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Volumn 77, Issue 11, 2009, Pages 1665-1673

Acute and chronic in vivo therapeutic resistance

Author keywords

Angiogenesis; Drug resistance; Hypoxia inducible factor; Immune privilege; Microenvironment; Transforming growth factor beta

Indexed keywords

ANGIOGENIC FACTOR; CARBONATE DEHYDRATASE IX; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 64249086885     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.01.006     Document Type: Note
Times cited : (37)

References (103)
  • 2
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: significance and impact on clinical outcome
    • Vaupel P., and Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev 26 (2007) 225-239
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 3
  • 4
    • 34547103992 scopus 로고    scopus 로고
    • Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment
    • Moeller B.J., Richardson R.A., and Dewhirst M.W. Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment. Cancer Metastasis Rev 26 (2007) 241-248
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 241-248
    • Moeller, B.J.1    Richardson, R.A.2    Dewhirst, M.W.3
  • 5
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • Dewhirst M.W., Cao Y., and Moeller B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 8 (2008) 425-437
    • (2008) Nat Rev Cancer , vol.8 , pp. 425-437
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 6
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia, DNA repair and genetic instability
    • Bristow R.G., and Hill R.P. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 8 (2008) 180-192
    • (2008) Nat Rev Cancer , vol.8 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 7
    • 48349098840 scopus 로고    scopus 로고
    • Resistance to chemotherapy: new treatments and novel insights into an old problem
    • Raguz S., and Yague E. Resistance to chemotherapy: new treatments and novel insights into an old problem. Brit J Cancer 99 (2008) 387-391
    • (2008) Brit J Cancer , vol.99 , pp. 387-391
    • Raguz, S.1    Yague, E.2
  • 8
    • 34547124062 scopus 로고    scopus 로고
    • Hypoxia: a key regulator of angiogenesis in cancer
    • Liao D., and Johnson R.S. Hypoxia: a key regulator of angiogenesis in cancer. Cancer Metastasis Rev 26 (2007) 281-290
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 281-290
    • Liao, D.1    Johnson, R.S.2
  • 9
    • 34547125574 scopus 로고    scopus 로고
    • Hypoxia, gene expression and metastasis
    • Chan D.A., and Giaccia A.J. Hypoxia, gene expression and metastasis. Cancer Metastasis Rev 26 (2007) 333-339
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 333-339
    • Chan, D.A.1    Giaccia, A.J.2
  • 11
    • 28644437424 scopus 로고    scopus 로고
    • In vitro hypoxia-conditioned colon cancer cell lines derived from HCT116 and HT29 exhibit altered apoptosis susceptibility and a more angiogenic profile in vivo
    • Yao K., Gietema J.A., Shida S., Selvakumaran M., Fonrose X., Haas N.B., et al. In vitro hypoxia-conditioned colon cancer cell lines derived from HCT116 and HT29 exhibit altered apoptosis susceptibility and a more angiogenic profile in vivo. Brit J Cancer 93 (2005) 1356-1363
    • (2005) Brit J Cancer , vol.93 , pp. 1356-1363
    • Yao, K.1    Gietema, J.A.2    Shida, S.3    Selvakumaran, M.4    Fonrose, X.5    Haas, N.B.6
  • 13
    • 0035502588 scopus 로고    scopus 로고
    • Cell adhesion is a key determinant in de novo multidrug resistance (MDR): new targets for the prevention of acquired MDR
    • Shain K.H., and Dalton W.S. Cell adhesion is a key determinant in de novo multidrug resistance (MDR): new targets for the prevention of acquired MDR. Mol Cancer Ther 1 (2001) 69-78
    • (2001) Mol Cancer Ther , vol.1 , pp. 69-78
    • Shain, K.H.1    Dalton, W.S.2
  • 14
    • 34547130302 scopus 로고    scopus 로고
    • Effects of hypoxia on tumor metabolism
    • Kim J.W., Gao P., and Dang C.V. Effects of hypoxia on tumor metabolism. Cancer Metastasis Rev 26 (2007) 291-298
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 291-298
    • Kim, J.W.1    Gao, P.2    Dang, C.V.3
  • 15
    • 35448961939 scopus 로고    scopus 로고
    • The Warburg effect and its cancer therapeutic implications
    • Chen Z., Lu W., Garcia-Prieto C., and Huang P. The Warburg effect and its cancer therapeutic implications. J Bioenerg Biomembr 39 (2007) 267-274
    • (2007) J Bioenerg Biomembr , vol.39 , pp. 267-274
