 , Issue.17 , pp. 6394-6399
    • Loncaster, J.A.1    Harris, A.L.2    Davidson, S.E.3    Logue, J.P.4    Hunter, R.D.5    Wycoff, C.C.6    Pastorek, J.7    Ratcliffe, P.J.8    Stratford, I.J.9    West, C.M.10
  • 62
    • 33846661210 scopus 로고    scopus 로고
    • Tumor carbonic anhydrase 9 expression is associated with the presence of lymph node metastases in uterine cervical cancer
    • Lee, S.; Shin, H.J.; Han, I.O.; Hong, E.K.; Park, S.Y.; Roh, J.W.; Shin, K.H.; Kim, T.H.; Kim, J.Y. Tumor carbonic anhydrase 9 expression is associated with the presence of lymph node metastases in uterine cervical cancer. Cancer Sci., 2007, 98(3), 329-333.
    • (2007) Cancer Sci. , vol.98 , Issue.3 , pp. 329-333
    • Lee, S.1    Shin, H.J.2    Han, I.O.3    Hong, E.K.4    Park, S.Y.5    Roh, J.W.6    Shin, K.H.7    Kim, T.H.8    Kim, J.Y.9
  • 64
    • 0242298213 scopus 로고    scopus 로고
    • GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: Relationship with vascularity and proliferation as predictors of outcome of ARCON
    • Hoskin, P.J.; Sibtain, A.; Daley, F.M.; Wilson, G.D. GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: relationship with vascularity and proliferation as predictors of outcome of ARCON. Brit. J. Cancer, 2003, 89(7), 1290-1297.
    • (2003) Brit. J. Cancer , vol.89 , Issue.7 , pp. 1290-1297
    • Hoskin, P.J.1    Sibtain, A.2    Daley, F.M.3    Wilson, G.D.4
  • 65
    • 80052419706 scopus 로고    scopus 로고
    • Overexpression of carbonic anhydrase IX (CAIX) is an independent unfavorable prognostic marker in endometrioid ovarian cancer
    • Choschzick, M.; Oosterwijk, E.; Muller, V.; Woelber, L.; Simon, R.; Moch, H.; Tennstedt, P. Overexpression of carbonic anhydrase IX (CAIX) is an independent unfavorable prognostic marker in endometrioid ovarian cancer. Virchows Archiv., 2011, 459(2), 193-200.
    • (2011) Virchows Archiv. , vol.459 , Issue.2 , pp. 193-200
    • Choschzick, M.1    Oosterwijk, E.2    Muller, V.3    Woelber, L.4    Simon, R.5    Moch, H.6    Tennstedt, P.7
  • 66
    • 77950886638 scopus 로고    scopus 로고
    • The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: An association of CA IX with poor prognosis
    • Nordfors, K.; Haapasalo, J.; Korja, M.; Niemela, A.; Laine, J.; Parkkila, A.K.; Pastorekova, S.; Pastorek, J.; Waheed, A.; Sly, W.S.; Parkkila, S.; Haapasalo, H. The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis. BMC Cancer, 2010, 10, 148.
    • (2010) BMC Cancer , vol.10 , pp. 148
    • Nordfors, K.1    Haapasalo, J.2    Korja, M.3    Niemela, A.4    Laine, J.5    Parkkila, A.K.6    Pastorekova, S.7    Pastorek, J.8    Waheed, A.9    Sly, W.S.10    Parkkila, S.11    Haapasalo, H.12
  • 68
    • 26844468059 scopus 로고    scopus 로고
    • The prognostic value of the hypoxia markers CA IX and GLUT 1 and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy +/-chemotherapy
    • De Schutter, H.; Landuyt, W.; Verbeken, E.; Goethals, L.; Hermans, R.; Nuyts, S. The prognostic value of the hypoxia markers CA IX and GLUT 1 and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy +/-chemotherapy. BMC Cancer, 2005, 5, 42.
    • (2005) BMC Cancer , vol.5 , pp. 42
    • De Schutter, H.1    Landuyt, W.2    Verbeken, E.3    Goethals, L.4    Hermans, R.5    Nuyts, S.6
  • 69
    • 33644849887 scopus 로고    scopus 로고
    • Endogenous markers of two separate hypoxia response path ways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial
    • Koukourakis, M.I.; Bentzen, S.M.; Giatromanolaki, A.; Wilson, G.D.; Daley, F.M.; Saunders, M.I.; Dische, S.; Sivridis, E.; Harris, A.L. Endogenous markers of two separate hypoxia response path ways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial. J. Clin. Oncol., 2006, 24(5), 727-735.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.5 , pp. 727-735
    • Koukourakis, M.I.1    Bentzen, S.M.2    Giatromanolaki, A.3    Wilson, G.D.4    Daley, F.M.5    Saunders, M.I.6    Dische, S.7    Sivridis, E.8    Harris, A.L.9
  • 71
    • 48949096355 scopus 로고    scopus 로고
    • Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinoma
    • Choi, S.W.; Kim, J.Y.; Park, J.Y.; Cha, I.H.; Kim, J.; Lee, S. Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinoma. Human Pathol., 2008, 39(9), 1317-1322.
