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Volumn , Issue , 2012, Pages 185-210

Topoisomerase I inhibitors: Chemical biology

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EID: 84896828627     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-0323-4_10     Document Type: Chapter
Times cited : (4)

References (157)
  • 2
    • 0032791202 scopus 로고    scopus 로고
    • In vitro activation of irinotecan to SN-38 by human liver and intestine
    • Ahmed F, Vyas V, Cornfield A et al (1999) In vitro activation of irinotecan to SN-38 by human liver and intestine. Anticancer Res 19:2067-2071
    • (1999) Anticancer Res , vol.19 , pp. 2067-2071
    • Ahmed, F.1    Vyas, V.2    Cornfield, A.3
  • 3
    • 53949088908 scopus 로고    scopus 로고
    • Towards the individualization of lung cancer therapy
    • Anguiano A, Nevins JR, Potti A (2008) Towards the individualization of lung cancer therapy. Cancer 113:1760-1767
    • (2008) Cancer , vol.113 , pp. 1760-1767
    • Anguiano, A.1    Nevins, J.R.2    Potti, A.3
  • 4
    • 33747600400 scopus 로고    scopus 로고
    • Bisindenoisoquinoline bis-1,3-((5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino)propane bis(trifluoroacetate) (NSC727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity
    • Antony S, Agama KK, Miao ZH, Hollingshead M, Holbeck SL, Wright MH, Varticovski L, Nagarajan M, Morrell A, Cushman M, Pommier Y (2006) Bisindenoisoquinoline bis-1,3-((5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino)propane bis(trifluoroacetate) (NSC727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol 70:1109-1120
    • (2006) Mol Pharmacol , vol.70 , pp. 1109-1120
    • Antony, S.1    Agama, K.K.2    Miao, Z.H.3    Hollingshead, M.4    Holbeck, S.L.5    Wright, M.H.6    Varticovski, L.7    Nagarajan, M.8    Morrell, A.9    Cushman, M.10    Pommier, Y.11
  • 6
    • 0029072716 scopus 로고
    • Camptothecin induction of a time- and concentration-dependent decrease of topoisomerase I and its implication in camptothecin activity
    • Beidler DR, Cheng YC (1995) Camptothecin induction of a time- and concentration-dependent decrease of topoisomerase I and its implication in camptothecin activity. Mol Pharmacol 47:907-914
    • (1995) Mol Pharmacol , vol.47 , pp. 907-914
    • Beidler, D.R.1    Cheng, Y.C.2
  • 7
    • 33750552551 scopus 로고    scopus 로고
    • Mechanisms of cellular resistance to camptothecins
    • Beretta GL, Perego P, Zunino F (2006) Mechanisms of cellular resistance to camptothecins. Curr Med Chem 13:3291-3305
    • (2006) Curr Med Chem , vol.13 , pp. 3291-3305
    • Beretta, G.L.1    Perego, P.2    Zunino, F.3
  • 9
    • 0023127037 scopus 로고
    • Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA
    • Brill SJ, DiNardo S, Voelkel-Meiman K, Sternglanz R (1987) Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA. Nature 326:414-416
    • (1987) Nature , vol.326 , pp. 414-416
    • Brill, S.J.1    DiNardo, S.2    Voelkel-meiman, K.3    Sternglanz, R.4
  • 10
    • 0022409106 scopus 로고
    • Association of crossover points with topoisomerase I cleavage sites: A model for non-homologous recombination
    • Bullock P, Champoux JJ, Botchan M (1985) Association of crossover points with topoisomerase I cleavage sites: A model for non-homologous recombination. Science 230:954-958
    • (1985) Science , vol.230 , pp. 954-958
    • Bullock, P.1    Champoux, J.J.2    Botchan, M.3
  • 11
    • 0034884824 scopus 로고    scopus 로고
    • Therapeutic activity of the topoisomerase I inhibitor J-107088 [6-N-(1-hydroxymethyla-2-hydroxy)ethylamino-12,13-di-hydro-13-(b-D-glucopyranosyl)-5H-indolo[2,3-a]-pyrrolo[3,4-c]carbazole-5,7(6H)-dione] against pediatric and adult central nervous system tumor xenografts
    • Cavazos CM, Keir ST, Yoshinari T, Bigner DD, Friedman HS (2001) Therapeutic activity of the topoisomerase I inhibitor J-107088 [6-N-(1-hydroxymethyla-2-hydroxy)ethylamino-12,13-di-hydro-13-(b-D-glucopyranosyl)-5H-indolo[2,3-a]-pyrrolo[3,4-c]carbazole-5,7(6H)-dione] against pediatric and adult central nervous system tumor xenografts. Cancer Chemother Pharmacol 48:250-254
    • (2001) Cancer Chemother Pharmacol , vol.48 , pp. 250-254
    • Cavazos, C.M.1    Keir, S.T.2    Yoshinari, T.3    Bigner, D.D.4    Friedman, H.S.5
  • 12
    • 0034923502 scopus 로고    scopus 로고
    • DNA topoisomerases: Structure, function, and mechanism
    • Champoux JJ (2001) DNA topoisomerases: structure, function, and mechanism. Annu Rev Biochem 70:369-413
    • (2001) Annu Rev Biochem , vol.70 , pp. 369-413
    • Champoux, J.J.1
  • 13
    • 0030906434 scopus 로고    scopus 로고
    • Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rates
    • Chu X, Kato Y, Sugiyama Y (1997) Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rates. Cancer Res 57:1934-1938
    • (1997) Cancer Res , vol.57 , pp. 1934-1938
    • Chu, X.1    Kato, Y.2    Sugiyama, Y.3
  • 14
    • 33646733010 scopus 로고    scopus 로고
    • Antitumor efficacy of edotecarin as a single agent and in combination with chemotherapy agents in a xenograft model
    • Ciomei M, Croci V, Ciavolella A, Ballinari D, Pesenti E (2006) Antitumor efficacy of edotecarin as a single agent and in combination with chemotherapy agents in a xenograft model. Clin Cancer Res 12:2856-2861
    • (2006) Clin Cancer Res , vol.12 , pp. 2856-2861
    • Ciomei, M.1    Croci, V.2    Ciavolella, A.3    Ballinari, D.4    Pesenti, E.5
  • 16
    • 0033600191 scopus 로고    scopus 로고
    • Glucuronidation of 7-ethyl-10-hydroxycamp-tothecin (SN-38) by human UDP-glucuronosyltransferases encoded at the UGT1 locus
    • Ciotti M, Basu N, Brangi M, Owens IS (1999) Glucuronidation of 7-ethyl-10-hydroxycamp-tothecin (SN-38) by human UDP-glucuronosyltransferases encoded at the UGT1 locus. Biochem Biophys Res Commun 260:199-202
    • (1999) Biochem Biophys Res Commun , vol.260 , pp. 199-202
    • Ciotti, M.1    Basu, N.2    Brangi, M.3    Owens, I.S.4
  • 17
    • 0036321137 scopus 로고    scopus 로고
    • Human DNA topoisomerase I: An anticancer drug target present in human sarcomas