    • Chen, Z.1    Lu, W.2    Garcia-Prieto, C.3    Huang, P.4
  • 17
    • 34547124566 scopus 로고    scopus 로고
    • Hypoxia and adaptive landscapes in the evolution of carcinogenesis
    • Gillies R.J., and Gatenby R.A. Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metastasis Rev 26 (2007) 311-317
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 311-317
    • Gillies, R.J.1    Gatenby, R.A.2
  • 18
    • 34547098129 scopus 로고    scopus 로고
    • Targeting hypoxia cell signaling for cancer therapy
    • Melillo G. Targeting hypoxia cell signaling for cancer therapy. Cancer Metastasis Rev 26 (2007) 333-339
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 333-339
    • Melillo, G.1
  • 19
    • 34748860952 scopus 로고    scopus 로고
    • Hypoxic radiosensitization: adored and ignored
    • Overgaard J. Hypoxic radiosensitization: adored and ignored. J Clin Oncol 25 (2007) 4066-4074
    • (2007) J Clin Oncol , vol.25 , pp. 4066-4074
    • Overgaard, J.1
  • 20
    • 33750631842 scopus 로고    scopus 로고
    • Tumor microenvironment and drug resistance in hematologic malignancies
    • Li Z.W., and Dalton W.S. Tumor microenvironment and drug resistance in hematologic malignancies. Blood Rev 20 (2006) 333-342
    • (2006) Blood Rev , vol.20 , pp. 333-342
    • Li, Z.W.1    Dalton, W.S.2
  • 21
    • 46449130084 scopus 로고    scopus 로고
    • Witz IP. Tumor microenvironment interactions: dangerous liaisons. In: George F, Vande Woude, George Klein, editors. Adv Cancer Res 2008;100:203-29.
    • Witz IP. Tumor microenvironment interactions: dangerous liaisons. In: George F, Vande Woude, George Klein, editors. Adv Cancer Res 2008;100:203-29.
  • 22
    • 33745082823 scopus 로고    scopus 로고
    • Role of transforming growth factor-β in hematologic malignancies
    • Dong M., and Blobe G.C. Role of transforming growth factor-β in hematologic malignancies. Blood 107 (2006) 4589-4596
    • (2006) Blood , vol.107 , pp. 4589-4596
    • Dong, M.1    Blobe, G.C.2
  • 23
    • 0033625354 scopus 로고    scopus 로고
    • Resistance to TGF-β1 correlates with a reduction of TGF-β type II receptor expression in Burkitt's lymphoma and Epstein-Barr virus-transformed B lymphoblastoid cell lines
    • Inman G.J., and Allday M.J. Resistance to TGF-β1 correlates with a reduction of TGF-β type II receptor expression in Burkitt's lymphoma and Epstein-Barr virus-transformed B lymphoblastoid cell lines. J Gen Virol 81 (2000) 1567-1578
    • (2000) J Gen Virol , vol.81 , pp. 1567-1578
    • Inman, G.J.1    Allday, M.J.2
  • 24
    • 34547120458 scopus 로고    scopus 로고
    • Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues
    • Lukashev D., Ohta A., and Sitkovsky M. Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues. Cancer Metastasis Rev 26 (2007) 273-279
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 273-279
    • Lukashev, D.1    Ohta, A.2    Sitkovsky, M.3
  • 25
    • 0034630912 scopus 로고    scopus 로고
    • Retinoic acid resistance at late stages of human papillomavirus type 16-mediated transformation of human keratinocytes arises despite intact retinoid signaling and is due to a loss of sensitivity to transforming growth factor-β
    • Borger D.R., Mi Y., Gesiani G., Zyzak L.L., Batova A., Engin T.S.W., et al. Retinoic acid resistance at late stages of human papillomavirus type 16-mediated transformation of human keratinocytes arises despite intact retinoid signaling and is due to a loss of sensitivity to transforming growth factor-β. Virology 270 (2000) 397-407
    • (2000) Virology , vol.270 , pp. 397-407
    • Borger, D.R.1    Mi, Y.2    Gesiani, G.3    Zyzak, L.L.4    Batova, A.5    Engin, T.S.W.6
  • 26
    • 36148967682 scopus 로고    scopus 로고
    • The role of autocrine motility factor in tumor and tumor microenvironment
    • Funasaka T., and Raz A. The role of autocrine motility factor in tumor and tumor microenvironment. Cancer Metastasis Rev 26 (2007) 725-735
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 725-735
    • Funasaka, T.1    Raz, A.2
  • 27
    • 2442674389 scopus 로고    scopus 로고
    • The role of Fas ligand and transforming growth factor β in tumor progression
    • Kim R., Emi M., Tanabe K., Uchida Y., and Toge T. The role of Fas ligand and transforming growth factor β in tumor progression. Cancer 100 (2004) 2281-2291
    • (2004) Cancer , vol.100 , pp. 2281-2291
    • Kim, R.1    Emi, M.2    Tanabe, K.3    Uchida, Y.4    Toge, T.5
