메뉴 건너뛰기




Volumn 14, Issue 1, 2014, Pages 147-169

Recent advances in multinuclear complexes as potential anticancer and DNA binding agents

Author keywords

Cytotoxicity; DNA binding; Metal based anticancer agents; Multinuclear complexes; Platinum complexes; Ruthenium complexes

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; CISPLATIN; DIRUTHENIUM ARENE COMPLEX; KP1019; OXALIPLATIN; PLATINUM COMPLEX; RUTHENIUM COMPLEX; TRIPLATIN TETRANITRATE; UNCLASSIFIED DRUG;

EID: 84899412809     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/18715206113139990313     Document Type: Review
Times cited : (35)

References (143)
  • 3
    • 11144242211 scopus 로고    scopus 로고
    • Timeline: Chemotherapy and the war on cancer
    • Chabner, B.A.; Roberts, T.G. Timeline: Chemotherapy and the war on cancer. Nat. Rev. Cancer, 2005, 5(1), 65-72.
    • (2005) Nat. Rev. Cancer , vol.5 , Issue.1 , pp. 65-72
    • Chabner, B.A.1    Roberts, T.G.2
  • 4
    • 0034777823 scopus 로고    scopus 로고
    • Current and future potential roles of the platinum drugs in the treatment of ovarian cancer
    • Piccart, M.J.; Lamb, H.; Vermorken, J.B. Current and future potential roles of the platinum drugs in the treatment of ovarian cancer. Ann. Oncol., 2001, 12, 1195-1203.
    • (2001) Ann. Oncol , vol.12 , pp. 1195-1203
    • Piccart, M.J.1    Lamb, H.2    Vermorken, J.B.3
  • 5
    • 2542422438 scopus 로고    scopus 로고
    • Structure, recognition, and processing of cisplatin-DNA adducts
    • Jamieson, E.R.; Lippard, S.J. Structure, recognition, and processing of cisplatin-DNA adducts. Chem. Rev., 1999, 99, 2467-2498.
    • (1999) Chem. Rev , vol.99 , pp. 2467-2498
    • Jamieson, E.R.1    Lippard, S.J.2
  • 6
    • 0029671174 scopus 로고    scopus 로고
    • Prevention of cisplatin nephrotoxicity by exogenous atrial natriuretic peptide
    • Deegan, P.M.; Basinger, M.A.; Jones, M.M.; Hande, K.R. Prevention of cisplatin nephrotoxicity by exogenous atrial natriuretic peptide. Toxicology, 1996, 106(1-3), 159-166.
    • (1996) Toxicology , vol.106 , Issue.1-3 , pp. 159-166
    • Deegan, P.M.1    Basinger, M.A.2    Jones, M.M.3    Hande, K.R.4
  • 7
    • 1242329822 scopus 로고    scopus 로고
    • Platinum-based chemotherapy in metastatic breast cancer: Current status
    • Decatris, M.P.; Sundar, S.; O'Byrne, K.J. Platinum-based chemotherapy in metastatic breast cancer: Current status. Cancer Treat. Rev., 2004, 30(1), 53-81.
    • (2004) Cancer Treat. Rev , vol.30 , Issue.1 , pp. 53-81
    • Decatris, M.P.1    Sundar, S.2    O'Byrne, K.J.3
  • 9
    • 33846404174 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance and toxicity associated with platinating agents
    • Rabik, C.A.; Dolan, M.E. Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treat. Rev., 2007, 33(1), 9-23.
    • (2007) Cancer Treat. Rev , vol.33 , Issue.1 , pp. 9-23
    • Rabik, C.A.1    Dolan, M.E.2
  • 10
    • 0037366133 scopus 로고    scopus 로고
    • Biochemical modulation of Cisplatin mechanisms of action: Enhancement of antitumor activity and circumvention of drug resistance
    • Fuertes, M.A.; Alonso, C.; Pérez, J.M. Biochemical modulation of Cisplatin mechanisms of action: Enhancement of antitumor activity and circumvention of drug resistance. Chem. Rev., 2003, 103(3), 645-662.
    • (2003) Chem. Rev , vol.103 , Issue.3 , pp. 645-662
    • Fuertes, M.A.1    Alonso, C.2    Pérez, J.M.3
  • 11
    • 63449107893 scopus 로고    scopus 로고
    • Towards antitumor active trans-platinum compounds
    • Aris, S.M.; Farrell, P.N. Towards antitumor active trans-platinum compounds. Eur. J. Inorg. Chem., 2009, 2009(10), 1293-1302.
    • (2009) Eur. J. Inorg. Chem , vol.2009 , Issue.10 , pp. 1293-1302
    • Aris, S.M.1    Farrell, P.N.2
  • 12
    • 79961131166 scopus 로고    scopus 로고
    • Mono-carboxylated diaminedichloridoplatinum(IV) complexes - selective synthesis,characterization, and cytotoxicity
    • Pichler, V.; Valiahdi, M.S.; Jakupec, A.M.; Arion, B.V.; Galanski, M.; Keppler, K.B. Mono-carboxylated diaminedichloridoplatinum(IV) complexes - selective synthesis, characterization, and cytotoxicity. Dalton Trans., 2011, 40, 8187-8192.
    • (2011) Dalton Trans , vol.40 , pp. 8187-8192
    • Pichler, V.1    Valiahdi, M.S.2    Jakupec, A.M.3    Arion, B.V.4    Galanski, M.5    Keppler, K.B.6
  • 15
    • 0042948708 scopus 로고    scopus 로고
    • Ruthenium metallopharmaceuticals
    • Clarke, M.J. Ruthenium metallopharmaceuticals. Coord. Chem. Rev., 2003, 236, 209-233.
    • (2003) Coord. Chem. Rev , vol.236 , pp. 209-233
    • Clarke, M.J.1
  • 17
    • 79958173252 scopus 로고    scopus 로고
    • Synthesis, characterization, interaction with DNA, and cytotoxic effect in vitro of new mono- and dinuclear Pd(II) and Pt(II) complexes with benzo[d]thiazol-2-amine as the primary ligand
    • Gao, E.J.; Liu, L.; Zhu, M.C.; Huang, Y.; Guan, F.; Gao, X.N.; Zhang, M.; Wang, L.; Zhang, W.Z.; Sun, Y.G. Synthesis, characterization, interaction with DNA, and cytotoxic effect in vitro of new mono- and dinuclear Pd(II) and Pt(II) complexes with benzo[d]thiazol-2-amine as the primary ligand. Inorg. Chem., 2011, 50, 4732-4741.
    • (2011) Inorg. Chem , vol.50 , pp. 4732-4741
    • Gao, E.J.1    Liu, L.2    Zhu, M.C.3    Huang, Y.4    Guan, F.5    Gao, X.N.6    Zhang, M.7    Wang, L.8    Zhang, W.Z.9    Sun, Y.G.10
  • 19
    • 40549126597 scopus 로고    scopus 로고
    • Towards the rational design of platinum(II) and gold(III) complexes as antitumour agents
    • Wang, X.Y.; Guo, Z.J. Towards the rational design of platinum(II) and gold(III) complexes as antitumour agents. Dalton Trans., 2008, 12, 1521-1532.
    • (2008) Dalton Trans , vol.12 , pp. 1521-1532
    • Wang, X.Y.1    Guo, Z.J.2
  • 20
    • 48749112919 scopus 로고    scopus 로고
    • A platinum supramolecular square as an effective G-Quadruplex binder and telomerase inhibitor
    • Kieltyka, R.; Englebienne, P.; Fakhoury, J.; Autexier, C.; Moitessier N.; Sleiman, F.H. A platinum supramolecular square as an effective G-Quadruplex binder and telomerase inhibitor. J. Am. Chem. Soc., 2008, 130 (31), 10040-10041.
    • (2008) J. Am. Chem. Soc , vol.130 , Issue.31 , pp. 10040-10041
    • Kieltyka, R.1    Englebienne, P.2    Fakhoury, J.3    Autexier, C.4    Moitessier, N.5    Sleiman, F.H.6
  • 21
    • 34250652117 scopus 로고    scopus 로고
    • Targeting the mitochondrial cell death pathway with gold compounds
    • Barnard, P.J.; Berners-Price, S.J. Targeting the mitochondrial cell death pathway with gold compounds. Coord. Chem. Rev., 2007, 251(13-14), 1889-1902.