    • (2008) Human Pathol. , vol.39 , Issue.9 , pp. 1317-1322
    • Choi, S.W.1    Kim, J.Y.2    Park, J.Y.3    Cha, I.H.4    Kim, J.5    Lee, S.6
  • 75
    • 0035181306 scopus 로고    scopus 로고
    • Hypoxiaregulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy
    • Koukourakis, M.I.; Giatromanolaki, A.; Sivridis, E.; Simopoulos, K.; Pastorek, J.; Wykoff, C.C.; Gatter, K.C.; Harris, A.L. Hypoxiaregulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy. Clin. Cancer Res., 2001, 7(11), 3399-3403.
    • (2001) Clin. Cancer Res. , vol.7 , Issue.11 , pp. 3399-3403
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3    Simopoulos, K.4    Pastorek, J.5    Wykoff, C.C.6    Gatter, K.C.7    Harris, A.L.8
  • 76
    • 0345491970 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas
    • Hedley, D.; Pintilie, M.; Woo, J.; Morrison, A.; Birle, D.; Fyles, A.; Milosevic, M.; Hill, R. Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas. Clin. Cancer Res., 2003, 9(15), 5666-5674.
    • (2003) Clin. Cancer Res. , vol.9 , Issue.15 , pp. 5666-5674
    • Hedley, D.1    Pintilie, M.2    Woo, J.3    Morrison, A.4    Birle, D.5    Fyles, A.6    Milosevic, M.7    Hill, R.8
  • 78
    • 0035503362 scopus 로고    scopus 로고
    • Expression of hypoxiainducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer
    • Giatromanolaki, A.; Koukourakis, M.I.; Sivridis, E.; Pastorek, J.; Wykoff, C.C.; Gatter, K.C.; Harris, A.L. Expression of hypoxiainducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res., 2001, 61(21), 7992-7998.
    • (2001) Cancer Res. , vol.61 , Issue.21 , pp. 7992-7998
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3    Pastorek, J.4    Wykoff, C.C.5    Gatter, K.C.6    Harris, A.L.7
  • 80
    • 33751277287 scopus 로고    scopus 로고
    • CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance
    • Brennan, D.J.; Jirstrom, K.; Kronblad, A.; Millikan, R.C.; Landberg, G.; Duffy, M.J.; Ryden, L.; Gallagher, W.M.; O'Brien, S.L. CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance. Clin. Cancer Res., 2006, 12(21), 6421-6431.
    • (2006) Clin. Cancer Res. , vol.12 , Issue.21 , pp. 6421-6431
    • Brennan, D.J.1    Jirstrom, K.2    Kronblad, A.3    Millikan, R.C.4    Landberg, G.5    Duffy, M.J.6    Ryden, L.7    Gallagher, W.M.8    O'Brien, S.L.9
  • 82
    • 68749119336 scopus 로고    scopus 로고
    • Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours
    • Ahlskog, J.K.; Schliemann, C.; Marlind, J.; Qureshi, U.; Ammar, A.; Pedley, R.B.; Neri, D. Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours. Brit. J. Cancer, 2009, 101(4), 645-657.
    • (2009) Brit. J. Cancer , vol.101 , Issue.4 , pp. 645-657
    • Ahlskog, J.K.1    Schliemann, C.2    Marlind, J.3    Qureshi, U.4    Ammar, A.5    Pedley, R.B.6    Neri, D.7
  • 83
    • 69949128698 scopus 로고    scopus 로고
    • Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model
    • Dubois, L.; Lieuwes, N.G.; Maresca, A.; Thiry, A.; Supuran, C.T.; Scozzafava, A.; Wouters, B.G.; Lambin, P. Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model. Radiother. Oncol., 2009, 92(3), 423-428.
    • (2009) Radiother. Oncol. , vol.92 , Issue.3 , pp. 423-428
    • Dubois, L.1    Lieuwes, N.G.2    Maresca, A.3    Thiry, A.4    Supuran, C.T.5    Scozzafava, A.6    Wouters, B.G.7    Lambin, P.8
  • 84
    • 67649946943 scopus 로고    scopus 로고
    • The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms
    • Parkkila, S.; Innocenti, A.; Kallio, H.; Hilvo, M.; Scozzafava, A.; Supuran, C.T. The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms. Bioorg. Med. Chem. Lett., 2009, 19(15), 4102-4106.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , Issue.15 , pp. 4102-4106
    • Parkkila, S.1    Innocenti, A.2    Kallio, H.3    Hilvo, M.4    Scozzafava, A.5    Supuran, C.T.6
  • 85
    • 80052712201 scopus 로고    scopus 로고
    • The ins and outs of the epithelial to mesenchymal transition in health and disease
    • Nieto, M.A. The ins and outs of the epithelial to mesenchymal transition in health and disease. Ann. Rev. Cell Develop. Biol., 2011, 27, 347-376.
    • (2011) Ann. Rev. Cell Develop. Biol. , vol.27 , pp. 347-376
    • Nieto, M.A.1
  • 86
    • 27144477683 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition
    • Thomson, S.; Buck, E.; Petti, F.; Griffin, G.; Brown, E.; Ramnarine, N.; Iwata, K.K.; Gibson, N.; Haley, J.D. Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. Cancer Res., 2005, 65(20), 9455-9462.