  • 29
    • 0035689762 scopus 로고    scopus 로고
    • Malignant cells, directors of the malignant process: role of transforming growth factor-beta
    • Teicher B.A. Malignant cells, directors of the malignant process: role of transforming growth factor-beta. Cancer Metastasis Rev 20 (2001) 133-143
    • (2001) Cancer Metastasis Rev , vol.20 , pp. 133-143
    • Teicher, B.A.1
  • 30
    • 33745515023 scopus 로고    scopus 로고
    • TGFβ: the molecular Jekyll and Hyde of cancer
    • Bierie B., and Moses H.L. TGFβ: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer 6 (2006) 506-520
    • (2006) Nat Rev Cancer , vol.6 , pp. 506-520
    • Bierie, B.1    Moses, H.L.2
  • 31
    • 0000031048 scopus 로고    scopus 로고
    • Transcriptional repression of the transforming growth factor-β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer
    • Kang S.H., Bang Y.J., Im Y.H., Yang H.K., Lee D.A., Lee H.Y., et al. Transcriptional repression of the transforming growth factor-β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer. Oncogene 18 (1999) 7280-7286
    • (1999) Oncogene , vol.18 , pp. 7280-7286
    • Kang, S.H.1    Bang, Y.J.2    Im, Y.H.3    Yang, H.K.4    Lee, D.A.5    Lee, H.Y.6
  • 32
    • 0037444273 scopus 로고    scopus 로고
    • Loss of c-myc repression coincides with ovarian cancer resistance to transforming growth factor β growth arrest independent of transforming growth factor β/smad signaling
    • Baldwin R.L., Tran H., and Karlan B.Y. Loss of c-myc repression coincides with ovarian cancer resistance to transforming growth factor β growth arrest independent of transforming growth factor β/smad signaling. Cancer Res 63 (2003) 1413-1419
    • (2003) Cancer Res , vol.63 , pp. 1413-1419
    • Baldwin, R.L.1    Tran, H.2    Karlan, B.Y.3
  • 34
    • 0025228518 scopus 로고
    • Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo
    • Teicher B.A., Herman T.S., Holden S.A., Wang Y., Pfeffer M.R., Crawford J.M., et al. Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo. Science 247 (1990) 1457-1461
    • (1990) Science , vol.247 , pp. 1457-1461
    • Teicher, B.A.1    Herman, T.S.2    Holden, S.A.3    Wang, Y.4    Pfeffer, M.R.5    Crawford, J.M.6
  • 35
    • 0030993935 scopus 로고    scopus 로고
    • Reversal of in vivo drug resistance by the transforming growth factor-β inhibitor decorin
    • Teicher B.A., Maehara Y., Kakeji Y., Ara G., Keyes S.R., Wong J., et al. Reversal of in vivo drug resistance by the transforming growth factor-β inhibitor decorin. Inst J Cancer 71 (1997) 49-58
    • (1997) Inst J Cancer , vol.71 , pp. 49-58
    • Teicher, B.A.1    Maehara, Y.2    Kakeji, Y.3    Ara, G.4    Keyes, S.R.5    Wong, J.6
  • 37
    • 22644431614 scopus 로고    scopus 로고
    • Expression of mRNA coding for TGF-β and its receptors in irradiated human breast carcinoma MCF-7 cells differing in their sensitivity to doxorubicin
    • Chorna I., Fedorenko O., Datsyuk L., and Stoika R. Expression of mRNA coding for TGF-β and its receptors in irradiated human breast carcinoma MCF-7 cells differing in their sensitivity to doxorubicin. Exp Oncol 27 (2005) 156-158
    • (2005) Exp Oncol , vol.27 , pp. 156-158
    • Chorna, I.1    Fedorenko, O.2    Datsyuk, L.3    Stoika, R.4
  • 38
    • 2642578233 scopus 로고    scopus 로고
    • Tamoxifen treatment failure in cancer and the nonlinear dynamics of TGFβ
    • Turner S., Sherratt J.A., and Cameron D. Tamoxifen treatment failure in cancer and the nonlinear dynamics of TGFβ. J Theor Biol 229 (2004) 101-111
    • (2004) J Theor Biol , vol.229 , pp. 101-111
    • Turner, S.1    Sherratt, J.A.2    Cameron, D.3
  • 39
    • 0041379638 scopus 로고    scopus 로고
    • Potential role of transforming growth factor β1 in drug resistance of tumor cells
    • Stoika R., Yakymovych M., Souchelnytskyi S., and Yakymovych. Potential role of transforming growth factor β1 in drug resistance of tumor cells. Acta Biochim Polonica 50 (2003) 497-508
    • (2003) Acta Biochim Polonica , vol.50 , pp. 497-508
    • Stoika, R.1    Yakymovych, M.2    Souchelnytskyi, S.3    Yakymovych4
  • 40
    • 0030914430 scopus 로고    scopus 로고
    • Enhancement of mdr1 gene expression by transforming growth factor-beta 1 in a new adriamycin-resistant human leukemia cell line ME-F2/ADM
    • Utsunomiya Y., Hasegawa H., Yanagisawa K., and Fujita S. Enhancement of mdr1 gene expression by transforming growth factor-beta 1 in a new adriamycin-resistant human leukemia cell line ME-F2/ADM. Leukemia 11 (1997) 894-895