    • (2007) Coord. Chem. Rev , vol.251 , Issue.13-14 , pp. 1889-1902
    • Barnard, P.J.1    Berners-Price, S.J.2
  • 24
    • 0038607957 scopus 로고    scopus 로고
    • Multinuclear platinum complexes as anticancer drugs
    • Wheate, N.J.; Collins, J.G. Multinuclear platinum complexes as anticancer drugs. Coord. Chem. Rev., 2003, 241, 133-145.
    • (2003) Coord. Chem. Rev , vol.241 , pp. 133-145
    • Wheate, N.J.1    Collins, J.G.2
  • 25
    • 0007279088 scopus 로고    scopus 로고
    • DNA binding of properties of trinuclear platinum complex
    • Qu, Y.; Farrell, N.; Kasparkova, J.; Brabec, V. DNA binding of properties of trinuclear platinum complex. J. Inorg. Biochem., 1997, 67, 174.
    • (1997) J. Inorg. Biochem , vol.67 , pp. 174
    • Qu, Y.1    Farrell, N.2    Kasparkova, J.3    Brabec, V.4
  • 27
    • 5344249332 scopus 로고    scopus 로고
    • Potential adenine and minor groove binding platinum complexes
    • Collins, J.G.; Wheate, J.N. Potential adenine and minor groove binding platinum complexes, J. Inorg. Biochem., 2004, 98(10), 1578-1584.
    • (2004) J. Inorg. Biochem , vol.98 , Issue.10 , pp. 1578-1584
    • Collins, J.G.1    Wheate, J.N.2
  • 28
    • 68149114459 scopus 로고    scopus 로고
    • Tetranuclear coordination assemblies based on half-sandwich Ruthenium(II) complexes: Noncovalent binding to DNA and cyctoxicity
    • Linares, F.; Galindo, A.M.; Galli, S.; Romero, M.A.; Navarro, A.R.J.; Barea, E. Tetranuclear coordination assemblies based on half-sandwich Ruthenium(II) complexes: Noncovalent binding to DNA and cyctoxicity. Inorg. Chem., 2009, 48(15), 7413-7420.
    • (2009) Inorg. Chem , vol.48 , Issue.15 , pp. 7413-7420
    • Linares, F.1    Galindo, A.M.2    Galli, S.3    Romero, M.A.4    Navarro, A.R.J.5    Barea, E.6
  • 29
    • 56349146078 scopus 로고    scopus 로고
    • Interaction of dinuclear ruthenium(JJ) supramolecular cylinders with DNA: Sequence-specific binding, unwingding, and photocleavage
    • Malina, J.; Hannon, J.M.; Brabec, V. Interaction of dinuclear ruthenium(JJ) supramolecular cylinders with DNA: Sequence-specific binding, unwingding, and photocleavage. Chem. Eur. J., 2008, 14, 10408-10414.
    • (2008) Chem. Eur. J , vol.14 , pp. 10408-10414
    • Malina, J.1    Hannon, J.M.2    Brabec, V.3
  • 30
    • 34247856045 scopus 로고    scopus 로고
    • A trinuclear copper(II) complex of 2, 4, 6-tirs(di-2-pyridylamine) -1, 3, 5-triazine shows prominent DNA cleavage activity
    • Chen, J.W.; Wang, X.Y.; Shao, Y.; Zhu, J.H.; Zhu, Y.G.; Li, Y.Z.; Xu, Q.; Guo, Z.J. A trinuclear copper(II) complex of 2, 4, 6-tirs(di-2-pyridylamine) -1, 3, 5-triazine shows prominent DNA cleavage activity. Inorg. Chem., 2007, 46, 3306-3312.
    • (2007) Inorg. Chem , vol.46 , pp. 3306-3312
    • Chen, J.W.1    Wang, X.Y.2    Shao, Y.3    Zhu, J.H.4    Zhu, Y.G.5    Li, Y.Z.6    Xu, Q.7    Guo, Z.J.8
  • 31
    • 0002007781 scopus 로고    scopus 로고
    • Binuclear ruthenium(II) phenanthroline compounds with extreme binding affinity for DNA
    • Lincoln, P.; Nordén, B. Binuclear ruthenium(II) phenanthroline compounds with extreme binding affinity for DNA. Chem. Commun., 1996, 2145-2146.
    • (1996) Chem. Commun , pp. 2145-2146
    • Lincoln, P.1    Nordén, B.2
  • 33
    • 57849105915 scopus 로고    scopus 로고
    • DNA hydrolytic cleavage catalyzed by synthetic multinuclear metallonucleases
    • Liu, C.L.; Wang, L. DNA hydrolytic cleavage catalyzed by synthetic multinuclear metallonucleases. Dalton Trans., 2009, 227-239.
    • (2009) Dalton Trans , pp. 227-239
    • Liu, C.L.1    Wang, L.2
  • 34
    • 1142267465 scopus 로고    scopus 로고
    • DNA hydrolysis promoted by di- and multi-nuclear metal complexes
    • Liu, C.L.; Wang, M.; Zhang, T.L.; Sun, H.Z. DNA hydrolysis promoted by di- and multi-nuclear metal complexes. Coord. Chem. Rev., 2004, 248, 147-168.
    • (2004) Coord. Chem. Rev , vol.248 , pp. 147-168
    • Liu, C.L.1    Wang, M.2    Zhang, T.L.3    Sun, H.Z.4
  • 36
    • 31044449467 scopus 로고    scopus 로고
    • Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Ehance-ment of cellular uptake with charge
    • Harris, L.A.; Yang, X.H.; Hegmans, A.; Povirk, L.; Ryan, J.; Kelland, L.; Farrell, P.N. Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Ehance-ment of cellular uptake with charge. Inorg. Chem., 2005, 44, 9598-9600.
    • (2005) Inorg. Chem , vol.44 , pp. 9598-9600
    • Harris, L.A.1    Yang, X.H.2    Hegmans, A.3    Povirk, L.4    Ryan, J.5    Kelland, L.6    Farrell, P.N.7
  • 37
    • 31044440218 scopus 로고    scopus 로고
    • 4+ (BBR 3464) with its noncovalent congeners
    • 4+ (BBR 3464) with its noncovalent congeners. Mol. Pharm., 2006, 69(2), 666-672.
    • (2006) Mol. Pharm , vol.69 , Issue.2 , pp. 666-672
    • Harris, A.L.1    Ryan, J.J.2    Farrell, N.3
  • 38
    • 79958261953 scopus 로고    scopus 로고
    • Effects of noncovalent platinum drug-protein interactions on drug efficacy: Use of fluorescent conjugates as probes for drug metabolism
    • Benedetti, B.T.; Peterson, E.J.; Kabolizadeh, P.; Martínez, A.; Kipping, R.; Farrell, N.P. Effects of noncovalent platinum drug-protein interactions on drug efficacy: Use of fluorescent conjugates as probes for drug metabolism. Mol. Pharmaceutics., 2011, 8, 940-948.
    • (2011) Mol. Pharmaceutics , vol.8 , pp. 940-948
    • Benedetti, B.T.1    Peterson, E.J.2    Kabolizadeh, P.3    Martínez, A.4    Kipping, R.5    Farrell, N.P.6
  • 42
    • 32344437845 scopus 로고    scopus 로고
    • Mono- and polynulcear [alkylamine] platinum(U) complexes of [1, 2-bis(4-fluorophenyl) ethylenediamine] platinum(U): Synthesis and investigations on cyctotoxicity, cellular distribution, and DNA and protein binding
    • Kapp, T.; Dullin, A.; Gust, R. Mono- and polynulcear [alkylamine] platinum(U) complexes of [1, 2-bis(4-fluorophenyl) ethylenediamine] platinum(U): synthesis and investigations on cyctotoxicity, cellular distribution, and DNA and protein binding. J. Med. Chem., 2006, 49, 1182-1190.
    • (2006) J. Med. Chem , vol.49 , pp. 1182-1190
    • Kapp, T.1    Dullin, A.2    Gust, R.3
  • 43
    • 77049106919 scopus 로고    scopus 로고
    • Platinum(II)-dendrimer conjugates: Synthesis, and investigations on cyctotoxicity, cell distribution, platinum release, DNA, and protein binding
    • Kapp, T.; Dullin, A.; Gust, R platinum(II)-dendrimer conjugates: Synthesis, and investigations on cyctotoxicity, cell distribution, platinum release, DNA, and protein binding. Bioconjugate Chem., 2010, 21, 328-337.