    • (2005) Cancer Res. , vol.65 , Issue.20 , pp. 9455-9462
    • Thomson, S.1    Buck, E.2    Petti, F.3    Griffin, G.4    Brown, E.5    Ramnarine, N.6    Iwata, K.K.7    Gibson, N.8    Haley, J.D.9
  • 87
    • 57049132745 scopus 로고    scopus 로고
    • Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy
    • Thomson, S.; Petti, F.; Sujka-Kwok, I.; Epstein, D.; Haley, J.D. Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy. Clin. Exp. Metast., 2008, 25(8), 843-854.
    • (2008) Clin. Exp. Metast. , vol.25 , Issue.8 , pp. 843-854
    • Thomson, S.1    Petti, F.2    Sujka-Kwok, I.3    Epstein, D.4    Haley, J.D.5
  • 90
    • 33947192053 scopus 로고    scopus 로고
    • Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel
    • Cheng, G.Z.; Chan, J.; Wang, Q.; Zhang, W.; Sun, C.D.; Wang, L.H. Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res., 2007, 67(5), 1979-1987.
    • (2007) Cancer Res. , vol.67 , Issue.5 , pp. 1979-1987
    • Cheng, G.Z.1    Chan, J.2    Wang, Q.3    Zhang, W.4    Sun, C.D.5    Wang, L.H.6
  • 94
    • 54249151684 scopus 로고    scopus 로고
    • Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction
    • Das, B.; Tsuchida, R.; Malkin, D.; Koren, G.; Baruchel, S.; Yeger, H. Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction. Stem Cells, 2008, 26(7), 1818-1830.
    • (2008) Stem Cells , vol.26 , Issue.7 , pp. 1818-1830
    • Das, B.1    Tsuchida, R.2    Malkin, D.3    Koren, G.4    Baruchel, S.5    Yeger, H.6
  • 96
    • 13244299109 scopus 로고    scopus 로고
    • FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development
    • Chamorro, M.N.; Schwartz, D.R.; Vonica, A.; Brivanlou, A.H.; Cho, K.R.; Varmus, H.E. FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. EMBO J., 2005, 24(1), 73-84.
    • (2005) EMBO J. , vol.24 , Issue.1 , pp. 73-84
    • Chamorro, M.N.1    Schwartz, D.R.2    Vonica, A.3    Brivanlou, A.H.4    Cho, K.R.5    Varmus, H.E.6
  • 97
    • 63849108139 scopus 로고    scopus 로고
    • Dickkopf-1 enhances migration of HEK293 cell by betacatenin/E-cadherin degradation
    • Kuang, H.B.; Miao, C.L.; Guo, W.X.; Peng, S.; Cao, Y.J.; Duan, E.K. Dickkopf-1 enhances migration of HEK293 cell by betacatenin/E-cadherin degradation. Front. Biosci., 2009, 14, 2212-2220.
    • (2009) Front. Biosci. , vol.14 , pp. 2212-2220
    • Kuang, H.B.1    Miao, C.L.2    Guo, W.X.3    Peng, S.4    Cao, Y.J.5    Duan, E.K.6
  • 98
    • 59949090255 scopus 로고    scopus 로고
    • Wnt signaling pathways meet Rho GTPases
    • Schlessinger, K.; Hall, A.; Tolwinski, N. Wnt signaling pathways meet Rho GTPases. Gene. Develop., 2009, 23(3), 265-277.
    • (2009) Gene. Develop. , vol.23 , Issue.3 , pp. 265-277
    • Schlessinger, K.1    Hall, A.2    Tolwinski, N.3
  • 99
    • 0032891720 scopus 로고    scopus 로고
    • Ecadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation
    • Orsulic, S.; Huber, O.; Aberle, H.; Arnold, S.; Kemler, R. Ecadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1- mediated transactivation. J. Cell Sci., 1999, 112( Pt 8), 1237-1245.
    • (1999) J. Cell Sci. , vol.112 , Issue.PART 8 , pp. 1237-1245
    • Orsulic, S.1    Huber, O.2    Aberle, H.3    Arnold, S.4    Kemler, R.5
  • 101
    • 0034015125 scopus 로고    scopus 로고
    • The epidemiology of tongue cancer: A review of global incidence
    • Moore, S.R.; Johnson, N.W.; Pierce, A.M.; Wilson, D.F. The epidemiology of tongue cancer: a review of global incidence. Oral Dis., 2000, 6(2), 75-84.
    • (2000) Oral Dis. , vol.6 , Issue.2 , pp. 75-84
    • Moore, S.R.1    Johnson, N.W.2    Pierce, A.M.3    Wilson, D.F.4
  • 102
    • 33846705750 scopus 로고    scopus 로고
    • Epithelial stem cells: Turning over new leaves
    • Blanpain, C.; Horsley, V.; Fuchs, E. Epithelial stem cells: turning over new leaves. Cell, 2007, 128(3), 445-458.
    • (2007) Cell , vol.128 , Issue.3 , pp. 445-458
    • Blanpain, C.1    Horsley, V.2    Fuchs, E.3
  • 104
    • 34249827550 scopus 로고    scopus 로고
    • Chromatin assembly factor-1 (CAF-1)-mediated regulation of cell proliferation and DNA repair: A link with the biological behaviour of squamous cell carcinoma of the tongue?