    • Coleman LW, Rohr LR, Bronstein IB, Holden JA (2002) Human DNA topoisomerase I: an anticancer drug target present in human sarcomas. Hum Pathol 33:599-607
    • (2002) Hum Pathol , vol.33 , pp. 599-607
    • Coleman, L.W.1    Rohr, L.R.2    Bronstein, I.B.3    Holden, J.A.4
  • 18
    • 0037085032 scopus 로고    scopus 로고
    • Enhanced clearance of topoisomerase I inhibitors from human colon cancer cells by glucuronidation
    • Cummings J, Boyd G, Ethell BT et al (2002) Enhanced clearance of topoisomerase I inhibitors from human colon cancer cells by glucuronidation. Biochem Pharmacol 63:607-613
    • (2002) Biochem Pharmacol , vol.63 , pp. 607-613
    • Cummings, J.1    Boyd, G.2    Ethell, B.T.3
  • 19
    • 0025133118 scopus 로고
    • Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons
    • D'Arpa P, Beardmore C, Liu LF (1990) Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res 50:6919-6924
    • (1990) Cancer Res , vol.50 , pp. 6919-6924
    • D'Arpa, P.1    Beardmore, C.2    Liu, L.F.3
  • 20
    • 0009607249 scopus 로고
    • Simian virus 40 (SC40) DNA replication: SV40 large T antigen unwinds DNA containing the SV40 origin of replication
    • Dean FB, Bullock P, Murakami Y, Wobbe CR, Weissback L, Hurwitz J (1987) Simian virus 40 (SC40) DNA replication: SV40 large T antigen unwinds DNA containing the SV40 origin of replication. Proc Natl Acad Sci USA 84:16-20
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 16-20
    • Dean, F.B.1    Bullock, P.2    Murakami, Y.3    Wobbe, C.R.4    Weissback, L.5    Hurwitz, J.6
  • 21
    • 0023587849 scopus 로고
    • Simian virus 40 large tumor antigen requires three core replication origin domains for DNA unwinding and replication in vivo
    • Dean FB, Borowiec JA, Ishimi Y, Deb S, Tegtmyer P, Hurwitz J (1987) Simian virus 40 large tumor antigen requires three core replication origin domains for DNA unwinding and replication in vivo. Proc Natl Acad Sci USA 84:8267-8271
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8267-8271
    • Dean, F.B.1    Borowiec, J.A.2    Ishimi, Y.3    Deb, S.4    Tegtmyer, P.5    Hurwitz, J.6
  • 22
    • 8444222650 scopus 로고    scopus 로고
    • Efficacy of the novel camptothecin gimatecan against orthotopic and metastatic human tumor xenograft models
    • De Cesare M, Pratesi G, Veneroni S, Bergottini R, Zunino F (2004) Efficacy of the novel camptothecin gimatecan against orthotopic and metastatic human tumor xenograft models. Clin Cancer Res 10:7357-7364
    • (2004) Clin Cancer Res , vol.10 , pp. 7357-7364
    • De Cesare, M.1    Pratesi, G.2    Veneroni, S.3    Bergottini, R.4    Zunino, F.5
  • 28
    • 0030854371 scopus 로고    scopus 로고
    • Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin
    • Desai SD, Liu LF, Vazquez-Abad D, D'Arpa P (1997) Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin. J Biol Chem 272:24159-24164
    • (1997) J Biol Chem , vol.272 , pp. 24159-24164
    • Desai, S.D.1    Liu, L.F.2    Vazquez-abad, D.3    D'Arpa, P.4
  • 29
    • 0035422206 scopus 로고    scopus 로고
    • Ubiquitin-26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells
    • Desai SD, Li TK, Rodriguez-Bauman A, Rubin EH, Liu LF (2001) Ubiquitin-26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells. Cancer Res 61:5926-5932
    • (2001) Cancer Res , vol.61 , pp. 5926-5932
    • Desai, S.D.1    Li, T.K.2    Rodriguez-bauman, A.3    Rubin, E.H.4    Liu, L.F.5
  • 30
    • 0024278459 scopus 로고
    • Inhibitors of DNA topoisomerases
    • Drlica K, Franco RJ (1988) Inhibitors of DNA topoisomerases. Biochem 27:2252-2259
    • (1988) Biochem , vol.27 , pp. 2252-2259
    • Drlica, K.1    Franco, R.J.2
  • 31
    • 0014250741 scopus 로고
    • Studies on the therapeutic effectiveness of drugs with tumor weight and survival time indices of Walker 256 carcinosarcoma
    • DeWys WD, Humphreys SR, Goldin A (1968) Studies on the therapeutic effectiveness of drugs with tumor weight and survival time indices of Walker 256 carcinosarcoma. Cancer Chemo Rep 52:229-242
    • (1968) Cancer Chemo Rep , vol.52 , pp. 229-242
    • DeWys, W.D.1    Humphreys, S.R.2    Goldin, A.3
  • 32
    • 58749110485 scopus 로고    scopus 로고
    • DNA cleavage assay for the identification of topoisomerase I inhibitors
    • Dexheimer TS, Pommier Y (2008) DNA cleavage assay for the identification of topoisomerase I inhibitors. Nature Protocols 3: 1736-1750
    • (2008) Nature Protocols , vol.3 , pp. 1736-1750
    • Dexheimer, T.S.1    Pommier, Y.2
  • 33
    • 0031054593 scopus 로고    scopus 로고
    • Differentialtoxicity of Camptothecin, Topotecanand 9-Aminocamptothecin to Human, Canine, and Murine Myeloid Progenitors (CFU-GM) In Vitro
    • 1997;
    • Erickson-Miller C (1997) Differentialtoxicity of Camptothecin, Topotecanand 9-Aminocamptothecin to Human, Canine, and Murine Myeloid Progenitors (CFU-GM) In Vitro. Cancer Chemother Pharmacol 1997; 39:467-472
    • (1997) Cancer Chemother Pharmacol , vol.39 , pp. 467-472
    • Erickson-miller, C.1
  • 34
    • 44649191682 scopus 로고    scopus 로고
    • Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylene-dioxydibenzo[c,h][1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates
    • Feng W, Satyanarayana M, Tsai YC, Liu AA, Liu LF, LaVoie EJ (2008) Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylene-dioxydibenzo[c,h][1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates. Bioorg Med Chem Lett 18:3570-3572
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 3570-3572
    • Feng, W.1    Satyanarayana, M.2    Tsai, Y.C.3    Liu, A.A.4    Liu, L.F.5    LaVoie, E.J.6
  • 35
    • 51449119022 scopus 로고    scopus 로고
    • 11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents
    • Feng W, Satyanarayana M, Tsai YC, Liu AA, Liu LF, LaVoie EJ (2008) 11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents. Bioorg Med Chem 16:8598-8606
    • (2008) Bioorg Med Chem , vol.16 , pp. 8598-8606
    • Feng, W.1    Satyanarayana, M.2    Tsai, Y.C.3    Liu, A.A.4    Liu, L.F.5    LaVoie, E.J.6
  • 36
    • 53249087738 scopus 로고    scopus 로고
    • Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]-naphthyridines as novel topoisomerase I-targeting antitumor agents
    • Feng W, Satyanarayana M, Cheng L, Liu AA, Tsai YC, Liu LF, LaVoie EJ (2008) Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]-naphthyridines as novel topoisomerase I-targeting antitumor agents. Bioorg Med Chem 16:9295-9301
    • (2008) Bioorg Med Chem , vol.16 , pp. 9295-9301
    • Feng, W.1    Satyanarayana, M.2    Cheng, L.3    Liu, A.A.4    Tsai, Y.C.5    Liu, L.F.6    LaVoie, E.J.7
  • 37
    • 62949117616 scopus 로고    scopus 로고
    • 12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents
    • Feng W, Satyanarayana M, Tsai YC, Liu AA, Liu LF, LaVoie EJ (2009) 12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents. Bioorg Med Chem 17:2877-2885
    • (2009) Bioorg Med Chem , vol.17 , pp. 2877-2885
    • Feng, W.1    Satyanarayana, M.2    Tsai, Y.C.3    Liu, A.A.4    Liu, L.F.5    LaVoie, E.J.6
  • 38
    • 0015044313 scopus 로고
    • Studies on the antitumor activity, mechanism of action, and cell cycle effects of camptothecin
    • Gallo RC, Whang-Peng J, Adamson RH (1971) Studies on the antitumor activity, mechanism of action, and cell cycle effects of camptothecin. J Natl Cancer Inst 46:789-795
    • (1971) J Natl Cancer Inst , vol.46 , pp. 789-795
    • Gallo, R.C.1    Whang-peng, J.2    Adamson, R.H.3
  • 39
    • 0023277908 scopus 로고
    • Role of DNA Topoisomerase I in the transcription of supercoiled rRNA gene
    • Garg LC, DiAngelo S, Jacob ST (1987) Role of DNA Topoisomerase I in the transcription of supercoiled rRNA gene. Proc Natl Acad Sci USA 84: 3185-3188
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 3185-3188
    • Garg, L.C.1    DiAngelo, S.2    Jacob, S.T.3
  • 40
    • 33749658088 scopus 로고    scopus 로고
    • Topoisomerase enzymes as therapeutic targets for cancer chemotherapy
    • Giles I, Sharma RP (2005) Topoisomerase enzymes as therapeutic targets for cancer chemotherapy. Med Chem 1:383-394
    • (2005) Med Chem , vol.1 , pp. 383-394
    • Giles, I.1    Sharma, R.P.2
  • 43
    • 0022342251 scopus 로고
    • Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and topoisomerase II
    • Goto T, Wang JC (1985) Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and topoisomerase II. Proc Natl Acad Sci USA 82:7178-7182
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 7178-7182
    • Goto, T.1    Wang, J.C.2
  • 46
    • 0020478771 scopus 로고
    • Intra- and inter-molecular strand transfer by HeLa DNA topoisomerase I
    • Halligan BD, Davis JL, Edwards KA, Liu LF (1982) Intra- and inter-molecular strand transfer by HeLa DNA topoisomerase I. J Biol Chem 257:3995-4000
    • (1982) J Biol Chem , vol.257 , pp. 3995-4000
    • Halligan, B.D.1    Davis, J.L.2    Edwards, K.A.3    Liu, L.F.4
  • 47
    • 0034778246 scopus 로고    scopus 로고
    • Human liver UDP-glucuro-nosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin
    • Hanioka N, Ozawa S, Jinno H, Ando M, Saito Y, Sawada J (2001) Human liver UDP-glucuro-nosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin. Xenobiotica 31:687-699
    • (2001) Xenobiotica , vol.31 , pp. 687-699
    • Hanioka, N.1    Ozawa, S.2    Jinno, H.3    Ando, M.4    Saito, Y.5    Sawada, J.6
  • 50
    • 0015150039 scopus 로고
    • On the mechanism of topoisomerase I inhibition by camptothecin: Evidence for binding to an enzyme-DNA complex
    • Horwitz SB, Chang CK, Grollman AP (1971) On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex. Biochemistry 7:632-644
    • (1971) Biochemistry , vol.7 , pp. 632-644
    • Horwitz, S.B.1    Chang, C.K.2    Grollman, A.P.3
  • 51
    • 85013083402 scopus 로고    scopus 로고
    • Phase I trial and pharmacokinetic study or oral gimatecan in adults with malignant glioma
    • abstr 1559
    • Hochberg FH, Supko J, Amato A, Salem N, Carminati P, Wen P (2006) Phase I trial and pharmacokinetic study or oral gimatecan in adults with malignant glioma. J Clin Oncol 24 suppl:abstr 1559
    • (2006) J Clin Oncol , vol.24
    • Hochberg, F.H.1    Supko, J.2    Amato, A.3    Salem, N.4    Carminati, P.5    Wen, P.6
  • 52
    • 0024388737 scopus 로고
    • Differeential requirement of DNA replication for the cytotoxicity of DNA topoiosmerase I and II inhibitors in Chinese hamster DC3F cells
    • Holm C, Covey JM, Kerrigan D, Pommier Y (1989) Differeential requirement of DNA replication for the cytotoxicity of DNA topoiosmerase I and II inhibitors in Chinese hamster DC3F cells. Cancer Res 49:6365-6368
    • (1989) Cancer Res , vol.49 , pp. 6365-6368
    • Holm, C.1    Covey, J.M.2    Kerrigan, D.3    Pommier, Y.4
  • 53
    • 0022340594 scopus 로고
    • Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerse I
    • Hsiang YH, Hertzberg R, Hecht S, Liu LF (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerse I. J Biol Chem 260:14873-14878
    • (1985) J Biol Chem , vol.260 , pp. 14873-14878
    • Hsiang, Y.H.1    Hertzberg, R.2    Hecht, S.3    Liu, L.F.4
  • 54
    • 0023924786 scopus 로고
    • Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin
    • Hsiang YH, Liu LF (1988) Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res 48:1722-1726
    • (1988) Cancer Res , vol.48 , pp. 1722-1726
    • Hsiang, Y.H.1    Liu, L.F.2
  • 55
    • 0024420685 scopus 로고
    • Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
    • Hsiang YH, Lihou MG, Liu LF (1989) Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res 49:5077-5082
    • (1989) Cancer Res , vol.49 , pp. 5077-5082
    • Hsiang, Y.H.1    Lihou, M.G.2    Liu, L.F.3
  • 57
    • 33751292216 scopus 로고    scopus 로고
    • A phase I study of the safety and pharmacokinetics of edotecarin (J-107088), a novel toposiosmerase I inhibitor, in patients with advanced solid tumors
    • Hurwitz HI, Cohen RB, McGovren JP, Hirawat S, Petros WP, Natsumeda Y, Yoshinari T (2007) A phase I study of the safety and pharmacokinetics of edotecarin (J-107088), a novel toposiosmerase I inhibitor, in patients with advanced solid tumors. Cancer Chemother Pharmacol 59:139-147
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 139-147