    • (2010) Bioconjugate Chem , vol.21 , pp. 328-337
    • Kapp, T.1    Dullin, A.2    Gust, R.3
  • 44
    • 33847404019 scopus 로고    scopus 로고
    • 8 (en=ethylenediamine, N-N= 4, 4-bipyridine or 1, 4-bis(4-pyridyl)tetrafluorobenzene)
    • Mounir, M.; Lorenzo, J.; Ferrer, M.; Prieto, J.M.; Rossell, O.; Avilès, X.F.; Moreno, V. DNA interaction and antiproliferative behavior of the water soluble platinum supramolecular squares [(en)Pt(N-N)4(NO3)]8 (en=ethylenediamine, N-N= 4, 4-bipyridine or 1, 4-bis(4-pyridyl)tetrafluorobenzene). J. Inorg. Biochem., 2007, 101, 660-666.
    • (2007) J. Inorg. Biochem , vol.101 , pp. 660-666
    • Mounir, M.1    Lorenzo, J.2    Ferrer, M.3    Prieto, J.M.4    Rossell, O.5    Avilès, X.F.6    Moreno, V.7
  • 45
    • 25144494552 scopus 로고    scopus 로고
    • Synthesis and anti-cancer activity of dinuclear platinum(U) complexes containing bis(thioalkyl) dicarba-closo-dodecaborane(12) ligands
    • Woodhouse, L.S.; Ziolkowski, J.E.; Rendina, M.L. Synthesis and anti-cancer activity of dinuclear platinum(U) complexes containing bis(thioalkyl) dicarba-closo-dodecaborane(12) ligands. Dalton Trans., 2005, 17, 2827-2829.
    • (2005) Dalton Trans , vol.17 , pp. 2827-2829
    • Woodhouse, L.S.1    Ziolkowski, J.E.2    Rendina, M.L.3
  • 46
    • 33745675502 scopus 로고    scopus 로고
    • A positively charged trinuclear 3N-chelated monofunctional platinum complex with high DNA affinity and potent cytotoxicity
    • Zhao, Y.M.; He, W.J.; Shi, P.F.; Zhu, J.H.; Qiu, L.; Lin, L.P.; Guo, Z.J. A positively charged trinuclear 3N-chelated monofunctional platinum complex with high DNA affinity and potent cytotoxicity. Dalton Trans., 2006, 22, 2617-2619.
    • (2006) Dalton Trans , vol.22 , pp. 2617-2619
    • Zhao, Y.M.1    He, W.J.2    Shi, P.F.3    Zhu, J.H.4    Qiu, L.5    Lin, L.P.6    Guo, Z.J.7
  • 47
    • 66249130986 scopus 로고    scopus 로고
    • DNA cross-linking patterns induced by an antitumor active trinuclear platinum complex and comparison with its dinuclear analog
    • Zhu, J.H.; Zhao, Y.M.; Zhu, Y.Y.; Wu, Z.Y.; Lin, M.X.; He, W.J.; Wang, Y.; Chen, G.J.; Dong, L.; Zhang, J.F.; Lu, Y.; Guo, Z.J. DNA cross-linking patterns induced by an antitumor active trinuclear platinum complex and comparison with its dinuclear analog. Chem. Eur. J., 2009, 15, 5245-5253.
    • (2009) Chem. Eur. J , vol.15 , pp. 5245-5253
    • Zhu, J.H.1    Zhao, Y.M.2    Zhu, Y.Y.3    Wu, Z.Y.4    Lin, M.X.5    He, W.J.6    Wang, Y.7    Chen, G.J.8    Dong, L.9    Zhang, J.F.10    Lu, Y.11    Guo, Z.J.12
  • 48
    • 84055221948 scopus 로고    scopus 로고
    • Noncovalent interactions between a trinuclear monofunctional platinum complex and human serum albumin
    • Wang, Y.Q.; Wang, X.Y.; Wang, J.; Zhao, Y.M.; He, W.J.; Guo, Z.J. Noncovalent interactions between a trinuclear monofunctional platinum complex and human serum albumin. Inorg. Chem., 2011, 50, 12661-12668.
    • (2011) Inorg. Chem , vol.50 , pp. 12661-12668
    • Wang, Y.Q.1    Wang, X.Y.2    Wang, J.3    Zhao, Y.M.4    He, W.J.5    Guo, Z.J.6
  • 49
    • 34548512846 scopus 로고    scopus 로고
    • Mono and polynuclear complexes of Pt(U) with polypyridyl ligands. synthesis, spectroscopic and structural characterization and cytotoxic activity
    • Rubino, S.; Portanova, P.; Albanese, A.; Calvaruso, G.; Orecchio, S.; Fontana, G.; Stocco, G.C. Mono and polynuclear complexes of Pt(U) with polypyridyl ligands. synthesis, spectroscopic and structural characterization and cytotoxic activity. J. Inorg. Biochem., 2007, 101, 1473-1482.
    • (2007) J. Inorg. Biochem , vol.101 , pp. 1473-1482
    • Rubino, S.1    Portanova, P.2    Albanese, A.3    Calvaruso, G.4    Orecchio, S.5    Fontana, G.6    Stocco, G.C.7
  • 50
    • 34249906440 scopus 로고    scopus 로고
    • A dinuclear monofunctional platinum(U) complex with an aromatic linker show low reactivity towards glutathione but high DNA binding ability and antitumor activity
    • Fan, D.M.; Yang, X.L.; Wang, X.Y.; Zhang, S.C.; Mao, J.F; Ding, J.; Lin, L.P.; Guo, Z.J. A dinuclear monofunctional platinum(U) complex with an aromatic linker show low reactivity towards glutathione but high DNA binding ability and antitumor activity. J. Biol. Inorg. Chem., 2007, 12, 655-665.
    • (2007) J. Biol. Inorg. Chem , vol.12 , pp. 655-665
    • Fan, D.M.1    Yang, X.L.2    Wang, X.Y.3    Zhang, S.C.4    Mao, J.F.5    Ding, J.6    Lin, L.P.7    Guo, Z.J.8
  • 51
    • 71549145300 scopus 로고    scopus 로고
    • The role of bridging ligands in determining DNA binding ability and cross linking patterns of dinuclear platinum antitumour complexes
    • Zhu, J.H.; Lin, M.X.; Fan, D.M.; Wu, Z.Y.; Chen, Y.C.; Zhang, J.F.; Lu, Y.; Guo, Z.J. The role of bridging ligands in determining DNA binding ability and cross linking patterns of dinuclear platinum antitumour complexes. Dalton Trans., 2009, 48, 10889-10895.
    • (2009) Dalton Trans , vol.48 , pp. 10889-10895
    • Zhu, J.H.1    Lin, M.X.2    Fan, D.M.3    Wu, Z.Y.4    Chen, Y.C.5    Zhang, J.F.6    Lu, Y.7    Guo, Z.J.8
  • 52
    • 33646956829 scopus 로고    scopus 로고
    • Non-platinum chemotherapeutic metallopharmaceuticals
    • Clarke, M.J.; Zhu, F.C. Frasca, D. R Non-platinum chemotherapeutic metallopharmaceuticals. Chem. Rev., 1999, 99, 2511-2533.
    • (1999) Chem. Rev , vol.99 , pp. 2511-2533
    • Clarke, M.J.1    Zhu, F.C.2    Frasca, D.R.3
  • 53
    • 0043073120 scopus 로고    scopus 로고
    • New metal complexes as potential therapeutics
    • Zhang, C.X.; Lippard, S.J. New metal complexes as potential therapeutics. Curr. Opin. Chem. Biol., 2003, 7, 481-489.
    • (2003) Curr. Opin. Chem. Biol , vol.7 , pp. 481-489
    • Zhang, C.X.1    Lippard, S.J.2
  • 54
    • 0141811013 scopus 로고    scopus 로고
    • Recent developments in the field of tumor-ihibiting metal complexes
    • Galanski, M.; Arion, V.B.; Jakupec, M.A.; Keppler, B.K. Recent developments in the field of tumor-ihibiting metal complexes. Curr. Pharm., 2003, 9, 2078-2089.
    • (2003) Curr. Pharm , vol.9 , pp. 2078-2089
    • Galanski, M.1    Arion, V.B.2    Jakupec, M.A.3    Keppler, B.K.4
  • 55
    • 84865677118 scopus 로고    scopus 로고
    • Light acivated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window
    • Wachter, E.; Heidary, D.; Howerton, B.S.; Parkin, S.; Glazer, E.C. Light acivated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window. Chem. Commun., 2012, 48, 9649-9651.