    • Staibano, S.; Mignogna, C.; Lo Muzio, L.; Mascolo, M.; Salvatore, G.; Di Benedetto, M.; Califano, L.; Rubini, C.; De Rosa, G. Chromatin assembly factor-1 (CAF-1)-mediated regulation of cell proliferation and DNA repair: a link with the biological behaviour of squamous cell carcinoma of the tongue? Histopathology, 2007, 50(7), 911-919.
    • (2007) Histopathology , vol.50 , Issue.7 , pp. 911-919
    • Staibano, S.1    Mignogna, C.2    Lo Muzio, L.3    Mascolo, M.4    Salvatore, G.5    Di Benedetto, M.6    Califano, L.7    Rubini, C.8    De Rosa, G.9
  • 106
    • 84862915006 scopus 로고    scopus 로고
    • Expression of carbonic anhydrase IX in genitourinary and adrenal tumours
    • Donato, D.P.; Johnson, M.T.; Yang, X.J.; Zynger, D.L. Expression of carbonic anhydrase IX in genitourinary and adrenal tumours. Histopathology, 2011, 59(6), 1229-1239.
    • (2011) Histopathology , vol.59 , Issue.6 , pp. 1229-1239
    • Donato, D.P.1    Johnson, M.T.2    Yang, X.J.3    Zynger, D.L.4
  • 108
    • 70249150678 scopus 로고    scopus 로고
    • Comparing oxygen-sensitive MRI (BOLD R2) with oxygen electrode measurements: A pilot study in men with prostate cancer
    • Chopra, S.; Foltz, W.D.; Milosevic, M.F.; Toi, A.; Bristow, R.G.; Menard, C.; Haider, M.A. Comparing oxygen-sensitive MRI (BOLD R2) with oxygen electrode measurements: a pilot study in men with prostate cancer. Int. J. Rad. Biol., 2009, 85(9), 805-813.
    • (2009) Int. J. Rad. Biol. , vol.85 , Issue.9 , pp. 805-813
    • Chopra, S.1    Foltz, W.D.2    Milosevic, M.F.3    Toi, A.4    Bristow, R.G.5    Menard, C.6    Haider, M.A.7
  • 109
    • 34249815207 scopus 로고    scopus 로고
    • Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas
    • Cleven, A.H.; van Engeland, M.; Wouters, B.G.; de Bruine, A.P. Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas. Cell. Oncol., 2007, 29(3), 229-240.
    • (2007) Cell. Oncol. , vol.29 , Issue.3 , pp. 229-240
    • Cleven, A.H.1    Van Engeland, M.2    Wouters, B.G.3    De Bruine, A.P.4
  • 110
    • 50249122264 scopus 로고    scopus 로고
    • Poorer outcome in stromal HIF-2 alpha-and CA9-positive colorectal adenocarcinomas is associated with wild-type TP53 but not with BNIP3 promoter hypermethylation or apoptosis
    • Cleven, A.H.; Wouters, B.G.; Schutte, B.; Spiertz, A.J.; van Engeland, M.; de Bruine, A.P. Poorer outcome in stromal HIF-2 alpha-and CA9-positive colorectal adenocarcinomas is associated with wild-type TP53 but not with BNIP3 promoter hypermethylation or apoptosis. Brit. J. Cancer, 2008, 99(5), 727-733.
    • (2008) Brit. J. Cancer , vol.99 , Issue.5 , pp. 727-733
    • Cleven, A.H.1    Wouters, B.G.2    Schutte, B.3    Spiertz, A.J.4    Van Engeland, M.5    De Bruine, A.P.6
  • 111
    • 0141751743 scopus 로고    scopus 로고
    • The presence of a fibrotic focus in invasive breast carcinoma correlates with the expression of carbonic anhydrase IX and is a marker of hypoxia and poor prognosis
    • Colpaert, C.G.; Vermeulen, P.B.; Fox, S.B.; Harris, A.L.; Dirix, L.Y.; Van Marck, E.A. The presence of a fibrotic focus in invasive breast carcinoma correlates with the expression of carbonic anhydrase IX and is a marker of hypoxia and poor prognosis. Breast Cancer Res. Treat., 2003, 81(2), 137-147.
    • (2003) Breast Cancer Res. Treat. , vol.81 , Issue.2 , pp. 137-147
    • Colpaert, C.G.1    Vermeulen, P.B.2    Fox, S.B.3    Harris, A.L.4    Dirix, L.Y.5    Van Marck, E.A.6
  • 115
    • 79952110177 scopus 로고    scopus 로고
    • Identification of carbonic anhydrase 9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells
    • Zheng, G.; Zhou, M.; Ou, X.; Peng, B.; Yu, Y.; Kong, F.; Ouyang, Y.; He, Z. Identification of carbonic anhydrase 9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells. FEBS J., 2010, 277(21), 4506-4518.
    • (2010) FEBS J. , vol.277 , Issue.21 , pp. 4506-4518
    • Zheng, G.1    Zhou, M.2    Ou, X.3    Peng, B.4    Yu, Y.5    Kong, F.6    Ouyang, Y.7    He, Z.8
  • 119
    • 65449131740 scopus 로고    scopus 로고
    • The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas
    • Kong, C.S.; Narasimhan, B.; Cao, H.; Kwok, S.; Erickson, J.P.; Koong, A.; Pourmand, N.; Le, Q.T. The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas. Int. J. Rad. Oncol. Biol. Phys., 2009, 74(2), 553-561.