    • (1997) Leukemia , vol.11 , pp. 894-895
    • Utsunomiya, Y.1    Hasegawa, H.2    Yanagisawa, K.3    Fujita, S.4
  • 41
    • 34848851037 scopus 로고    scopus 로고
    • Interplay of distinct growth factors during epithelial-mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies
    • Mimeault M., and Batra S.K. Interplay of distinct growth factors during epithelial-mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies. Ann Oncol 18 (2007) 1605-1619
    • (2007) Ann Oncol , vol.18 , pp. 1605-1619
    • Mimeault, M.1    Batra, S.K.2
  • 42
    • 33746475270 scopus 로고    scopus 로고
    • Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors
    • Muller A.J., and Scherle P.A. Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors. Nat Rev Cancer 6 (2006) 613-625
    • (2006) Nat Rev Cancer , vol.6 , pp. 613-625
    • Muller, A.J.1    Scherle, P.A.2
  • 43
    • 35948933046 scopus 로고    scopus 로고
    • Transforming growth factor-β and the immune response to malignant disease
    • Teicher B.A. Transforming growth factor-β and the immune response to malignant disease. Clin Cancer Res 13 (2007) 6247-6251
    • (2007) Clin Cancer Res , vol.13 , pp. 6247-6251
    • Teicher, B.A.1
  • 44
    • 33745978399 scopus 로고    scopus 로고
    • Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    • Mempel T.R., Pittet M.J., Khazaie K., Weninger W., Weissieder R., von Boehmer H., et al. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity 25 (2006) 129-141
    • (2006) Immunity , vol.25 , pp. 129-141
    • Mempel, T.R.1    Pittet, M.J.2    Khazaie, K.3    Weninger, W.4    Weissieder, R.5    von Boehmer, H.6
  • 45
    • 31644440642 scopus 로고    scopus 로고
    • The impact of CD4+ CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer
    • Khazaie K., and von Boehmer H. The impact of CD4+ CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer. Semin Cancer Biol 16 (2006) 124-136
    • (2006) Semin Cancer Biol , vol.16 , pp. 124-136
    • Khazaie, K.1    von Boehmer, H.2
  • 46
    • 33746351318 scopus 로고    scopus 로고
    • Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer
    • Kretschmer K., Apostlou I., Jaeckel E., Khazaie K., and von Boehmer. Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer. Immunol Rev 212 (2006) 163-169
    • (2006) Immunol Rev , vol.212 , pp. 163-169
    • Kretschmer, K.1    Apostlou, I.2    Jaeckel, E.3    Khazaie, K.4    von Boehmer5
  • 47
    • 16844363097 scopus 로고    scopus 로고
    • A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
    • Fontenot J.D., and Rudensky A.Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 6 (2005) 331-337
    • (2005) Nat Immunol , vol.6 , pp. 331-337
    • Fontenot, J.D.1    Rudensky, A.Y.2
  • 49
    • 58149147369 scopus 로고    scopus 로고
    • Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia
    • Sitkovsky M.V., Kjaergaard J., Lukashev D., and Ohta A. Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia. Clin Cancer Res 14 (2008) 5947-5952
    • (2008) Clin Cancer Res , vol.14 , pp. 5947-5952
    • Sitkovsky, M.V.1    Kjaergaard, J.2    Lukashev, D.3    Ohta, A.4
  • 50
    • 34547120458 scopus 로고    scopus 로고
    • Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues
    • Lukashev D., Ohta A., and Sitkovsky M. Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues. Cancer Met Rev 26 (2007) 273-279
    • (2007) Cancer Met Rev , vol.26 , pp. 273-279
    • Lukashev, D.1    Ohta, A.2    Sitkovsky, M.3
  • 51
    • 53049083445 scopus 로고    scopus 로고
    • The relationship between the systemic inflammatory response, tumor proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer
    • Murri A.M.A., Hilmy M., Bell J., Wilson C., McNicol A.M., Lannigan A., et al. The relationship between the systemic inflammatory response, tumor proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer. Brit J Cancer 99 (2008) 1013-1019
    • (2008) Brit J Cancer , vol.99 , pp. 1013-1019
    • Murri, A.M.A.1    Hilmy, M.2    Bell, J.3    Wilson, C.4    McNicol, A.M.5    Lannigan, A.6
  • 52
    • 35348909046 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1-independent pathways in tumor angiogenesis
    • Mizukami Y., Kohgo Y., and Chung D.C. Hypoxia inducible factor-1-independent pathways in tumor angiogenesis. Clin Cancer Res 13 (2007) 5670-5678
    • (2007) Clin Cancer Res , vol.13 , pp. 5670-5678
    • Mizukami, Y.1    Kohgo, Y.2    Chung, D.C.3
