A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464

Journal of Biological Inorganic Chemistry

Volumn 7, Issue 4-5, 2002, Pages 397-404

  McGregor, Tracey D ^a   Hegmans, Alexander ^a   Kašpárková, Jana ^a   Neplechová, Kamila ^b   Nováková, Olga ^b   Peňazová, Hana ^b   Vrána, Oldrich ^b   Brabec, Viktor ^b   Farrell, Nicholas ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b INSTITUTE OF BIOPHYSICS   (Czech Republic)

Author keywords

Crosslinks; Dinuclear platinum; Hydrogen bonding; Unwinding

Indexed keywords

BBR 3436; BBR 3464; DNA; DNA POLYMERASE; NUCLEOTIDE; PLATINUM; POLYAMINE;

ARTICLE; CROSS LINKING; DNA BINDING; DNA DENATURATION; DNA SUPERCOILING; DNA TEMPLATE; DRUG ACTIVITY; HYDROGEN BOND; KINETICS; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA TRANSCRIPTION;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BINDING SITES; CLINICAL TRIALS, PHASE II; CROSS-LINKING REAGENTS; DNA; FLUORESCENCE; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; ORGANOPLATINUM COMPOUNDS; PLATINUM COMPOUNDS; SPERMIDINE; SPERMINE;

EID: 0036933447     PISSN: 09498257     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00775-001-0312-4     Document Type: Article

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