    • (2009) Int. J. Rad. Oncol. Biol. Phys. , vol.74 , Issue.2 , pp. 553-561
    • Kong, C.S.1    Narasimhan, B.2    Cao, H.3    Kwok, S.4    Erickson, J.P.5    Koong, A.6    Pourmand, N.7    Le, Q.T.8
  • 120
    • 34250182435 scopus 로고    scopus 로고
    • Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: An evaluation of the DAHANCA 5 study
    • Eriksen, J.G.; Overgaard, J. Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: an evaluation of the DAHANCA 5 study. Radiother. Oncol., 2007, 83(3), 383-388.
    • (2007) Radiother. Oncol. , vol.83 , Issue.3 , pp. 383-388
    • Eriksen, J.G.1    Overgaard, J.2
  • 121
    • 0026636125 scopus 로고
    • Second primary tumors in patients with oral cancer
    • Day, G.L.; Blot, W.J. Second primary tumors in patients with oral cancer. Cancer, 1992, 70(1), 14-19.
    • (1992) Cancer , vol.70 , Issue.1 , pp. 14-19
    • Day, G.L.1    Blot, W.J.2
  • 122
    • 0023902853 scopus 로고
    • Estimates of the worldwide frequency of sixteen major cancers in 1980
    • Parkin, D.M.; Laara, E.; Muir, C.S. Estimates of the worldwide frequency of sixteen major cancers in 1980. Int. J. Cancer, 1988, 41(2), 184-197.
    • (1988) Int. J. Cancer , vol.41 , Issue.2 , pp. 184-197
    • Parkin, D.M.1    Laara, E.2    Muir, C.S.3
  • 123
    • 14844321323 scopus 로고    scopus 로고
    • Trends in incidence and prognosis for head and neck cancer in the United States: A site-specific analysis of the SEER database
    • Carvalho, A.L.; Nishimoto, I.N.; Califano, J.A.; Kowalski, L.P. Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database. Int. J. Cancer, 2005, 114(5), 806-816.
    • (2005) Int. J. Cancer , vol.114 , Issue.5 , pp. 806-816
    • Carvalho, A.L.1    Nishimoto, I.N.2    Califano, J.A.3    Kowalski, L.P.4
  • 125
    • 4344699403 scopus 로고    scopus 로고
    • Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion
    • Robertson, N.; Potter, C.; Harris, A.L. Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion. Cancer Res., 2004, 64(17), 6160-6165.
    • (2004) Cancer Res. , vol.64 , Issue.17 , pp. 6160-6165
    • Robertson, N.1    Potter, C.2    Harris, A.L.3
  • 126
    • 0035927544 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells
    • Shi, Q.; Le, X.; Wang, B.; Abbruzzese, J.L.; Xiong, Q.; He, Y.; Xie, K. Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells. Oncogene, 2001, 20(28), 3751-3756.
    • (2001) Oncogene , vol.20 , Issue.28 , pp. 3751-3756
    • Shi, Q.1    Le, X.2    Wang, B.3    Abbruzzese, J.L.4    Xiong, Q.5    He, Y.6    Xie, K.7
  • 127
    • 0038215389 scopus 로고    scopus 로고
    • Pericellular cathepsin B and malignant progression
    • Roshy, S.; Sloane, B.F.; Moin, K. Pericellular cathepsin B and malignant progression. Cancer Metast. Rev., 2003, 22(2-3), 271-286.
    • (2003) Cancer Metast. Rev. , vol.22 , Issue.2-3 , pp. 271-286
    • Roshy, S.1    Sloane, B.F.2    Moin, K.3
  • 128
    • 0028618307 scopus 로고
    • Pericellular pH affects distribution and secretion of cathepsin B in malignant cells
    • Rozhin, J.; Sameni, M.; Ziegler, G.; Sloane, B.F. Pericellular pH affects distribution and secretion of cathepsin B in malignant cells. Cancer Res., 1994, 54(24), 6517-6525.
    • (1994) Cancer Res. , vol.54 , Issue.24 , pp. 6517-6525
    • Rozhin, J.1    Sameni, M.2    Ziegler, G.3    Sloane, B.F.4
  • 129
    • 84874532245 scopus 로고    scopus 로고
    • Carbonic anhydrase IX as a target for metastatic disease
    • Gieling, R.G.; Williams, K.J. Carbonic anhydrase IX as a target for metastatic disease. Bioorg. Med. Chem., 2013, 21(6), 1470-1476.
    • (2013) Bioorg. Med. Chem. , vol.21 , Issue.6 , pp. 1470-1476
    • Gieling, R.G.1    Williams, K.J.2
  • 130
    • 0031927798 scopus 로고    scopus 로고
    • Tumor pH: Implications for treatment and novel drug design
    • Gerweck, L.E. Tumor pH: implications for treatment and novel drug design. Semin. Rad. Oncol., 1998, 8(3), 176-182.