  • 53
    • 34447117552 scopus 로고    scopus 로고
    • A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an immune-based mechanism
    • Manning E.A., Ullman J.G.M., Leatherman J.M., Asquith J.M., Hansen T.R., Armstrong T.D., et al. A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an immune-based mechanism. Clin Cancer Res 13 (2007) 3951-3959
    • (2007) Clin Cancer Res , vol.13 , pp. 3951-3959
    • Manning, E.A.1    Ullman, J.G.M.2    Leatherman, J.M.3    Asquith, J.M.4    Hansen, T.R.5    Armstrong, T.D.6
  • 54
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel R.S. Tumor angiogenesis. New Engl J Med 358 (2008) 2039-2049
    • (2008) New Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 55
    • 1942486848 scopus 로고    scopus 로고
    • Recognition of tumor blood vessel normalization as a new antiangiogenic concept
    • Hellmann K. Recognition of tumor blood vessel normalization as a new antiangiogenic concept. Nat Med 10 (2004) 329
    • (2004) Nat Med , vol.10 , pp. 329
    • Hellmann, K.1
  • 56
    • 0015493534 scopus 로고
    • Metastases and the normalization of tumor blood vessels ay ICRF 159: a new type of drug action
    • Le Serve A.W., and Hellmann K. Metastases and the normalization of tumor blood vessels ay ICRF 159: a new type of drug action. Brit Med J 1 (1972) 597-601
    • (1972) Brit Med J , vol.1 , pp. 597-601
    • Le Serve, A.W.1    Hellmann, K.2
  • 57
    • 35748970483 scopus 로고    scopus 로고
    • Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization
    • Fukumura D., and Jain R.K. Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. Microvascul Res 74 (2007) 72-84
    • (2007) Microvascul Res , vol.74 , pp. 72-84
    • Fukumura, D.1    Jain, R.K.2
  • 58
    • 0028305809 scopus 로고
    • Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents
    • Teicher B.A., Holden S.A., Ara G., Alvarez Sotomayor E., Huang Z.D., Chen Y.-N., et al. Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents. Int J Cancer 57 (1994) 920-925
    • (1994) Int J Cancer , vol.57 , pp. 920-925
    • Teicher, B.A.1    Holden, S.A.2    Ara, G.3    Alvarez Sotomayor, E.4    Huang, Z.D.5    Chen, Y.-N.6
  • 59
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: mechanisms of anti-tumor activity
    • Ellis L.M., and Hicklin D.J. VEGF-targeted therapy: mechanisms of anti-tumor activity. Nat Rev Cancer 8 (2008) 579-591
    • (2008) Nat Rev Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 60
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumor angiogenesis
    • Murdoch C., Muthana M., Coffelt S.B., and Lewis C.E. The role of myeloid cells in the promotion of tumor angiogenesis. Nat Rev Cancer 8 (2008) 618-631
    • (2008) Nat Rev Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 61
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G., and Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8 (2008) 592-603
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 62
    • 21344437729 scopus 로고    scopus 로고
    • Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 with in the tumor microenvironment
    • Dong D., Ko B., Baumeister P., Swenson S., Costa F., Markland F., et al. Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 with in the tumor microenvironment. Cancer Res 65 (2005) 5785-5791
    • (2005) Cancer Res , vol.65 , pp. 5785-5791
    • Dong, D.1    Ko, B.2    Baumeister, P.3    Swenson, S.4    Costa, F.5    Markland, F.6
  • 64
    • 47949102937 scopus 로고    scopus 로고
    • The semaphorins: versatile regulators of tumor progression and tumor angiogenesis
    • Neufeld G., and Kessler O. The semaphorins: versatile regulators of tumor progression and tumor angiogenesis. Nat Rev Cancer 8 (2008) 632-645
    • (2008) Nat Rev Cancer , vol.8 , pp. 632-645
    • Neufeld, G.1    Kessler, O.2
  • 65
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T., Butterfield C.E., Kraling B.M., Shi B., Marshall B., O'Reilly M.S., et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 60 (2000) 1878-1886
    • (2000) Cancer Res , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3    Shi, B.4    Marshall, B.5    O'Reilly, M.S.6
  • 66
    • 34748921698 scopus 로고    scopus 로고
    • Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers
    • Duda D.G., Jain R.K., and Willett C.G. Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers. J Clin Oncol 25 (2007) 4033-4042
    • (2007) J Clin Oncol , vol.25 , pp. 4033-4042
