1,2-GG intrastrand cross-link of antitumor dinuclear bifunctional platinum compound with spermidine linker inhibits DNA polymerization more effectively than the cross-link of conventional cisplatin

Archives of Biochemistry and Biophysics

Volumn 459, Issue 2, 2007, Pages 264-272

  Moriarity, Branden ^a   Nováková, Olga ^a   Farrell, Nicholas ^b   Brabec, Viktor ^a   Kašpárková, Jana ^a  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Antitumor platinum drugs; Chemical probes of DNA conformation; Cisplatin; DNA conformation; DNA replication; Gel electrophoresis; Translesion DNA synthesis

Indexed keywords

BBR 3571; CISPLATIN; DNA DIRECTED DNA POLYMERASE BETA; DNA FRAGMENT; DNA POLYMERASE; EXONUCLEASE; PLATINUM; SPERMIDINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CROSS LINKING; DNA DAMAGE; DNA HELIX; DNA POLYMORPHISM; DNA REPLICATION; ENZYME ACTIVITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; POLYMERIZATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTINEOPLASTIC AGENTS; CISPLATIN; CROSS-LINKING REAGENTS; DNA; DNA DAMAGE; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; ORGANOPLATINUM COMPOUNDS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33847612467     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2006.11.022     Document Type: Article

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