    • (1998) Semin. Rad. Oncol. , vol.8 , Issue.3 , pp. 176-182
    • Gerweck, L.E.1
  • 131
    • 77952878558 scopus 로고    scopus 로고
    • Carbonic anhydrase IX in renal cell carcinoma: Implications for prognosis, diagnosis, and therapy
    • Stillebroer, A.B.; Mulders, P.F.; Boerman, O.C.; Oyen, W.J.; Oosterwijk, E. Carbonic anhydrase IX in renal cell carcinoma: implications for prognosis, diagnosis, and therapy. Eur. Urol., 2010, 58(1), 75-83.
    • (2010) Eur. Urol. , vol.58 , Issue.1 , pp. 75-83
    • Stillebroer, A.B.1    Mulders, P.F.2    Boerman, O.C.3    Oyen, W.J.4    Oosterwijk, E.5
  • 133
    • 78649636616 scopus 로고    scopus 로고
    • Carbonic anhydrase 9 in clear cell renal cell carcinoma: A marker for diagnosis, prognosis and treatment
    • Tostain, J.; Li, G.; Gentil-Perret, A.; Gigante, M. Carbonic anhydrase 9 in clear cell renal cell carcinoma: a marker for diagnosis, prognosis and treatment. Eur. J. Cancer, 2010, 46(18), 3141-3148.
    • (2010) Eur. J. Cancer , vol.46 , Issue.18 , pp. 3141-3148
    • Tostain, J.1    Li, G.2    Gentil-Perret, A.3    Gigante, M.4
  • 134
    • 57749096407 scopus 로고    scopus 로고
    • Carbonic anhydrase IX has chaperone-like functions and is an immunoadjuvant
    • Wang, Y.; Wang, X.Y.; Subjeck, J.R.; Kim, H.L. Carbonic anhydrase IX has chaperone-like functions and is an immunoadjuvant. Mol. Cancer Ther., 2008, 7(12), 3867-3877.
    • (2008) Mol. Cancer Ther. , vol.7 , Issue.12 , pp. 3867-3877
    • Wang, Y.1    Wang, X.Y.2    Subjeck, J.R.3    Kim, H.L.4
  • 135
    • 28244451574 scopus 로고    scopus 로고
    • The role of carbonic anhydrase IX overexpression in kidney cancer
    • Dorai, T.; Sawczuk, I.S.; Pastorek, J.; Wiernik, P.H.; Dutcher, J.P. The role of carbonic anhydrase IX overexpression in kidney cancer. Eur. J. Cancer, 2005, 41(18), 2935-2947.
    • (2005) Eur. J. Cancer , vol.41 , Issue.18 , pp. 2935-2947
    • Dorai, T.1    Sawczuk, I.S.2    Pastorek, J.3    Wiernik, P.H.4    Dutcher, J.P.5
  • 138
    • 0035902856 scopus 로고    scopus 로고
    • Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma
    • Cho, M.; Uemura, H.; Kim, S.C.; Kawada, Y.; Yoshida, K.; Hirao, Y.; Konishi, N.; Saga, S.; Yoshikawa, K. Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma. Brit. J. Cancer, 2001, 85(4), 563-567.
    • (2001) Brit. J. Cancer , vol.85 , Issue.4 , pp. 563-567
    • Cho, M.1    Uemura, H.2    Kim, S.C.3    Kawada, Y.4    Yoshida, K.5    Hirao, Y.6    Konishi, N.7    Saga, S.8    Yoshikawa, K.9
  • 139
    • 79951831757 scopus 로고    scopus 로고
    • Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer
    • Nakamura, J.; Kitajima, Y.; Kai, K.; Hashiguchi, K.; Hiraki, M.; Noshiro, H.; Miyazaki, K. Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer. Am. J. Pathol., 2011, 178(2), 515-524.
    • (2011) Am. J. Pathol. , vol.178 , Issue.2 , pp. 515-524
    • Nakamura, J.1    Kitajima, Y.2    Kai, K.3    Hashiguchi, K.4    Hiraki, M.5    Noshiro, H.6    Miyazaki, K.7
  • 141
    • 84866524615 scopus 로고    scopus 로고
    • Carbonic anhydrase IX upregulation is associated with adverse clinicopathologic and biologic factors in neuroblastomas
    • Dungwa, J.V.; Hunt, L.P.; Ramani, P. Carbonic anhydrase IX upregulation is associated with adverse clinicopathologic and biologic factors in neuroblastomas. Human Pathol., 2012, 43(10), 1651-1660.
    • (2012) Human Pathol. , vol.43 , Issue.10 , pp. 1651-1660
    • Dungwa, J.V.1    Hunt, L.P.2    Ramani, P.3
  • 142
    • 84887609665 scopus 로고    scopus 로고
    • Cancer heterogeneity and The Struggle for Existence: Diagnostic and analytical challenges
    • Horswell, S.; Matthews, N.; Swanton, C. Cancer heterogeneity and The Struggle for Existence: Diagnostic and analytical challenges. Cancer Lett., 2013, 340(2), 220-226.
    • (2013) Cancer Lett. , vol.340 , Issue.2 , pp. 220-226
    • Horswell, S.1    Matthews, N.2    Swanton, C.3
  • 144
    • 84859426003 scopus 로고    scopus 로고
    • Second-generation BCR-ABL inhibitors for frontline treatment of chronic myeloid leukemia in chronic phase
    • Rosti, G.; Castagnetti, F.; Gugliotta, G.; Palandri, F.; Baccarani, M. Second-generation BCR-ABL inhibitors for frontline treatment of chronic myeloid leukemia in chronic phase. Crit. Rev. Oncol. Hematol., 2012, 82(2), 159-170.