    • Duda, D.G.1    Jain, R.K.2    Willett, C.G.3
  • 67
    • 34147220392 scopus 로고    scopus 로고
    • Mediators of vascular remodeling co-opted for sequential steps in lung metastasis
    • Gupta G.P., Nguyen D.X., Chiang A.C., Bos P.D., Kim J.Y., Nadal C., et al. Mediators of vascular remodeling co-opted for sequential steps in lung metastasis. Nature 446 (2007) 765-770
    • (2007) Nature , vol.446 , pp. 765-770
    • Gupta, G.P.1    Nguyen, D.X.2    Chiang, A.C.3    Bos, P.D.4    Kim, J.Y.5    Nadal, C.6
  • 68
    • 21744433347 scopus 로고    scopus 로고
    • CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells
    • Hartmann T.N., Burger J.A., Glodek A., Fujii N., and Burger M. CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells. Oncogene 24 (2005) 4462-4471
    • (2005) Oncogene , vol.24 , pp. 4462-4471
    • Hartmann, T.N.1    Burger, J.A.2    Glodek, A.3    Fujii, N.4    Burger, M.5
  • 69
    • 54249151684 scopus 로고    scopus 로고
    • Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction
    • Das B., Tsuchida R., Malkin D., Koren G., Baruchel S., and Yeger. Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction. Stem Cells 26 (2008) 1818-1830
    • (2008) Stem Cells , vol.26 , pp. 1818-1830
    • Das, B.1    Tsuchida, R.2    Malkin, D.3    Koren, G.4    Baruchel, S.5    Yeger6
  • 72
    • 55249126800 scopus 로고    scopus 로고
    • The role of endothelial-to-mesenchymal transition in cancer progression
    • Potenta S., Zeisberg E., and Kalluri R. The role of endothelial-to-mesenchymal transition in cancer progression. Brit J Cancer 99 (2008) 1375-1379
    • (2008) Brit J Cancer , vol.99 , pp. 1375-1379
    • Potenta, S.1    Zeisberg, E.2    Kalluri, R.3
  • 73
    • 33846130929 scopus 로고    scopus 로고
    • Functional alterations in macrophages after hypoxia selection
    • Degrossoli A., and Giorgio S. Functional alterations in macrophages after hypoxia selection. Exp Biol Med 232 (2007) 88-95
    • (2007) Exp Biol Med , vol.232 , pp. 88-95
    • Degrossoli, A.1    Giorgio, S.2
  • 74
    • 43249121177 scopus 로고    scopus 로고
    • Stromal gene expression predicts clinical outcome in breast cancer
    • Finak G., Bertos N., Pepin F., Sadekova S., Souleimanova M., Zhao H., et al. Stromal gene expression predicts clinical outcome in breast cancer. Nat Med 14 (2008) 518-527
    • (2008) Nat Med , vol.14 , pp. 518-527
    • Finak, G.1    Bertos, N.2    Pepin, F.3    Sadekova, S.4    Souleimanova, M.5    Zhao, H.6
  • 75
    • 4544275002 scopus 로고    scopus 로고
    • Expression of transforming growth factor-beta 1 and growth in soft agar differentiate prostate carcinoma-associated fibroblasts from normal prostate fibroblasts
    • San Francisco I.F., DeWolf W.C., Peehl D.M., and Olumi A.F. Expression of transforming growth factor-beta 1 and growth in soft agar differentiate prostate carcinoma-associated fibroblasts from normal prostate fibroblasts. Int J Cancer 112 (2004) 123-128
    • (2004) Int J Cancer , vol.112 , pp. 123-128
    • San Francisco, I.F.1    DeWolf, W.C.2    Peehl, D.M.3    Olumi, A.F.4
  • 77
    • 9344245148 scopus 로고    scopus 로고
    • Transforming growth factor b receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment
    • Hayashi T., Hideshima T., Nguyen A.N., Munoz O., Podar K., Hamasaki M., et al. Transforming growth factor b receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment. Clin Cancer Res 10 (2004) 7540-7546
    • (2004) Clin Cancer Res , vol.10 , pp. 7540-7546
    • Hayashi, T.1    Hideshima, T.2    Nguyen, A.N.3    Munoz, O.4    Podar, K.5    Hamasaki, M.6
  • 78
    • 33746851956 scopus 로고    scopus 로고
    • Tumor metastasis: mechanistic insights and clinical challenges
    • Steeg P.S. Tumor metastasis: mechanistic insights and clinical challenges. Nat med 12 (2006) 895-904
    • (2006) Nat med , vol.12 , pp. 895-904
    • Steeg, P.S.1
  • 80
    • 34547107592 scopus 로고    scopus 로고
    • Hypoxia-driven selection of the metastatic phenotype
    • Sullivan R., and Graham C.H. Hypoxia-driven selection of the metastatic phenotype. Cancer Mets Rev 26 (2007) 319-331
    • (2007) Cancer Mets Rev , vol.26 , pp. 319-331
    • Sullivan, R.1    Graham, C.H.2
  • 82
    • 0033032317 scopus 로고    scopus 로고
    • Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo
    • Sethi T, Rintoul RC, Moore SM, MacKinnon AC, Salter D, Choo C, et al. Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo. Nat Med 199;5:662-68.