    • Hurwitz, H.I.1    Cohen, R.B.2    McGovren, J.P.3    Hirawat, S.4    Petros, W.P.5    Natsumeda, Y.6    Yoshinari, T.7
  • 58
    • 0026544211 scopus 로고
    • Topoisomerase II plays an essential role as a swivelase in the late stage of SV40 chromosome replication in vitro
    • Ishimi Y, Sugasawa K, Hanaoka F, Eki T, Hurwitz J (1992) Topoisomerase II plays an essential role as a swivelase in the late stage of SV40 chromosome replication in vitro. J Biol Chem 267:462-466
    • (1992) J Biol Chem , vol.267 , pp. 462-466
    • Ishimi, Y.1    Sugasawa, K.2    Hanaoka, F.3    Eki, T.4    Hurwitz, J.5
  • 59
    • 0027143718 scopus 로고
    • Synthesis and evaluation of new 6-amino-substituted benzo[c]phenanthridine derivatives
    • Janin YL, Croisy A, Rious JL, Bisagni E (1993) Synthesis and evaluation of new 6-amino-substituted benzo[c]phenanthridine derivatives. J Med Chem 36:3686-3692
    • (1993) J Med Chem , vol.36 , pp. 3686-3692
    • Janin, Y.L.1    Croisy, A.2    Rious, J.L.3    Bisagni, E.4
  • 61
    • 0034282809 scopus 로고    scopus 로고
    • Proficient metabolism of irinotecan by a human intestinal carboxylesterase
    • Khanna R, Morton CL, Danks MK, Potter PM (2000) Proficient metabolism of irinotecan by a human intestinal carboxylesterase. Cancer Res 60:4725-4738
    • (2000) Cancer Res , vol.60 , pp. 4725-4738
    • Khanna, R.1    Morton, C.L.2    Danks, M.K.3    Potter, P.M.4
  • 62
    • 0018628599 scopus 로고
    • Escherechia coli mutants thermosensitive for deoxyribonucleic acid gyrase subunit A: Effects on deoxyribonucleic acid replication, transcription, and bacterial growth
    • Kreuzer KN, Cozzarelli NR (1979) Escherechia coli mutants thermosensitive for deoxyribonucleic acid gyrase subunit A: Effects on deoxyribonucleic acid replication, transcription, and bacterial growth. J Bacteriol 140:424-435
    • (1979) J Bacteriol , vol.140 , pp. 424-435
    • Kreuzer, K.N.1    Cozzarelli, N.R.2
  • 63
    • 67649373026 scopus 로고    scopus 로고
    • Diflomotecan, a promising homocamptothecin for cancer therapy
    • Kroep JR, Gelderblom H (2009) Diflomotecan, a promising homocamptothecin for cancer therapy. Exp Opin Invest Drugs 18:69-75
    • (2009) Exp Opin Invest Drugs , vol.18 , pp. 69-75
    • Kroep, J.R.1    Gelderblom, H.2
  • 64
    • 0035300476 scopus 로고    scopus 로고
    • Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP- binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure
    • Komatani H, Kotani H, Hara Y, Nakagawa R, Matsumoto M, Arakawa H, Nishimura S (2001) Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP- binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure. Cancer Res 61:2827-2832
    • (2001) Cancer Res , vol.61 , pp. 2827-2832
    • Komatani, H.1    Kotani, H.2    Hara, Y.3    Nakagawa, R.4    Matsumoto, M.5    Arakawa, H.6    Nishimura, S.7
  • 65
    • 78650395550 scopus 로고    scopus 로고
    • Design, synthesis and evaluation of dibenzo[c,h][1,6]naphthyridines as topoisomerase I inhibitors and potential anticancer agents
    • Kiselev E, Dexheimer TS, Pommier Y, Cushman MC (2010) Design, synthesis and evaluation of dibenzo[c,h][1,6]naphthyridines as topoisomerase I inhibitors and potential anticancer agents. J Med Chem 53:8716-8726
    • (2010) J Med Chem , vol.53 , pp. 8716-8726
    • Kiselev, E.1    Dexheimer, T.S.2    Pommier, Y.3    Cushman, M.C.4
  • 66
    • 33746879918 scopus 로고    scopus 로고
    • Drug development in oncology: Classical cytotoxics and molecularly targeted agents
    • Kummar S, Gutierrez M, Doroshow JH, Murgo AJ (2006) Drug development in oncology: classical cytotoxics and molecularly targeted agents. Brit J Clin Pharmacol 62:15-26
    • (2006) Brit J Clin Pharmacol , vol.62 , pp. 15-26
    • Kummar, S.1    Gutierrez, M.2    Doroshow, J.H.3    Murgo, A.J.4
  • 72
    • 22744457037 scopus 로고    scopus 로고
    • Human DNA topoiosmerase I: Relaxation, roles and damage control
    • Leppard JB, Champoux JJ (2005) Human DNA topoiosmerase I: relaxation, roles and damage control. Chromosoma 114:75-85
    • (2005) Chromosoma , vol.114 , pp. 75-85
    • Leppard, J.B.1    Champoux, J.J.2
  • 73
    • 0033564494 scopus 로고    scopus 로고
    • Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties
    • Lesueur-Ginot L, Demarquay D, Kiss R, Kasprzyk PG, Dassonneville L, Bailly C, Camara J, Lavergne O, Bigg DCH (1999) Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties. Cancer Res 59:2939-2943
    • (1999) Cancer Res , vol.59 , pp. 2939-2943
    • Lesueur-ginot, L.1    Demarquay, D.2    Kiss, R.3    Kasprzyk, P.G.4    Dassonneville, L.5    Bailly, C.6    Camara, J.7    Lavergne, O.8    Bigg, D.C.H.9
  • 74
    • 0035029153 scopus 로고    scopus 로고
    • Tumor cell death induced by topoisomerase -targeting drugs
    • Li TK, Liu LF (2001) Tumor cell death induced by topoisomerase -targeting drugs. Ann Rev Pharmacol Toxicol 41:53-77
    • (2001) Ann Rev Pharmacol Toxicol , vol.41 , pp. 53-77
    • Li, T.K.1    Liu, L.F.2
  • 76
    • 0024316466 scopus 로고
    • DNA topoisomerase poisons as antitumor drugs
    • Liu LF (1989) DNA topoisomerase poisons as antitumor drugs. Ann Rev Biochem 58:351-375
    • (1989) Ann Rev Biochem , vol.58 , pp. 351-375
    • Liu, L.F.1
  • 77
    • 0034117357 scopus 로고    scopus 로고
    • Non-camptothecin topoisomerase I active compounds as potential anticancer agents
    • Long BH, Balasubramanian BN (2000) Non-camptothecin topoisomerase I active compounds as potential anticancer agents. Exp Opin Ther Patents 10:655-686
    • (2000) Exp Opin Ther Patents , vol.10 , pp. 655-686
    • Long, B.H.1    Balasubramanian, B.N.2
  • 79
    • 0031787528 scopus 로고    scopus 로고
    • Expression of DNA topoisomerase I, DNA topoisomerase II-D and p53 in metastatic malignant melanoma
    • Lynch BJ, Komaromy-Hiller G, Bronstein IB, Holden JA (1998) Expression of DNA topoisomerase I, DNA topoisomerase II-D and p53 in metastatic malignant melanoma. Hum Pathol 29:1240-1245
    • (1998) Hum Pathol , vol.29 , pp. 1240-1245
    • Lynch, B.J.1    Komaromy-hiller, G.2    Bronstein, I.B.3    Holden, J.A.4
  • 81