    • (2012) Chem. Commun , vol.48 , pp. 9649-9651
    • Wachter, E.1    Heidary, D.2    Howerton, B.S.3    Parkin, S.4    Glazer, E.C.5
  • 57
    • 57949087525 scopus 로고    scopus 로고
    • A fluorinated ruthenium porphyrin as a potential photodynamic therapy agent: Synthesis, characterization, DNA binding and melanoma cell studies
    • Rani-Beeram, S.; Meyer, K.; McCrate, A.; Hong, Y.; Nielsen, M.; Swavey, S. A fluorinated ruthenium porphyrin as a potential photodynamic therapy agent: Synthesis, characterization, DNA binding and melanoma cell studies. Inorg. Chem., 2008, 47, 11278-11283.
    • (2008) Inorg. Chem , vol.47 , pp. 11278-11283
    • Rani-Beeram, S.1    Meyer, K.2    McCrate, A.3    Hong, Y.4    Nielsen, M.5    Swavey, S.6
  • 59
    • 77956074303 scopus 로고    scopus 로고
    • Selective mitochondrial accumulation of cyctotoxic dinuclear polypyridy ruthenium(H) complexes
    • Pisani, M.J.; Weber, D.K.; Heimann, K.; Collins, J.G.; Keene, F.R. Selective mitochondrial accumulation of cyctotoxic dinuclear polypyridy ruthenium(H) complexes. Metallomics, 2010, 2, 393-396.
    • (2010) Metallomics , vol.2 , pp. 393-396
    • Pisani, M.J.1    Weber, D.K.2    Heimann, K.3    Collins, J.G.4    Keene, F.R.5
  • 60
    • 33745384809 scopus 로고    scopus 로고
    • From bench to bedside -preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)
    • Hartinger, C.G.; Zorbas-Seifried, S.; Jakupec, M.A.; Kynast, B.; Zorbas, H.; Keppler, B.K. From bench to bedside -preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A). J. Inorg. Biochem., 2006, 100, 891-904.
    • (2006) J. Inorg. Biochem , vol.100 , pp. 891-904
    • Hartinger, C.G.1    Zorbas-Seifried, S.2    Jakupec, M.A.3    Kynast, B.4    Zorbas, H.5    Keppler, B.K.6
  • 61
    • 2542625358 scopus 로고    scopus 로고
    • A phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuth, a novel ruthenium anticancer agent
    • Rademaker-Lakhai, J.M.; Bongard, D.V.D.; Pluim, D.; Beijnen, J.H.; Schellens, J.H.M. A phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuth, a novel ruthenium anticancer agent. Clin. Cancer Res., 2004, 10, 3717-3727.
    • (2004) Clin. Cancer Res , vol.10 , pp. 3717-3727
    • Rademaker-Lakhai, J.M.1    Bongard, D.V.D.2    Pluim, D.3    Beijnen, J.H.4    Schellens, J.H.M.5
  • 62
    • 79551485516 scopus 로고    scopus 로고
    • Oligonulcear polypyridyruthenium(H) complexes incorporating flexible polar and non-polar brigdes: Synthesis, DNA-binding and cytotoxicity
    • Mulyana, Y.; Webber, D.K.; Buck, D.P.; Motti, C.A; Collins, J.G.; Keene, F.R. Oligonulcear polypyridyruthenium(H) complexes incorporating flexible polar and non-polar brigdes: Synthesis, DNA-binding and cytotoxicity. Dalton Trans., 2011, 40, 1510-1523.
    • (2011) Dalton Trans , vol.40 , pp. 1510-1523
    • Mulyana, Y.1    Webber, D.K.2    Buck, D.P.3    Motti, C.A.4    Collins, J.G.5    Keene, F.R.6
  • 63
    • 84856279815 scopus 로고    scopus 로고
    • Synthesis, nucleic acid binding and cyctotoxicity of oligonuclear ruthenium complexes containing labile ligands
    • Mulyana, Y.; Collins, G.; Keene, R. Synthesis, nucleic acid binding and cyctotoxicity of oligonuclear ruthenium complexes containing labile ligands. J. Incl. Phenom. Macrocycl. Chem., 2011, 71, 371-379.
    • (2011) J. Incl. Phenom. Macrocycl. Chem , vol.71 , pp. 371-379
    • Mulyana, Y.1    Collins, G.2    Keene, R.3
  • 67
    • 34249744968 scopus 로고    scopus 로고
    • Osmium(II) and ruthenium(II) arene maltolato complexes: Rapid hydrolysis and nucleobase binding
    • Peacock, A.F.A.; Melchart, M.; Deeth, R. J.; Habtemariam, A.; Parsons, S.; Sadler, P. J. Osmium(II) and ruthenium(II) arene maltolato complexes: Rapid hydrolysis and nucleobase binding. Chem. J. Eur., 2007, 13, 2601-2613.
    • (2007) Chem. J. Eur , vol.13 , pp. 2601-2613
    • Peacock, A.F.A.1    Melchart, M.2    Deeth, R.J.3    Habtemariam, A.4    Parsons, S.5    Sadler, P.J.6
  • 68
    • 70350735998 scopus 로고    scopus 로고
    • Influence of the arene ligand, the number and type of metal centers and the leaving group on the in vitro anticancer activity of polynuclear organometallic compounds
    • Mendoza-Ferri, M.G.; Hartinger, C.G.; Nazarov, A.A.; Eichinger, R.E.; Jakupec, M.A.; Jakupec, M.A.; Keppler, B.K. Influence of the arene ligand, the number and type of metal centers and the leaving group on the in vitro anticancer activity of polynuclear organometallic compounds. Organometallics, 2009, 28, 6260-6265.
    • (2009) Organometallics , vol.28 , pp. 6260-6265
    • Mendoza-Ferri, M.G.1    Hartinger, C.G.2    Nazarov, A.A.3    Eichinger, R.E.4    Jakupec, M.A.5    Jakupec, M.A.6    Keppler, B.K.7
  • 69
    • 38949087862 scopus 로고    scopus 로고
    • Ferrocenoyl pyridine arene ruthenium complexes with anticancer properties: Synthesis, structure, electrochemistry, and cytotoxicity
    • Auzias, M.; Therrien, B.; Suss-Fink, G.; Stepnicka, P.; Ang, W.H.; Dyson, P.J. Ferrocenoyl pyridine arene ruthenium complexes with anticancer properties: Synthesis, structure, electrochemistry, and cytotoxicity. Inorg. Chem., 2008, 47, 578-583.
    • (2008) Inorg. Chem , vol.47 , pp. 578-583
    • Auzias, M.1    Therrien, B.2    Suss-Fink, G.3    Stepnicka, P.4    Ang, W.H.5    Dyson, P.J.6
  • 70
    • 84858651711 scopus 로고    scopus 로고
    • 2]
    • Ibao, A.F.; Gras, M.; Therrien, B.; Suss-Fink, G.; Zava, O.; Dyson, P.J. Thiolato-bridged arene-ruthenium complexes: Synethesis, molecular structure, reactivity and anticancer activity of the dinuclear complexes [(arene)2Ru2(SR)2Cl2]. Eur. J. Inorg. Chem., 2012, 9, 1531-1535.
    • (2012) Eur. J. Inorg. Chem , vol.9 , pp. 1531-1535
    • Ibao, A.F.1    Gras, M.2    Therrien, B.3    Suss-Fink, G.4    Zava, O.5    Dyson, P.J.6
  • 71
    • 77958057724 scopus 로고    scopus 로고
    • Thiophenolato-bridged dinuclear arene ruthenium complexes: A new family of highly cyctotoxic anticancer agents
    • Gras, M.; Therrien, B.; Suss-Fink, G.; Zava, O.; Dyson, P.J. Thiophenolato-bridged dinuclear arene ruthenium complexes: A new family of highly cyctotoxic anticancer agents. Dalton Trans., 2010, 39, 10305-10313.
    • (2010) Dalton Trans , vol.39 , pp. 10305-10313
    • Gras, M.1    Therrien, B.2    Suss-Fink, G.3    Zava, O.4    Dyson, P.J.5
  • 72
    • 0000775959 scopus 로고
    • 8, which recognizes an oraganic molecule in aqueous media
    • Fujita, M.; Yazaki, J.; Ogura, K. Preparation of a macrocylic polynuclear complex, [(en)Pd(4, 4'-bpy)]4(NO3)8, which recognizes an oraganic molecule in aqueous media. J. Am. Chem. Soc, 1990, 112, 5645-5647.
