Conversion of the LXR-agonist TO-901317-From inverse to normal modulation of γ-secretase by addition of a carboxylic acid and a lipophilic anchor

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 19, 2007, Pages 5428-5431

  Narlawar, Rajeshwar ^a   Baumann, Karlheinz ^b   Czech, Christian ^b   Schmidt, Boris ^a  

^a DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Secretase inhibitor; Secretase modulator; Alzheimer's disease; Aspartic protease; LXR agonist; Membrane protease

Indexed keywords

CARBOXYLIC ACID; GAMMA SECRETASE; HORMONE RECEPTOR STIMULATING AGENT; LIVER X RECEPTOR AGONIST; TO 901317; TO 901317 DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY;

AMYLOID PRECURSOR PROTEIN SECRETASES; CARBOXYLIC ACIDS; CELL SURVIVAL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROCARBONS, FLUORINATED; INDICATORS AND REAGENTS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 34548576853     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.07.044     Document Type: Article

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