    • (2012) Crit. Rev. Oncol. Hematol. , vol.82 , Issue.2 , pp. 159-170
    • Rosti, G.1    Castagnetti, F.2    Gugliotta, G.3    Palandri, F.4    Baccarani, M.5
  • 147
    • 84863652136 scopus 로고    scopus 로고
    • Circumventing cancer drug resistance in the era of personalized medicine
    • Garraway, L.A.; Janne, P.A. Circumventing cancer drug resistance in the era of personalized medicine. Cancer Discov., 2012, 2(3), 214-226.
    • (2012) Cancer Discov. , vol.2 , Issue.3 , pp. 214-226
    • Garraway, L.A.1    Janne, P.A.2
  • 148
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell, P.C. The clonal evolution of tumor cell populations. Science, 1976, 194(4260), 23-28.
    • (1976) Science , vol.194 , Issue.4260 , pp. 23-28
    • Nowell, P.C.1
  • 149
    • 84857555235 scopus 로고    scopus 로고
    • Carbonic anhydrase IX as a target for designing novel anticancer drugs
    • Monti, S.M.; Supuran, C.T.; De Simone, G. Carbonic anhydrase IX as a target for designing novel anticancer drugs. Curr. Med. Chem., 2012, 19(6), 821-830.
    • (2012) Curr. Med. Chem. , vol.19 , Issue.6 , pp. 821-830
    • Monti, S.M.1    Supuran, C.T.2    De Simone, G.3
  • 150
    • 84857538594 scopus 로고    scopus 로고
    • Zinc metallo-enzymes as target for drug design
    • De Simone, G. Zinc metallo-enzymes as target for drug design. Curr. Med. Chem., 2012, 19(6), 820.
    • (2012) Curr. Med. Chem. , vol.19 , Issue.6 , pp. 820
    • De Simone, G.1
  • 151
    • 77953521863 scopus 로고    scopus 로고
    • Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII
    • Guler, O.O.; De Simone, G.; Supuran, C.T. Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII. Curr. Med. Chem., 2010, 17(15), 1516-1526.
    • (2010) Curr. Med. Chem. , vol.17 , Issue.15 , pp. 1516-1526
    • Guler, O.O.1    De Simone, G.2    Supuran, C.T.3
  • 153
    • 78649813619 scopus 로고    scopus 로고
    • Carbonic anhydrase IX as an anticancer therapy target: Preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain
    • Zatovicova, M.; Jelenska, L.; Hulikova, A.; Csaderova, L.; Ditte, Z.; Ditte, P.; Goliasova, T.; Pastorek, J.; Pastorekova, S. Carbonic anhydrase IX as an anticancer therapy target: preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain. Curr. Pharm. Des., 2010, 16(29), 3255-3263.
    • (2010) Curr. Pharm. Des. , vol.16 , Issue.29 , pp. 3255-3263
    • Zatovicova, M.1    Jelenska, L.2    Hulikova, A.3    Csaderova, L.4    Ditte, Z.5    Ditte, P.6    Goliasova, T.7    Pastorek, J.8    Pastorekova, S.9
  • 155
    • 77949716901 scopus 로고    scopus 로고
    • Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology
    • Xu, C.; Lo, A.; Yammanuru, A.; Tallarico, A.S.; Brady, K.; Murakami, A.; Barteneva, N.; Zhu, Q.; Marasco, W.A. Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology. PloS One, 2010, 5(3), e9625.
    • (2010) PloS One , vol.5 , Issue.3
    • Xu, C.1    Lo, A.2    Yammanuru, A.3    Tallarico, A.S.4    Brady, K.5    Murakami, A.6    Barteneva, N.7    Zhu, Q.8    Marasco, W.A.9
  • 156
    • 77955424195 scopus 로고    scopus 로고
    • Coumarins incorporating hydroxy-and chloro-moieties selectively inhibit the transmembrane, tumorassociated carbonic anhydrase isoforms IX and XII over the cytosolic ones i and II
    • Maresca, A.; Supuran, C.T. Coumarins incorporating hydroxy-and chloro-moieties selectively inhibit the transmembrane, tumorassociated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II. Bioorg. Med. Chem. Lett., 2010, 20(15), 4511-4514.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , Issue.15 , pp. 4511-4514
    • Maresca, A.1    Supuran, C.T.2
  • 157
    • 78449303755 scopus 로고    scopus 로고
    • 7,8-disubstituted-but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones i and II in the low nanomolar/subnanomolar range
    • Maresca, A.; Scozzafava, A.; Supuran, C.T. 7,8-disubstituted-but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range. Bioorg. Med. Chem. Lett., 2010, 20(24), 7255-7258.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , Issue.24 , pp. 7255-7258
    • Maresca, A.1    Scozzafava, A.2    Supuran, C.T.3
  • 158
    • 3442883664 scopus 로고    scopus 로고
    • Carbonic anhydrases: Current state of the art, therapeutic applications and future prospects
    • Pastorekova, S.; Parkkila, S.; Pastorek, J.; Supuran, C.T. Carbonic anhydrases: current state of the art, therapeutic applications and future prospects. J. Enzyme Inhib. Med. Chem., 2004, 19(3), 199-229.