    • (1990) J. Am. Chem. Soc , vol.112 , pp. 5645-5647
    • Fujita, M.1    Yazaki, J.2    Ogura, K.3
  • 73
    • 68249118615 scopus 로고    scopus 로고
    • Extracellularly activated nanocarriers: A new paradigm of tumor targeted drug delivery
    • Gullotti, E.; Yeo, Y. Extracellularly activated nanocarriers: A new paradigm of tumor targeted drug delivery. Mol. Pharmaceutics, 2009, 6, 1041-1051.
    • (2009) Mol. Pharmaceutics , vol.6 , pp. 1041-1051
    • Gullotti, E.1    Yeo, Y.2
  • 74
    • 79960032887 scopus 로고    scopus 로고
    • Anticancer activity of tetracationic arene ruthenium metalla-cycles
    • Barry, N.P.E.; Edafe, F.; Therrien, B. Anticancer activity of tetracationic arene ruthenium metalla-cycles. Dalton Trans., 2011, 40, 7172-7180.
    • (2011) Dalton Trans , vol.40 , pp. 7172-7180
    • Barry, N.P.E.1    Edafe, F.2    Therrien, B.3
  • 76
    • 79959413795 scopus 로고    scopus 로고
    • Coordination-deriven self-assembly and anticancer activity of molecular rectangles containing octahedral ruthenium metal centers
    • Vajpayee, V.; Song, Y.H.; Yang, Y.J.; Kang, S.C.; Kim, H.; Kim, I.S.; Wang, M.; Stang, P.J.; Chi, K.W. Coordination-deriven self-assembly and anticancer activity of molecular rectangles containing octahedral ruthenium metal centers. Organametallics, 2011, 30, 3242-3245.
    • (2011) Organametallics , vol.30 , pp. 3242-3245
    • Vajpayee, V.1    Song, Y.H.2    Yang, Y.J.3    Kang, S.C.4    Kim, H.5    Kim, I.S.6    Wang, M.7    Stang, P.J.8    Chi, K.W.9
  • 77
    • 82955169691 scopus 로고    scopus 로고
    • Selt-assembly of cationic, hetero-or homonuclear ruthinum(II) macrocyclic rectangles and their photophysical, electrochemical, and biological studies
    • Vajpayee, V.; Song, Y.H.; Yang, Y.J.; Kang, S.C.; Cook, T.R.; Kim, D.W.; Lah, M.S.; Kim, I.S.; Wang, M.; Stang, P.J.; Chi, K.W. Selt-assembly of cationic, hetero-or homonuclear ruthinum(II) macrocyclic rectangles and their photophysical, electrochemical, and biological studies. Organametallics, 2011, 30, 6482-6489.
    • (2011) Organametallics , vol.30 , pp. 6482-6489
    • Vajpayee, V.1    Song, Y.H.2    Yang, Y.J.3    Kang, S.C.4    Cook, T.R.5    Kim, D.W.6    Lah, M.S.7    Kim, I.S.8    Wang, M.9    Stang, P.J.10    Chi, K.W.11
  • 78
    • 77954891943 scopus 로고    scopus 로고
    • Molecular architecture of redox-active half sandwich Ru(U) cyclic assemblies. Interactions with biomolecules and anticancer activity
    • Linares, F.; Procopio, E.Q.; Galindo, M.A.; Romero, M.A.; Navarro, J.A.R.; Barea, E. Molecular architecture of redox-active half sandwich Ru(U) cyclic assemblies. Interactions with biomolecules and anticancer activity. CrystEngComm., 2010, 12, 2343-2346.
    • (2010) CrystEngComm , vol.12 , pp. 2343-2346
    • Linares, F.1    Procopio, E.Q.2    Galindo, M.A.3    Romero, M.A.4    Navarro, J.A.R.5    Barea, E.6
  • 80
    • 52649178305 scopus 로고    scopus 로고
    • Encapsulation of aromatic molecules in hexanuclear arene ruthenium cages: A strategy to build up oragnametallic carceplex prisms with a dangling arm standing out
    • Mattsson, J.; Govindaswamy, P.; Furrer, J.; Sei, Y.; Yamaguchi, K.; Süss-Fink, G.; Terrien, B. Encapsulation of aromatic molecules in hexanuclear arene ruthenium cages: A strategy to build up oragnametallic carceplex prisms with a dangling arm standing out. Organometallics, 2008, 27, 4346-4356.
    • (2008) Organometallics , vol.27 , pp. 4346-4356
    • Mattsson, J.1    Govindaswamy, P.2    Furrer, J.3    Sei, Y.4    Yamaguchi, K.5    Süss-Fink, G.6    Terrien, B.7
  • 81
    • 77955954834 scopus 로고    scopus 로고
    • Drug delivery of lipophilic pyrenyl derivatives by encapsulation in a water soluble metalla-cage
    • Mattsson, J.; Zava, O.; Renfrew, A.K.; Sei, Y.; Yamaguchi, K.; Dyson, P.J.; Terrien, B. Drug delivery of lipophilic pyrenyl derivatives by encapsulation in a water soluble metalla-cage. Dalton, Trans., 2010, 39, 8248-8255.
    • (2010) Dalton, Trans , vol.39 , pp. 8248-8255
    • Mattsson, J.1    Zava, O.2    Renfrew, A.K.3    Sei, Y.4    Yamaguchi, K.5    Dyson, P.J.6    Terrien, B.7
  • 82
    • 75849131138 scopus 로고    scopus 로고
    • Evidence for drug release from a metalla-cage delivery vector following cellular internalization
    • Zava, O.; Mattsson, J.; Terrien, B.; Dyson, P.J. Evidence for drug release from a metalla-cage delivery vector following cellular internalization. Chem. Eur. J., 2010, 16, 1428-1431.
    • (2010) Chem. Eur. J , vol.16 , pp. 1428-1431
    • Zava, O.1    Mattsson, J.2    Terrien, B.3    Dyson, P.J.4
  • 83
    • 80051730152 scopus 로고    scopus 로고
    • Excellent correlation between drug release and portal size in metalla-cage drug delivery systems
    • Barry, N.P.E.; Zava, O.; Dyson, P.J.; Terrien, B. Excellent correlation between drug release and portal size in metalla-cage drug delivery systems. Chem. Eur. J., 2011, 17, 9669-9677.
    • (2011) Chem. Eur. J , vol.17 , pp. 9669-9677
    • Barry, N.P.E.1    Zava, O.2    Dyson, P.J.3    Terrien, B.4
  • 84
    • 57149133944 scopus 로고    scopus 로고
    • Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy
    • Schmit, F.; Govindaswamy, P.; Zava, O.; Fink, G.S.; Jeanneret, L.J.; Terrien, B. Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy. J. Biol. Inorg. Chem., 2009, 14, 101-109.
    • (2009) J. Biol. Inorg. Chem , vol.14 , pp. 101-109
    • Schmit, F.1    Govindaswamy, P.2    Zava, O.3    Fink, G.S.4    Jeanneret, L.J.5    Terrien, B.6
  • 86
    • 77953568053 scopus 로고    scopus 로고
    • Luminescent dendritic cyclometalated Iridium(JJI) polypyridine complexes: Synthesis, emission behavior and biological properties
    • Zhang, K.K.; Liu, H.W., Fong, T.T.H.; Chen, X.G.; Lo, K. K.W. Luminescent dendritic cyclometalated Iridium(JJI) polypyridine complexes: Synthesis, emission behavior and biological properties, Inorg. Chem., 2010, 49, 5432-5443.
    • (2010) Inorg. Chem , vol.49 , pp. 5432-5443
    • Zhang, K.K.1    Liu, H.W.2    Fong, T.T.H.3    Chen, X.G.4    Lo, K.K.W.5
  • 87
    • 77749264476 scopus 로고    scopus 로고
    • Anticancer activity of osmium metalla-rectangles
    • Barry, N.P.E.; Edafe, F.; Dyson, P.J.; Therrien, B. Anticancer activity of osmium metalla-rectangles. Dalton Trans., 2010, 39, 2816-2820.
    • (2010) Dalton Trans , vol.39 , pp. 2816-2820
    • Barry, N.P.E.1    Edafe, F.2    Dyson, P.J.3    Therrien, B.4
  • 88
    • 53149138190 scopus 로고    scopus 로고
    • DNA binding and biological studies of some novel water soluble polymer-copper (II) phenanthroline complexes
    • Kumar, S.R.; Arunachalam, S.; Periasamy, V.S.; Preethy, C.P.; Riyasdeen, A.; Akbarsha, M.A. DNA binding and biological studies of some novel water soluble polymer-copper (II) phenanthroline complexes. Eur. J. Med. Chem., 2008, 43, 2082-2091.
