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Volumn 40, Issue 24, 2001, Pages 6108-6114
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Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum-spermidine species through hydrolytic cleavage of carbamates
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Author keywords
[No Author keywords available]
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Indexed keywords
ANTINEOPLASTIC AGENT;
BBR 3464;
BUTANE;
CARBAMIC ACID DERIVATIVE;
CHLORINE;
CYTOTOXIC AGENT;
NITROGEN;
PLATINUM COMPLEX;
PLATINUM DERIVATIVE;
POLYAMINE;
PRODRUG;
PROPANE;
SPERMIDINE;
SPERMIDINE DERIVATIVE;
SPERMINE;
ANIMAL;
ANIMAL CELL;
ARTICLE;
CATALYSIS;
CELL CULTURE;
CHEMICAL BOND;
CHEMICAL REACTION KINETICS;
CHEMICAL STRUCTURE;
CHEMISTRY;
CLINICAL TRIAL;
COMPARATIVE STUDY;
CONTROLLED CLINICAL TRIAL;
CONTROLLED STUDY;
CYTOTOXICITY;
DNA ADDUCT;
DRUG EFFECT;
DRUG HYDROLYSIS;
DRUG POTENCY;
DRUG RELEASE;
DRUG SYNTHESIS;
DRUG UPTAKE;
ELECTRICITY;
FEMALE;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HUMAN;
HUMAN CELL;
HYDROGEN BOND;
HYDROLYSIS;
IC 50;
ISOMER;
LEUKEMIA L 1210;
MOUSE;
NONHUMAN;
NUCLEAR MAGNETIC RESONANCE;
OVARY TUMOR;
PH;
PHASE 2 CLINICAL TRIAL;
PROTON NUCLEAR MAGNETIC RESONANCE;
STEREOISOMERISM;
STRUCTURE ACTIVITY RELATION;
SYNTHESIS;
TEMPERATURE;
ANIMALS;
ANTINEOPLASTIC AGENTS;
CARBAMATES;
CATALYSIS;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
FEMALE;
HUMANS;
HYDROGEN-ION CONCENTRATION;
HYDROLYSIS;
INHIBITORY CONCENTRATION 50;
LEUKEMIA L1210;
MICE;
MOLECULAR STRUCTURE;
NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR;
ORGANOPLATINUM COMPOUNDS;
OVARIAN NEOPLASMS;
POLYAMINES;
PRODRUGS;
SPERMIDINE;
SPERMINE;
STEREOISOMERISM;
STRUCTURE-ACTIVITY RELATIONSHIP;
TEMPERATURE;
TUMOR CELLS, CULTURED;
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EID: 0035914687
PISSN: 00201669
EISSN: None
Source Type: Journal
DOI: 10.1021/ic010509a Document Type: Article |
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Times cited : (40)
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References (20)
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