    • Nat Med , vol.199 , Issue.5 , pp. 662-668
    • Sethi, T.1    Rintoul, R.C.2    Moore, S.M.3    MacKinnon, A.C.4    Salter, D.5    Choo, C.6
  • 83
    • 37549013776 scopus 로고    scopus 로고
    • A microenvironmental model of carcinogenesis
    • Gatenby R.A., and Gillies R.J. A microenvironmental model of carcinogenesis. Nat Rev Cancer 8 (2008) 56-61
    • (2008) Nat Rev Cancer , vol.8 , pp. 56-61
    • Gatenby, R.A.1    Gillies, R.J.2
  • 85
    • 34548578994 scopus 로고    scopus 로고
    • The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling
    • Ide T., Kitajima Y., Miyoshi A., Ohtsuka T., Mitsuno M., Ohtaka K., et al. The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling. Ann Surg Oncol 14 (2007) 2600-2607
    • (2007) Ann Surg Oncol , vol.14 , pp. 2600-2607
    • Ide, T.1    Kitajima, Y.2    Miyoshi, A.3    Ohtsuka, T.4    Mitsuno, M.5    Ohtaka, K.6
  • 86
    • 36349006961 scopus 로고    scopus 로고
    • Development and characterization of gemcitabine-resistant pancreatic tumor cells
    • Shah A.N., Summy J.M., Zhang J., Park S.I., Parikh N.U., and Gallick G.E. Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann Surg Oncol 14 (2007) 3629-3637
    • (2007) Ann Surg Oncol , vol.14 , pp. 3629-3637
    • Shah, A.N.1    Summy, J.M.2    Zhang, J.3    Park, S.I.4    Parikh, N.U.5    Gallick, G.E.6
  • 87
    • 40949143108 scopus 로고    scopus 로고
    • Gemcitabine resistance in pancreatic cancer: picking the key players
    • Kim M.P., and Gallick G.E. Gemcitabine resistance in pancreatic cancer: picking the key players. Clin Cancer Res 14 (2008) 1284-1285
    • (2008) Clin Cancer Res , vol.14 , pp. 1284-1285
    • Kim, M.P.1    Gallick, G.E.2
  • 88
    • 33645302628 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition: new insights in signaling, development and disease
    • Lee J.M., Dedhar S., Kalluri R., and Thompson E.W. The epithelial-mesenchymal transition: new insights in signaling, development and disease. J Cell Biol 172 (2006) 973-981
    • (2006) J Cell Biol , vol.172 , pp. 973-981
    • Lee, J.M.1    Dedhar, S.2    Kalluri, R.3    Thompson, E.W.4
  • 89
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani S.A., Guo W., Liao M.J., Eaton E.N., Ayyanan A., Zhou A.Y., et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133 (2008) 704-715
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 90
    • 47549102418 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition traits in human breast cancer cell lines
    • Blick T., Widodo E., Hugo H., Waltham M., Lenburg M.E., Neve R.M., et al. Epithelial mesenchymal transition traits in human breast cancer cell lines. Clin Exp Mets 25 (2008) 629-642
    • (2008) Clin Exp Mets , vol.25 , pp. 629-642
    • Blick, T.1    Widodo, E.2    Hugo, H.3    Waltham, M.4    Lenburg, M.E.5    Neve, R.M.6
  • 91
    • 33847345143 scopus 로고    scopus 로고
    • Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition
    • Buck E., Eyzaguirre A., Barr S., Thompson S., Sennello R., Young D., et al. Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition. Mol Cancer Ther 6 (2007) 532-541
    • (2007) Mol Cancer Ther , vol.6 , pp. 532-541
    • Buck, E.1    Eyzaguirre, A.2    Barr, S.3    Thompson, S.4    Sennello, R.5    Young, D.6
  • 92
    • 34250711876 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma
    • Frederick B.A., Helfrich B.A., Coldren C.D., Zheng D., Chan D., Bunn Jr. P.A., et al. Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma. Mol Cancer Ther 6 (2007) 1683-1691
    • (2007) Mol Cancer Ther , vol.6 , pp. 1683-1691
    • Frederick, B.A.1    Helfrich, B.A.2    Coldren, C.D.3    Zheng, D.4    Chan, D.5    Bunn Jr., P.A.6