    • (2008) Eur. J. Med. Chem , vol.43 , pp. 2082-2091
    • Kumar, S.R.1    Arunachalam, S.2    Periasamy, V.S.3    Preethy, C.P.4    Riyasdeen, A.5    Akbarsha, M.A.6
  • 89
    • 79960214819 scopus 로고    scopus 로고
    • Ternary dinuclear copper(U) complexes of a hydroxybenzamide ligand with diimine coligands: The 5, 6-dmp ligand enhances DNA binding and cleavage and induces apoptosis
    • Ramakrishnan, S.; Shakthipriya, D.; Suresh, E.; Periasamy, S.V.; Akbarsha, M.A.; Palaniandavar, M. Ternary dinuclear copper(U) complexes of a hydroxybenzamide ligand with diimine coligands: the 5, 6-dmp ligand enhances DNA binding and cleavage and induces apoptosis. Inorg. Chem., 2011, 50, 6458-6471.
    • (2011) Inorg. Chem , vol.50 , pp. 6458-6471
    • Ramakrishnan, S.1    Shakthipriya, D.2    Suresh, E.3    Periasamy, S.V.4    Akbarsha, M.A.5    Palaniandavar, M.6
  • 90
    • 71549145298 scopus 로고    scopus 로고
    • Anticancer activity of heteroleptic diimine complexes of dirhodium: A study of intercalating properties, hydrophobicity and in cellulo activity
    • Aguirre, J.D.; Angeles-Boza, A.M.; Chouai, A.; Turro, C; Pellois, J.P.; Dunbar, K.R. Anticancer activity of heteroleptic diimine complexes of dirhodium: A study of intercalating properties, hydrophobicity and in cellulo activity. Dalton Trans., 2009, 10806-10812.
    • (2009) Dalton Trans , pp. 10806-10812
    • Aguirre, J.D.1    Angeles-Boza, A.M.2    Chouai, A.3    Turro, C.4    Pellois, J.P.5    Dunbar, K.R.6
  • 91
    • 38749097073 scopus 로고    scopus 로고
    • Synthesis, characterization and in vitro evaluation of a potentially selective anticancer, mixed metal [Ruthenium(III)-Platinum(II)] trinulcear complex
    • Herman, A.; Tanski, J.M.; Tibbetts, M.F.; Anderson, CM. Synthesis, characterization and in vitro evaluation of a potentially selective anticancer, mixed metal [Ruthenium(III)-Platinum(II)] trinulcear complex. Inorg. Chem., 2008, 47, 274-280.
    • (2008) Inorg. Chem , vol.47 , pp. 274-280
    • Herman, A.1    Tanski, J.M.2    Tibbetts, M.F.3    Anderson, C.M.4
  • 92
    • 78651281573 scopus 로고    scopus 로고
    • Redox, spectroscopic, and photophysical properties of Ru-Pt mixed-metal complexes incorporating 4, 7-diphenyl-1, 10-phenanthroline as efficient DNA binding and photocleaving agents
    • Higgins, S.L.H.; White, T.A.; Winkel, B.S.J.; Brewer, K.J. Redox, spectroscopic, and photophysical properties of Ru-Pt mixed-metal complexes incorporating 4, 7-diphenyl-1, 10-phenanthroline as efficient DNA binding and photocleaving agents. Inorg. Chem., 2011, 50, 463-470.
    • (2011) Inorg. Chem , vol.50 , pp. 463-470
    • Higgins, S.L.H.1    White, T.A.2    Winkel, B.S.J.3    Brewer, K.J.4
  • 93
    • 59649125889 scopus 로고    scopus 로고
    • DNA interaction studies of tridentate bridged Ru-Pt mixed-metal supramolecules
    • Prussin, A.J.; Zhao, S.L.; Jain, A.; Winkel, B.S.J.; Brewer, K.J. DNA interaction studies of tridentate bridged Ru-Pt mixed-metal supramolecules. J. Inorg. Biochem., 2009, 103, 427-431.
    • (2009) J. Inorg. Biochem , vol.103 , pp. 427-431
    • Prussin, A.J.1    Zhao, S.L.2    Jain, A.3    Winkel, B.S.J.4    Brewer, K.J.5
  • 94
    • 77649104786 scopus 로고    scopus 로고
    • Promotive effect of the platinum moiety on the DNA cleavage activity of Copper-based artificial nucleases
    • Dong, X.D.; Wang, X.Y.; Lin, M.X.; Yang, X.L.; Guo, Z.J. Promotive effect of the platinum moiety on the DNA cleavage activity of Copper-based artificial nucleases. Inorg. Chem., 2010, 49, 2541-2549.
    • (2010) Inorg. Chem , vol.49 , pp. 2541-2549
    • Dong, X.D.1    Wang, X.Y.2    Lin, M.X.3    Yang, X.L.4    Guo, Z.J.5
  • 97
    • 34249900982 scopus 로고    scopus 로고
    • Direct cellular responses to platinum induced DNA damage
    • Jung, Y.; Lippard, S.J. Direct cellular responses to platinum induced DNA damage. Chem. Rev., 2007, 107, 1387-1407.
    • (2007) Chem. Rev , vol.107 , pp. 1387-1407
    • Jung, Y.1    Lippard, S.J.2
  • 98
    • 77956333636 scopus 로고    scopus 로고
    • Excursions in polynuclear platinum DNA binding
    • Mangrum, B.J.; Farrell, P.N. Excursions in polynuclear platinum DNA binding. Chem. Commun., 2010, 46, 6640-6650.
    • (2010) Chem. Commun , vol.46 , pp. 6640-6650
    • Mangrum, B.J.1    Farrell, P.N.2
  • 99
    • 0040366470 scopus 로고    scopus 로고
    • Consequences of nucleic acid conformation on the binding of a trinuclear platinum drug
    • Kloster, M.B.G.; Hannis, J.C.; Muddiman, D.C.; Farrell, N. Consequences of nucleic acid conformation on the binding of a trinuclear platinum drug. Biochemistry, 1999, 38, 14731-14737.
    • (1999) Biochemistry , vol.38 , pp. 14731-14737
    • Kloster, M.B.G.1    Hannis, J.C.2    Muddiman, D.C.3    Farrell, N.4
  • 100
    • 0037073777 scopus 로고    scopus 로고
    • DNA interstrand cross-links of the novel antitumor trinuclear platinum complex BBR3464
    • Kasparkova, J.; Zehnulova, J.; Farrell, N.; Brabec, V. DNA interstrand cross-links of the novel antitumor trinuclear platinum complex BBR3464. J. Biol.Chem., 2002, 277, 48076-48086.
    • (2002) J. Biol.Chem , vol.277 , pp. 48076-48086
    • Kasparkova, J.1    Zehnulova, J.2    Farrell, N.3    Brabec, V.4
  • 101
    • 0037254816 scopus 로고    scopus 로고
    • Cooperative effects in long-range 1, 4 DNA DNA interstrand cross-links formed by polynuclear platinum complexes: An unexpexted syn orientation of ademine bases outside the binding sites
    • Qu, Y.; Sarsdal, J.N.; Tran, M.C.; Farrell, N. Cooperative effects in long-range 1, 4 DNA DNA interstrand cross-links formed by polynuclear platinum complexes: An unexpexted syn orientation of ademine bases outside the binding sites. J. Biol. Inorg. Chem., 2003, 8, 19-28.
    • (2003) J. Biol. Inorg. Chem , vol.8 , pp. 19-28
    • Qu, Y.1    Sarsdal, J.N.2    Tran, M.C.3    Farrell, N.4
  • 102
    • 0033600598 scopus 로고    scopus 로고
    • Effect of geometric isomerism in dinuclear platinum antitumor complexes on DNA interstrand cross linking
    • Kaspárková, J.; Nováková, O.; Vrána, O.; Farrell, N.; Brabec, V. Effect of geometric isomerism in dinuclear platinum antitumor complexes on DNA interstrand cross linking. Biochemistry, 1999, 38, 10997-11005.
    • (1999) Biochemistry , vol.38 , pp. 10997-11005
    • Kaspárková, J.1    Nováková, O.2    Vrána, O.3    Farrell, N.4    Brabec, V.5
  • 103
    • 0028879428 scopus 로고
    • Effects of geometric isomerism and ligand substitution in bifunctional dinuclear platinum complexes on binding properties and conformational changes in DNA
    • Farrell, N.; Appleton, T.G.; Qu, Y.; Roberts, J.D.; Soares Fontes, A.P.; Skov, K.A.; Wu, P.; Zou, Y. Effects of geometric isomerism and ligand substitution in bifunctional dinuclear platinum complexes on binding properties and conformational changes in DNA. Biochemistry, 1995, 34, 15480-15486.
