Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 20, 2008, Pages 9295-9301

  Feng, Wei ^a   Satyanarayana, Mavurapu ^a   Cheng, Liang ^a   Liu, Angela ^b   Tsai, Yuan Chin ^b   Liu, Leroy F ^b,c   LaVoie, Edmond J ^a,c  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Antitumor; Cytotoxicity; MDA MB 435; Non camptothecin; Structure activity; Topoisomerase I

Indexed keywords

ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE INHIBITOR; NAPHTHYRIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN;

ALKYLATION; AMINES; ANTINEOPLASTIC AGENTS; BENZENE; CELL LINE, TUMOR; CELL SURVIVAL; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; NAPHTHYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 53249087738     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.002     Document Type: Article

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