  • 93
    • 53249130662 scopus 로고    scopus 로고
    • Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers
    • Sabbah M., Emami S., Redeuilh G., Julien S., Prevost G., Zimber A., et al. Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers. Drug Resist Updates 11 (2008) 123-151
    • (2008) Drug Resist Updates , vol.11 , pp. 123-151
    • Sabbah, M.1    Emami, S.2    Redeuilh, G.3    Julien, S.4    Prevost, G.5    Zimber, A.6
  • 94
    • 0031418669 scopus 로고    scopus 로고
    • Prostate carcinoma response to cytotoxic therapy: in vivo resistance
    • Teicher B.A., Kakeji Y., Ara G., Herbst R.S., and Northey D. Prostate carcinoma response to cytotoxic therapy: in vivo resistance. In Vivo 11 (1997) 453-462
    • (1997) In Vivo , vol.11 , pp. 453-462
    • Teicher, B.A.1    Kakeji, Y.2    Ara, G.3    Herbst, R.S.4    Northey, D.5
  • 95
    • 10744227500 scopus 로고    scopus 로고
    • Genotypic and phenotypic comparisons of de novo and acquired melphalan resistance in an isogenic multiple myeloma cell line model
    • Hazlehurst L.A., Enkemann S.A., Beam C.A., Argilagos R.F., Painter J., Shain K.H., et al. Genotypic and phenotypic comparisons of de novo and acquired melphalan resistance in an isogenic multiple myeloma cell line model. Cancer Res 63 (2003) 7900-7906
    • (2003) Cancer Res , vol.63 , pp. 7900-7906
    • Hazlehurst, L.A.1    Enkemann, S.A.2    Beam, C.A.3    Argilagos, R.F.4    Painter, J.5    Shain, K.H.6
  • 97
    • 31544445218 scopus 로고    scopus 로고
    • Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms
    • Wu W., Luo Y., Sun C., Kuo P., Varga J., Xiang R., et al. Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms. Cancer Res 66 (2006) 970-980
    • (2006) Cancer Res , vol.66 , pp. 970-980
    • Wu, W.1    Luo, Y.2    Sun, C.3    Kuo, P.4    Varga, J.5    Xiang, R.6
  • 98
    • 34547580590 scopus 로고    scopus 로고
    • HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation
    • Gordan J.D., Thompson C.B., and Simon M.C. HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 12 (2007) 108-113
    • (2007) Cancer Cell , vol.12 , pp. 108-113
    • Gordan, J.D.1    Thompson, C.B.2    Simon, M.C.3
  • 100
    • 2942622376 scopus 로고    scopus 로고
    • The potential pf positron-emission tomography to study anticancer-drug resistance
    • West C.M.L., Jones T., and Price P. The potential pf positron-emission tomography to study anticancer-drug resistance. Nat Rev Cancer 4 (2004) 457-469
    • (2004) Nat Rev Cancer , vol.4 , pp. 457-469
    • West, C.M.L.1    Jones, T.2    Price, P.3
  • 101
    • 46449101522 scopus 로고    scopus 로고
    • Hematopoietic cell transplantation for non-Hodgkin's lymphoma: yesterday, today and tomorrow
    • Appelbaum F.R. Hematopoietic cell transplantation for non-Hodgkin's lymphoma: yesterday, today and tomorrow. J Clin Oncol 26 (2008) 2927-2929
    • (2008) J Clin Oncol , vol.26 , pp. 2927-2929
    • Appelbaum, F.R.1
  • 102
    • 33947596504 scopus 로고    scopus 로고
    • Why is cancer drug discovery so difficult?
    • Kamb A., Wee S., and Lengauer C. Why is cancer drug discovery so difficult?. Nat Rev Drug Discov 6 (2007) 115-120
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 115-120
    • Kamb, A.1    Wee, S.2    Lengauer, C.3
  • 103
    • 33846646004 scopus 로고    scopus 로고
    • The prospects for "personalized medicine" in drug development and drug therapy
    • Woodcock J. The prospects for "personalized medicine" in drug development and drug therapy. Nature 81 (2007) 164-169
    • (2007) Nature , vol.81 , pp. 164-169
    • Woodcock, J.1


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