Cooperative effects in long-range 1,4 DNA-DNA interstrand cross-links formed by polynuclear platinum complexes: An unexpected syn orientation of adenine bases outside the binding sites

Journal of Biological Inorganic Chemistry

Volumn 8, Issue 1-2, 2003, Pages 19-28

  Qu, Yun ^a   Scarsdale, Neel J ^a   Tran, My Chau ^a   Farrell, Nicholas P ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

BBR3464; Interstrand cross link; NMR spectroscopy; Oligonucleotide; Syn conformation

Indexed keywords

ANTINEOPLASTIC AGENT; BBR 3464; CISPLATIN; DNA; PLATINUM COMPLEX;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CANCER CHEMOTHERAPY; CLINICAL TRIAL; COLON CANCER; CROSS LINKING; DNA BINDING; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG DNA INTERACTION; DRUG TARGETING; HUMAN; LUNG NON SMALL CELL CANCER; MASS SPECTROMETRY; MOLECULAR WEIGHT; OVARY CANCER; PANCREAS CANCER; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STOMACH CANCER;

ADENINE; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BINDING SITES; CROSS-LINKING REAGENTS; DNA; DNA ADDUCTS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID CONFORMATION; ORGANOPLATINUM COMPOUNDS; STEREOISOMERISM;

EID: 0037254816     PISSN: 09498257     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00775-002-0383-x     Document Type: Article

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