A dinuclear monofunctional platinum(II) complex with an aromatic linker shows low reactivity towards glutathione but high DNA binding ability and antitumor activity

Journal of Biological Inorganic Chemistry

Volumn 12, Issue 5, 2007, Pages 655-665

  Fan, Damin ^a   Yang, Xiaoliang ^a   Wang, Xiaoyong ^b   Zhang, Shouchun ^a   Mao, Jiafei ^a   Ding, Jian ^c   Lin, Liping ^c   Guo, Zijian ^a  

^a NANJING UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Antitumor agent; Dinuclear platinum complex; DNA; Glutathione; Guanosine 5 monophosphate

Indexed keywords

CISPLATIN; GUANOSINE PHOSPHATE; PLATINUM COMPLEX;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; DNA BINDING; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; FINITE ELEMENT ANALYSIS; HUMAN; HUMAN CELL; HYDROLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

5'-GUANYLIC ACID; ANILINE COMPOUNDS; ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CIRCULAR DICHROISM; DNA; GLUTATHIONE; HUMANS; HYDROLYSIS; INDICATORS AND REAGENTS; LEUKEMIA P388; LUNG NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; ORGANOPLATINUM COMPOUNDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

MURINAE;

EID: 34249906440     PISSN: 09498257     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00775-007-0214-1     Document Type: Article

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