    • (1995) Biochemistry , vol.34 , pp. 15480-15486
    • Farrell, N.1    Appleton, T.G.2    Qu, Y.3    Roberts, J.D.4    Soares Fontes, A.P.5    Skov, K.A.6    Wu, P.7    Zou, Y.8
  • 105
    • 0030452294 scopus 로고    scopus 로고
    • Site specific (dGpG) intrastrand cross links formed by dinuclear platinum complexes. Bending and NMR studies
    • Kaspárková, J.; Mellish, K.J.; Qu, Y.; Brabec, V.; Farrell, N. Site specific (dGpG) intrastrand cross links formed by dinuclear platinum complexes. Bending and NMR studies. Biochemisty, 1996, 35, 16705-16713.
    • (1996) Biochemisty , vol.35 , pp. 16705-16713
    • Kaspárková, J.1    Mellish, K.J.2    Qu, Y.3    Brabec, V.4    Farrell, N.5
  • 107
    • 0035873558 scopus 로고    scopus 로고
    • Thermodynamic properties of duplex DNA containing a site specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex
    • Hofr, C; Farrell, N.; Brabec, V. Thermodynamic properties of duplex DNA containing a site specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex. Nucl. Acids Res., 2001, 29, 2034-2040.
    • (2001) Nucl. Acids Res , vol.29 , pp. 2034-2040
    • Hofr, C.1    Farrell, N.2    Brabec, V.3
  • 108
    • 0034717289 scopus 로고    scopus 로고
    • Sequence specificity, conformation, and recognition by HMG1 protein of major interstrand cross links of antitumor dinuclear platinum complexes
    • Kasparkova, J.; Farrell, N.; Brabec, V. Sequence specificity, conformation, and recognition by HMG1 protein of major interstrand cross links of antitumor dinuclear platinum complexes. J. Biol. Chem., 2000, 275, 15789-15798.
    • (2000) J. Biol. Chem , vol.275 , pp. 15789-15798
    • Kasparkova, J.1    Farrell, N.2    Brabec, V.3
  • 109
    • 33847612467 scopus 로고    scopus 로고
    • 1, 2-GG intrastrand cross link of antitumor dinuclear bifunctional platinum compound with spermidine linker inhibits DNA polymerization more effectively than the cross link of conventional cisplatin
    • Moriarity, B.; Nováková, O.; Farrell, N.; Brabec, V.; Kaspárková, J. 1, 2-GG intrastrand cross link of antitumor dinuclear bifunctional platinum compound with spermidine linker inhibits DNA polymerization more effectively than the cross link of conventional cisplatin. Arch. Biochem. Biophys., 2007, 459, 264-272.
    • (2007) Arch. Biochem. Biophys , vol.459 , pp. 264-272
    • Moriarity, B.1    Nováková, O.2    Farrell, N.3    Brabec, V.4    Kaspárková, J.5
  • 110
    • 71749110529 scopus 로고    scopus 로고
    • Conformation and recognition of DNA modified by a new antitumor dinuclear platinum H complex resistant to decomposition by sulfur nucleophiles
    • Zerzankova, L.; Suchankova, T.; Vrana, O.; Farrell, N.P.; Brabec, V.; Kasparkova, J. Conformation and recognition of DNA modified by a new antitumor dinuclear platinum H complex resistant to decomposition by sulfur nucleophiles. Biochem. Pharm., 2010, 79, 112-121.
    • (2010) Biochem. Pharm , vol.79 , pp. 112-121
    • Zerzankova, L.1    Suchankova, T.2    Vrana, O.3    Farrell, N.P.4    Brabec, V.5    Kasparkova, J.6
  • 111
    • 84861204340 scopus 로고    scopus 로고
    • Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second generation antitumor dinuclear PtH complexes
    • Florian, J.; Kasparkova, J.; Farrell, N.P.; Brabec, V. Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second generation antitumor dinuclear PtH complexes. J. Biol. Inorg. Chem., 2012, 17, 187-196.
    • (2012) J. Biol. Inorg. Chem , vol.17 , pp. 187-196
    • Florian, J.1    Kasparkova, J.2    Farrell, N.P.3    Brabec, V.4
  • 115
    • 79551483886 scopus 로고    scopus 로고
    • Walking of antitumor bifunctinal trinuclear PtH complex on double-helical DNA
    • Malina, J.; Kasparkova, J.; Farrell, N.P.; Brabec, V. Walking of antitumor bifunctinal trinuclear PtH complex on double-helical DNA. Nucl. Acids Res., 2011, 39, 720-728.
    • (2011) Nucl. Acids Res , vol.39 , pp. 720-728
    • Malina, J.1    Kasparkova, J.2    Farrell, N.P.3    Brabec, V.4
  • 117
    • 0035925158 scopus 로고    scopus 로고
    • Kinetic analysis of the stepwise formation of a long range DNA interstrand cross link by a dinuclear platinum antitumor complex: Evidince for aquated intermediates and formation of both kinetically and thermodynamically controlled conformers
    • Cox, J.W.; Berners-Price, S.J.; Davies, M.S.; Qu, Y.; Farrell, N. Kinetic analysis of the stepwise formation of a long range DNA interstrand cross link by a dinuclear platinum antitumor complex: evidince for aquated intermediates and formation of both kinetically and thermodynamically controlled conformers. J. Am. Chem. Soc, 2001, 123, 1316-1326.
    • (2001) J. Am. Chem. Soc , vol.123 , pp. 1316-1326
    • Cox, J.W.1    Berners-Price, S.J.2    Davies, M.S.3    Qu, Y.4    Farrell, N.5
  • 118
    • 70349267819 scopus 로고    scopus 로고
    • Factors affecting DNA-DNA interstrand cross-links in the antiparallel 3'-3' sense: A comparison with 5'-5' directional isomer
    • Ruhayel, R.A.; Moniodis, J.J.; Yang, X.; Kasparkova, J.; Brabec, V.; Berners-Price, S.J.; Farrell, N. Factors affecting DNA-DNA interstrand cross-links in the antiparallel 3'-3' sense: A comparison with 5'-5' directional isomer. Chem. Eur. J., 2009, 15, 9365-9374.
    • (2009) Chem. Eur. J , vol.15 , pp. 9365-9374
    • Ruhayel, R.A.1    Moniodis, J.J.2    Yang, X.3    Kasparkova, J.4    Brabec, V.5    Berners-Price, S.J.6    Farrell, N.7
  • 119
    • 79957674892 scopus 로고    scopus 로고
    • DNA interstrand cross-links of an antitumor trinuclear platinum(II) complex: Thermodynamic analysis and chemical probing
    • Malina, J.; Farrell, N.P.; Brabec, V. DNA interstrand cross-links of an antitumor trinuclear platinum(II) complex: Thermodynamic analysis and chemical probing. Chem. Asian J., 2011, 6, 1566-1574.
    • (2011) Chem. Asian J , vol.6 , pp. 1566-1574
    • Malina, J.1    Farrell, N.P.2    Brabec, V.3
  • 120
    • 73049085473 scopus 로고    scopus 로고
    • 6+ -DNA adducts with various cross linking mode
    • 6+ -DNA adducts with various cross linking mode. Nucl. Acids Res., 2009, 37, 5930-5942.
    • (2009) Nucl. Acids Res , vol.37 , pp. 5930-5942
    • Zhu, Y.Y.1    Wang, Y.2    Chen, G.J.3
  • 121
    • 0036937316 scopus 로고    scopus 로고
    • Biophysical analysis of natural, double helical DNA modified by a dinuclear platinum (II) organometallic compound in a cell free medium
    • Marini, V.; Kasparkova, J.; Novakova, O.; Scolaro, L.M.; Romeo, R.; Brabec, V. Biophysical analysis of natural, double helical DNA modified by a dinuclear platinum (II) organometallic compound in a cell free medium. J. Biol. Inorg. Chem., 2002, 7, 725-734.
    • (2002) J. Biol. Inorg. Chem , vol.7 , pp. 725-734
    • Marini, V.1    Kasparkova, J.2    Novakova, O.3    Scolaro, L.M.4    Romeo, R.5    Brabec, V.6
  • 122
    • 84861939717 scopus 로고    scopus 로고
    • DNA conformation and repair of polymeric natural DNA damaged by antitumor azolato brigdged dinuclear platinum H complex
    • Mlcouskova, J.; Kasparkova, J.; Suchankova, T.; Komeda, S.; Brabec, V. DNA conformation and repair of polymeric natural DNA damaged by antitumor azolato brigdged dinuclear platinum H complex. J. Inorg. Biochem., 2012, 114, 15-23.