    • 0034635958 scopus 로고    scopus 로고
    • SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage
    • Mao Y, Sun M, Desai SD, Liu LF (2000) SUMO-1 conjugation to topoisomerase I: a possible repair response to topoisomerase-mediated DNA damage. Proc Natl Acad Sci USA 97:4046-4051
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4046-4051
    • Mao, Y.1    Sun, M.2    Desai, S.D.3    Liu, L.F.4
  • 82
  • 83
    • 33644970269 scopus 로고    scopus 로고
    • A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex
    • Marchand C, Antony S, Kohn KW, Cushman M, Ioanoviciu A, Staker BL, Burgin AB, Stewart L, Pommier Y (2006) A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex. Mol Cancer Ther 5:287-295
    • (2006) Mol Cancer Ther , vol.5 , pp. 287-295
    • Marchand, C.1    Antony, S.2    Kohn, K.W.3    Cushman, M.4    Ioanoviciu, A.5    Staker, B.L.6    Burgin, A.B.7    Stewart, L.8    Pommier, Y.9
  • 84
    • 5144226837 scopus 로고    scopus 로고
    • A predictive model of human myelotoxicity using five camptothecin derivatives and the in vitro colony-forming unit granulocyte/macrophage assay
    • Masubuchi N (2004) A predictive model of human myelotoxicity using five camptothecin derivatives and the in vitro colony-forming unit granulocyte/macrophage assay. Clin Cancer Res 10:6722-6731
    • (2004) Clin Cancer Res , vol.10 , pp. 6722-6731
    • Masubuchi, N.1
  • 86
    • 0015291595 scopus 로고
    • Phase II study of camptothecin (NSC 100880) in the treatment of advanced gastrointestinal cancer
    • Moertel CG, Schutt AJ, Reitemeier RJ, Hahn RG (1972) Phase II study of camptothecin (NSC 100880) in the treatment of advanced gastrointestinal cancer. Cancer Chemo Rep 56:95-101
    • (1972) Cancer Chemo Rep , vol.56 , pp. 95-101
    • Moertel, C.G.1    Schutt, A.J.2    Reitemeier, R.J.3    Hahn, R.G.4
  • 88
    • 33845955224 scopus 로고    scopus 로고
    • A systematic study of nityrated indenoisoquinolines reveals a potent topoiosmerase I inhibitor
    • Morrell A, Antony S, Kohlhagen G, Pommier Y, Cushman M (2006) A systematic study of nityrated indenoisoquinolines reveals a potent topoiosmerase I inhibitor. J Med Chem 49:7740-7753
    • (2006) J Med Chem , vol.49 , pp. 7740-7753
    • Morrell, A.1    Antony, S.2    Kohlhagen, G.3    Pommier, Y.4    Cushman, M.5
  • 89
    • 34247613433 scopus 로고    scopus 로고
    • Investigation of the lactam side chain length necessary for optimal indenoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures
    • Morrell A, Placzek MS, Steffen JD, Antony S, Agama K, Pommier Y, Cushman M (2007) Investigation of the lactam side chain length necessary for optimal indenoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures. J Med Chem 50:2040-2048
    • (2007) J Med Chem , vol.50 , pp. 2040-2048
    • Morrell, A.1    Placzek, M.S.2    Steffen, J.D.3    Antony, S.4    Agama, K.5    Pommier, Y.6    Cushman, M.7
  • 94
    • 0029847080 scopus 로고    scopus 로고
    • Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA
    • Nitiss JL, Wang JC (1996) Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA. Mol Pharmaol 50:1095-1102
    • (1996) Mol Pharmaol , vol.50 , pp. 1095-1102
    • Nitiss, J.L.1    Wang, J.C.2
  • 95
    • 0025933514 scopus 로고
    • S-Phase population analysis does not correlate with the cytotoxicity of camptothecin and 10,11-methylene-dooxycamptothecin in human colon carcinoma HT-29 cells
    • O'Connor PM, Nieves-Neira W, Kerrigan D et al (1991) S-Phase population analysis does not correlate with the cytotoxicity of camptothecin and 10,11-methylene-dooxycamptothecin in human colon carcinoma HT-29 cells. Cancer Commun 3:233-240
    • (1991) Cancer Commun , vol.3 , pp. 233-240
    • O'Connor, P.M.1    Nieves-neira, W.2    Kerrigan, D.3
  • 97
    • 32144450806 scopus 로고    scopus 로고
    • Sensitization to gimatecan-induced apoptosis by tumor necrosis factor-related apoptosis inducing ligand in prostate carcinoma cells
    • Perego P, Ciusani E, Gatti L, Carenini N, Corna E, Zunino F (2006) Sensitization to gimatecan-induced apoptosis by tumor necrosis factor-related apoptosis inducing ligand in prostate carcinoma cells. Biochem Pharm 71:791-798
    • (2006) Biochem Pharm , vol.71 , pp. 791-798
    • Perego, P.1    Ciusani, E.2    Gatti, L.3    Carenini, N.4    Corna, E.5    Zunino, F.6
  • 99
    • 2642515148 scopus 로고    scopus 로고
    • Phase II trials of J-107088, a non-camptothecin topoisomerase I inhibitor, in irinotecan naïve/refractory metastatic colorectal cancer
    • abstr 632
    • Perez RP, Hurwitz HI, Nahum K, Lee J, Shiba D, Garcia M et al (2002) Phase II trials of J-107088, a non-camptothecin topoisomerase I inhibitor, in irinotecan naïve/refractory metastatic colorectal cancer. Proc Am Soc Clin Oncol 21:abstr 632
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Perez, R.P.1    Hurwitz, H.I.2    Nahum, K.3    Lee, J.4    Shiba, D.5    Garcia, M.6
  • 100
    • 10744231168 scopus 로고    scopus 로고
    • Application of the CFU-GM assay to predict acute drug-induced neutropenia: An international blind trial tovalidate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics
    • Pessina A (2003) Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial tovalidate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics. Toxicological Sciences 75:355-367
    • (2003) Toxicological Sciences , vol.75 , pp. 355-367
    • Pessina, A.1
  • 101
    • 0028677817 scopus 로고
    • Mechanisms of topoisomerase I inhibition by anticancer drugs
    • Liu, L.F.; Academic Press: New York
    • Pommier Y, Tanizawa A, Kohn KW (1994) Mechanisms of topoisomerase I inhibition by anticancer drugs. In Advances in Pharmacology; Liu, L.F.; Academic Press: New York, 29B, 73-92
    • (1994) Advances in Pharmacology , vol.29 B , pp. 73-92
    • Pommier, Y.1    Tanizawa, A.2    Kohn, K.W.3
  • 103
    • 67650682519 scopus 로고    scopus 로고
    • DNA topoisomerase I inhibitors: Chemistry, biology and interfacial inhibition
    • Pommier Y (2009) DNA topoisomerase I inhibitors: chemistry, biology and interfacial inhibition. Chem Rev 109:2894-2902