    • (2004) J. Enzyme Inhib. Med. Chem. , vol.19 , Issue.3 , pp. 199-229
    • Pastorekova, S.1    Parkkila, S.2    Pastorek, J.3    Supuran, C.T.4
  • 159
    • 84863651163 scopus 로고    scopus 로고
    • Combinatorial drug therapy for cancer in the post-genomic era
    • Al-Lazikani, B.; Banerji, U.; Workman, P. Combinatorial drug therapy for cancer in the post-genomic era. Nat. Biotechnol., 2012, 30(7), 679-692.
    • (2012) Nat. Biotechnol. , vol.30 , Issue.7 , pp. 679-692
    • Al-Lazikani, B.1    Banerji, U.2    Workman, P.3
  • 160
    • 0141887319 scopus 로고    scopus 로고
    • Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients
    • Zavada, J.; Zavadova, Z.; Zat'ovicova, M.; Hyrsl, L.; Kawaciuk, I. Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Brit. J. Cancer, 2003, 89(6), 1067-1071.
    • (2003) Brit. J. Cancer , vol.89 , Issue.6 , pp. 1067-1071
    • Zavada, J.1    Zavadova, Z.2    Zat'Ovicova, M.3    Hyrsl, L.4    Kawaciuk, I.5
  • 161
    • 68149108604 scopus 로고    scopus 로고
    • Soluble form of carbonic anhydrase IX (CAIX) in transitional cell carcinoma of urinary tract
    • Hyrsl, L.; Zavada, J.; Zavadova, Z.; Kawaciuk, I.; Vesely, S.; Skapa, P. Soluble form of carbonic anhydrase IX (CAIX) in transitional cell carcinoma of urinary tract. Neoplasma, 2009, 56(4), 298-302.
    • (2009) Neoplasma , vol.56 , Issue.4 , pp. 298-302
    • Hyrsl, L.1    Zavada, J.2    Zavadova, Z.3    Kawaciuk, I.4    Vesely, S.5    Skapa, P.6
  • 162
    • 75349092529 scopus 로고    scopus 로고
    • Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: Prognostic and diagnostic potentials
    • Zhou, G.X.; Ireland, J.; Rayman, P.; Finke, J.; Zhou, M. Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials. Urology, 2010, 75(2), 257-261.
    • (2010) Urology , vol.75 , Issue.2 , pp. 257-261
    • Zhou, G.X.1    Ireland, J.2    Rayman, P.3    Finke, J.4    Zhou, M.5
  • 163
    • 27944500753 scopus 로고    scopus 로고
    • Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17
    • Zatovicova, M.; Sedlakova, O.; Svastova, E.; Ohradanova, A.; Ciampor, F.; Arribas, J.; Pastorek, J.; Pastorekova, S. Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17. Brit. J. Cancer, 2005, 93(11), 1267-1276.
    • (2005) Brit. J. Cancer , vol.93 , Issue.11 , pp. 1267-1276
    • Zatovicova, M.1    Sedlakova, O.2    Svastova, E.3    Ohradanova, A.4    Ciampor, F.5    Arribas, J.6    Pastorek, J.7    Pastorekova, S.8
  • 165
    • 79960074590 scopus 로고    scopus 로고
    • Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer
    • Muller, V.; Riethdorf, S.; Rack, B.; Janni, W.; Fasching, P.A.; Solomayer, E.; Aktas, B.; Kasimir-Bauer, S.; Zeitz, J.; Pantel, K.; Fehm, T. Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer. Breast Cancer Res., 2011, 13(4), R71.
    • (2011) Breast Cancer Res. , vol.13 , Issue.4
    • Muller, V.1    Riethdorf, S.2    Rack, B.3    Janni, W.4    Fasching, P.A.5    Solomayer, E.6    Aktas, B.7    Kasimir-Bauer, S.8    Zeitz, J.9    Pantel, K.10    Fehm, T.11
  • 166
    • 46449104314 scopus 로고    scopus 로고
    • Serum carbonic anhydrase 9 level is associated with postoperative recurrence of conventional renal cell cancer
    • discussion 513-514
    • Li, G.; Feng, G.; Gentil-Perret, A.; Genin, C.; Tostain, J. Serum carbonic anhydrase 9 level is associated with postoperative recurrence of conventional renal cell cancer. J. Urol., 2008, 180(2), 510-513; discussion 513-514.
    • (2008) J. Urol. , vol.180 , Issue.2 , pp. 510-513
    • Li, G.1    Feng, G.2    Gentil-Perret, A.3    Genin, C.4    Tostain, J.5
  • 168
    • 78449294101 scopus 로고    scopus 로고
    • Assessing the clinical utility of diagnostics used in drug therapy
    • Woodcock, J. Assessing the clinical utility of diagnostics used in drug therapy. Clin. Pharmacol. Ther., 2010, 88(6), 765-773.
    • (2010) Clin. Pharmacol. Ther. , vol.88 , Issue.6 , pp. 765-773
    • Woodcock, J.1


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