Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators

Biochemistry

Volumn 53, Issue 12, 2014, Pages 1947-1957

  Jung, Joo In ^a   Ran, Yong ^a   Cruz, Pedro E ^a   Rosario, Awilda M ^a   Ladd, Thomas B ^a   Kukar, Thomas L ^b   Koo, Edward H ^c   Felsenstein, Kevin M ^a   Golde, Todd E ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; CARBOXYLATION; GLYCOPROTEINS; MODULATION; NEURODEGENERATIVE DISEASES; PROTEINS;

ALZHEIMERS DISEASE; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEINS; ANTI-INFLAMMATORIES; COMPLEX RELATIONSHIPS; EXTRACELLULAR DOMAINS; PHENYLIMIDAZOLE; TRANSMEMBRANE DOMAIN;

SUBSTRATES;

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CARBOXYLIC ACID; GAMMA SECRETASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CHO CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOPRECIPITATION; IN VITRO STUDY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; WESTERN BLOTTING;

AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DOWN-REGULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SUBSTRATE SPECIFICITY; UP-REGULATION;

EID: 84898080760     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi401521t     Document Type: Article

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