    • (2009) Chem Rev , vol.109 , pp. 2894-2902
    • Pommier, Y.1
  • 104
    • 33749034730 scopus 로고    scopus 로고
    • Topoisomerase I inhibitors: Camptothecins and beyond
    • Pommier Y (2006) Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer 6:789-802
    • (2006) Nat Rev Cancer , vol.6 , pp. 789-802
    • Pommier, Y.1
  • 105
    • 66849113688 scopus 로고    scopus 로고
    • The indenoisoquinoline non-camptothecin topoisomerase I inhibitors: Update and perspectives
    • Pommier Y, Cushman M (2009) The indenoisoquinoline non-camptothecin topoisomerase I inhibitors: update and perspectives. Molec Cancer Therap 8: 1008-1014
    • (2009) Molec Cancer Therap , vol.8 , pp. 1008-1014
    • Pommier, Y.1    Cushman, M.2
  • 106
    • 0032189683 scopus 로고    scopus 로고
    • Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme
    • Pommier Y, Pourquier P, Fan Y, Strumberg D (1998) Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme. Biochem Biophys Acta 1400:83-105
    • (1998) Biochem Biophys Acta , vol.1400 , pp. 83-105
    • Pommier, Y.1    Pourquier, P.2    Fan, Y.3    Strumberg, D.4
  • 108
    • 77954187741 scopus 로고    scopus 로고
    • DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
    • Pommier Y, Leo E, Zhang HL, Marchand C (2010) DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem Biol 17:421-33
    • (2010) Chem Biol , vol.17 , pp. 421-433
    • Pommier, Y.1    Leo, E.2    Zhang, H.L.3    Marchand, C.4
  • 110
    • 43749124409 scopus 로고    scopus 로고
    • Utilization of genomic signatures to direct use of primary chemotherapy
    • Potti A, Nevins JR (2008) Utilization of genomic signatures to direct use of primary chemotherapy. Curr Opin Genet Develop 18:62-67
    • (2008) Curr Opin Genet Develop , vol.18 , pp. 62-67
    • Potti, A.1    Nevins, J.R.2
  • 111
    • 0024469050 scopus 로고
    • The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I
    • Porter SE, Champoux JJ (1989) The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I. Nuc Acids Res 17:8521-8532
    • (1989) Nuc Acids Res , vol.17 , pp. 8521-8532
    • Porter, S.E.1    Champoux, J.J.2
  • 112
    • 0024578495 scopus 로고
    • DNA supercoiling and prokaryotic transcription
    • Pruss GJ, Drlica K (1989) DNA supercoiling and prokaryotic transcription. Cell 56:521-523
    • (1989) Cell , vol.56 , pp. 521-523
    • Pruss, G.J.1    Drlica, K.2
  • 113
    • 0033813050 scopus 로고    scopus 로고
    • Insights into the pharmacokinetics and pharmacodynamics of irinotecan
    • Ratain MJ (2000) Insights into the pharmacokinetics and pharmacodynamics of irinotecan. Clin Cancer Res 6:3393-3394
    • (2000) Clin Cancer Res , vol.6 , pp. 3393-3394
    • Ratain, M.J.1
  • 114
    • 0036138777 scopus 로고    scopus 로고
    • Irinotecan dosing: Does the CPT in CPT-11 stand for "Can't predict toxicity"?
    • Ratain MJ (2002) Irinotecan dosing: does the CPT in CPT-11 stand for "Can't predict toxicity"? J Clin Oncol 20:7-8
    • (2002) J Clin Oncol , vol.20 , pp. 7-8
    • Ratain, M.J.1
  • 116
    • 13444291906 scopus 로고    scopus 로고
    • 5-(2-aminothyl) dibenzo[c,h]naphthyridin-6-ones: Variation of N-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance
    • Ruchelman AL, Houghton PJ, Zhou N, Liu AA, Liu LF, LaVoie EJ (2005) 5-(2-aminothyl) dibenzo[c,h]naphthyridin-6-ones: variation of N-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance. J Med Chem 48:792-804
    • (2005) J Med Chem , vol.48 , pp. 792-804
    • Ruchelman, A.L.1    Houghton, P.J.2    Zhou, N.3    Liu, A.A.4    Liu, L.F.5    LaVoie, E.J.6
  • 117
    • 0037131728 scopus 로고    scopus 로고
    • Diaza- and triazachrysenes: Potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft MDA-MB-435
    • Ruchelman AL, Singh SK, Wu XH, Ray A, Yang JM, Li TK, Liu AA, Liu LF, LaVoie EJ (2002) Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft MDA-MB-435. Bioog Med Chem Lett 12:3333-3336
    • (2002) Bioog Med Chem Lett , vol.12 , pp. 3333-3336
    • Ruchelman, A.L.1    Singh, S.K.2    Wu, X.H.3    Ray, A.4    Yang, J.M.5    Li, T.K.6    Liu, A.A.7    Liu, L.F.8    LaVoie, E.J.9
  • 118
  • 119
    • 5144223304 scopus 로고    scopus 로고
    • Dimethoxybenzo[i]phenanthri-dine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity
    • Ruchelman AL, Zhu S, Zhou N, Liu AA, Liu LF, LaVoie EJ (2004) Dimethoxybenzo[i]phenanthri-dine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity. Biorg Med Chem Lett 14:5585-5589
    • (2004) Biorg Med Chem Lett , vol.14 , pp. 5585-5589
    • Ruchelman, A.L.1    Zhu, S.2    Zhou, N.3    Liu, A.A.4    Liu, L.F.5    LaVoie, E.J.6
  • 120
    • 49149111130 scopus 로고    scopus 로고
    • Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino) ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC31)
    • Satyanarayana M, Feng W, Cheng L, Liu AA, Tsai YC, Liu LF, LaVoie EJ (2008) Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino) ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC31). Bioorg Med Chem 16:7824-7831
    • (2008) Bioorg Med Chem , vol.16 , pp. 7824-7831
    • Satyanarayana, M.1    Feng, W.2    Cheng, L.3    Liu, A.A.4    Tsai, Y.C.5    Liu, L.F.6    LaVoie, E.J.7
  • 124
    • 34248579748 scopus 로고    scopus 로고
    • The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
    • Stracker TH, Morales M, Couto SS, Hussein H, Petrini JHJ (2007) The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature 447:218-221
    • (2007) Nature , vol.447 , pp. 218-221
    • Stracker, T.H.1    Morales, M.2    Couto, S.S.3    Hussein, H.4    Petrini, J.H.J.5
  • 126
    • 0023614833 scopus 로고
    • Camptothecin-induced in vivo induced topoisomerase cleavages in the transcriptionally active tyrosine aminotransferase gene
    • Stewart AF, Schutz G (1987) Camptothecin-induced in vivo induced topoisomerase cleavages in the transcriptionally active tyrosine aminotransferase gene. Cell 50:1109-1117
    • (1987) Cell , vol.50 , pp. 1109-1117
    • Stewart, A.F.1    Schutz, G.2
  • 128
    • 0018958519 scopus 로고
    • Terminal stages of SV40 DNA replication proceed via multiply intertwined catenated dimers