    • (2012) J. Inorg. Biochem , vol.114 , pp. 15-23
    • Mlcouskova, J.1    Kasparkova, J.2    Suchankova, T.3    Komeda, S.4    Brabec, V.5
  • 123
    • 33646531427 scopus 로고    scopus 로고
    • A pyrazolato-bridged dinuclear platinum(II) complex induces only minor distortions upon DNA binding
    • Teletchéa, S.; Komeda, S.; Teuben, J.M.; Elizondo-Riojas, M.A.; Reedijk, J.; Kozelka, J. A pyrazolato-bridged dinuclear platinum(II) complex induces only minor distortions upon DNA binding. Chem. Eur. J., 2006, 12, 3741-3753.
    • (2006) Chem. Eur. J , vol.12 , pp. 3741-3753
    • Teletchéa, S.1    Komeda, S.2    Teuben, J.M.3    Elizondo-Riojas, M.A.4    Reedijk, J.5    Kozelka, J.6
  • 124
    • 12444262343 scopus 로고    scopus 로고
    • Kinetic study of azole-bridged dinuclear platinum(II) complexes reacting with a hairpin stabilized double stranded oligonucleotide
    • Komeda, S.; Bombard, S.; Perrier, S.; Reedijk, J.; Kozelka, J. Kinetic study of azole-bridged dinuclear platinum(II) complexes reacting with a hairpin stabilized double stranded oligonucleotide. J. Inorg. Biochem., 2003, 96, 357-366.
    • (2003) J. Inorg. Biochem , vol.96 , pp. 357-366
    • Komeda, S.1    Bombard, S.2    Perrier, S.3    Reedijk, J.4    Kozelka, J.5
  • 126
    • 84863480984 scopus 로고    scopus 로고
    • Energetics, conformation, and recognition of DNA duplexes containing a major adduct of an anticancer azolato-bridged dinuclear PtH complex
    • Mlcouskova, J.; Malina, J.; Novohradsky, V.; Kasparkova, J.; Komeda, S.; Brabec, V. Energetics, conformation, and recognition of DNA duplexes containing a major adduct of an anticancer azolato-bridged dinuclear PtH complex. Biochim. Biophys. Acta, 2012, 1820, 1502-1511.
    • (2012) Biochim. Biophys. Acta , vol.1820 , pp. 1502-1511
    • Mlcouskova, J.1    Malina, J.2    Novohradsky, V.3    Kasparkova, J.4    Komeda, S.5    Brabec, V.6
  • 129
    • 84861208729 scopus 로고    scopus 로고
    • Antitumor bifunctional dinuclear PtH complex BBR3535 forms interduplex DNA cross links under molecular crowding conditions
    • Muchova, T.; Quintal, S.M.; Farrell, N.P.; Brabec, V.; Kasparkova, J. Antitumor bifunctional dinuclear PtH complex BBR3535 forms interduplex DNA cross links under molecular crowding conditions. J. Biol. Inorg. Chem., 2012, 17, 239-245.
    • (2012) J. Biol. Inorg. Chem , vol.17 , pp. 239-245
    • Muchova, T.1    Quintal, S.M.2    Farrell, N.P.3    Brabec, V.4    Kasparkova, J.5
  • 130
    • 15944429355 scopus 로고    scopus 로고
    • DNA protein crosslinks: Their induction, repair and biological consequences
    • Barker, S.; Weinfeld, M.; Murray, D. DNA protein crosslinks: their induction, repair and biological consequences. Mutation Res., 2005, 589, 111-135.
    • (2005) Mutation Res , vol.589 , pp. 111-135
    • Barker, S.1    Weinfeld, M.2    Murray, D.3
  • 132
    • 0018771949 scopus 로고
    • DNA-protein and DNA interstrand cross-linking by cis- and trans- platinum(II) diamminedichloride in L1210 mouse leukemia cells and relation to cytotoxicity
    • Zwelling, L.A.; Anderson, T.; Kohn, K.W. DNA-protein and DNA interstrand cross-linking by cis- and trans- platinum(II) diamminedichloride in L1210 mouse leukemia cells and relation to cytotoxicity. Cancer Res., 1979, 39, 365-369.
    • (1979) Cancer Res , vol.39 , pp. 365-369
    • Zwelling, L.A.1    Anderson, T.2    Kohn, K.W.3
  • 133
    • 34247614959 scopus 로고    scopus 로고
    • Mechanism of the formation of DNA-protein cross-links by antitumor cisplatin
    • Chválová, K.; Brabec, V.; Kaspárková, J. Mechanism of the formation of DNA-protein cross-links by antitumor cisplatin. Nucl. Acids Res., 2007, 35(6), 1812-1821.
    • (2007) Nucl. Acids Res , vol.35 , Issue.6 , pp. 1812-1821
    • Chválová, K.1    Brabec, V.2    Kaspárková, J.3
  • 135
    • 3843105727 scopus 로고    scopus 로고
    • Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells
    • Farrell, N.; Povirk, L.F.; Dange, Y.; DeMasters, G.; Gupta, M.S.; Kohlhagen, G.; Khan, Q.A.; Pommier, Y.; Gewirtz, D.A. Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells. Biochem. Pharm., 2004, 68, 857-866.
    • (2004) Biochem. Pharm , vol.68 , pp. 857-866
    • Farrell, N.1    Povirk, L.F.2    Dange, Y.3    Demasters, G.4    Gupta, M.S.5    Kohlhagen, G.6    Khan, Q.A.7    Pommier, Y.8    Gewirtz, D.A.9
  • 136
    • 0027482289 scopus 로고
    • Homodinuclear (Pt, Pt) and heterodinclear (Ru, Pt) metal compounds as DNA-protein cross-linkings agents: Potential suicide DNA lesions
    • Houten, B.V.; Illenye, S.; Qu, Y.; Farrell, N. Homodinuclear (Pt, Pt) and heterodinclear (Ru, Pt) metal compounds as DNA-protein cross-linkings agents: potential suicide DNA lesions. Biochemistry, 1993, 32, 11794-11801.
    • (1993) Biochemistry , vol.32 , pp. 11794-11801
    • Houten, B.V.1    Illenye, S.2    Qu, Y.3    Farrell, N.4
  • 139
    • 34447137400 scopus 로고    scopus 로고
    • DNA intercalators in cancer therapy: Organic and inorganic drugs and their spectroscopic tools of analysis
    • Wheate, N.J.; Brodie, C.R.; Collins, J.G.; Kemp, S.; Aldrich-Wright, J.R. DNA intercalators in cancer therapy: Organic and inorganic drugs and their spectroscopic tools of analysis. Mini. Rev. Med. Chem., 2007, 7, 627-648.
    • (2007) Mini. Rev. Med. Chem , vol.7 , pp. 627-648
    • Wheate, N.J.1    Brodie, C.R.2    Collins, J.G.3    Kemp, S.4    Aldrich-Wright, J.R.5
  • 142
    • 70349410204 scopus 로고    scopus 로고
    • Dinuclear organoiridium(III) mono- and bis-intercalators with rigid bridging ligands: Synthesis, cystotoxicity and DNA binding
    • Nazif, M.A.; Bangert, J.A.; Ott, I.; Gust, R.; Stoll, R.; Sheldrick, W.S. Dinuclear organoiridium(III) mono- and bis-intercalators with rigid bridging ligands: Synthesis, cystotoxicity and DNA binding. J. Inorg. Biochem., 2009, 103, 1405-1414.
    • (2009) J. Inorg. Biochem , vol.103 , pp. 1405-1414
    • Nazif, M.A.1    Bangert, J.A.2    Ott, I.3    Gust, R.4    Stoll, R.5    Sheldrick, W.S.6
  • 143
    • 77950464808 scopus 로고    scopus 로고
    • Sequence-selective organoiridium DNA bis-intercalators with flexible dithiaalkane linker chains
    • Kokoschka, M.; Bangert, J.A.; Stoll, R.; Sheldrick, W.S. Sequence-selective organoiridium DNA bis-intercalators with flexible dithiaalkane linker chains. Eur. J. Inorg. Chem., 2010, 1507-1515.
    • (2010) Eur. J. Inorg. Chem , pp. 1507-1515
    • Kokoschka, M.1    Bangert, J.A.2    Stoll, R.3    Sheldrick, W.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.