    • Sundin O, Varshavsky A (1980) Terminal stages of SV40 DNA replication proceed via multiply intertwined catenated dimers. Cell 21:103-114
    • (1980) Cell , vol.21 , pp. 103-114
    • Sundin, O.1    Varshavsky, A.2
  • 129
    • 0019417775 scopus 로고
    • Arrest of segregation leads to accumulation of highly intertwined catenated dimers
    • Sundin O, Varshavsky A (1981) Arrest of segregation leads to accumulation of highly intertwined catenated dimers. Cell 25:659-669
    • (1981) Cell , vol.25 , pp. 659-669
    • Sundin, O.1    Varshavsky, A.2
  • 130
    • 37549071516 scopus 로고    scopus 로고
    • Novel E-ring campotethecin keto analogues 9S38809 and S39625 are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters
    • Takagi K, Dexheimer TS, Redon C, Sordet O, Agama K, Lavielle G, Pierre A, Bates SE, Pommier Y (2007) Novel E-ring campotethecin keto analogues 9S38809 and S39625 are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters. Mol Cancer Therap 6: 3229-3238
    • (2007) Mol Cancer Therap , vol.6 , pp. 3229-3238
    • Takagi, K.1    Dexheimer, T.S.2    Redon, C.3    Sordet, O.4    Agama, K.5    Lavielle, G.6    Pierre, A.7    Bates, S.E.8    Pommier, Y.9
  • 131
    • 33749028012 scopus 로고    scopus 로고
    • Defective Mre-1-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks
    • Takemura H, Rao VA, Sordet O, Furuta T, Miao Z-H, Meng LH, Zhang H, Pommier Y (2006) Defective Mre-1-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. J Biol Chem 41:30814-30823
    • (2006) J Biol Chem , vol.41 , pp. 30814-30823
    • Takemura, H.1    Rao, V.A.2    Sordet, O.3    Furuta, T.4    Miao, Z.-H.5    Meng, L.H.6    Zhang, H.7    Pommier, Y.8
  • 132
    • 33645744463 scopus 로고    scopus 로고
    • Phase I dose-finding study and a pharmacokinetic/pharmacodynamic analysis of the neutropenic response of intravenous diflomotecan in patients with advanced malignant tumors
    • Troconiz IF, Garrido MJ, Segura C, Cendros J-M, Principe P, Peraire C, Obach R (2006) Phase I dose-finding study and a pharmacokinetic/pharmacodynamic analysis of the neutropenic response of intravenous diflomotecan in patients with advanced malignant tumors. Cancer Chemother Pharmacol 57:727-735
    • (2006) Cancer Chemother Pharmacol , vol.57 , pp. 727-735
    • Troconiz, I.F.1    Garrido, M.J.2    Segura, C.3    Cendros, J.-M.4    Principe, P.5    Peraire, C.6    Obach, R.7
  • 133
    • 0026625512 scopus 로고
    • The involvement of active DNA synthesis in camptothecin-induced G2 arrest: Altered regulation of p34cdc2/cyclin B
    • Tsao YP, D'Arpa P, Liu LF (1992) The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2/cyclin B. Cancer Res 52:1823-1829
    • (1992) Cancer Res , vol.52 , pp. 1823-1829
    • Tsao, Y.P.1    D'Arpa, P.2    Liu, L.F.3
  • 134
    • 0019332581 scopus 로고
    • Covalent bonds between protein and DNA: Formation of phosphotyrosine linkage between certain DNA topoisomerases and DNA
    • Tse-Dinh Y-C, Kirkegaard K, Wang JC (1980) Covalent bonds between protein and DNA: Formation of phosphotyrosine linkage between certain DNA topoisomerases and DNA. J Biol Chem 255:5560-5565
    • (1980) J Biol Chem , vol.255 , pp. 5560-5565
    • Tse-dinh, Y.-C.1    Kirkegaard, K.2    Wang, J.C.3
  • 135
    • 0035863393 scopus 로고    scopus 로고
    • Use of campthecin-resistant mammalian cell lines to evaluate the role of topoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site
    • Urasaki Y, Laco G, Takebayashi Y, Bailly C, Kohlhagen G, Pommier Y (2001) Use of campthecin-resistant mammalian cell lines to evaluate the role of topoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site. Cancer Res 61:504-508
    • (2001) Cancer Res , vol.61 , pp. 504-508
    • Urasaki, Y.1    Laco, G.2    Takebayashi, Y.3    Bailly, C.4    Kohlhagen, G.5    Pommier, Y.6
  • 136
    • 0034548379 scopus 로고    scopus 로고
    • Activity of a novel camptothecin analogue, homocamptothecin, in camptothecin-resistant cell lines with topoisomerase I alterations
    • Urasaki Y, Takebayashi Y, Pommier Y (2000) Activity of a novel camptothecin analogue, homocamptothecin, in camptothecin-resistant cell lines with topoisomerase I alterations. Cancer Res 60:6577-6580
    • (2000) Cancer Res , vol.60 , pp. 6577-6580
    • Urasaki, Y.1    Takebayashi, Y.2    Pommier, Y.3
  • 137
    • 85028609645 scopus 로고    scopus 로고
    • The topoisomerase I inhibitor gimatecan exhibits synergistic antitumor activity in combination with imatinib mesylate and everolimus against malignant glioma xenografts
    • abstr 2073
    • Vassal G, Hamelin N, Opolon P, Versace R, Geoerger B (2008) The topoisomerase I inhibitor gimatecan exhibits synergistic antitumor activity in combination with imatinib mesylate and everolimus against malignant glioma xenografts. J Clin Oncol 26 suppl:abstr 2073
    • (2008) J Clin Oncol , vol.26
    • Vassal, G.1    Hamelin, N.2    Opolon, P.3    Versace, R.4    Geoerger, B.5
  • 138
    • 0028719174 scopus 로고
    • DNA Topoisomerases as targets of therapeutics: An overview
    • Liu, L.F.; Academic Press: New York
    • Wang JC (1994) DNA Topoisomerases as targets of therapeutics: An overview. In Advances in Pharmacology, vol 29A; Liu, L.F.; Academic Press: New York, pp 1-19
    • (1994) Advances in Pharmacology , vol.29 A , pp. 1-19
    • Wang, J.C.1
  • 139
    • 67650713925 scopus 로고    scopus 로고
    • A journey in the world of DNA rings and beyond
    • Wang JC (2009) A journey in the world of DNA rings and beyond. Annu Rev Biochem 78:31-54
    • (2009) Annu Rev Biochem , vol.78 , pp. 31-54
    • Wang, J.C.1
  • 140
    • 70450237538 scopus 로고    scopus 로고
    • Untangling the Double Helix
    • Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Wang JC (2009) Untangling the Double Helix. DNA Entanglement and the Action of the DNA Topoisomerases, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 245 pp
    • (2009) DNA Entanglement and the Action of the DNA Topoisomerases , pp. 245
    • Wang, J.C.1
  • 141
    • 0025800372 scopus 로고
    • DNA topoisomerases: Why so many?
    • Wang JC (1991) DNA topoisomerases: why so many? J Biol Chem 266:6659-6662
    • (1991) J Biol Chem , vol.266 , pp. 6659-6662
    • Wang, J.C.1
  • 142
    • 0021891888 scopus 로고
    • DNA topoisomerases
    • Wang JC (1985) DNA topoisomerases. Ann Rev Biochem 54:665-697
    • (1985) Ann Rev Biochem , vol.54 , pp. 665-697
    • Wang, J.C.1
  • 143
    • 0024997668 scopus 로고
    • The role of DNA topoisomerases in recombination and genome stability: A double-edged sword?
    • Wang JC, Caron PR, Kim RA (1990) The role of DNA topoisomerases in recombination and genome stability: A double-edged sword? Cell 62:403-406
    • (1990) Cell , vol.62 , pp. 403-406
    • Wang, J.C.1    Caron, P.R.2    Kim, R.A.3
  • 145
    • 0028896166 scopus 로고
    • Camptothecin and taxol: Discovery to clinic - thirteenth Bruce F
    • Wall ME, Wani MC (1995) Camptothecin and taxol: discovery to clinic - thirteenth Bruce F. Cain Memorial Award lecture. Cancer Res 55:753-760
    • (1995) Cain Memorial Award lecture. Cancer Res , vol.55 , pp. 753-760
    • Wall, M.E.1    Wani, M.C.2
  • 147
    • 33750856861 scopus 로고    scopus 로고
    • Connecting genes, drugs and disease
    • Weinstein JN, Pommier Y (2006) Connecting genes, drugs and disease. Nature Biotech 24:1365-1366
    • (2006) Nature Biotech , vol.24 , pp. 1365-1366
    • Weinstein, J.N.1    Pommier, Y.2
  • 149
    • 85028595769 scopus 로고    scopus 로고
    • Clinical pharmacokinetics (PK) of two oral dosing schedules of gimatecan in a phase I study: Implications for safety and efficacy
    • abstr 2512
    • Woo MM, Zhang J, Rocha F, Fandi A, Schran HF (2008) Clinical pharmacokinetics (PK) of two oral dosing schedules of gimatecan in a phase I study: implications for safety and efficacy. J Clin Oncol 26 suppl:abstr 2512
    • (2008) J Clin Oncol , vol.26
    • Woo, M.M.1    Zhang, J.2    Rocha, F.3    Fandi, A.4    Schran, H.F.5
  • 152
    • 85028588775 scopus 로고    scopus 로고
    • Pharmacokinetics (PK) of edotecarin (J-107088), a topoismerase I inhibitor, in patients with metastatic breast cancer (mBC) or glioblastoma (GBM)
    • abstr 2073
    • Yin D, Toler S, Guo F, Duncan B, Sharma A (2005) Pharmacokinetics (PK) of edotecarin (J-107088), a topoismerase I inhibitor, in patients with metastatic breast cancer (mBC) or glioblastoma (GBM). J Clin Soc 23 suppl:abstr 2073
    • (2005) J Clin Soc , vol.23
    • Yin, D.1    Toler, S.2    Guo, F.3    Duncan, B.4    Sharma, A.5
  • 153
    • 0016423038 scopus 로고
    • Preparation and antileukemic activity of some alkoxybenzo[c] phenanthridinium salts and corresponding dihydro derivatives
    • Zee-Cheng KY, Cheng CC (1975) Preparation and antileukemic activity of some alkoxybenzo[c] phenanthridinium salts and corresponding dihydro derivatives. J Med Chem 18:66-71
    • (1975) J Med Chem , vol.18 , pp. 66-71
    • Zee-cheng, K.Y.1    Cheng, C.C.2
  • 154
    • 0023958908 scopus 로고
    • Involvement of DNA topoisomerase I in the transcription of human ribosomal RNA genes
    • Zhang H, Wang JC, Liu LF (1988) Involvement of DNA topoisomerase I in the transcription of human ribosomal RNA genes. Proc Natl Acad Sci USA 85:1060-1064
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 1060-1064
    • Zhang, H.1    Wang, J.C.2    Liu, L.F.3
  • 155
    • 27644546583 scopus 로고    scopus 로고
    • Esters and amides of 2,3-dim-ethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents
    • Zhu S, Ruchelman AL, Zhou N, Liu AA, Liu LF, LaVoie EJ (2005) Esters and amides of 2,3-dim-ethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: potent cytotoxic and topoisomerase I-targeting agents. Bioorg Med Chem 13:6782-6794
    • (2005) Bioorg Med Chem , vol.13 , pp. 6782-6794
    • Zhu, S.1    Ruchelman, A.L.2    Zhou, N.3    Liu, A.A.4    Liu, L.F.5    LaVoie, E.J.6
  • 156
    • 33644987261 scopus 로고    scopus 로고
    • 6-Substituted 6H-dibenzo[c,h] [2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity
    • Zhu S, Ruchelman AL, Zhou N, Liu AA, Liu LF, LaVoie EJ (2006) 6-Substituted 6H-dibenzo[c,h] [2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity. Bioorg Med Chem 14:3131-3143
    • (2006) Bioorg Med Chem , vol.14 , pp. 3131-3143
    • Zhu, S.1    Ruchelman, A.L.2    Zhou, N.3    Liu, A.A.4    Liu, L.F.5    LaVoie, E.J.6


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